124
Views
3
CrossRef citations to date
0
Altmetric
Expert Opinion

Overcoming Therapeutic Inertia to Reduce the Risk of COPD Exacerbations: Four Action Points for Healthcare Professionals

, , ORCID Icon, ORCID Icon & ORCID Icon
Pages 3009-3016 | Published online: 01 Nov 2021

References

  • Suissa S, Dell’Aniello S, Ernst P. Long-term natural history of chronic obstructive pulmonary disease: severe exacerbations and mortality. Thorax. 2012;67(11):957–963. doi:10.1136/thoraxjnl-2011-201518
  • Hurst JR, Vestbo J, Anzueto A, et al. Susceptibility to exacerbation in chronic obstructive pulmonary disease. NEJM. 2010;363(12):1128–1138. doi:10.1056/NEJMoa0909883
  • Rothnie KJ, Müllerová H, Smeeth L, Quint JK. Natural history of chronic obstructive pulmonary disease exacerbations in a general practice-based population with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2018;198(4):464–471. doi:10.1164/rccm.201710-2029OC
  • Hillas G, Perlikos F, Tzanakis N. Acute exacerbation of COPD: is it the “stroke of the lungs”? Int J Chron Obstruct Pulmon Dis. 2016;11:1579–1586. doi:10.2147/COPD.S106160
  • Ko FW, Chan KP, Hui DS, et al. Acute exacerbation of COPD. Respirology. 2016;21(7):1152–1165. doi:10.1111/resp.12780
  • Kim JK, Lee SH, Lee BH, et al. Factors associated with exacerbation in mild- to-moderate COPD patients. Int J Chron Obstruct Pulmon Dis. 2016;11:1327–1333. doi:10.2147/COPD.S105583
  • Müllerová H, Shukla A, Hawkins A, Quint J. Risk factors for acute exacerbations of COPD in a primary care population: a retrospective observational cohort study. BMJ Open. 2014;4(12):e006171. doi:10.1136/bmjopen-2014-006171
  • Andreas S, Taube C. Inhaled therapy reduces COPD mortality. ERJ Open Res. 2020;6(4):00634–02020. doi:10.1183/23120541.00634-2020
  • Han MK, Quibrera PM, Carretta EE, et al. Frequency of exacerbations in patients with chronic obstructive pulmonary disease: an analysis of the SPIROMICS cohort. Lancet Respir Med. 2017;5(8):619–626. doi:10.1016/s2213-2600(17)30207-2
  • Merinopoulou E, Raluy-Callado M, Ramagopalan S, MacLachlan S, Khalid JM. COPD exacerbations by disease severity in England. Int J Chron Obstruct Pulmon Dis. 2016;11:697–709. doi:10.2147/copd.s100250
  • Donaldson GC, Seemungal TA, Bhowmik A, Wedzicha JA. Relationship between exacerbation frequency and lung function decline in chronic obstructive pulmonary disease. Thorax. 2002;57(10):847–852. doi:10.1136/thorax.57.10.847
  • Kerkhof M, Voorham J, Dorinsky P, et al. The long-term burden of COPD exacerbations during maintenance therapy and lung function decline. Int J Chron Obstruct Pulmon Dis. 2020;15:1909–1918. doi:10.2147/copd.s253812
  • Hurst JR, Donaldson GC, Quint JK, Goldring JJP, Baghai-Ravary R, Wedzicha JA. Temporal clustering of exacerbations in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2009;179(5):369–374. doi:10.1164/rccm.200807-1067OC
  • Baker CL, Zou KH, Su J. Risk assessment of readmissions following an initial COPD-related hospitalization. Int J Chron Obstruct Pulmon Dis. 2013;8:551–559. doi:10.2147/copd.s51507
  • Milne RJ, Beasley R. Hospital admissions for chronic obstructive pulmonary disease in New Zealand. N Z Med J. 2015;128(1408):23–35.
  • Harries TH, Thornton H, Crichton S, Schofield P, Gilkes A, White PT. Hospital readmissions for COPD: a retrospective longitudinal study. NPJ Prim Care Respir Med. 2017;27(1):31. doi:10.1038/s41533-017-0028-8
  • Hurst J, Shanahan L, Imoedemhe E, et al.; National Asthma and Chronic Obstructive Pulmonary Disease Audit Programme (NACAP). Outcomes of patients included in the 2017/18 COPD clinical audit (patients with COPD exacerbations discharged from acute hospitals in England and Wales between September 2017 and September 2018). Audit report. London: Royal College of Physicians; 2020. Available from: https://www.nacap.org.uk/nacap/welcome.nsf/vwFiles/NACAP-COPD-SC-202007a/$File/NACAP_COPD_SC_Outcomes_2017-18_Report_290620.pdf?openelement. Accessed September 17, 2020.
