Clinical Features and Outcomes of Acute Exacerbation in Chronic Obstructive Pulmonary Disease Patients with Pulmonary Heart Disease: A Multicenter Observational Study

References

• Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease 2021 report. Available from: https://goldcopd.org/2021-gold-reports/. Accessed October 8, 2021.
   Google Scholar
• Global and regional estimates of COPD prevalence: systematic review and meta-analysis - PubMed [Internet]; [ cited June 16, 2021]. Available from: https://pubmed.ncbi.nlm.nih.gov/26755942/. Accessed October 8, 2021.
   Google Scholar
• World Health Organization. Projections of mortality and causes of death, 2016 and 2060. Available from: http://www.who.int/healthinfo/global_burden_disease/projections/en/. Accessed October, 2020.
   Google Scholar
• Wang C, Xu J, Yang L, et al. Prevalence and risk factors of chronic obstructive pulmonary disease in China (the China Pulmonary Health [CPH] study): a national cross-sectional study. Lancet. 2018;391(10131):1706–1717. doi:10.1016/S0140-6736(18)30841-9
   PubMed Web of Science ®Google Scholar
• Zhou M, Wang H, Zhu J, et al. Cause-specific mortality for 240 causes in China during 1990–2013: a systematic subnational analysis for the Global Burden of Disease Study 2013. Lancet. 2016;387(10015):251–272. doi:10.1016/S0140-6736(15)00551-6
   PubMed Web of Science ®Google Scholar
• Washko GR, Nardelli P, Ash SY, et al. Arterial vascular pruning, right ventricular size, and clinical outcomes in Chronic Obstructive Pulmonary Disease. A longitudinal observational study. Am J Respir Crit Care Med. 2019;200(4):454–461. doi:10.1164/rccm.201811-2063OC
   PubMed Web of Science ®Google Scholar
• Medrek SK, Sharafkhaneh A, Spiegelman AM, et al. Admission for COPD exacerbation is associated with the clinical diagnosis of pulmonary hypertension: results from a retrospective longitudinal study of a Veteran population. COPD. 2017;14(5):484–489. doi:10.1080/15412555.2017.1336209
   PubMedGoogle Scholar
• Roversi S, Fabbri LM, Sin DD, et al. Chronic Obstructive Pulmonary Disease and cardiac diseases. an urgent need for integrated care. Am J Respir Crit Care Med. 2016;194(11):1319–1336. doi:10.1164/rccm.201604-0690SO
   PubMed Web of Science ®Google Scholar
• Pei Z, Sun Y, Wang S, et al. Estimating mortality among inpatients with acute exacerbation of chronic obstructive pulmonary disease using registry data. Npj Prim Care Respir Med. 2020;30(1):28. doi:10.1038/s41533-020-0186-y
   PubMed Web of Science ®Google Scholar
• Ge J, Xu Y. Internal Medicine. 8th ed. China: People’s Medical Publishing House; March, 2013:113.
   Google Scholar
• Jones PW, Harding G, Berry P, et al. Development and first validation of the COPD assessment test. Eur Respir J. 2009;34(3):648–654. doi:10.1183/09031936.00102509
   PubMed Web of Science ®Google Scholar
• Cheng S-L, Lin C-H, Wang -C-C, et al. Comparison between COPD Assessment Test (CAT) and modified Medical Research Council (mMRC) dyspnea scores for evaluation of clinical symptoms, comorbidities and medical resources utilization in COPD patients. J Formos Med Assoc. 2019;118(1):429–435. doi:10.1016/j.jfma.2018.06.018
   PubMed Web of Science ®Google Scholar
• Liang C, Mao X, Niu H, et al. Characteristics, management and in-hospital clinical outcomes among inpatients with acute exacerbation of Chronic Obstructive Pulmonary Disease in China: results from the phase I data of ACURE study. Int J Chron Obstruct Pulmon Dis. 2021;16:451–465. doi:10.2147/COPD.S281957
   PubMed Web of Science ®Google Scholar
• Weitzenblum E. Chronic cor pulmonale. Heart. 2003;89(2):225–230. doi:10.1136/heart.89.2.225
   PubMed Web of Science ®Google Scholar
• Shujaat A, Minkin R, Eden E. Pulmonary hypertension and chronic cor pulmonale in COPD. Int J Chron Obstruct Pulmon Dis. 2007;2:273–282.
