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Original Research

Small Airways Response to Bronchodilators in Adults with Asthma or COPD: A Systematic Review

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Pages 3065-3082 | Published online: 11 Nov 2021

References

  • Chhabra SK. Test of reversibility of airway obstruction: time for a review? Editorial. Lung India. 2013;30(1):3–4. doi:10.4103/0970-2113.106118
  • Graham BL, Steenbruggen I, Miller MR, et al. Standardization of spirometry 2019 update. An Official American Thoracic Society and European Respiratory Society technical statement. Am J Respir Crit Care Med. 2019;200(8):e70–e88. doi:10.1164/rccm.201908-1590ST
  • Higham A, Quinn AM, Cancado JED, Singh D. The pathology of small airways disease in COPD: historical aspects and future directions. Respir Res. 2019;20(1):49. doi:10.1186/s12931-019-1017-y
  • Usmani OS, Singh D, Spinola M, Bizzi A, Barnes PJ. The prevalence of small airways disease in adult asthma: a systematic literature review. Respir Med. 2016;116:19–27. doi:10.1016/j.rmed.2016.05.006
  • BTS/SIGN. British guideline on the management of asthma. Available from: https://www.brit-thoracic.org.uk/quality-improvement/guidelines/asthma/. Accessed October 30, 2020.
  • Quanjer PH, Weiner DJ, Pretto JJ, Brazzale DJ, Boros PW. Measurement of FEF25–75% and FEF75% does not contribute to clinical decision making. Eur Respir J. 2014;43(4):1051–1058. doi:10.1183/09031936.00128113
  • Miller MR, Hankinson J, Brusasco V, et al. Standardisation of spirometry. Eur Respir J. 2005;26(2):319. doi:10.1183/09031936.05.00034805
  • Coates AL, Allen PD, MacNeish CF, Ho SL, Lands LC. Effect of size and disease on estimated deposition of drugs administered using jet nebulization in children with cystic fibrosis. Chest. 2001;119(4):1123–1130. doi:10.1378/chest.119.4.1123
  • Newhouse MT. Asthma therapy with aerosols: are nebulizers obsolete? A continuing controversy. J Pediatr. 1999;135(1):5–8. doi:10.1016/s0022-3476(99)70317-3
  • Molimard M, Bourcereau J, Le Gros V, Bourdeix I. Total reversibility testing as indicator of the clinical efficacy of formoterol in COPD. Respir Med. 2005;99(6):695–702. doi:10.1016/j.rmed.2004.11.009
  • Calverley PMA, Burge PS, Spencer S, Anderson JA, Jones PW. Bronchodilator reversibility testing in chronic obstructive pulmonary disease. Thorax. 2003;58(8):659. doi:10.1136/thorax.58.8.659
  • National Institute for Health Care Excellence (NICE). Diagnosis: Bronchodilator Reversibility. National Institute for Health and Care Excellence (UK); 2017.
  • Tweeddale PM, Alexander F, McHardy GJ. Short term variability in FEV1 and bronchodilator responsiveness in patients with obstructive ventilatory defects. Thorax. 1987;42(7):487–490. doi:10.1136/thx.42.7.487
  • Pellegrino R, Viegi G, Brusasco V, et al. Interpretative strategies for lung function tests. Eur Respir J. 2005;26(5):948–968. doi:10.1183/09031936.05.00035205
  • British Thoracic Society. BTS guidelines for the management of chronic obstructive pulmonary disease. The COPD Guidelines Group of the Standards of Care Committee of the BTS. Thorax. 1997;52(Suppl 5):S1–S28. doi:10.1136/thx.52.2008.S1.5
  • Chhabra SK. Acute bronchodilator response has limited value in differentiating bronchial asthma from COPD. J Asthma. 2005;42(5):367–372. doi:10.1081/JAS-62992
  • Janson C, Malinovschi A, Amaral AFS, et al. Bronchodilator reversibility in asthma and COPD: findings from three large population studies. Eur Respir J. 2019;54:1900561. doi:10.1183/13993003.00561-2019
  • Albert P, Agusti A, Edwards L, et al. Bronchodilator responsiveness as a phenotypic characteristic of established chronic obstructive pulmonary disease. Thorax. 2012;67(8):701. doi:10.1136/thoraxjnl-2011-201458
  • Tan WC, Vollmer WM, Lamprecht B, et al. Worldwide patterns of bronchodilator responsiveness: results from the Burden of Obstructive Lung Disease study. Thorax. 2012;67(8):718–726. doi:10.1136/thoraxjnl-2011-201445
  • Denlinger LC, Phillips BR, Ramratnam S, et al. Inflammatory and comorbid features of patients with severe asthma and frequent exacerbations. Am J Respir Crit Care Med. 2017;195(3):302–313. doi:10.1164/rccm.201602-0419OC
