Advanced search
Publication Cover
International Journal of Chronic Obstructive Pulmonary Disease Volume 17, 2022 - Issue
Submit an article Journal homepage
119
Views
2
CrossRef citations to date
0
Altmetric
Original Research

Differential Outcomes Following 4 Weeks of Aclidinium/Formoterol in Patients with COPD: A Reanalysis of the ACTIVATE Study

Maud Koopman1 Department of Research and Development, CIRO+, Center of Expertise for Chronic Organ Failure, Horn, the Netherlands;2 NUTRIM, School of Nutrition and Translational Research in Metabolism, Faculty of Health, Medicine and Life Sciences, Maastricht, the Netherlands;3 Department of Respiratory Medicine, Maastricht University Medical Center (MUMC+), Maastricht, the NetherlandsCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0003-3306-5479View further author information
ORCID Icon,
Frits M E Franssen1 Department of Research and Development, CIRO+, Center of Expertise for Chronic Organ Failure, Horn, the Netherlands;2 NUTRIM, School of Nutrition and Translational Research in Metabolism, Faculty of Health, Medicine and Life Sciences, Maastricht, the Netherlands;3 Department of Respiratory Medicine, Maastricht University Medical Center (MUMC+), Maastricht, the NetherlandsORCID Iconhttps://orcid.org/0000-0002-1633-6356View further author information
ORCID Icon,
Swetlana Gaffron4 Viscovery Software GmbH, Vienna, AustriaView further author information
,
Henrik Watz5 Pulmonary Research Institute at LungenClinic Grosshansdorf, Airway Research Center North (ARCN), Member of the German Center for Lung Research (DZL), Grosshansdorf, GermanyView further author information
,
Thierry Troosters6 Department of Rehabilitation Sciences, KU Leuven – University of Leuven, Leuven, Belgium;7 Department of Respiratory Diseases, University Hospitals Leuven, Leuven, BelgiumView further author information
,
Judith Garcia-Aymerich8 Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain;9 Universitat Pompeu Fabra (UPF), Barcelona, Spain;10 CIBER Epidemiología y Salud Publica (CIBERESP), Madrid, SpainORCID Iconhttps://orcid.org/0000-0002-7097-4586View further author information
ORCID Icon,
Pierluigi Paggiaro11 Department of Surgery, Medicine, Molecular Biology and Critical Care, University of Pisa, Pisa, ItalyView further author information
,
Eduard Molins12 AstraZeneca, Barcelona, SpainView further author information
,
Miguel Moya12 AstraZeneca, Barcelona, SpainView further author information
,
Lindy van Burk13 AstraZeneca, Den Haag, the NetherlandsView further author information
,
Dieter Maier14 Biomax Informatics AB, Planegg, 82152, GermanyView further author information
,
Esther Garcia Gil12 AstraZeneca, Barcelona, SpainView further author information
,
Emiel F M Wouters1 Department of Research and Development, CIRO+, Center of Expertise for Chronic Organ Failure, Horn, the Netherlands;3 Department of Respiratory Medicine, Maastricht University Medical Center (MUMC+), Maastricht, the Netherlands;15 Ludwig Boltzmann Institute for Lung Health, Vienna, AustriaView further author information
,
Lowie E G W Vanfleteren16 COPD Center, Sahlgrenska University Hospital, Institute of Medicine, University of Gothenburg, Gothenburg, SwedenORCID Iconhttps://orcid.org/0000-0002-4387-4096View further author information
ORCID Icon &
