286
Views
1
CrossRef citations to date
0
Altmetric
Original Research

Disease Burden and Healthcare Utilization Among Patients with Chronic Obstructive Pulmonary Disease (COPD) in England

, ORCID Icon, , , & ORCID Icon
Pages 415-426 | Published online: 03 Mar 2022

References

  • GOLD. Global initiative for Chronic Obstructive Pulmonary Disease (GOLD). 2021 Report; 2021. Available from: https://goldcopd.org/2021-gold-reports/. Accessed February, 2021.
  • Rayner L, Sherlock J, Creagh-Brown B, Williams J, deLusignan S. The prevalence of COPD in England: an ontological approach to case detection in primary care. Respir Med. 2017;132:217–225. doi:10.1016/j.rmed.2017.10.024
  • British Lung Foundation. Chronic obstructive pulmonary disease (COPD) statistics; 2020. Available from: https://statistics.blf.org.uk/copd. Accessed July, 2020.
  • Schnell K, Weiss CO, Lee T, et al. The prevalence of clinically-relevant comorbid conditions in patients with physician-diagnosed COPD: a cross-sectional study using data from NHANES 1999-2008. BMC Pulm Med. 2012;12:26. doi:10.1186/1471-2466-12-26
  • Murtagh E, O’Neill C, McAllister D, Kee F, Macmahon J, Heaney LG. A cross-sectional comparison of direct medical care costs among COPD and asthma patients living in the community in Northern Ireland. Treat Respir Med. 2006;5(6):495–501. doi:10.2165/00151829-200605060-00012
  • Punekar YS, Landis SH, Wurst K, Le H. Characteristics, disease burden and costs of COPD patients in the two years following initiation of long-acting bronchodilators in UK primary care. Respir Res. 2015;16:141. doi:10.1186/s12931-015-0295-2
  • NICE. NICE guideline - Chronic obstructive pulmonary disease in over 16s: diagnosis and management; 2018. Available from: https://www.nice.org.uk/guidance/ng115. Accessed January, 2021.
  • GOLD. Global initiative for Chronic Obstructive Pulmonary Disease (GOLD). 2017 Report; 2017. Available from: https://goldcopd.org/wp-content/uploads/2017/02/wms-GOLD-2017-FINAL.pdf. Accessed July, 2020.
  • Asche CV, Leader S, Plauschinat C, et al. Adherence to current guidelines for chronic obstructive pulmonary disease (COPD) among patients treated with combination of long-acting bronchodilators or inhaled corticosteroids. Int J Chron Obstruct Pulmon Dis. 2012;7:201–209. doi:10.2147/COPD.S25805
  • Visentin E, Nieri D, Vagaggini B, Peruzzi E, Paggiaro P. An observation of prescription behaviors and adherence to guidelines in patients with COPD: real world data from October 2012 to September 2014. Curr Med Res Opin. 2016;32(9):1493–1502. doi:10.1080/03007995.2016.1182900
  • Sansbury LB, Bains C, Lipson DA, Ismaila AS, Landis SH. Real-world treatment patterns of multiple-inhaler triple therapy among patients with chronic obstructive pulmonary disease in UK general practice. Int J Chron Obstruct Pulmon Dis. 2021;16:1255–1264. doi:10.2147/COPD.S290773
  • MRC. Medical Research Council dyspnea scale; 1986. Available from: https://mrc.ukri.org/research/facilities-and-resources-for-researchers/mrc-scales/mrc-dyspnoea-scale-mrc-breathlessness-scale/. Accessed January, 2021.
