Inspiratory Flow Parameters Through Dry Powder Inhalers in Healthy Volunteers and Patients with Chronic Obstructive Pulmonary Disease (COPD): Device Resistance Does Not Limit Use in COPD

References

• Singh D, Agusti A, Anzueto A, et al. Global strategy for the diagnosis, management, and prevention of chronic obstructive lung disease: the GOLD science committee report 2019. Eur Respir J. 2019;53(5):1900164. doi:10.1183/13993003.00164-2019
   PubMed Web of Science ®Google Scholar
• Lopez-Campos JL, Soler-Cataluna JJ, Miravitlles M. Global strategy for the diagnosis, management, and prevention of chronic obstructive lung disease 2019 report: future challenges. Arch Bronconeumol. 2020;56(2):65–67. doi:10.1016/j.arbres.2019.06.001
   PubMed Web of Science ®Google Scholar
• Keating GM. Tiotropium bromide inhalation powder: a review of its use in the management of chronic obstructive pulmonary disease. Drugs. 2012;72(2):273–300. doi:10.2165/11208620-000000000-00000
   PubMed Web of Science ®Google Scholar
• Lavorini F. Easyhaler((R)): an overview of an inhaler device for day-to-day use in patients with asthma and chronic obstructive pulmonary disease. Drugs Context. 2019;8:212596. doi:10.7573/dic.212596
   PubMedGoogle Scholar
• Lavorini F. Inhaled drug delivery in the hands of the patient. J Aerosol Med Pulm Drug Deliv. 2014;27(6):414–418. doi:10.1089/jamp.2014.1132
   PubMed Web of Science ®Google Scholar
• Lavorini F, Fontana GA. Inhaler technique and patient’s preference for dry powder inhaler devices. Expert Opin Drug Deliv. 2014;11(1):1–3. doi:10.1517/17425247.2014.846907
   PubMed Web of Science ®Google Scholar
• Haughney J, Lee AJ, McKnight E, Pertsovskaya I, O’Driscoll M, Usmani OS. Peak inspiratory flow measured at different inhaler resistances in patients with Asthma. J Allergy Clin Immunol Pract. 2020.
   Web of Science ®Google Scholar
• Vincken W, Levy ML, Scullion J, Usmani OS, Dekhuijzen PNR, Corrigan CJ. Spacer devices for inhaled therapy: why use them, and how? ERJ Open Res. 2018;4(2):00065–2018. doi:10.1183/23120541.00065-2018
   PubMedGoogle Scholar
• Lavorini F, Pistolesi M, Usmani OS. Recent advances in capsule-based dry powder inhaler technology. Multidiscip Respir Med. 2017;12:11. doi:10.1186/s40248-017-0092-5
   PubMed Web of Science ®Google Scholar
• Laube BL, Janssens HM, de Jongh FH, et al. What the pulmonary specialist should know about the new inhalation therapies. Eur Respir J. 2011;37(6):1308–1331. doi:10.1183/09031936.00166410
   PubMed Web of Science ®Google Scholar
• Boehringer Ingelheim Limited. Spiriva 18 microgram inhalation powder, hard capsule; 2019. Available from: https://www.medicines.org.uk/emc/product/1693/smpc. Accessed April 7, 2021.