   PubMedGoogle Scholar
• Opitz I, Ulrich S. Pulmonary hypertension in chronic obstructive pulmonary disease and emphysema patients: prevalence, therapeutic options and pulmonary circulatory effects of lung volume reduction surgery. J Thorac Dis. 2018;10(S23):S2763–74. doi:10.21037/jtd.2018.07.63
   PubMedGoogle Scholar
• Cuttica MJ, Kalhan R, Shlobin OA, et al. Categorization and impact of pulmonary hypertension in patients with advanced COPD. Respir Med. 2010;104(12):1877–1882. doi:10.1016/j.rmed.2010.05.009
   PubMed Web of Science ®Google Scholar
• Naeije R. Pulmonary hypertension and right heart failure in chronic obstructive pulmonary disease. Proc Am Thorac Soc. 2005;2(1):20–22. doi:10.1513/pats.200407-037MS
   PubMedGoogle Scholar
• NICE Guideline Updates Team (UK). Managing Pulmonary Hypertension and Cor Pulmonale: Chronic Obstructive Pulmonary Disease in Over 16s: Diagnosis and Management: Evidence Review a [Internet]. London: National Institute for Health and Care Excellence (UK); 2018 [ cited June 17, 2021]. Available from: http://www.ncbi.nlm.nih.gov/books/NBK560180/. Accessed October 8, 2021.
   Google Scholar
• Lu Q, Gottlieb E, Rounds S. Effects of cigarette smoke on pulmonary endothelial cells. Am J Physiol Lung Cell Mol Physiol. 2018;314(5):L743–56. doi:10.1152/ajplung.00373.2017
   PubMed Web of Science ®Google Scholar
• Wright J, Levy R, Churg A. Pulmonary hypertension in chronic obstructive pulmonary disease: current theories of pathogenesis and their implications for treatment. Thorax. 2005;60(7):605–609. doi:10.1136/thx.2005.042994
   PubMed Web of Science ®Google Scholar
• Wright JL, Zhou S, Churg A. Pulmonary hypertension and vascular oxidative damage in cigarette smoke exposed eNOS(-/-) mice and human smokers. Inhal Toxicol. 2012;24(11):732–740. doi:10.3109/08958378.2012.715698
   PubMed Web of Science ®Google Scholar
• Soumagne T, Guillien A, Roche N, et al. In patients with mild-to-moderate COPD, tobacco smoking, and not COPD, is associated with a higher risk of cardiovascular comorbidity. Int J Chron Obstruct Pulmon Dis. 2020;15:1545–1555. doi:10.2147/COPD.S253417
   PubMed Web of Science ®Google Scholar
• Piccari L, Del Pozo R, Blanco I, et al. Association between systemic and pulmonary vascular dysfunction in COPD. Int J Chron Obstruct Pulmon Dis. 2020;15:2037–2047. doi:10.2147/COPD.S257679
   PubMed Web of Science ®Google Scholar
• Martínez-García MA, de la Rosa Carrillo D, Soler-Cataluña JJ, et al. Prognostic value of bronchiectasis in patients with moderate-to-severe chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2013;187(8):823–831. doi:10.1164/rccm.201208-1518OC
   PubMed Web of Science ®Google Scholar
• Putcha N, Drummond MB, Wise RA, et al. Comorbidities and Chronic Obstructive Pulmonary Disease: prevalence, influence on outcomes, and management. Semin Respir Crit Care Med. 2015;36(04):575–591. doi:10.1055/s-0035-1556063
   PubMedGoogle Scholar
• Kaushal M, Shah PS, Shah AD, et al. Chronic obstructive pulmonary disease and cardiac comorbidities: a cross-sectional study. Lung India. 2016;33(4):404–409. doi:10.4103/0970-2113.184874
   PubMedGoogle Scholar
• Buklioska-Ilievska D, Minov J, Kochovska-Kamchevska N, et al. Cardiovascular comorbidity in patients with Chronic Obstructive Pulmonary Disease: echocardiography changes and their relation to the level of airflow limitation. Open Access Maced J Med Sci. 2019;7(21):3568–3573. doi:10.3889/oamjms.2019.848
   PubMedGoogle Scholar
• Soriano JB, Lamprecht B, Ramírez AS, et al. Mortality prediction in chronic obstructive pulmonary disease comparing the GOLD 2007 and 2011 staging systems: a pooled analysis of individual patient data. Lancet Respir Med. 2015;3(6):443–450. doi:10.1016/S2213-2600(15)00157-5