Martijn A Spruit1 Department of Research and Development, CIRO+, Center of Expertise for Chronic Organ Failure, Horn, the Netherlands;2 NUTRIM, School of Nutrition and Translational Research in Metabolism, Faculty of Health, Medicine and Life Sciences, Maastricht, the Netherlands;3 Department of Respiratory Medicine, Maastricht University Medical Center (MUMC+), Maastricht, the NetherlandsORCID Iconhttps://orcid.org/0000-0003-3822-7430View further author information
ORCID Icon show all
Pages 517-533 | Published online: 08 Mar 2022

References

  • Vogelmeier CF, Criner GJ, Martinez FJ, et al. Global strategy for the diagnosis, management, and prevention of chronic obstructive lung disease 2017 Report: GOLD executive summary. Eur Respir J. 2017;49(3):1700214. PubMed PMID: 28182564. doi:10.1183/13993003.00214-2017
  • O’Donnell DE, Casaburi R, Vincken W, et al. Effect of indacaterol on exercise endurance and lung hyperinflation in COPD. Respir Med. 2011;105(7):1030–1036. PubMed PMID: 21498063. doi:10.1016/j.rmed.2011.03.014
  • Troosters T, Sciurba FC, Decramer M, et al. Tiotropium in patients with moderate COPD naive to maintenance therapy: a randomised placebo-controlled trial. NPJ Prim Care Respir Med. 2014;24(1):14003. PubMed PMID: 24841833; PMCID: PMC4373257. doi:10.1038/npjpcrm.2014.3
  • Beeh KM, Watz H, Puente-Maestu L, et al. Aclidinium improves exercise endurance, dyspnea, lung hyperinflation, and physical activity in patients with COPD: a randomized, placebo-controlled, crossover trial. BMC Pulm Med. 2014;14(1):209. PubMed PMID: 25539654; PMCID: PMC4364572. doi:10.1186/1471-2466-14-209
  • Ni H, Moe S, Soe Z, Myint KT, Viswanathan KN. Combined Aclidinium bromide and long-acting beta2-agonist for chronic obstructive pulmonary disease (COPD). Cochrane Database Syst Rev PubMed PMID: 30536566; PMCID: PMC6517126. 2018;12:CD011594. doi:10.1002/14651858.CD011594.pub2
  • Maltais F, Hamilton A, Marciniuk D, et al. Improvements in symptom-limited exercise performance over 8 h with once-daily tiotropium in patients with COPD. Chest. 2005;128(3):1168–1178. PubMed PMID: 16162703. doi:10.1378/chest.128.3.1168
  • Beeh KM, Singh D, Di Scala L, Drollmann A. Once-daily NVA237 improves exercise tolerance from the first dose in patients with COPD: the GLOW3 trial. Int J Chron Obstruct Pulmon Dis PubMed PMID: 22973092; PMCID: PMC3430121. 2012;7:503–513. doi:10.2147/COPD.S32451
  • Di Marco F, Sotgiu G, Santus P, et al. Long-acting bronchodilators improve exercise capacity in COPD patients: a systematic review and meta-analysis. Respir Res. 2018;19(1):18. PubMed PMID: 29368604; PMCID: PMC5784692. doi:10.1186/s12931-018-0721-3
  • Watz H, Troosters T, Beeh KM, et al. ACTIVATE: the effect of Aclidinium/formoterol on hyperinflation, exercise capacity, and physical activity in patients with COPD. Int J Chron Obstruct Pulmon Dis PubMed PMID: 28883722; PMCID: PMC5574699. 2017;12:2545–2558. doi:10.2147/COPD.S143488
  • Wedzicha JA, Banerji D, Chapman KR, et al. Indacaterol-Glycopyrronium versus Salmeterol-Fluticasone for COPD. N Engl J Med. 2016;374(23):2222–2234. PubMed PMID: 27181606. doi:10.1056/NEJMoa1516385
  • Watz H, Krippner F, Kirsten A, Magnussen H, Vogelmeier C. Indacaterol improves lung hyperinflation and physical activity in patients with moderate chronic obstructive pulmonary disease–a randomized, multicenter, double-blind, placebo-controlled study. BMC Pulm Med. 2014;14(1):158. PubMed PMID: 25280934; PMCID: PMC4197315. doi:10.1186/1471-2466-14-158
