Clinical Indicators for Asthma-COPD Overlap: A Systematic Review and Meta-Analysis

References

• Yanagisawa S, Ichinose M. Definition and diagnosis of asthma-COPD overlap (ACO). Allergol Int. 2018;67(2):172–178. doi:10.1016/j.alit.2018.01.002
   PubMed Web of Science ®Google Scholar
• Hosseini M, Almasi-Hashiani A, Sepidarkish M, Maroufizadeh S. Global prevalence of asthma-COPD overlap (ACO) in the general population: a systematic review and meta-analysis. Respir Res. 2019;20(1):229. doi:10.1186/s12931-019-1198-4
   PubMed Web of Science ®Google Scholar
• Global Initiative for Asthma. Global strategy for asthma management and prevention; 2021. Available from: https://ginasthma.org/wp-content/uploads/2021/05/GINA-Main-Report-2021-V2-WMS.pdf. Accessed 5 June, 2021.
   Google Scholar
• Nuñez A, Sarasate M, Loeb E, Esquinas C, Miravitlles M, Barrecheguren M. Practical guide to the identification and diagnosis of asthma-COPD overlap (ACO). COPD. 2019;16(1):1–7. doi:10.1080/15412555.2019.1575802
   PubMedGoogle Scholar
• Fahy JV. Type 2 inflammation in asthma – present in most, absent in many. Nat Rev Immunol. 2015;15(1):57–65. doi:10.1038/nri3786
   PubMed Web of Science ®Google Scholar
• Barnes PJ. Inflammatory mechanisms in patients with chronic obstructive pulmonary disease. J Allergy Clin Immunol. 2016;138(1):16–27. doi:10.1016/j.jaci.2016.05.011
   PubMed Web of Science ®Google Scholar
• Fu JJ, Gibson PG, Simpson JL, et al. Longitudinal changes in clinical outcomes in older patients with asthma, COPD and asthma-COPD overlap syndrome. Respiration. 2014;87(1):63–74. doi:10.1159/000352053
   PubMed Web of Science ®Google Scholar
• Inoue H, Nagase T, Morita S, et al. Prevalence and characteristics of asthma-COPD overlap syndrome identified by a stepwise approach. Int J Chron Obstruct Pulmon Dis. 2017;12:1803–1810. doi:10.2147/COPD.S133859
   PubMed Web of Science ®Google Scholar
• Kawamatawong T, Charoenniwassakul S, Rerkpattanapipat T. The asthma and chronic obstructive pulmonary disease overlap syndrome in tertiary care setting Thailand. Asia Pac Allergy. 2017;7(4):227–233. doi:10.5415/apallergy.2017.7.4.227
   PubMed Web of Science ®Google Scholar
• Shirai T, Hirai K, Gon Y, et al. Combined assessment of serum periostin and YKL-40 may identify asthma-COPD overlap. J Allergy Clin Immunol Pract. 2019;7(1):134–145.e1. doi:10.1016/j.jaip.2018.06.015
   PubMed Web of Science ®Google Scholar
• Stroup DF, Berlin JA, Morton SC, et al. Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis of observational studies in epidemiology (MOOSE) group. JAMA. 2000;283(15):2008–2012. doi:10.1001/jama.283.15.2008
   PubMed Web of Science ®Google Scholar
• Global Initiative for Chronic Obstructive Lung Disease. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease (2021 report); 2020. Available from: https://goldcopd.org/wp-content/uploads/2020/11/GOLD-REPORT-2021-v1.1-25Nov20. Accessed 5 June, 2021.
   Google Scholar
• Luo D, Wan X, Liu J, et al. Optimally estimating the sample mean from the sample size, median, mid-range, and/or mid-quartile range. Stat Methods Med Res. 2018;27(6):1785–1805. doi:10.1177/0962280216669183
   PubMed Web of Science ®Google Scholar
• Wan X, Wang W, Liu J, et al. Estimating the sample mean and standard deviation from the sample size, median, range and/or interquartile range. BMC Med Res Methodol. 2014;14(1):135. doi:10.1186/1471-2288-14-135
   PubMed Web of Science ®Google Scholar
• Higgins JPT, Thomas J, Chandler J, et al. Cochrane handbook for systematic reviews of interventions version 6.2 (updated February 2021). Cochrane; 2021. Available from: www.training.cochrane.org/handbook. Accessed October 5, 2022.
