114
Views
28
CrossRef citations to date
0
Altmetric
Review

Update on the pathological processes, molecular biology, and clinical utility of N-acetylcysteine in chronic obstructive pulmonary disease

&
Pages 825-836 | Published online: 06 Aug 2014

References

  • MakitaHNasuharaYNagaiKHokkaido COPD Cohort Study GroupCharacterisation of phenotypes based on severity of emphysema in chronic obstructive pulmonary diseaseThorax2007621193293717573447
  • PatelBMakeBCoxsonHOAirway and parenchymal disease in chronic obstructive pulmonary disease are distinct phenotypesProc Am Thorac Soc200636533
  • HoggJCChuFUtokaparchSThe nature of small-airway obstruction in chronic obstructive pulmonary diseaseN Engl J Med2004350262645265315215480
  • HurstJRVestboJAnzuetoASusceptibility to exacerbation in chronic obstructive pulmonary diseaseN Engl J Med2010363121128113820843247
  • YaoHRahmanICurrent concepts on oxidative/carbonyl stress, inflammation and epigenetics in pathogenesis of chronic obstructive pulmonary diseaseToxicol Appl Pharmacol20112542728521296096
  • ToyoshimaMChidaKSudaTSatoMIs autoimmunity really related to the pathogenesis of COPD?Am J Respir Crit Care Med2011184101212121322086993
  • BarbuCIordacheMManMGInflammation in COPD: pathogenesis, local and systemic effectsRom J Morphol Embryol2011521212721424028
  • CornwellWDKimVSongCRogersTJPathogenesis of inflammation and repair in advanced COPDSemin Respir Crit Care Med201031325726620496295
  • FukeSBetsuyakuTNasuharaYMorikawaTKatohHNishimuraMChemokines in bronchiolar epithelium in the development of chronic obstructive pulmonary diseaseAm J Respir Cell Mol Biol200431440541215220136
  • LamsBESousaARReesPJLeeTHSubepithelial immunopathology of the large airways in smokers with and without chronic obstructive pulmonary diseaseEur Respir J200015351251610759445
  • O’ShaughnessyTCAnsariTWBarnesNCJefferyPKInflammation in bronchial biopsies of subjects with chronic bronchitis: inverse relationship of CD8+ T lymphocytes with FEV1Am J Respir Crit Care Med199715538528579117016
  • SaettaMDi StefanoATuratoGCD8+ T-lymphocytes in peripheral airways of smokers with chronic obstructive pulmonary diseaseAm J Respir Crit Care Med19981573 Pt 18228269517597
  • BaraldoSTuratoGBadinCNeutrophilic infiltration within the airway smooth muscle in patients with COPDThorax200459430831215047950
  • MiottoDRuggieriMPBoschettoPInterleukin-13 and -4 expression in the central airways of smokers with chronic bronchitisEur Respir J200322460260814582911
  • SaettaMTuratoGMaestrelliPMappCEFabbriLMCellular and structural bases of chronic obstructive pulmonary diseaseAm J Respir Crit Care Med200116361304130911371392
  • DaheshiaMTherapeutic inhibition of matrix metalloproteinases for the treatment of chronic obstructive pulmonary disease (COPD)Curr Med Res Opin200521458759415899108
  • MacneeWRahmanIOxidants and antioxidants as therapeutic targets in chronic obstructive pulmonary diseaseAm J Respir Crit Care Med19991605 Pt 2S58S6510556172
  • MocchegianiEGiacconiRCostarelliLMetalloproteases/anti-metalloproteases imbalance in chronic obstructive pulmonary disease: genetic factors and treatment implicationsCurr Opin Pulm Med201117Suppl 1S11S1922209925
  • ChurgAZhouSWrightJLSeries “matrix metalloproteinases in lung health and disease”: matrix metalloproteinases in COPDEur Respir J201239119720921920892
  • MalemudCJMatrix metalloproteinases (MMPs) in health and disease: an overviewFront Biosci2006111696170116368548
  • HautamakiRDKobayashiDKSeniorRMShapiroSDRequirement for macrophage elastase for cigarette smoke-induced emphysema in miceScience19972775334200220049302297
  • HassettDJBorchersMTPanosRJChronic obstructive pulmonary disease (COPD): evaluation from clinical, immunological and bacterial pathogenesis perspectivesJ Microbiol201452321122624585052
  • WozniakAGoreckiDSzpindaMMila-KierzenkowskaCWozniakBOxidant-antioxidant balance in the blood of patients with chronic obstructive pulmonary disease after smoking cessationOxid Med Cell Longev2013201389707524089631
  • CristovaoCCristovaoLNogueiraFBichoMEvaluation of the oxidant and antioxidant balance in the pathogenesis of chronic obstructive pulmonary diseaseRev Port Pneumol2013192707523199890
