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International Journal of Chronic Obstructive Pulmonary Disease Volume 16, 2021 - Issue
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Original Research

The Impact of Exacerbation History on the Safety and Efficacy of Aclidinium in Patients with Chronic Obstructive Pulmonary Disease and Increased Cardiovascular Risk: ASCENT-COPD Trial

Robert A Wise1 Medicine, Pulmonary and Critical Care, Johns Hopkins University School of Medicine, Baltimore, MD, USACorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-8353-2349View further author information
ORCID Icon,
Kenneth R Chapman2 Department of Medicine, University of Toronto, Toronto, ON, CanadaORCID Iconhttps://orcid.org/0000-0002-2498-9859View further author information
ORCID Icon,
Benjamin M Scirica3 Cardiovascular Division, Brigham and Women’s Hospital, Boston, MA, USA;4 Department of Medicine, Harvard Medical School, Boston, MA, USAView further author information
,
Sami Z Daoud5 Late-Stage Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, USAView further author information
,
Dan Lythgoe6 Statistics, Phastar, Chiswick, London, UKORCID Iconhttps://orcid.org/0000-0002-4682-772XView further author information
ORCID Icon &
Esther Garcia-Gil7 Respiratory & Immunology, BioPharmaceuticals Medical, AstraZeneca, Barcelona, SpainView further author information
Pages 689-699 | Published online: 18 Mar 2021

References

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  • Wise RA, Chapman KR, Scirica BM, et al. Effect of aclidinium bromide on major cardiovascular events and exacerbations in high-risk patients with chronic obstructive pulmonary disease: the ASCENT-COPD randomized clinical trial. JAMA. 2019;321(17):1693–1701. doi:10.1001/jama.2019.4973
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  • Wise RA, Chapman KR, Scirica BM, et al. Long-term evaluation of the effects of aclidinium bromide on major adverse cardiovascular events and COPD exacerbations in patients with moderate to very severe COPD: rationale and design of the ASCENT COPD study. Chronic Obstr Pulm Dis. 2018;5(1):5–15.
  • Halpin DMG, Tashkin DP, Celli BR, Leimer I, Metzdorf N, Decramer M. Effect of tiotropium on outcomes in patients with COPD, categorized using the new GOLD Grading System: results of the UPLIFT(R) Randomized controlled trial. Chronic Obstr Pulm Dis. 2015;2(3):236–251.
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