   Google Scholar
• Rostom A, Dube C, Cranney A, et al.; Celiac Disease. Agency for healthcare research and quality (US). Rockville (MD); 2004. Available from: https://www.ncbi.nlm.nih.gov/books/NBK35156/. Accessed 5 June, 2021.
   Google Scholar
• Doidge JC, Harron KL. Reflections on modern methods: linkage error bias. Int J Epidemiol. 2019;48(6):2050–2060. doi:10.1093/ije/dyz203
   PubMed Web of Science ®Google Scholar
• Fu JJ, McDonald VM, Gibson PG, et al. Systemic inflammation in older adults with asthma-COPD overlap syndrome. Allergy Asthma Immunol Res. 2014;6(4):316–324. doi:10.4168/aair.2014.6.4.316
   PubMed Web of Science ®Google Scholar
• Lee HY, Kang JY, Yoon HK, et al. Clinical characteristics of asthma combined with COPD feature. Yonsei Med J. 2014;55(4):980–986. doi:10.3349/ymj.2014.55.4.980
   PubMed Web of Science ®Google Scholar
• Carpagnano GE, Lacedonia D, Carone M, et al. Study of mitochondrial DNA alteration in the exhaled breath condensate of patients affected by obstructive lung diseases. J Breath Res. 2016;10(2):026005. doi:10.1088/1752-7155/10/2/026005
   PubMed Web of Science ®Google Scholar
• Cosio BG, Soriano JB, López-Campos JL, et al. Defining the asthma-COPD overlap syndrome in a COPD cohort. Chest. 2016;149(1):45–52. doi:10.1378/chest.15-1055
   PubMed Web of Science ®Google Scholar
• Gao J, Iwamoto H, Koskela J, et al. Characterization of sputum biomarkers for asthma-COPD overlap syndrome. Int J Chron Obstruct Pulmon Dis. 2016;11:2457–2465. doi:10.2147/COPD.S113484
   PubMed Web of Science ®Google Scholar
• Goto T, Camargo CA, Hasegawa K. Fractional exhaled nitric oxide levels in asthma-COPD overlap syndrome: analysis of the National Health and nutrition examination survey, 2007–2012. Int J Chron Obstruct Pulmon Dis. 2016;11:2149–2155. doi:10.2147/COPD.S110879
   PubMed Web of Science ®Google Scholar
• Kalinina EP, Denisenko YK, Vitkina TI, et al. The mechanisms of the regulation of immune response in patients with comorbidity of chronic obstructive pulmonary disease and asthma. Can Respir J. 2016;2016:4503267. doi:10.1155/2016/4503267
   PubMed Web of Science ®Google Scholar
• Bai JW, Mao B, Yang WL, et al. Asthma-COPD overlap syndrome showed more exacerbations however lower mortality than COPD. QJM. 2017;110(7):431–436. doi:10.1093/qjmed/hcx005
   PubMed Web of Science ®Google Scholar
• Gao J, Zhou W, Chen B, et al. Sputum cell count: biomarkers in the differentiation of asthma, COPD and asthma-COPD overlap. Int J Chron Obstruct Pulmon Dis. 2017;12:2703–2710. doi:10.2147/COPD.S142466
   PubMed Web of Science ®Google Scholar
• Kodama Y, Kishimoto Y, Muramatsu Y, et al. Antioxidant nutrients in plasma of Japanese patients with chronic obstructive pulmonary disease, asthma-COPD overlap syndrome and bronchial asthma. Clin Respir J. 2017;11(6):915–924. doi:10.1111/crj.12436
   PubMed Web of Science ®Google Scholar
• Kurashima K, Takaku Y, Ohta C, et al. Smoking history and emphysema in asthma-COPD overlap. Int J Chron Obstruct Pulmon Dis. 2017;12:3523–3532. doi:10.2147/COPD.S149382