  • Watz H, Mailander C, Baier M, Kirsten A. Effects of indacaterol/glycopyrronium (QVA149) on lung hyperinflation and physical activity in patients with moderate to severe COPD: a randomised, placebo-controlled, crossover study (The MOVE Study). BMC Pulm Med. 2016;16(1):95. PubMed PMID: 27301417; PMCID: PMC4908762. doi:10.1186/s12890-016-0256-7
  • O’Donnell DE, Fluge T, Gerken F, et al. Effects of tiotropium on lung hyperinflation, dyspnoea and exercise tolerance in COPD. Eur Respir J. 2004;23(6):832–840. PubMed PMID: 15218994. doi:10.1183/09031936.04.00116004
  • Troosters T, Maltais F, Leidy N, et al. Effect of bronchodilation, exercise training, and behavior modification on symptoms and physical activity in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2018;198(8):1021–1032. PubMed PMID: 29664681. doi:10.1164/rccm.201706-1288OC
  • Augustin IML, Wouters EFM, Houben-Wilke S, et al. Comprehensive lung function assessment does not allow to infer response to pulmonary rehabilitation in patients with COPD. J Clin Med. 2018;8(1):27. PubMed PMID: 30591662. doi:10.3390/jcm8010027
  • Augustin IML, Spruit MA, Houben-Wilke S, et al. The respiratory physiome: clustering based on a comprehensive lung function assessment in patients with COPD. PLoS One. 2018;13(9):e0201593. PubMed PMID: 30208035; PMCID: PMC6135389 (SCO115406). doi:10.1371/journal.pone.0201593
  • Spruit MA, Augustin IM, Vanfleteren LE, et al. Differential response to pulmonary rehabilitation in COPD: multidimensional profiling. Eur Respir J. 2015;46(6):1625–1635. PubMed PMID: 26453626. doi:10.1183/13993003.00350-2015
  • Naya IP, Tombs L, Muellerova H, Compton C, Jones PW. Long-term outcomes following first short-term clinically important deterioration in COPD. Respir Res. 2018;19(1):222. PubMed PMID: 30453972; PMCID: PMC6245880. doi:10.1186/s12931-018-0928-3
  • Kostikas K, Greulich T, Mackay AJ, et al. Treatment response in COPD: does FEV1 say it all? A post hoc analysis of the CRYSTAL study. ERJ Open Res. 2019;5(1):00243–2018. PubMed PMID: 30815470; PMCID: PMC6387992. doi:10.1183/23120541.00243-2018
  • Spruit MA, Singh SJ, Garvey C, et al. An official American Thoracic Society/European Respiratory Society statement: key concepts and advances in pulmonary rehabilitation. Am J Respir Crit Care Med. 2013;188(8):e13–64. PubMed PMID: 24127811. doi:10.1164/rccm.201309-1634ST
  • Wanger J, Clausen JL, Coates A, et al. Standardisation of the measurement of lung volumes. Eur Respir J. 2005;26(3):511–522. PubMed PMID: 16135736. doi:10.1183/09031936.05.00035005
  • Coates AL, Peslin R, Rodenstein D, Stocks J. Measurement of lung volumes by plethysmography. Eur Respir J. 1997;10(6):1415–1427. PubMed PMID: 9192953. doi:10.1183/09031936.97.10061415
  • Miller MR, Hankinson J, Brusasco V, et al. Standardisation of spirometry. Eur Respir J. 2005;26(2):319–338. PubMed PMID: 16055882. doi:10.1183/09031936.05.00034805
  • Gimeno-Santos E, Raste Y, Demeyer H, et al. The PROactive instruments to measure physical activity in patients with chronic obstructive pulmonary disease. Eur Respir J. 2015;46(4):988–1000. PubMed PMID: 26022965; PMCID: PMC4589432. doi:10.1183/09031936.00183014
  • Watz H, Waschki B, Meyer T, Magnussen H. Physical activity in patients with COPD. Eur Respir J. 2009;33(2):262–272. PubMed PMID: 19010994. doi:10.1183/09031936.00024608
  • Kohonen T. 3.1 A Qualitative Introduction to the SOM and 3.2 The Original Incremental SOM Algorithm. In: Self-Organizing Maps. Springer; 2001: 106–115.
