Eosinopenia Predicting Long-term Mortality in Hospitalized Acute Exacerbation of COPD Patients with Community-acquired Pneumonia—A Retrospective Analysis

References

• Labaki WW, Rosenberg SR. Chronic obstructive pulmonary disease. Ann Intern Med. 2020;173(3):Itc17–Itc32. doi:10.7326/AITC202008040
   PubMed Web of Science ®Google Scholar
• MacLeod M, Papi A, Contoli M, et al. Chronic obstructive pulmonary disease exacerbation fundamentals: diagnosis, treatment, prevention and disease impact. Respirology. 2021;26(6):532–551. doi:10.1111/resp.14041
   PubMed Web of Science ®Google Scholar
• Bordon J, Slomka M, Gupta R, et al. Hospitalization due to community-acquired pneumonia in patients with chronic obstructive pulmonary disease: incidence, epidemiology and outcomes. Clin Microbiol Infect. 2020;26(2):220–226. doi:10.1016/j.cmi.2019.06.025
   PubMed Web of Science ®Google Scholar
• Cilli A, Erdem H, Karakurt Z, et al. Community-acquired pneumonia in patients with chronic obstructive pulmonary disease requiring admission to the intensive care unit: risk factors for mortality. J Crit Care. 2013;28(6):975–979. doi:10.1016/j.jcrc.2013.08.004
   PubMed Web of Science ®Google Scholar
• Kim YH, Park HB, Kim MJ, et al. Prognostic usefulness of eosinopenia in the pediatric intensive care unit. J Korean Med Sci. 2013;28(1):114–119. doi:10.3346/jkms.2013.28.1.114
   PubMed Web of Science ®Google Scholar
• Al Duhailib Z, Farooqi M, Piticaru J, Alhazzani W, Nair P. The role of eosinophils in sepsis and acute respiratory distress syndrome: a scoping review. Can J Anaesth. 2021;68(5):715–726. doi:10.1007/s12630-021-01920-8
   PubMed Web of Science ®Google Scholar
• Hirosawa T, Harada Y, Morinaga K, Takase H, Nin M, Shimizu T. Eosinopenia as a diagnostic marker of bloodstream infection in a general internal medicine setting: a cohort study. BMC Infect Dis. 2020;20(1):85. doi:10.1186/s12879-020-4814-5
   PubMed Web of Science ®Google Scholar
• Abidi K, Belayachi J, Derras Y, et al. Eosinopenia, an early marker of increased mortality in critically ill medical patients. Intensive Care Med. 2011;37(7):1136–1142. doi:10.1007/s00134-011-2170-z
   PubMed Web of Science ®Google Scholar
• Kolsum U, Donaldson GC, Singh R, et al. Blood and sputum eosinophils in COPD; relationship with bacterial load. Respir Res. 2017;18(1):88. doi:10.1186/s12931-017-0570-5
   PubMed Web of Science ®Google Scholar
• Holland M, Alkhalil M, Chandromouli S, Janjua A, Babores M. Eosinopenia as a marker of mortality and length of stay in patients admitted with exacerbations of chronic obstructive pulmonary disease. Respirology. 2010;15(1):165–167. doi:10.1111/j.1440-1843.2009.01651.x
   PubMed Web of Science ®Google Scholar
• Steer J, Gibson J, Bourke SC. The DECAF score: predicting hospital mortality in exacerbations of chronic obstructive pulmonary disease. Thorax. 2012;67(11):970–976. doi:10.1136/thoraxjnl-2012-202103
   PubMed Web of Science ®Google Scholar
• MacDonald MI, Osadnik CR, Bulfin L, et al. Low and high blood eosinophil counts as biomarkers in hospitalized acute exacerbations of COPD. Chest. 2019;156(1):92–100. doi:10.1016/j.chest.2019.02.406
   PubMed Web of Science ®Google Scholar
• Restrepo MI, Mortensen EM, Pugh JA, Anzueto A. COPD is associated with increased mortality in patients with community-acquired pneumonia. Eur Respir J. 2006;28(2):346–351. doi:10.1183/09031936.06.00131905
   PubMed Web of Science ®Google Scholar