   PubMed Web of Science ®Google Scholar
• Lacedonia D, Palladino GP, Foschino-Barbaro MP, et al. Expression profiling of miRNA-145 and miRNA-338 in serum and sputum of patients with COPD, asthma, and asthma-COPD overlap syndrome phenotype. Int J Chron Obstruct Pulmon Dis. 2017;12:1811–1817. doi:10.2147/COPD.S130616
   PubMed Web of Science ®Google Scholar
• Boulet LP, Boulay MÈ, Dérival JL, et al. Asthma-COPD Overlap Phenotypes and Smoking: comparative features of asthma in smoking or non-smoking patients with an incomplete reversibility of airway obstruction. COPD. 2018;15(2):130–138. doi:10.1080/15412555.2017.1395834
   PubMedGoogle Scholar
• de Llano LP, Cosío BG, Iglesias A, et al. Mixed Th2 and non-Th2 inflammatory pattern in the asthma-COPD overlap: a network approach. Int J Chron Obstruct Pulmon Dis. 2018;13:591–601. doi:10.2147/COPD.S153694
   PubMed Web of Science ®Google Scholar
• Duong-Quy S, Tran Van H, Vo Thi Kim A, et al. Clinical and functional characteristics of subjects with asthma, COPD, and asthma-COPD overlap: a multicentre study in Vietnam. Can Respir J. 2018;2018:1732946. doi:10.1155/2018/1732946
   PubMed Web of Science ®Google Scholar
• Ekerljung L, Mincheva R, Hagstad S, et al. Prevalence, clinical characteristics and morbidity of the Asthma-COPD overlap in a general population sample. J Asthma. 2018;55(5):461–469. doi:10.1080/02770903.2017.1339799
   PubMed Web of Science ®Google Scholar
• Guo Y, Hong C, Liu Y, et al. Diagnostic value of fractional exhaled nitric oxide for asthma-chronic obstructive pulmonary disease overlap syndrome. Medicine. 2018;97(23):e10857. doi:10.1097/MD.0000000000010857
   PubMed Web of Science ®Google Scholar
• Jo YS, Kwon SO, Kim J, et al. Neutrophil gelatinase-associated lipocalin as a complementary biomarker for the asthma-chronic obstructive pulmonary disease overlap. J Thorac Dis. 2018;10(8):5047–5056. doi:10.21037/jtd.2018.07.86
   PubMed Web of Science ®Google Scholar
• Oh JY, Lee YS, Min KH, et al. Increased urinary l-histidine in patients with asthma-COPD overlap: a pilot study. Int J Chron Obstruct Pulmon Dis. 2018;13:1809–1818. doi:10.2147/COPD.S163189
   PubMed Web of Science ®Google Scholar
• Ojanguren I, Moullec G, Hobeika J, et al. Clinical and inflammatory characteristics of Asthma-COPD overlap in workers with occupational asthma. PLoS One. 2018;13(3):e0193144. doi:10.1371/journal.pone.0193144
   PubMed Web of Science ®Google Scholar
• Park HY, Lee SY, Kang D, et al. Favorable longitudinal change of lung function in patients with asthma-COPD overlap from a COPD cohort. Respir Res. 2018;19(1):36. doi:10.1186/s12931-018-0737-8
   PubMed Web of Science ®Google Scholar
• Shi F, Qiu C, Yu J, et al. Comparison of fractional exhaled nitric oxide in elderly patients with asthma-chronic obstructive pulmonary disease overlap and other airway inflammatory diseases. Iran J Allergy Asthma Immunol. 2018;17(3):232–239.