  • AhmadAShameemMHusainQAltered oxidant-antioxidant levels in the disease prognosis of chronic obstructive pulmonary diseaseInt J Tuberc Lung Dis20131781104110923827037
  • NicksMEO’BrienMMBowlerRPPlasma antioxidants are associated with impaired lung function and COPD exacerbations in smokersCOPD20118426426921627570
  • IvesSJHarrisRAWitmanMAVascular dysfunction and chronic obstructive pulmonary disease: the role of redox balanceHypertension201463345946724324045
  • AaronSDAngelJBLunauMGranulocyte inflammatory markers and airway infection during acute exacerbation of chronic obstructive pulmonary diseaseAm J Respir Crit Care Med2001163234935511179105
  • GompertzSBayleyDLHillSLStockleyRARelationship between airway inflammation and the frequency of exacerbations in patients with smoking related COPDThorax2001561364111120902
  • PinamontiSLeisMBarbieriADetection of xanthine oxidase activity products by EPR and HPLC in bronchoalveolar lavage fluid from patients with chronic obstructive pulmonary diseaseFree Radic Biol Med19982577717799823542
  • BindoliAFukutoJMFormanHJThiol chemistry in peroxidase catalysis and redox signalingAntioxid Redox Signal20081091549156418479206
  • ChurchDFPryorWAFree-radical chemistry of cigarette smoke and its toxicological implicationsEnviron Health Perspect1985641111263007083
  • RahmanIvan SchadewijkAACrowtherAJ4-Hydroxy-2-nonenal, a specific lipid peroxidation product, is elevated in lungs of patients with chronic obstructive pulmonary diseaseAm J Respir Crit Care Med2002166449049512186826
  • CantinAMNorthSLHubbardRCCrystalRGNormal alveolar epithelial lining fluid contains high levels of glutathioneJ Appl Physiol (1985)19876311521573040659
  • YaoHArunachalamGHwangJWExtracellular superoxide dismutase protects against pulmonary emphysema by attenuating oxidative fragmentation of ECMProc Natl Acad Sci U S A201010735155711557620713693
  • ChristmanJWSadikotRTBlackwellTSThe role of nuclear factor-kappa B in pulmonary diseasesChest200011751482148710807839
  • PantanoCReynaertNLvan der VlietAJanssen-HeiningerYMRedox-sensitive kinases of the nuclear factor-kappaB signaling pathwayAntioxid Redox Signal200689–101791180616987032
  • SenguptaNSetoERegulation of histone deacetylase activitiesJ Cell Biochem2004931576715352162
  • ItoKItoMElliottWMDecreased histone deacetylase activity in chronic obstructive pulmonary diseaseN Engl J Med2005352191967197615888697
  • YangSRChidaASBauterMRCigarette smoke induces proinflammatory cytokine release by activation of NF-kappaB and posttranslational modifications of histone deacetylase in macrophagesAm J Physiol Lung Cell Mol Physiol20062911L46L5716473865
  • PotenteMDimmelerSEmerging roles of SIRT1 in vascular endothelial homeostasisCell Cycle20087142117212218641460
  • RajendrasozhanSYangSRKinnulaVLRahmanISIRT1, an antiinflammatory and antiaging protein, is decreased in lungs of patients with chronic obstructive pulmonary diseaseAm J Respir Crit Care Med2008177886187018174544
  • KenslerTWWakabayashiNBiswalSCell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathwayAnnu Rev Pharmacol Toxicol2007478911616968214
  • GovenDBouttenALecon-MalasVAltered Nrf2/Keap1-Bach1 equilibrium in pulmonary emphysemaThorax2008631091692418559366
  • MalhotraDThimmulappaRNavas-AcienADecline in NRF2-regulated antioxidants in chronic obstructive pulmonary disease lungs due to loss of its positive regulator, DJ-1Am J Respir Crit Care Med2008178659260418556627
  • SuzukiMBetsuyakuTItoYDown-regulated NF-E2-related factor 2 in pulmonary macrophages of aged smokers and patients with chronic obstructive pulmonary diseaseAm J Respir Cell Mol Biol200839667368218566336
  • AdenugaDCaitoSYaoHNrf2 deficiency influences susceptibility to steroid resistance via HDAC2 reductionBiochem Biophys Res Commun20104033–445245621094147
  • MercadoNThimmulappaRThomasCMDecreased histone deacetylase 2 impairs Nrf2 activation by oxidative stressBiochem Biophys Res Commun2011406229229821320471
  • BrittonJRPavordIDRichardsKADietary antioxidant vitamin intake and lung function in the general populationAm J Respir Crit Care Med19951515138313877735589