• Fine MJ, Singer DE, Hanusa BH, Lave JR, Kapoor WN. Validation of a pneumonia prognostic index using the MedisGroups comparative hospital database. Am J Med. 1993;94(2):153–159. doi:10.1016/0002-9343(93)90177-Q
   PubMed Web of Science ®Google Scholar
• Cao B, Huang Y, She DY, et al. Diagnosis and treatment of community-acquired pneumonia in adults: 2016 clinical practice guidelines by the Chinese thoracic society, Chinese medical association. Clin Respir J. 2018;12(4):1320–1360. doi:10.1111/crj.12674
   PubMed Web of Science ®Google Scholar
• Müllerova H, Chigbo C, Hagan GW, et al. The natural history of community-acquired pneumonia in COPD patients: a population database analysis. Respir Med. 2012;106(8):1124–1133. doi:10.1016/j.rmed.2012.04.008
   PubMed Web of Science ®Google Scholar
• Cilli A. Community-acquired pneumonia in patients with chronic obstructive pulmonary disease. Curr Infect Dis Rep. 2015;17(1):444. doi:10.1007/s11908-014-0444-7
   PubMed Web of Science ®Google Scholar
• Lu Z, Cheng Y, Tu X, et al. Community-acquired pneumonia and survival of critically ill acute exacerbation of COPD patients in respiratory intensive care units. Int J Chron Obstruct Pulmon Dis. 2016;11:1867–1872. doi:10.2147/COPD.S113510
   PubMed Web of Science ®Google Scholar
• Molinos L, Clemente MG, Miranda B, et al. Community-acquired pneumonia in patients with and without chronic obstructive pulmonary disease. J Infect. 2009;58(6):417–424. doi:10.1016/j.jinf.2009.03.003
   PubMed Web of Science ®Google Scholar
• Shin B, Kim SH, Yong SJ, et al. Early readmission and mortality in acute exacerbation of chronic obstructive pulmonary disease with community-acquired pneumonia. Chron Respir Dis. 2019;16:1479972318809480. doi:10.1177/1479972318809480
   Web of Science ®Google Scholar
• Snijders D, van der Eerden M, de Graaff C, Boersma W. The influence of COPD on mortality and severity scoring in community-acquired pneumonia. Respiration. 2010;79(1):46–53. doi:10.1159/000213757
   PubMed Web of Science ®Google Scholar
• Loke YK, Kwok CS, Wong JM, Sankaran P, Myint PK. Chronic obstructive pulmonary disease and mortality from pneumonia: meta-analysis. Int J Clin Pract. 2013;67(5):477–487. doi:10.1111/ijcp.12120
   PubMed Web of Science ®Google Scholar
• Jiang HL, Chen HX, Liu W, Fan T, Liu GJ, Mao B. Is COPD associated with increased mortality and morbidity in hospitalized pneumonia? A systematic review and meta-analysis. Respirology. 2015;20(7):1046–1054. doi:10.1111/resp.12597
   PubMed Web of Science ®Google Scholar
• Mycroft K, Krenke R, Górska K. Eosinophils in COPD-current concepts and clinical implications. J Allergy Clin Immunol Pract. 2020;8(8):2565–2574. doi:10.1016/j.jaip.2020.03.017
   PubMed Web of Science ®Google Scholar
• Pascoe S, Locantore N, Dransfield MT, Barnes NC, Pavord ID. Blood eosinophil counts, exacerbations, and response to the addition of inhaled fluticasone furoate to vilanterol in patients with chronic obstructive pulmonary disease: a secondary analysis of data from two parallel randomised controlled trials. Lancet Respir Med. 2015;3(6):435–442. doi:10.1016/S2213-2600(15)00106-X
   PubMed Web of Science ®Google Scholar
• Siddiqui SH, Guasconi A, Vestbo J, et al. Blood eosinophils: a biomarker of response to extrafine beclomethasone/formoterol in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2015;192(4):523–525. doi:10.1164/rccm.201502-0235LE
   PubMed Web of Science ®Google Scholar
