TRPV4 Inhibition Exerts Protective Effects Against Resistive Breathing Induced Lung Injury

References

• Alvarez DF, King JA, Weber D, Addison E, Liedtke W, Townsley MI. Transient receptor potential vanilloid 4-mediated disruption of the alveolar septal barrier: a novel mechanism of acute lung injury. Circ Res. 2006;99(9):988–995. doi:10.1161/01.RES.0000247065.11756.19
   PubMed Web of Science ®Google Scholar
• Hamanaka K, Jian MY, Townsley MI, et al. TRPV4 channels augment macrophage activation and ventilator-induced lung injury. Am J Physiol Lung Cell Mol Physiol. 2010;299(3):L353–362. doi:10.1152/ajplung.00315.2009
   PubMed Web of Science ®Google Scholar
• McAlexander MA, Luttmann MA, Hunsberger GE, Undem BJ. Transient receptor potential vanilloid 4 activation constricts the human bronchus via the release of cysteinyl leukotrienes. J Pharmacol Exp Ther. 2014;349(1):118–125. doi:10.1124/jpet.113.210203
   PubMed Web of Science ®Google Scholar
• Yin J, Michalick L, Tang C, et al. Role of Transient Receptor Potential Vanilloid 4 in Neutrophil Activation and Acute Lung Injury. Am J Respir Cell Mol Biol. 2016;54(3):370–383. doi:10.1165/rcmb.2014-0225OC
   PubMed Web of Science ®Google Scholar
• Morty RE, Kuebler WM. TRPV4: an exciting new target to promote alveolocapillary barrier function. Am J Physiol Lung Cell Mol Physiol. 2014;307(11):L817–821. doi:10.1152/ajplung.00254.2014
   PubMed Web of Science ®Google Scholar
• Scheraga RG, Southern BD, Grove LM, Olman MA. The Role of Transient Receptor Potential Vanilloid 4 in Pulmonary Inflammatory Diseases. Front Immunol. 2017;8:503. doi:10.3389/fimmu.2017.00503
   PubMed Web of Science ®Google Scholar
• O’Donnell DE, Parker CM. COPD exacerbations. 3: pathophysiology. Thorax. 2006;61(4):354–361. doi:10.1136/thx.2005.041830
   PubMed Web of Science ®Google Scholar
• Veerati PC, Mitchel JA, Reid AT, et al. Airway mechanical compression: its role in asthma pathogenesis and progression. Eur Respir Rev. 2020;29:157. doi:10.1183/16000617.0123-2019
   Web of Science ®Google Scholar
• Glynos C, Toumpanakis D, Loverdos K, et al. Guanylyl cyclase activation reverses resistive breathing-induced lung injury and inflammation. Am J Respir Cell Mol Biol. 2015;52(6):762–771. doi:10.1165/rcmb.2014-0092OC
   PubMed Web of Science ®Google Scholar
• Toumpanakis D, Vassilakopoulou V, Sigala I, et al. The role of Src & ERK1/2 kinases in inspiratory resistive breathing induced acute lung injury and inflammation. Respir Res. 2017;18(1):209. doi:10.1186/s12931-017-0694-7
   PubMed Web of Science ®Google Scholar
• Toumpanakis D, Mizi E, Vassilakopoulou V, et al. Spontaneous Breathing Through Increased Airway Resistance Augments Elastase-Induced Pulmonary Emphysema. Int J Chron Obstruct Pulmon Dis. 2020;15:1679–1688. doi:10.2147/COPD.S256750
   PubMed Web of Science ®Google Scholar
• Everaerts W, Zhen X, Ghosh D, et al. Inhibition of the cation channel TRPV4 improves bladder function in mice and rats with cyclophosphamide-induced cystitis. Proc Natl Acad Sci U S A. 2010;107(44):19084–19089. doi:10.1073/pnas.1005333107
   PubMed Web of Science ®Google Scholar
• Bates JH, Irvin CG. Measuring lung function in mice: the phenotyping uncertainty principle. J Appl Physiol. 2003;94(4):1297–1306. doi:10.1152/japplphysiol.00706.2002
   PubMed Web of Science ®Google Scholar