  • Oja E, Kaski S, Eds. Kohonen Maps. Elsevier Science B.V.; 1999.
  • Bhatt SP, Soler X, Wang X, et al. Association between functional small airway disease and FEV1 decline in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2016;194(2):178–184. PubMed PMID: 26808615; PMCID: PMC5003216. doi:10.1164/rccm.201511-2219OC
  • Maltais F, Celli B, Casaburi R, et al. Aclidinium bromide improves exercise endurance and lung hyperinflation in patients with moderate to severe COPD. Respir Med. 2011;105(4):580–587. PubMed PMID: 21183326. doi:10.1016/j.rmed.2010.11.019
  • Jones PW, Rennard SI, Agusti A, et al. Efficacy and safety of once-daily Aclidinium in chronic obstructive pulmonary disease. Respir Res. 2011;12(1):55. PubMed PMID: 21518460; PMCID: PMC3098801. doi:10.1186/1465-9921-12-55
  • Burge PS, Calverley PM, Jones PW, Spencer S, Anderson JA. Prednisolone response in patients with chronic obstructive pulmonary disease: results from the ISOLDE study. Thorax. 2003;58(8):654–658. PubMed PMID: 12885977; PMCID: PMC1746769. doi:10.1136/thorax.58.8.654
  • Jones PW, Donohue JF, Nedelman J, Pascoe S, Pinault G, Lassen C. Correlating changes in lung function with patient outcomes in chronic obstructive pulmonary disease: a pooled analysis. Respir Res. 2011;12(1):161. PubMed PMID: 22206353; PMCID: PMC3287973. doi:10.1186/1465-9921-12-161
  • Bhatt SP, Wells JM, Kim V, et al. Radiological correlates and clinical implications of the paradoxical lung function response to beta(2) agonists: an observational study. Lancet Respir Med. 2014;2(11):911–918. PubMed PMID: 25217076; PMCID: PMC4306040. doi:10.1016/S2213-2600(14)70185-7
  • Rossi A, Aisanov Z, Avdeev S, et al. Mechanisms, assessment and therapeutic implications of lung hyperinflation in COPD. Respir Med. 2015;109(7):785–802. PubMed PMID: 25892293. doi:10.1016/j.rmed.2015.03.010
  • O’Donnell DE, Forkert L, Webb KA. Evaluation of bronchodilator responses in patients with “irreversible” emphysema. Eur Respir J. 2001;18(6):914–920. PubMed PMID: 11829096. doi:10.1183/09031936.01.00216501
  • Schermer T, Heijdra Y, Zadel S, et al. Flow and volume responses after routine salbutamol reversibility testing in mild to very severe COPD. Respir Med. 2007;101(6):1355–1362. PubMed PMID: 17098407. doi:10.1016/j.rmed.2006.09.024
  • Kosteli MC, Heneghan NR, Roskell C, et al. Barriers and enablers of physical activity engagement for patients with COPD in primary care. Int J Chron Obstruct Pulmon Dis. 2017;12:1019–1031. PubMed PMID: 28405162; PMCID: PMC5378459. doi:10.2147/COPD.S119806
  • Wilson T, Holt T, Greenhalgh T. Complexity science: complexity and clinical care. BMJ. 2001;323(7314):685–688. PubMed PMID: 11566836; PMCID: PMC1121241. doi:10.1136/bmj.323.7314.685
  • Sulaiman I, Cushen B, Greene G, et al. Objective assessment of adherence to inhalers by patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2017;195(10):1333–1343. PubMed PMID: 27409253. doi:10.1164/rccm.201604-0733OC

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.