   Google Scholar
• Delvadia R, Hindle M, Longest PW, Byron PR. In vitro tests for aerosol deposition II: IVIVCs for different dry powder inhalers in normal adults. J Aerosol Med Pulm Drug Deliv. 2013;26(3):138–144. doi:10.1089/jamp.2012.0975
   PubMed Web of Science ®Google Scholar
• Malmberg LP, Rytila P, Happonen P, Haahtela T. Inspiratory flows through dry powder inhaler in chronic obstructive pulmonary disease: age and gender rather than severity matters. Int J Chron Obstruct Pulmon Dis. 2010;5:257–262. doi:10.2147/COPD.S11474
   PubMedGoogle Scholar
• Vestbo J, Hurd SS, Agusti AG, et al. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. Am J Respir Crit Care Med. 2013;187(4):347–365. doi:10.1164/rccm.201204-0596PP
   PubMed Web of Science ®Google Scholar
• Jogi R, Lahelma S, Vahteristo M, Happonen A, Haikarainen J. In vitro flow rate dependency of delivered dose and fine particle dose of salmeterol/fluticasone propionate easyhaler and seretide diskus with patient flow rates collected in a randomized controlled trial. J Aerosol Med Pulm Drug Deliv. 2019;32(2):88–98. doi:10.1089/jamp.2018.1463
   PubMed Web of Science ®Google Scholar
• Malmberg LP, Everard ML, Haikarainen J, Lahelma S. Evaluation of in vitro and in vivo flow rate dependency of budesonide/formoterol Easyhaler(R). J Aerosol Med Pulm Drug Deliv. 2014;27(5):329–340. doi:10.1089/jamp.2013.1099
   PubMed Web of Science ®Google Scholar
• Altman P, Wehbe L, Dederichs J, et al. Comparison of peak inspiratory flow rate via the Breezhaler(R), Ellipta(R) and HandiHaler(R) dry powder inhalers in patients with moderate to very severe COPD: a randomized cross-over trial. BMC Pulm Med. 2018;18(1):100. doi:10.1186/s12890-018-0662-0
   PubMedGoogle Scholar
• Chapman KR, Fogarty CM, Peckitt C, et al. Delivery characteristics and patients’ handling of two single-dose dry-powder inhalers used in COPD. Int J Chron Obstruct Pulmon Dis. 2011;6:353–363. doi:10.2147/COPD.S18529
   PubMed Web of Science ®Google Scholar
• Levy ML, Carroll W, Izquierdo Alonso JL, Keller C, Lavorini F, Lehtimaki L. Understanding dry powder inhalers: key technical and patient preference attributes. Adv Ther. 2019;36(10):2547–2557. doi:10.1007/s12325-019-01066-6
   PubMed Web of Science ®Google Scholar
• Molimard M, Colthorpe P. Inhaler devices for chronic obstructive pulmonary disease: insights from patients and healthcare practitioners. J Aerosol Med Pulm Drug Deliv. 2015;28(3):219–228. doi:10.1089/jamp.2014.1142
   PubMed Web of Science ®Google Scholar
• Chrystyn H, van der Palen J, Sharma R, et al. Device errors in asthma and COPD: systematic literature review and meta-analysis. NPJ Prim Care Respir Med. 2017;27(1):22. doi:10.1038/s41533-017-0016-z
   PubMed Web of Science ®Google Scholar
• Melani AS, Bonavia M, Cilenti V, et al. Inhaler mishandling remains common in real life and is associated with reduced disease control. Respir Med. 2011;105(6):930–938. doi:10.1016/j.rmed.2011.01.005
   PubMed Web of Science ®Google Scholar
• Pothirat C, Chaiwong W, Phetsuk N, Pisalthanapuna S, Chetsadaphan N, Choomuang W. Evaluating inhaler use technique in COPD patients. Int J Chron Obstruct Pulmon Dis. 2015;10:1291–1298. doi:10.2147/COPD.S85681
   PubMed Web of Science ®Google Scholar
• Sriram KB, Percival M. Suboptimal inhaler medication adherence and incorrect technique are common among chronic obstructive pulmonary disease patients. Chron Respir Dis. 2016;13(1):13–22. doi:10.1177/1479972315606313
   PubMed Web of Science ®Google Scholar
• Sandler N, Hollander J, Langstrom D, Santtila P, Saukkonen A, Torvinen S. Evaluation of inhaler handling-errors, inhaler perception and preference with Spiromax, Easyhaler and Turbuhaler devices among healthy Finnish volunteers: a single site, single visit crossover study (Finhaler). BMJ Open Respir Res. 2016;3(1):e000119. doi:10.1136/bmjresp-2015-000119
   PubMed Web of Science ®Google Scholar