  • Galant SP, Morphew T, Newcomb RL, Hioe K, Guijon O, Liao O. The relationship of the bronchodilator response phenotype to poor asthma control in children with normal spirometry. J Pediatr. 2011;158(6):953–959 e1. doi:10.1016/j.jpeds.2010.11.029
  • Almeshari MA, Alobaidi NY, Edgar RG, Stockley J, Sapey E. Physiological tests of small airways function in diagnosing asthma: a systematic review. BMJ Open Respir Res. 2020;7(1):e000770. doi:10.1136/bmjresp-2020-000770
  • O’Donnell DE, Revill SM, Webb KA. Dynamic hyperinflation and exercise intolerance in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2001;164(5):770–777. doi:10.1164/ajrccm.164.5.2012122
  • Schermer T, Heijdra Y, Zadel S, et al. Flow and volume responses after routine salbutamol reversibility testing in mild to very severe COPD. Respir Med. 2007;101(6):1355–1362. doi:10.1016/j.rmed.2006.09.024
  • Wouters EFM, Verschoof AC, Polko AH, Visser BF. Impedance measurements of the respiratory system before and after salbutamol in COPD patients. Respir Med. 1989;83(4):309–313. doi:10.1016/S0954-6111(89)80202-1
  • Borrill ZL, Houghton CM, Woodcock AA, Vestbo J, Singh D. Measuring bronchodilation in COPD clinical trials. Br J Clin Pharmacol. 2005;59(4):379–384. doi:10.1111/j.1365-2125.2004.02261.x
  • Bosken CH, Wiggs BR, Paré PD, Hogg JC. Small airway dimensions in smokers with obstruction to airflow. Am Rev Respir Dis. 1990;142(3):563–570. doi:10.1164/ajrccm/142.3.563
  • Hogg JC, Macklem PT, Thurlbeck WM. Site and nature of airway obstruction in chronic obstructive lung disease. N Engl J Med. 1968;278(25):1355–1360. doi:10.1056/nejm196806202782501
  • Stockley JA, Ismail AM, Hughes SM, Edgar R, Stockley RA, Sapey E. Maximal mid-expiratory flow detects early lung disease in alpha1-antitrypsin deficiency. Eur Respir J. 2017;49(3):1602055. doi:10.1183/13993003.02055-2016
  • Papi A, Vestbo J, Fabbri L, et al. Extrafine inhaled triple therapy versus dual bronchodilator therapy in chronic obstructive pulmonary disease (TRIBUTE): a double-blind, parallel group, randomised controlled trial. Lancet. 2018;391(10125):1076–1084. doi:10.1016/S0140-6736(18)30206-X
  • Liberati A, Altman DG, Tetzlaff J, et al. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration. BMJ. 2009;339:b2700. doi:10.1136/bmj.b2700
  • Ouzzani M, Hammady H, Fedorowicz Z, Elmagarmid A. Rayyan—a web and mobile app for systematic reviews. Syst Rev. 2016;5(1):210. doi:10.1186/s13643-016-0384-4
  • Sterne JAC, Savović J, Page MJ, et al. RoB 2: a revised tool for assessing risk of bias in randomised trials. BMJ. 2019;366:l4898. doi:10.1136/bmj.l4898
  • National Heart, Lung, and Blood institute. Study quality assessment tools. Available from: https://www.nhlbi.nih.gov/health-topics/study-quality-assessment-tools. Accessed October 19, 2021.
  • El-Khatib MF, Jamaleddine G, Kanj N, et al. Effect of heliox- and air-driven nebulized bronchodilator therapy on lung function in patients with asthma. Lung. 2014;192(3):377–383. doi:10.1007/s00408-014-9570-0
  • Fakharian A, Fahimi F, Salamzadeh J, Mohammadi M, Masjedi MR. Spirometric improvements with two commonly used spacers in asthmatic patients. Tanaffos. 2008;7(3):37–40.
  • Lipworth BJ, Clark DJ. Effects of airway calibre on lung delivery of nebulised salbutamol. Thorax. 1997;52(12):1036–1039. doi:10.1136/thx.52.12.1036
  • Mariotta S, Sposato B, Ricci A, Bruno P, Aquilini M, Mannino F. Reversibility test in the early stages of bronchial asthma. J Asthma. 2005;42(6):487–491. doi:10.1081/JAS-67536
  • Nair A, Ward J, Lipworth BJ. Comparison of bronchodilator response in patients with asthma and healthy subjects using spirometry and oscillometry. Ann Allerg Asthma Immunol. 2011;107(4):317–322. doi:10.1016/j.anai.2011.07.011
  • Ohwada A, Inami K, Onuma E, Matsumoto-Yamazaki M, Atsuta R, Takahashi K. Bronchial reversibility with a short-acting beta2-agonist predicts the FEV1 response to administration of a long-acting beta2-agonist with inhaled corticosteroids in patients with bronchial asthma. Exp Ther Med. 2011;2(4):619–623. doi:10.3892/etm.2011.268
  • Rajkumar VHK, Gaur SN. Comparative evaluation of market spacer and home made spacer in the management of bronchial asthma. J Assoc Phys India. 2002;50:397–399.
