104
Views
29
CrossRef citations to date
0
Altmetric
Original Research

Effect of high-dose N-acetylcysteine on airway geometry, inflammation, and oxidative stress in COPD patients

, , , , , & show all
Pages 569-579 | Published online: 22 Nov 2013

References

  • HoggJCChronic obstructive pulmonary disease: an overview of pathology and pathogenesisNovartis Found Symp200123441911199102
  • KuwanoKBoskenCHParéPDBaiTRWiggsBRHoggJCSmall airways dimensions in asthma and in chronic obstructive pulmonary diseaseAm Rev Respir Dis19931485122012258239157
  • BoskenCHWiggsBRParéPDHoggJCSmall airway dimensions in smokers with obstruction to airflowAm Rev Respir Dis199014235635702389908
  • SadowskaAMVan OverveldFJGóreckaDThe interrelationship between markers of inflammation and oxidative stress in chronic obstructive pulmonary disease: modulation by inhaled steroids and antioxidantRespir Med200599224124915715193
  • SadowskaAMVerbraeckenJDarquennesKDe BackerWARole of N-acetylcysteine in the management of COPDInt J Chron Obstruct Pulmon Dis20061442543418044098
  • SadowskaAMManuel-y-KeenoyBVertongenTEffect of N-acetylcysteine on neutrophil activation markers in healthy volunteers: in vivo and in vitro studyPharmacol Res200653321622516384711
  • SadowskaAMLuytenCVintsA-MVerbraeckenJVan RanstDDe BackerWASystemic antioxidant defences during acute exacerbation of chronic obstructive pulmonary diseaseRespirology200611674174717052302
  • DecramerMRutten-van MölkenMDekhuijzenPNREffects of N-acetylcysteine on outcomes in chronic obstructive pulmonary disease (Bronchitis Randomized on NAC Cost-Utility Study, BRONCUS): a randomised placebo-controlled trialLancet200536594701552156015866309
  • SadowskaAMManuel-Y-KeenoyBDe BackerWAAntioxidant and anti-inflammatory efficacy of NAC in the treatment of COPD: discordant in vitro and in vivo dose-effects: a reviewPulm Pharmacol Ther200720192216458553
  • De BackerLAVosWDe BackerJVan HolsbekeCVinchurkarSDe BackerWThe acute effect of budesonide/formoterol in COPD: a multi-slice computed tomography and lung function studyEur Respir J201240229830522183484
  • De BackerJWVosWGGorléCDFlow analyses in the lower airways: patient-specific model and boundary conditionsMed Eng Phys200830787287918096425
  • VinchurkarSBackerLDVosWHolsbekeCVBackerJDBackerWDA case series on lung deposition analysis of inhaled medication using functional imaging based computational fluid dynamics in asthmatic patients: effect of upper airway morphology and comparison with in vivo dataInhal Toxicol2012242818822260527
  • De BackerJWVosWGVinchurkarSCValidation of computational fluid dynamics in CT-based airway models with SPECT/CTRadiology2010257385486221084417
  • De RochefortLVialLFodilRIn vitro validation of computational fluid dynamic simulation in human proximal airways with hyperpolarized 3He magnetic resonance phase-contrast velocimetryJ Appl Physiol200710252012202317289906
  • De BackerJWVosWGDevolderAComputational fluid dynamics can detect changes in airway resistance in asthmatics after acute bronchodilationJ Biomech200841110611317698073
  • De BackerLVosWSalgadoRFunctional imaging using computer methods to compare the effect of salbutamol and ipratropium bromide in patient-specific airway models of COPDInt J Chron Obstruct Pulmon Dis 201120116637646
  • LappasMPermezelMRiceGEN-Acetyl-cysteine inhibits phospholipid metabolism, proinflammatory cytokine release, protease activity, and nuclear factor-kappaB deoxyribonucleic acid-binding activity in human fetal membranes in vitroJ Clin Endocrinol Metabol200388417231729
  • UngheriDPisaniCSansonGProtective effect of n-acetylcysteine in a model of influenza infection in miceInt J Immunopathol Pharmacol200013312312812657201
  • CaiSChenPZhangCChenJ-BWuJOral N-acetylcysteine attenuates pulmonary emphysema and alveolar septal cell apoptosis in smoking-induced COPD in ratsRespirology200914335435919341424
  • DekhuijzenPNVan BeurdenWJThe role for N-acetylcysteine in the management of COPDInt J Chron Obstruct Pulmon Dis2006129910618046886
  • StavDRazMEffect of N-acetylcysteine on air trapping in COPD: a randomized placebo-controlled studyChest2009136238138619447919
  • CelliBCOPD, inflammation and its modulation by phosphodiesterase 4 inhibitors: time to look beyond the FEV1Chest200612915616424403
  • JonesPWHealth status measurement in chronic obstructive pulmonary diseaseThorax2001561188088711641515
  • WedzichaJDecramerMSeemungalTThe role of bronchodilator treatment in the prevention of exacerbations of COPDEur Respir J20124061545155422835613
  • ComeCEDivoMJSan José EstéparRLung deflation and oxygen pulse in COPD: results from the NETT randomized trialRespir Med2012106110911921843930