  • Soler-Cataluña JJ, Martínez-García MÁ, Sánchez LS, Tordera MP, Sánchez PR. Severe exacerbations and BODE index: two independent risk factors for death in male COPD patients. Resp Med. 2009;103(5):692–699. doi:10.1016/j.rmed.2008.12.005
  • Global Initiative for Chronic Obstructive Lung Disease. 2021 global strategy for prevention, diagnosis and management of COPD. Available from: https://goldcopd.org/2021-gold-reports/. Accessed December 18, 2020.
  • Chen X, Wang N, Chen Y, Xiao T, Fu C, Xu B. Costs of chronic obstructive pulmonary disease in urban areas of China: a cross-sectional study in four cities. Int J Chron Obstruct Pulmon Dis. 2016;11:2625–2632. doi:10.2147/COPD.S118523
  • Nishimura S, Zaher C. Cost impact of COPD in Japan: opportunities and challenges? Respirology. 2004;9(4):466–473. doi:10.1111/j.1440-1843.2004.00617.x
  • Seemungal TA, Donaldson GC, Paul EA, Bestall JC, Jeffries DJ, Wedzicha JA. Effect of exacerbation on quality of life in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 1998;157(5 Pt 1):1418–1422. doi:10.1164/ajrccm.157.5.9709032
  • Vijayasaratha K, Stockley RA. Reported and unreported exacerbations of COPD: analysis by diary cards. Chest. 2008;133(1):34–41. doi:10.1378/chest.07-1692
  • Wilkinson TMA, Donaldson GC, Hurst JR, Seemungal TAR, Wedzicha JA. Early therapy improves outcomes of exacerbations of chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2004;169(12):1298–1303. doi:10.1164/rccm.200310-1443OC
  • Leidy NK, Murray LT, Jones P, Sethi S. Performance of the EXAcerbations of chronic pulmonary disease tool patient-reported outcome measure in three clinical trials of chronic obstructive pulmonary disease. Ann Am Thorac Soc. 2014;11(3):316–325. doi:10.1513/AnnalsATS.201309-305OC
  • Jones PW, Lamarca R, Chuecos F, et al. Characterisation and impact of reported and unreported exacerbations: results from ATTAIN. Eur Respir J. 2014;44(5):1156–1165. doi:10.1183/09031936.00038814
  • Xu W, Collet JP, Shapiro S, et al. Negative impacts of unreported COPD exacerbations on health-related quality of life at 1 year. Eur Resp J. 2010;35(5):1022–1030. doi:10.1183/09031936.00079409
  • Langsetmo L, Platt RW, Ernst P, Bourbeau J. Underreporting exacerbation of chronic obstructive pulmonary disease in a longitudinal cohort. Am J Respir Crit Care Med. 2008;177(4):396–401. doi:10.1164/rccm.200708-1290OC
  • Price D, West D, Brusselle G, et al. Management of COPD in the UK primary-care setting: an analysis of real-life prescribing patterns. Int J Chron Obstruct Pulmon Dis. 2014;9:889–904. doi:10.2147/COPD.S62750
  • Albitar HAH, Iyer VN. Adherence to Global Initiative for Chronic Obstructive Lung Disease guidelines in the real world: current understanding, barriers, and solutions. Curr Opin Pulm Med. 2020;26(2):149–154. doi:10.1097/MCP.0000000000000655
  • Worth H, Buhl R, Criee CP, Kardos P, Mailander C, Vogelmeier C. The ‘real-life’ COPD patient in Germany: the DACCORD study. Respir Med. 2016;111:64–71. doi:10.1016/j.rmed.2015.12.010
  • Tabyshova A, Hurst JR, Soriano JB. Gaps in COPD guidelines of low- and middle-income countries: a systematic scoping review. Chest. 2021;159(2):575–584. doi:10.1016/j.chest.2020.09.260
  • Khunti K, Davies MJ. Clinical inertia-time to reappraise the terminology? Prim Care Diabetes. 2017;11(2):105–106. doi:10.1016/j.pcd.2017.01.007
  • Price DB, Yawn BP, Jones RCM. Improving the differential diagnosis of chronic obstructive pulmonary disease in primary care. Mayo Clin Proc. 2010;85(12):1122–1129. doi:10.4065/mcp.2010.0389
  • van Eerd EA, van der Meer RM, van Schayck OC, Kotz D. Smoking cessation for people with chronic obstructive pulmonary disease. Cochrane Database Syst Rev. 2016;2016(8):Cd010744. doi:10.1002/14651858.CD010744.pub2