   PubMed Web of Science ®Google Scholar
• Takayama Y, Ohnishi H, Ogasawara F, et al. Clinical utility of fractional exhaled nitric oxide and blood eosinophils counts in the diagnosis of asthma-COPD overlap. Int J Chron Obstruct Pulmon Dis. 2018;13:2525–2532. doi:10.2147/COPD.S167600
   PubMed Web of Science ®Google Scholar
• Wang J, Lv H, Luo Z, et al. Plasma YKL-40 and NGAL are useful in distinguishing ACO from asthma and COPD. Respir Res. 2018;19(1):47. doi:10.1186/s12931-018-0755-6
   PubMed Web of Science ®Google Scholar
• Cai C, Bian X, Xue M, et al. Eicosanoids metabolized through LOX distinguish asthma-COPD overlap from COPD by metabolomics study. Int J Chron Obstruct Pulmon Dis. 2019;14:1769–1778. doi:10.2147/COPD.S207023
   PubMed Web of Science ®Google Scholar
• Chen FJ, Lin GP, Huang XY, et al. Evaluation of the characteristics of asthma in severe and extremely severe COPD. Int J Chron Obstruct Pulmon Dis. 2019;14:2663–2671. doi:10.2147/COPD.S225258
   PubMed Web of Science ®Google Scholar
• Kyogoku Y, Sugiura H, Ichikawa T, et al. Nitrosative stress in patients with asthma-chronic obstructive pulmonary disease overlap. J Allergy Clin Immunol. 2019;144(4):972–983.e14. doi:10.1016/j.jaci.2019.04.023
   PubMed Web of Science ®Google Scholar
• Park SY, Jung H, Kim JH, et al. Longitudinal analysis to better characterize Asthma-COPD overlap syndrome: findings from an adult asthma cohort in Korea (COREA). Clin Exp Allergy. 2019;49(5):603–614. doi:10.1111/cea.13339
   PubMed Web of Science ®Google Scholar
• Sevimli N, Yapar D, Türktaş H. The prevalence of asthma-COPD overlap (ACO) among patients with asthma. Turk Thorac J. 2019;20(2):97–102. doi:10.5152/TurkThoracJ.2018.18055
   PubMed Web of Science ®Google Scholar
• Backer V, Klein DK, Bodtger U, et al. Clinical characteristics of the BREATHE cohort – a real-life study on patients with asthma and COPD. Eur Clin Respir J. 2020;7(1):1736934. doi:10.1080/20018525.2020.1736934
   PubMed Web of Science ®Google Scholar
• Ding Q, Sun S, Zhang Y, et al. Serum IL-8 and VEGFA are two promising diagnostic biomarkers of asthma-COPD overlap syndrome. Int J Chron Obstruct Pulmon Dis. 2020;15:357–365. doi:10.2147/COPD.S233461
   PubMed Web of Science ®Google Scholar
• Gava G, Núñez A, Esquinas C, et al. Analysis of blood biomarkers in patients with chronic obstructive pulmonary disease (COPD) and with asthma-COPD overlap (ACO). COPD. 2020;17(3):306–310. doi:10.1080/15412555.2020.1761314
   PubMedGoogle Scholar
• Ghosh N, Choudhury P, Kaushik SR, et al. Metabolomic fingerprinting and systemic inflammatory profiling of asthma COPD overlap (ACO). Respir Res. 2020;21(1):126. doi:10.1186/s12931-020-01390-4
   PubMed Web of Science ®Google Scholar
• Kang J, Zheng J, Cai B, et al. Current situation of asthma-COPD overlap in Chinese patients older than 40 years with airflow limitation: a multicenter, cross-sectional, non-interventional study. Ther Adv Respir Dis. 2020;14:1753466620961699. doi:10.1177/1753466620961699
   Web of Science ®Google Scholar
• Kobayashi S, Hanagama M, Ishida M, et al. Clinical characteristics and outcomes of patients with asthma-COPD overlap in Japanese patients with COPD. Int J Chron Obstruct Pulmon Dis. 2020;15:2923–2929. doi:10.2147/COPD.S276314
   PubMed Web of Science ®Google Scholar
• Kubysheva N, Boldina M, Eliseeva T, et al. Relationship of serum levels of IL-17, IL-18, TNF-α, and lung function parameters in patients with COPD, asthma-COPD overlap, and bronchial asthma. Mediators Inflamm. 2020;2020:4652898. doi:10.1155/2020/4652898
   PubMed Web of Science ®Google Scholar
• Li M, Yang T, He R, et al. The value of inflammatory biomarkers in differentiating asthma-COPD overlap from COPD. Int J Chron Obstruct Pulmon Dis. 2020;15:3025–3037. doi:10.2147/COPD.S273422