  • Rothnie KJ, Müllerová H, Thomas SL, et al. Recording of hospitalizations for acute exacerbations of COPD in UK electronic health care records. Clin Epidemiol. 2016;8:771–782. doi:10.2147/CLEP.S117867
  • Bogart M, Wu B, Germain G, et al. Real-world adherence to single-inhaler vs multiple-inhaler triple therapy among patients with COPD in a commercially insured US population. Chest. 2020;158(4):A1773–A1774. doi:10.1016/j.chest.2020.08.1548
  • Halpin D, Rothnie K, Banks V, et al. S27 Are patients with COPD more adherent to fluticasone furoate/umeclidinium/vilanterol (FF/UMEC/VI) compared with multiple-inhaler triple therapy in a real-world UK primary care treated population? Thorax. 2021;76(Suppl 2):A20–A21. Available from: https://thorax.bmj.com/content/76/Suppl_2/A20.2. Accessed February 17, 2022.
  • Rothnie K, Czira A, Compton C, et al. Are patients with COPD more adherent to single-inhaler compared with multiple-inhaler triple therapy in a real-world UK primary care treated population? Eur Respir J. 2021;58:OA2947. doi: 0.1183/13993003.congress-2021.OA2947
  • Gloeckl R, Schneeberger T, Jarosch I, Kenn K. Pulmonary rehabilitation and exercise training in chronic obstructive pulmonary disease. Dtsch Arztebl Int. 2018;115:117–123. doi:10.3238/arztebl.2018.0117
  • Dalon F, Devouassoux G, Belhassen M, et al. Impact of therapy persistence on exacerbations and resource use in patients who initiated COPD therapy. Int J Chron Obstruct Pulmon Dis. 2019;14:2905–2915. doi:10.2147/COPD.S222762
  • Chrystyn H, Small M, Milligan G, Higgins V, Gil EG, Estruch J. Impact of patients’ satisfaction with their inhalers on treatment compliance and health status in COPD. Respir Med. 2014;108(2):358–365. doi:10.1016/j.rmed.2013.09.021
  • Ismaila A, Corriveau D, Vaillancourt J, et al. Impact of adherence to treatment with tiotropium and fluticasone propionate/salmeterol in chronic obstructive pulmonary diseases patients. Curr Med Res Opin. 2014;30(7):1427–1436. doi:10.1185/03007995.2014.908828
  • Toy EL, Beaulieu NU, McHale JM, et al. Treatment of COPD: relationships between daily dosing frequency, adherence, resource use, and costs. Respir Med. 2011;105(3):435–441. doi:10.1016/j.rmed.2010.09.006
  • Vestbo J, Anderson JA, Calverley PMA, et al. Adherence to inhaled therapy, mortality and hospital admission in COPD. Thorax. 2009;64(11):939. doi:10.1136/thx.2009.113662
  • Covvey JR, Mullen AB, Ryan M, et al. A comparison of medication adherence/persistence for asthma and chronic obstructive pulmonary disease in the United Kingdom. Int J Clin Pract. 2014;68(10):1200–1208. doi:10.1111/ijcp.12451
  • Mueller S, Wilke T, Bechtel B, Punekar YS, Mitzner K, Virchow JC. Non-persistence and non-adherence to long-acting COPD medication therapy: a retrospective cohort study based on a large German claims dataset. Respir Med. 2017;122:1–11. doi:10.1016/j.rmed.2016.11.008
  • Wurst KE, St Laurent S, Mullerova H, Davis KJ. Characteristics of patients with COPD newly prescribed a long-acting bronchodilator: a retrospective cohort study. Int J Chron Obstruct Pulmon Dis. 2014;9:1021–1031. doi:10.2147/COPD.S58258
  • Bogart M, Stanford RH, Laliberté F, Germain G, Wu JW, Duh MS. Medication adherence and persistence in chronic obstructive pulmonary disease patients receiving triple therapy in a USA commercially insured population. Int J Chron Obstruct Pulmon Dis. 2019;14:343–352. doi:10.2147/COPD.S184653
  • European Medicines Agency. Trelegy Ellipta Summary of product characteristics; 2019. Available from: https://www.ema.europa.eu/en/documents/product-information/trelegy-ellipta-epar-product-information_en.pdf. Accessed July, 2020.