  • Maqsood U, Ho TN, Palmer K, et al. Once daily long-acting beta2-agonists and long-acting muscarinic antagonists in a combined inhaler versus placebo for chronic obstructive pulmonary disease. Cochrane Database Syst Rev. 2019;3(3):Cd012930. doi:10.1002/14651858.CD012930.pub2
  • Ni H, Moe S, Soe Z, Myint KT, Viswanathan KN. Combined Aclidinium bromide and long-acting beta2-agonist for chronic obstructive pulmonary disease (COPD). Cochrane Database Syst Rev. 2018;12(12):Cd011594. doi:10.1002/14651858.CD011594.pub2
  • Sliwka A, Jankowski M, Gross-Sondej I, Storman M, Nowobilski R, Bala MM. Once-daily long-acting beta2-agonists/inhaled corticosteroids combined inhalers versus inhaled long-acting muscarinic antagonists for people with chronic obstructive pulmonary disease. Cochrane Database Syst Rev. 2018;8(8):Cd012355. doi:10.1002/14651858.CD012355.pub2
  • McCarthy B, Casey D, Devane D, Murphy K, Murphy E, Lacasse Y. Pulmonary rehabilitation for chronic obstructive pulmonary disease. Cochrane Database Syst Rev. 2015;2:Cd003793. doi:10.1002/14651858.CD003793.pub3
  • Zwerink M, Brusse-Keizer M, van der Valk PD, et al. Self management for patients with chronic obstructive pulmonary disease. Cochrane Database Syst Rev. 2014;2014(3):Cd002990. doi:10.1002/14651858.CD002990.pub3
  • Make B, Dutro MP, Paulose-Ram R, Marton JP, Mapel DW. Undertreatment of COPD: a retrospective analysis of US managed care and medicare patients. Int J Chron Obstruct Pulmon Dis. 2012;7:1–9. doi:10.2147/COPD.S27032
  • Halpin DMG, de Jong HJI, Carter V, Skinner D, Price D. Distribution, temporal stability and appropriateness of therapy of patients with COPD in the UK in relation to GOLD 2019. EClinicalMedicine. 2019;14:32–41. doi:10.1016/j.eclinm.2019.07.003
  • Riley CM, Sciurba FC. Diagnosis and outpatient management of chronic obstructive pulmonary disease: a review. JAMA. 2019;321(8):786–797. doi:10.1001/jama.2019.0131
  • Hurst JR, Winders T, Worth H, et al. A patient charter for chronic obstructive pulmonary disease. Adv Ther. 2021;38(1):11–23. doi:10.1007/s12325-020-01577-7
  • Johnston KN, Young M, Grimmer-Somers KA, Antic R, Frith PA. Why are some evidence-based care recommendations in chronic obstructive pulmonary disease better implemented than others? Perspectives of medical practitioners. Int J Chron Obstruct Pulmon Dis. 2011;6:659–667. doi:10.2147/COPD.S26581
  • National Institute for Clinical Excellence. Chronic obstructive pulmonary disease; 2018. Available from: http://www.nice.org.uk/nicemedia/live/13029/49397/49397.pdf. Accessed August 17, 2020.
  • British Thoracic Society. BTS chronic obstructive pulmonary disease (COPD) discharge care bundle. Available from: https://www.brit-thoracic.org.uk/quality-improvement/clinical-resources/copd-spirometry/. Accessed August 31, 2020.
  • Davies F, Risør MB, Melbye H, et al. Primary and secondary care clinicians’ views on self-treatment of COPD exacerbations: a multinational qualitative study. Patient Educ Couns. 2014;96(2):256–263. doi:10.1016/j.pec.2014.05.011
  • Gavish R, Levy A, Dekel OK, Karp E, Maimon N. The association between hospital readmission and pulmonologist follow-up visits in patients with COPD. Chest. 2015;148(2):375–381. doi:10.1378/chest.14-1453
  • Sharma G, Kuo YF, Freeman JL, Zhang DD, Goodwin JS. Outpatient follow-up visit and 30-day emergency department visit and readmission in patients hospitalized for chronic obstructive pulmonary disease. Arch Intern Med. 2010;170(18):1664–1670. doi:10.1001/archinternmed.2010.345
  • Gómez-Angelats E, Sánchez C. Care bundles after discharging patients with chronic obstructive pulmonary disease exacerbation from the emergency department. Med Sci. 2018;6(3). doi:10.3390/medsci6030063
  • Morton K, Sanderson E, Dixon P, et al. Health Services and Delivery Research. Care bundles to reduce re-admissions for patients with chronic obstructive pulmonary disease: a mixed-methods study. Southampton (UK): NIHR Journals Library; 2019.