   PubMed Web of Science ®Google Scholar
• Blanco I, Tura-Ceide O, Peinado VI, et al. Updated perspectives on pulmonary hypertension in COPD. Int J Chron Obstruct Pulmon Dis. 2020;15:1315–1324. doi:10.2147/COPD.S211841
   PubMed Web of Science ®Google Scholar
• Sakao S. Chronic obstructive pulmonary disease and the early stage of cor pulmonale: a perspective in treatment with pulmonary arterial hypertension-approved drugs. Respir Investig. 2019;57(4):325–329. doi:10.1016/j.resinv.2019.03.013
   PubMed Web of Science ®Google Scholar
• Branson RD. Oxygen therapy in COPD. Respir Care. 2018;63(6):734–748. doi:10.4187/respcare.06312
   PubMed Web of Science ®Google Scholar
• Jennings JH, Thavarajah K, Mendez MP, et al. Predischarge bundle for patients with acute exacerbations of COPD to reduce readmissions and ED visits: a randomized controlled trial. Chest. 2015;147(5):1227–1234. doi:10.1378/chest.14-1123
   PubMed Web of Science ®Google Scholar
• Hunter LC, Lee RJ, Butcher I, et al. Patient characteristics associated with risk of first hospital admission and readmission for acute exacerbation of chronic obstructive pulmonary disease (COPD) following primary care COPD diagnosis: a cohort study using linked electronic patient records. BMJ Open. 2016;6(1):e009121. doi:10.1136/bmjopen-2015-009121
   PubMed Web of Science ®Google Scholar
• Jiang X, Xiao H, Segal R, Mobley WC, Park H. Trends in readmission rates, hospital charges, and mortality for patients with Chronic Obstructive Pulmonary Disease (COPD) in Florida from 2009 to 2014. Clin Ther. 2018;40(4):613–626.e1. doi:10.1016/j.clinthera.2018.03.006
   PubMed Web of Science ®Google Scholar
• Alqahtani JS, Aquilina J, Bafadhel M, et al. Research priorities for exacerbations of COPD. Lancet Respir Med. 2021;9(8):824–826. doi:10.1016/S2213-2600(21)00227-7
   PubMed Web of Science ®Google Scholar
• Rowan SC, Keane MP, Gaine S, et al. Hypoxic pulmonary hypertension in chronic lung diseases: novel vasoconstrictor pathways. Lancet Respir Med. 2016;4(3):225–236. doi:10.1016/S2213-2600(15)00517-2
   PubMed Web of Science ®Google Scholar
• Alajaji W, Baydoun A, Al-Kindi SG, et al. Digoxin therapy for cor pulmonale: a systematic review. Int J Cardiol. 2016;223:320–324. doi:10.1016/j.ijcard.2016.08.018
   PubMed Web of Science ®Google Scholar
• Sperrin M, Webb DJ, Patel P, et al. Chronic obstructive pulmonary disease exacerbation episodes derived from electronic health record data validated using clinical trial data. Pharmacoepidemiol Drug Saf. 2019;28(10):1369–1376. doi:10.1002/pds.4883
   PubMed Web of Science ®Google Scholar
• Qiu J, Guo Y, Xu X, et al. Ginkgo leaf extract and dipyridamole injection for chronic cor pulmonale: a PRISMA-compliant meta-analysis of randomized controlled trials. Biosci Rep. 2020;40(3):BSR20200099. doi:10.1042/BSR20200099
   PubMedGoogle Scholar
• Seeger W, Adir Y, Barberà JA, et al. Pulmonary hypertension in chronic lung diseases. J Am Coll Cardiol. 2013;62(25):D109–D116. doi:10.1016/j.jacc.2013.10.036
   PubMed Web of Science ®Google Scholar
• Mandoli GE, Sciaccaluga C, Bandera F, et al. Cor pulmonale: the role of traditional and advanced echocardiography in the acute and chronic settings. Heart Fail Rev. 2021;26(2):263–275. doi:10.1007/s10741-020-10014-4
   PubMed Web of Science ®Google Scholar
• Hilde JM, Skjørten I, Grøtta OJ, et al. Right ventricular dysfunction and remodeling in chronic obstructive pulmonary disease without pulmonary hypertension. J Am Coll Cardiol. 2013;62(12):1103–1111. doi:10.1016/j.jacc.2013.04.091
   PubMed Web of Science ®Google Scholar