  • European Medicines Agency. Trimbow - Summary of product characteristics; 2017. Available from: https://www.ema.europa.eu/en/documents/product-information/trimbow-epar-product-information_en.pdf. Accessed July, 2020.
  • European Medicines Agency. Trixeo aerosphere - Summary of product characteristics; 2020. Available from: https://www.ema.europa.eu/en/documents/product-information/trixeo-aerosphere-epar-product-information_en.pdf. Accessed January, 2021.
  • Lai CC, Chen CH, Lin CYH, Wang CY, Wang YH. The effects of single inhaler triple therapy vs single inhaler dual therapy or separate triple therapy for the management of chronic obstructive pulmonary disease: a systematic review and meta-analysis of randomized controlled trials. Int J Chron Obstruct Pulmon Dis. 2019;14:1539–1548. doi:10.2147/COPD.S200846
  • Langham S, Lewis J, Pooley N, et al. Single-inhaler triple therapy in patients with chronic obstructive pulmonary disease: a systematic review. Respir Res. 2019;20(1):242. doi:10.1186/s12931-019-1213-9
  • Lipson DA, Barnacle H, Birk R, et al. FULFIL trial: once-daily triple therapy for patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2017;196(4):438–446. doi:10.1164/rccm.201703-0449OC
  • Lipson DA, Barnhart F, Brealey N, et al. Once-daily single-inhaler triple versus dual therapy in patients with COPD. N Engl J Med. 2018;378(18):1671–1680. doi:10.1056/NEJMoa1713901
  • Lipson DA, Crim C, Criner GJ, et al. Reduction in all-cause mortality with fluticasone furoate/umeclidinium/vilanterol in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2020;201(12):1508–1516. doi:10.1164/rccm.201911-2207OC
  • Tabberer M, Lomas DA, Birk R, et al. Once-daily triple therapy in patients with COPD: patient-reported symptoms and quality of life. Adv Ther. 2018;35(1):56–71. doi:10.1007/s12325-017-0650-4
  • Singh D, Papi A, Corradi M, et al. Single inhaler triple therapy versus inhaled corticosteroid plus long-acting β2-agonist therapy for chronic obstructive pulmonary disease (TRILOGY): a double-blind, parallel group, randomised controlled trial. Lancet. 2016;388(10048):963–973. doi:10.1016/S0140-6736(16)31354-X
  • Rabe KF, Watz H. Chronic obstructive pulmonary disease. Lancet. 2017;389(10082):1931–1940. doi:10.1016/S0140-6736(17)31222-9
  • Halpin DMG, Worsley S, Ismaila AS, et al. INTREPID: single- versus multiple-inhaler triple therapy for COPD in usual clinical practice. ERJ Open Res. 2021;7:00950–02020. doi:10.1183/23120541.00950-2020
  • Yu AP, Guérin A, Ponce de Leon D, et al. Therapy persistence and adherence in patients with chronic obstructive pulmonary disease: multiple versus single long-acting maintenance inhalers. J Med Econ. 2011;14(4):486–496. doi:10.3111/13696998.2011.594123
  • Romagnoli A, Santoleri F, Costantin A. Adherence and persistence analysis after three years in real-life of inhalation therapies used in the treatment of COPD. Curr Med Res Opin. 2020;36(12):2055–2061. doi:10.1080/03007995.2020.1841617
  • Miravitlles M, Marín A, Huerta A, Carcedo D, Villacampa A, Puig-Junoy J. Estimation of the clinical and economic impact of an improvement in adherence based on the use of once-daily single-inhaler triple therapy in patients with COPD. Int J Chron Obstruct Pulmon Dis. 2020;15:643–1654. doi:10.2147/COPD.S253567
  • Herrett E, Gallagher AM, Bhaskaran K, et al. Data resource profile: Clinical Practice Research Datalink (CPRD). Int J Epidemiol. 2015;44(3):827–836. doi:10.1093/ije/dyv098