Advanced search
Publication Cover
International Journal of Chronic Obstructive Pulmonary Disease Volume 15, 2020 - Issue
Submit an article Journal homepage
156
Views
4
CrossRef citations to date
0
Altmetric
Study Protocol

Prevention of Acute Exacerbation in Subjects with Moderate-to-very Severe COPD by Modulating Lower Respiratory Microbiome: Protocol of a Prospective, Multicenter, Randomized Controlled Trial

Jian-lan HuaDepartment of Pulmonary and Critical Care Medicine, Zhongshan Hospital, Shanghai Medical College, Fudan University, Shanghai, People’s Republic of China
,
Wei-ping HuDepartment of Pulmonary and Critical Care Medicine, Zhongshan Hospital, Shanghai Medical College, Fudan University, Shanghai, People’s Republic of ChinaORCID Iconhttps://orcid.org/0000-0002-2432-5876
ORCID Icon,
Yi-hui ZuoDepartment of Pulmonary and Critical Care Medicine, Zhongshan Hospital, Shanghai Medical College, Fudan University, Shanghai, People’s Republic of China
&
Jing ZhangDepartment of Pulmonary and Critical Care Medicine, Zhongshan Hospital, Shanghai Medical College, Fudan University, Shanghai, People’s Republic of ChinaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0001-5305-6233
ORCID Icon
Pages 2985-2990 | Published online: 17 Nov 2020

References

  • MacNeeW. Pathogenesis of chronic obstructive pulmonary disease. Clin Chest Med. 2007;28(3):479–513. doi:10.1016/j.ccm.2007.06.00817720039
  • RosenbaumL, LamasD. Facing a “Slow-Motion Disaster” — the UN Meeting on Noncommunicable Diseases. N Engl J Med. 2011;365(25):2345–2348. doi:10.1056/NEJMp111223522087629
  • WangC, XuJ, YangL, et al. Prevalence and risk factors of chronic obstructive pulmonary disease in China (the China Pulmonary Health [CPH] study): a national cross-sectional study. Lancet. 2018;391(10131):1706–1717. doi:10.1016/S0140-6736(18)30841-929650248
  • CaiBQ, CaiSX, ChenRC, et al. Expert consensus on acute exacerbation of chronic obstructive pulmonary disease in the People’s Republic of China. Int J Chron Obstruct Pulmon Dis. 2014;9:381–395.24812503
  • SethiS, MurphyTF. Infection in the pathogenesis and course of chronic obstructive pulmonary disease. N Engl J Med. 2008;359(22):2355–2365. doi:10.1056/NEJMra080035319038881
  • MatkovicZ, MiravitllesM. Chronic bronchial infection in COPD. Is there an infective phenotype? Respir Med. 2013;107(1):10–22. doi:10.1016/j.rmed.2012.10.02423218452
  • WilkinsonTMA, PatelIS, WilksM, DonaldsonGC, WedzichaJA. Airway Bacterial Load and FEV 1 Decline in Patients with Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med. 2003;167(8):1090–1095. doi:10.1164/rccm.200210-1179OC12684248
  • SethiS. Infectious etiology of acute exacerbations of chronic bronchitis. Chest. 2000;117(Suppl 5):380s–385s. doi:10.1378/chest.117.5_suppl_2.380S10843981
  • MiravitllesM, AnzuetoA. Chronic Respiratory Infection in Patients with Chronic Obstructive Pulmonary Disease: what Is the Role of Antibiotics? Int J Mol Sci. 2010;45(7):7. doi:10.3390/ijms18071344
  • MaX, CuiJ, WangJ, et al. Multicentre investigation of pathogenic bacteria and antibiotic resistance genes in Chinese patients with acute exacerbation of chronic obstructive pulmonary disease. J Int Med Res. 2015;43(5):699–710. doi:10.1177/030006051558757726152913
  • LinY-L, JanR-L, Chen-H-H, WangJ-Y. Randomized placebo-controlled trial of lactobacillus on asthmatic children with allergic rhinitis. Pediatr Pulmonol. 2010;45(11):1111–1120. doi:10.1002/ppul.2129620658483
  • AlexandreY, Le BlayG, Boisrame-GastrinS, et al. Probiotics: a new way to fight bacterial pulmonary infections? Med Mal Infect. 2014;44(1):9–17. doi:10.1016/j.medmal.2013.05.00123820129
  • Lopez-CamposJL, Soler-CatalunaJJ, MiravitllesM. Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Lung Disease 2019 Report: future Challenges. Arch Bronconeumol. 2019;201.
  • WeinreichUM, KorsgaardJ. Bacterial colonisation of lower airways in health and chronic lung disease. Clin Respir J. 2008;2(2):116–122. doi:10.1111/j.1752-699X.2008.00048.x20298316
  • SethiS, SethiR, EschbergerK, et al. Airway bacterial concentrations and exacerbations of chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2007;176(4):356–361. doi:10.1164/rccm.200703-417OC17478618
  • TaylorAE, Finney-HaywardTK, QuintJK, et al. Defective macrophage phagocytosis of bacteria in COPD. Eur Respir J. 2010;35(5):1039–1047. doi:10.1183/09031936.0003670919897561
  • HeZY, OuLM, ZhangJQ, et al. Effect of 6 months of erythromycin treatment on inflammatory cells in induced sputum and exacerbations in chronic obstructive pulmonary disease. Respir Int Rev Thoracic Dis. 2010;80(6):445–452.
  • AlbertRK, ConnettJ, BaileyWC, et al. Azithromycin for prevention of exacerbations of COPD. N Engl J Med. 2011;365(8):689–698. doi:10.1056/NEJMoa110462321864166
  • Montserrat-CapdevilaJ, GodoyP, MarsalJ-R, CruzI, SolanesM. Efectividad de la vacunación antigripal para evitar el ingreso hospitalario por agudización de la enfermedad pulmonar obstructiva crónica. Enfermedades Infecciosas y Microbiología Clínica. 2014;32(2):70–75. doi:10.1016/j.eimc.2013.02.00923582192
  • Figueira-GonçalvesJM, Bethencourt-MartinN, Perez-MendezLI, et al. Impact of 13-valent pneumococcal conjugate polysaccharide vaccination in exacerbations rate of COPD patients with moderate to severe obstruction. Revista espanola de quimioterapia. 2017;30(4):269–275.28585796

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.