• Pavord ID, Lettis S, Locantore N, et al. Blood eosinophils and inhaled corticosteroid/long-acting β-2 agonist efficacy in COPD. Thorax. 2016;71(2):118–125. doi:10.1136/thoraxjnl-2015-207021
   PubMed Web of Science ®Google Scholar
• Bafadhel M, McKenna S, Terry S, et al. Blood eosinophils to direct corticosteroid treatment of exacerbations of chronic obstructive pulmonary disease: a randomized placebo-controlled trial. Am J Respir Crit Care Med. 2012;186(1):48–55. doi:10.1164/rccm.201108-1553OC
   PubMed Web of Science ®Google Scholar
• Rothenberg ME, Epstein FH. Eosinophilia. N Engl J Med. 1998;338(22):1592–1600. doi:10.1056/NEJM199805283382206
   PubMed Web of Science ®Google Scholar
• Bass DA. Behavior of eosinophil leukocytes in acute inflammation. II. Eosinophil dynamics during acute inflammation. J Clin Invest. 1975;56(4):870–879. doi:10.1172/JCI108166
   PubMed Web of Science ®Google Scholar
• Terradas R, Grau S, Blanch J, et al. Eosinophil count and neutrophil-lymphocyte count ratio as prognostic markers in patients with bacteremia: a retrospective cohort study. PLoS One. 2012;7(8):e42860. doi:10.1371/journal.pone.0042860
   PubMed Web of Science ®Google Scholar
• Yip B, Ho KM. Eosinopenia as a predictor of unexpected re-admission and mortality after intensive care unit discharge. Anaesth Intensive Care. 2013;41(2):231–241. doi:10.1177/0310057X1304100130
   PubMed Web of Science ®Google Scholar
• Linch SN, Danielson ET, Kelly AM, Tamakawa RA, Lee JJ, Gold JA. Interleukin 5 is protective during sepsis in an eosinophil-independent manner. Am J Respir Crit Care Med. 2012;186(3):246–254. doi:10.1164/rccm.201201-0134OC
   PubMed Web of Science ®Google Scholar
• Barnes PJ. Targeting cytokines to treat asthma and chronic obstructive pulmonary disease. Nat Rev Immunol. 2018;18(7):454–466. doi:10.1038/s41577-018-0006-6
   PubMed Web of Science ®Google Scholar
• Bass DA, Gonwa TA, Szejda P, Cousart MS, DeChatelet LR, McCall CE. Eosinopenia of acute infection: production of eosinopenia by chemotactic factors of acute inflammation. J Clin Invest. 1980;65(6):1265–1271. doi:10.1172/JCI109789
   PubMed Web of Science ®Google Scholar
• Bass DA. Reproduction of the eosinopenia of acute infection by passive transfer of a material obtained from inflammatory exudate. Infect Immun. 1977;15(2):410–416. doi:10.1128/iai.15.2.410-416.1977
   PubMed Web of Science ®Google Scholar
• Titova E, Christensen A, Henriksen AH, Steinshamn S, Åsberg A. Comparison of procalcitonin, C-reactive protein, white blood cell count and clinical status in diagnosing pneumonia in patients hospitalized with acute exacerbations of COPD: a prospective observational study. Chron Respir Dis. 2019;16:1479972318769762. doi:10.1177/1479972318769762
   Web of Science ®Google Scholar
• Gil H, Magy N, Mauny F, Dupond JL. [Value of eosinopenia in inflammatory disorders: an “old” marker revisited]. Rev Med Interne. 2003;24(7):431–435. French. doi:10.1016/S0248-8663(03)00138-3
   PubMed Web of Science ®Google Scholar
• Abidi K, Khoudri I, Belayachi J, et al. Eosinopenia is a reliable marker of sepsis on admission to medical intensive care units. Crit Care. 2008;12(2):R59. doi:10.1186/cc6883
   PubMed Web of Science ®Google Scholar
• Lieberman D, Lieberman D, Porath A. Seasonal variation in community-acquired pneumonia. Eur Respir J. 1996;9(12):2630–2634. doi:10.1183/09031936.96.09122630
   PubMed Web of Science ®Google Scholar