• Kastis GA, Toumpanakis D, Loverdos K, et al. Dose- and time-dependent effects of lipopolysaccharide on technetium-99-m-labeled diethylene-triamine pentaacetatic acid clearance, respiratory system mechanics and pulmonary inflammation. Exp Biol Med (Maywood). 2013;238(2):209–222. doi:10.1258/ebm.2012.012313
   PubMed Web of Science ®Google Scholar
• Toumpanakis D, Kastis GA, Zacharatos P, et al. Inspiratory resistive breathing induces acute lung injury. Am J Respir Crit Care Med. 2010;182(9):1129–1136. doi:10.1164/rccm.201001-0116OC
   PubMed Web of Science ®Google Scholar
• Vassilakopoulos T, Divangahi M, Rallis G, et al. Differential cytokine gene expression in the diaphragm in response to strenuous resistive breathing. Am J Respir Crit Care Med. 2004;170(2):154–161. doi:10.1164/rccm.200308-1071OC
   PubMed Web of Science ®Google Scholar
• Vassilakopoulos T, Katsaounou P, Karatza MH, Kollintza A, Zakynthinos S, Roussos C. Strenuous resistive breathing induces plasma cytokines: role of antioxidants and monocytes. Am J Respir Crit Care Med. 2002;166(12 Pt 1):1572–1578. doi:10.1164/rccm.200203-177OC
   PubMed Web of Science ®Google Scholar
• West JB. Invited review: pulmonary capillary stress failure. J Appl Physiol. 2000;89(6):2483–2489. doi:10.1152/jappl.2000.89.6.2483
   PubMed Web of Science ®Google Scholar
• Vassilakopoulos T, Toumpanakis D. Can resistive breathing injure the lung? Implications for COPD exacerbations. Int J Chron Obstruct Pulmon Dis. 2016;11:2377–2384. doi:10.2147/COPD.S113877
   PubMed Web of Science ®Google Scholar
• Curley GF, Laffey JG, Zhang H, Slutsky AS. Biotrauma and Ventilator-Induced Lung Injury: clinical Implications. Chest. 2016;150(5):1109–1117. doi:10.1016/j.chest.2016.07.019
   PubMed Web of Science ®Google Scholar
• Parker JC, Townsley MI. Control of TRPV4 and Its Effect on the Lung. In: Kamkin A, Kiseleva I, editors. Mechanosensitivity and Mechanotransduction. Springer; 2011:239–254.
   Google Scholar
• Michalick L, Erfinanda L, Weichelt U, van der Giet M, Liedtke W, Kuebler WM. Transient Receptor Potential Vanilloid 4 and Serum Glucocorticoid-regulated Kinase 1 Are Critical Mediators of Lung Injury in Overventilated Mice In Vivo. Anesthesiology. 2017;126(2):300–311. doi:10.1097/ALN.0000000000001443
   PubMed Web of Science ®Google Scholar
• Xu H, Zhao H, Tian W, Yoshida K, Roullet JB, Cohen DM. Regulation of a transient receptor potential (TRP) channel by tyrosine phosphorylation. SRC family kinase-dependent tyrosine phosphorylation of TRPV4 on TYR-253 mediates its response to hypotonic stress. J Biol Chem. 2003;278(13):11520–11527. doi:10.1074/jbc.M211061200
   PubMed Web of Science ®Google Scholar
• Balakrishna S, Song W, Achanta S, et al. TRPV4 inhibition counteracts edema and inflammation and improves pulmonary function and oxygen saturation in chemically induced acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2014;307(2):L158–172. doi:10.1152/ajplung.00065.2014
   PubMed Web of Science ®Google Scholar
• Villalta PC, Rocic P, Townsley MI. Role of MMP2 and MMP9 in TRPV4-induced lung injury. Am J Physiol Lung Cell Mol Physiol. 2014;307(8):L652–659. doi:10.1152/ajplung.00113.2014
   PubMed Web of Science ®Google Scholar
• Toumpanakis D, Noussia O, Sigala I, et al. Inspiratory resistive breathing induces MMP-9 and MMP-12 expression in the lung. Am J Physiol Lung Cell Mol Physiol. 2015;308(7):L683–692. doi:10.1152/ajplung.00133.2014
   PubMed Web of Science ®Google Scholar