  • Hurst J, Legg M, Shanahan L, et al.; National Asthma and Chronic Obstructive Pulmonary Disease Audit Programme (NACAP). COPD clinical audit 2018/19 (people with COPD exacerbations discharged from acute hospitals in England, Scotland and Wales between September 2018 and 2019). Clinical audit report London: Royal College of Physicians; 2020. Available from: https://www.rcplondon.ac.uk/projects/national-asthma-and-copd-audit-programme-nacap-secondary-care-workstream-copd. Accessed August 31, 2020.
  • Hopkinson NS, Englebretsen C, Cooley N, et al. Designing and implementing a COPD discharge care bundle. Thorax. 2012;67(1):90–92. doi:10.1136/thoraxjnl-2011-200233
  • Khdour MR, Kidney JC, Smyth BM, McElnay JC. Clinical pharmacy-led disease and medicine management programme for patients with COPD. Br J Clin Pharmacol. 2009;68(4):588–598. doi:10.1111/j.1365-2125.2009.03493.x
  • Khan A, Dickens AP, Adab P, Jordan RE. Self-management behaviour and support among primary care COPD patients: cross-sectional analysis of data from the Birmingham Chronic Obstructive Pulmonary Disease Cohort. NPJ Prim Care Respir Med. 2017;27(1):46. doi:10.1038/s41533-017-0046-6
  • McDonald VM, Osadnik CR, Gibson PG. Treatable traits in acute exacerbations of chronic airway diseases. Chron Respir Dis. 2019;16:1479973119867954. doi:10.1177/1479973119867954
  • Mantero M, Rogliani P, Di Pasquale M, et al. Acute exacerbations of COPD: risk factors for failure and relapse. Int J Chron Obstruct Pulmon Dis. 2017;12:2687–2693. doi:10.2147/COPD.S145253
  • Boutou AK, Shrikrishna D, Tanner RJ, et al. Lung function indices for predicting mortality in COPD. Eur Respir J. 2013;42(3):616–625. doi:10.1183/09031936.00146012
  • Chan SMH, Selemidis S, Bozinovski S, Vlahos R. Pathobiological mechanisms underlying metabolic syndrome (MetS) in chronic obstructive pulmonary disease (COPD): clinical significance and therapeutic strategies. Pharmacol Ther. 2019;198:160–188. doi:10.1016/j.pharmthera.2019.02.013
  • Barreiro E, Jaitovich A. Muscle atrophy in chronic obstructive pulmonary disease: molecular basis and potential therapeutic targets. J Thorac Dis. 2018;10(Suppl 12):S1415–s1424. doi:10.21037/jtd.2018.04.168
  • Vogelmeier CF, Román-Rodríguez M, Singh D, Han MK, Rodríguez-Roisin R, Ferguson GT. Goals of COPD treatment: focus on symptoms and exacerbations. Respir Med. 2020;166:105938. doi:10.1016/j.rmed.2020.105938
  • Bafadhel M, Peterson S, De Blas MA, et al. Predictors of exacerbation risk and response to budesonide in patients with chronic obstructive pulmonary disease: a post-hoc analysis of three randomised trials. Lancet Respir Med. 2018;6(2):117–126. doi:10.1016/s2213-2600(18)30006-7
  • Kerkhof M, Voorham J, Dorinsky P, et al. Association between COPD exacerbations and lung function decline during maintenance therapy. Thorax. 2020;75(9):744–753. doi:10.1136/thoraxjnl-2019-214457
  • Sundh J, Janson C, Lisspers K, Ställberg B, Montgomery S. The Dyspnoea, Obstruction, Smoking, Exacerbation (DOSE) index is predictive of mortality in COPD. Prim Care Respir J. 2012;21(3):295–301. doi:10.4104/pcrj.2012.00054
  • Vos T, Flaxman AD, Naghavi M, et al. Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet. 2012;380(9859):2163–2196. doi:10.1016/s0140-6736(12)61729-2