   PubMed Web of Science ®Google Scholar
• Lim JU, Kim DK, Lee MG, et al. Clinical characteristics and changes of clinical features in patients with asthma-COPD overlap in Korea according to different diagnostic criteria. Tuberc Respir Dis. 2020;83(Supple1):S34–S45. doi:10.4046/trd.2020.0031
   PubMed Web of Science ®Google Scholar
• Queiroz APA, Fonseca FR, Rê A, et al. Clinical, laboratory, and functional characteristics of asthma-COPD overlap in patients with a primary diagnosis of COPD. J Bras Pneumol. 2020;47(1):e20200033. doi:10.36416/1806-3756/e20200033
   PubMed Web of Science ®Google Scholar
• Chen YC, Tsai YH, Wang CC, et al. Epigenome-wide association study on asthma and chronic obstructive pulmonary disease overlap reveals aberrant DNA methylations related to clinical phenotypes. Sci Rep. 2021;11(1):5022. doi:10.1038/s41598-021-83185-1
   PubMed Web of Science ®Google Scholar
• Shi B, Li W, Hao Y, et al. Characteristics of inflammatory phenotypes among patients with asthma: relationships of blood count parameters with sputum cellular phenotypes. Allergy Asthma Clin Immunol. 2021;17(1):47. doi:10.1186/s13223-021-00548-z
   PubMed Web of Science ®Google Scholar
• Toyota H, Sugimoto N, Kobayashi K, et al. Comprehensive analysis of allergen-specific IgE in COPD: mite-specific IgE specifically related to the diagnosis of asthma-COPD overlap. Allergy Asthma Clin Immunol. 2021;17(1):13. doi:10.1186/s13223-021-00514-9
   PubMed Web of Science ®Google Scholar
• Lei J, Yang T, Liang C, et al. Comparison of clinical characteristics and short-term prognoses within hospitalized chronic obstructive pulmonary disease patients comorbid with asthma, bronchiectasis, and their overlaps: findings from the ACURE registry. Front Med. 2022;9:817048. doi:10.3389/fmed.2022.817048
   Web of Science ®Google Scholar
• Tamura K, Shirai T, Hirai K, et al. Mucus plugs and small airway dysfunction in asthma, COPD, and asthma-COPD overlap. Allergy Asthma Immunol Res. 2022;14(2):196–209. doi:10.4168/aair.2022.14.2.196
   PubMed Web of Science ®Google Scholar
• Hegewald MJ. Diffusing capacity. Clin Rev Allergy Immunol. 2009;37(3):159–166. doi:10.1007/s12016-009-8125-2
   PubMed Web of Science ®Google Scholar
• Enright MP. Office-based DLCO tests help pulmonologists to make important clinical decisions. Respir Investig. 2016;54(5):305–311. doi:10.1016/j.resinv.2016.03.006
   PubMedGoogle Scholar
• Fujino N, Sugiura H. ACO (asthma-COPD overlap) is independent from COPD, a case in favor: a systematic review. Diagnostics. 2021;11(5):859. doi:10.3390/diagnostics11050859
   Web of Science ®Google Scholar
• Novosad J, Krčmová I. Evolution of our view on the IgE molecule role in bronchial asthma and the clinical effect of its modulation by omalizumab: where do we stand today? Int J Immunopathol Pharmacol. 2020;34:2058738420942386. doi:10.1177/2058738420942386
   Web of Science ®Google Scholar
• Hersh CP, Zacharia S, Chelvan R P, et al. Immunoglobulin E as a biomarker for the overlap of atopic asthma and chronic obstructive pulmonary disease. Chronic Obstr Pulm Dis. 2020;7(1):1–12. doi:10.15326/jcopdf.7.1.2019.0138
   PubMed Web of Science ®Google Scholar
• Tashkin DP, Wechsler ME. Role of eosinophils in airway inflammation of chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis. 2018;13:335–349. doi:10.2147/COPD.S152291
   PubMed Web of Science ®Google Scholar
• Hammad H, Lambrecht BN. The basic immunology of asthma. Cell. 2021;184(6):1469–1485. doi:10.1016/j.cell.2021.02.016
   PubMed Web of Science ®Google Scholar
• Zhou XL, Zhao LY. Comparison of clinical features and outcomes for asthma-COPD overlap syndrome vs. COPD patients: a systematic review and meta-analysis. Eur Rev Med Pharmacol Sci. 2021;25(3):1495–1510. doi:10.26355/eurrev_202102_24857
   PubMed Web of Science ®Google Scholar