• Yin J, Hoffmann J, Kaestle SM, et al. Negative-feedback loop attenuates hydrostatic lung edema via a cGMP-dependent regulation of transient receptor potential vanilloid 4. Circ Res. 2008;102(8):966–974. doi:10.1161/CIRCRESAHA.107.168724
   PubMed Web of Science ®Google Scholar
• Eisner MD, Parsons P, Matthay MA, Ware L, Greene K. Acute Respiratory Distress Syndrome N. Plasma surfactant protein levels and clinical outcomes in patients with acute lung injury. Thorax. 2003;58(11):983–988. doi:10.1136/thorax.58.11.983
   PubMed Web of Science ®Google Scholar
• Sin DD, Leung R, Gan WQ, Man SP. Circulating surfactant protein D as a potential lung-specific biomarker of health outcomes in COPD: a pilot study. BMC Pulm Med. 2007;7:13. doi:10.1186/1471-2466-7-13
   PubMedGoogle Scholar
• Wu S, Jian MY, Xu YC, et al. Ca2+ entry via alpha1G and TRPV4 channels differentially regulates surface expression of P-selectin and barrier integrity in pulmonary capillary endothelium. Am J Physiol Lung Cell Mol Physiol. 2009;297(4):L650–657. doi:10.1152/ajplung.00015.2009
   PubMed Web of Science ®Google Scholar
• Rangelov BA, Young AL, Jacob J, et al. Thoracic Imaging at Exacerbation of Chronic Obstructive Pulmonary Disease: a Systematic Review. Int J Chron Obstruct Pulmon Dis. 2020;15:1751–1787. doi:10.2147/COPD.S250746
   PubMed Web of Science ®Google Scholar
• Zvezdin B, Milutinov S, Kojicic M, et al. A postmortem analysis of major causes of early death in patients hospitalized with COPD exacerbation. Chest. 2009;136(2):376–380. doi:10.1378/chest.08-2918
   PubMed Web of Science ®Google Scholar
• Williams NP, Ostridge K, Devaster JM, et al. Impact of radiologically stratified exacerbations: insights into pneumonia aetiology in COPD. Respir Res. 2018;19(1):143. doi:10.1186/s12931-018-0842-8
   PubMed Web of Science ®Google Scholar
• Jia Y, Wang X, Varty L, et al. Functional TRPV4 channels are expressed in human airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 2004;287(2):L272–278. doi:10.1152/ajplung.00393.2003
   PubMed Web of Science ®Google Scholar
• Bonvini SJ, Birrell MA, Grace MS, et al. Transient receptor potential cation channel, subfamily V, member 4 and airway sensory afferent activation: role of adenosine triphosphate. J Allergy Clin Immunol. 2016;138(1):249–261 e212. doi:10.1016/j.jaci.2015.10.044
   PubMed Web of Science ®Google Scholar
• Baxter M, Eltom S, Dekkak B, et al. Role of transient receptor potential and pannexin channels in cigarette smoke-triggered ATP release in the lung. Thorax. 2014;69(12):1080–1089. doi:10.1136/thoraxjnl-2014-205467
   PubMed Web of Science ®Google Scholar
• Zhu G, Investigators I, Gulsvik A, et al. Association of TRPV4 gene polymorphisms with chronic obstructive pulmonary disease. Hum Mol Genet. 2009;18(11):2053–2062. doi:10.1093/hmg/ddp111
   PubMed Web of Science ®Google Scholar
• Michalick L, Kuebler WM. TRPV4-A Missing Link Between Mechanosensation and Immunity. Front Immunol. 2020;11:413. doi:10.3389/fimmu.2020.00413
   PubMed Web of Science ®Google Scholar
• Gu QD, Moss CR 2nd, Kettelhut KL, Gilbert CA, Hu H. Activation of TRPV4 Regulates Respiration through Indirect Activation of Bronchopulmonary Sensory Neurons. Front Physiol. 2016;7:65. doi:10.3389/fphys.2016.00065
   PubMed Web of Science ®Google Scholar
• Goldenberg NM, Wang L, Ranke H, Liedtke W, Tabuchi A, Kuebler WM. TRPV4 Is Required for Hypoxic Pulmonary Vasoconstriction. Anesthesiology. 2015;122(6):1338–1348. doi:10.1097/ALN.0000000000000647
   PubMed Web of Science ®Google Scholar