  • Schecker MH, Wilson AF, Mukai DS, Hahn M, Crook D, Novey HS. A device for overcoming discoordination with metered-dose inhalers. J Allerg Clin Immunol. 1993;92(6):783–789. doi:10.1016/0091-6749(93)90054-j
  • Tavares e Castro A, Matos P, Tavares B, Matos MJ, Segorbe-Luis A. Alternative functional criteria to assess airflow-limitation reversibility in asthma. Rev Port Pneumol. 2015;21(2):69–75. doi:10.1016/j.rppnen.2014.08.002
  • Yaegashi M, Yalamanchili VA, Kaza V, Weedon J, Heurich AE, Akerman MJ. The utility of the forced oscillation technique in assessing bronchodilator responsiveness in patients with asthma. Respir Med. 2007;101(5):995–1000. doi:10.1016/j.rmed.2006.09.001
  • Park JH, Lee JH, Kim HJ, et al. Usefulness of impulse oscillometry for the assessment of bronchodilator response in elderly patients with chronic obstructive airway disease. J Thorac Dis. 2019;11(4):1485–1494. doi:10.21037/jtd.2019.03.34
  • Sylvester KP, Clayton N, Cliff I, et al. ARTP statement on pulmonary function testing 2020. BMJ Open Respir Res. 2020;7(1):e000575. doi:10.1136/bmjresp-2020-000575
  • Kesten S, Rebuck AS. Is the short-term response to inhaled beta-adrenergic agonist sensitive or specific for distinguishing between asthma and COPD? Chest. 1994;105(4):1042–1045. doi:10.1378/chest.105.4.1042
  • Han MK, Wise R, Mumford J, et al. Prevalence and clinical correlates of bronchoreversibility in severe emphysema. Eur Respir J. 2010;35(5):1048. doi:10.1183/09031936.00052509
  • Ioachimescu OC, Ramos JA, Hoffman M, McCarthy K, Stoller JK. Assessing bronchodilator response by changes in per cent predicted forced expiratory volume in one second. J Investig Med. 2021;69(5):1027–1034. doi:10.1136/jim-2020-001663
  • Hansen JE, Dilektasli AG, Porszasz J, et al. A new bronchodilator response grading strategy identifies distinct patient populations. Ann Am Thorac Soc. 2019;16(12):1504–1517. doi:10.1513/AnnalsATS.201901-030OC
  • Dandurand RJ, Lavoie J-P, Lands LC, Hantos Z. Comparison of oscillometry devices using active mechanical test loads. ERJ Open Res. 2019;5(4):00160–2019. doi:10.1183/23120541.00160-2019
  • Fabbri LM, Romagnoli M, Corbetta L, et al. Differences in airway inflammation in patients with fixed airflow obstruction due to asthma or chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2003;167(3):418–424. doi:10.1164/rccm.200203-183OC
  • Jiang D, Wang Z, Shen C, et al. Small airway dysfunction may be an indicator of early asthma: findings from high-resolution CT. Ann Allerg Asthma Immunol. 2019;122(5):498–501. doi:10.1016/j.anai.2019.02.024
  • Suzuki S, Miyashita A, Matsumoto Y, Okubo T. Bronchoconstriction induced by spirometric maneuvers in patients with bronchial asthma. Ann Allergy. 1990;65(4):315–320.
  • Froeb HF, Mead J. Relative hysteresis of the dead space and lung in vivo. J Appl Physiol. 1968;25(3):244–248. doi:10.1152/jappl.1968.25.3.244
  • Oostveen E, Boda K, van der Grinten CP, et al. Respiratory impedance in healthy subjects: baseline values and bronchodilator response. Multicenter study. Eur Respir J. 2013;42(6):1513–1523. doi:10.1183/09031936.00126212
  • Houghton CM, Woodcock AA, Singh D. A comparison of lung function methods for assessing dose-response effects of salbutamol. Br J Clin Pharmacol. 2004;58(2):134–141. doi:10.1111/j.1365-2125.2004.02105.x
  • Houghton CM, Woodcock AA, Singh D. A comparison of plethysmography, spirometry and oscillometry for assessing the pulmonary effects of inhaled ipratropium bromide in healthy subjects and patients with asthma. Br J Clin Pharmacol. 2005;59(2):152–159. doi:10.1111/j.1365-2125.2004.2262.x
  • Tommola M, Ilmarinen P, Tuomisto LE, et al. Differences between asthma–COPD overlap syndrome and adult-onset asthma. Eur Respir J. 2017;49(5):1602383. doi:10.1183/13993003.02383-2016
  • Ari A. Jet, ultrasonic, and mesh nebulizers: an evaluation of nebulizers for better clinical outcomes. Eur J Pulmonol. 2014;16:1–7. doi:10.5152/ejp.2014.00087
  • Cavallazzi RS, Polivka BJ, Beatty BL, et al. Current bronchodilator responsiveness criteria underestimate asthma in older adults. Respir Care. 2020;65:1104–1111. doi:10.4187/respcare.07132
  • Moher D, Liberati A, Tetzlaff J, Altman DG. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med. 2009;6(7):e1000097. doi:10.1371/journal.pmed.1000097