  • GrievinkLSmitHAOckeMCvan ‘t VeerPKromhoutDDietary intake of antioxidant (pro)-vitamins, respiratory symptoms and pulmonary function: the MORGEN studyThorax19985331661719659349
  • RautalahtiMVirtamoJHaukkaJThe effect of alpha-tocopherol and beta-carotene supplementation on COPD symptomsAm J Respir Crit Care Med19971565144714529372659
  • SargeantLAJaeckelAWarehamNJInteraction of vitamin C with the relation between smoking and obstructive airways disease in EPIC Norfolk. European Prospective Investigation into Cancer and NutritionEur Respir J200016339740311028650
  • ArtsICHollmanPCPolyphenols and disease risk in epidemiologic studiesAm J Clin Nutr200581Suppl 1317S325S15640497
  • TabakCArtsICSmitHAHeederikDKromhoutDChronic obstructive pulmonary disease and intake of catechins, flavonols, and flavones: the MORGEN StudyAm J Respir Crit Care Med20011641616411435239
  • SantusPSolaACarlucciPLipid peroxidation and 5-lipoxygenase activity in chronic obstructive pulmonary diseaseAm J Respir Crit Care Med2005171883884315579728
  • WaldaICTabakCSmitHADiet and 20-year chronic obstructive pulmonary disease mortality in middle-aged men from three European countriesEur J Clin Nutr200256763864312080403
  • KodeARajendrasozhanSCaitoSYangSRMegsonILRahmanIResveratrol induces glutathione synthesis by activation of Nrf2 and protects against cigarette smoke-mediated oxidative stress in human lung epithelial cellsAm J Physiol Lung Cell Mol Physiol20082943L478L48818162601
  • BiswasSKMcClureDJimenezLAMegsonILRahmanICurcumin induces glutathione biosynthesis and inhibits NF-kappaB activation and interleukin-8 release in alveolar epithelial cells: mechanism of free radical scavenging activityAntioxid Redox Signal200571–2324115650394
  • CulpittSVRogersDFFenwickPSInhibition by red wine extract, resveratrol, of cytokine release by alveolar macrophages in COPDThorax2003581194294614586044
  • MannaSKMukhopadhyayAAggarwalBBResveratrol suppresses TNF-induced activation of nuclear transcription factors NF-kappa B, activator protein-1, and apoptosis: potential role of reactive oxygen intermediates and lipid peroxidationJ Immunol2000164126509651910843709
  • ShishodiaSPotdarPGairolaCGAggarwalBBCurcumin (diferuloylmethane) down-regulates cigarette smoke-induced NF-kappaB activation through inhibition of IkappaBalpha kinase in human lung epithelial cells: correlation with suppression of COX-2, MMP-9 and cyclin D1Carcinogenesis20032471269127912807725
  • ZhengJPKangJHuangSGEffect of carbocisteine on acute exacerbation of chronic obstructive pulmonary disease (PEACE study): a randomised placebo-controlled studyLancet200837196292013201818555912
  • MorettiMBottrighiPDallariRThe effect of long-term treatment with erdosteine on chronic obstructive pulmonary disease: the EQUALIFE studyDrugs Exp Clin Res200430414315215553660
  • MorettiMMarchioniCFAn overview of erdosteine antioxidant activity in experimental researchPharmacol Res200755424925417267240
  • Dal NegroRWViscontiMMichelettoCTognellaSChanges in blood ROS, e-NO, and some pro-inflammatory mediators in bronchial secretions following erdosteine or placebo: a controlled study in current smokers with mild COPDPulm Pharmacol Ther200821230430817889580
  • RheeCKKangCMYouMBEffect of fudosteine on mucin productionEur Respir J20083251195120218579549
  • RahmanIAntioxidant therapeutic advances in COPDTher Adv Respir Dis20082635137419124382
  • RahmanIPharmacological antioxidant strategies as therapeutic interventions for COPDBiochim Biophys Acta20121822571472822101076
  • DavisSSScobieSInglisAThe effect of sulphydryl compounds and cross linking agents on the viscous and viscoelastic properties of mucusBiorheology1975123–42252321125
  • SadowskaAMN-Acetylcysteine mucolysis in the management of chronic obstructive pulmonary diseaseTher Adv Respir Dis20126312713522361928
  • SheffnerALThe reduction in vitro in viscosity of mucoprotein solutions by a new mucolytic agent, N-acetyl-L-cysteineAnn N Y Acad Sci196310629831013977050
  • MataMRuizACerdaMOral N-acetylcysteine reduces bleomycin-induced lung damage and mucin Muc5ac expression in ratsEur Respir J200322690090514680076
  • SadowskaAMManuelYKBDe BackerWAAntioxidant and anti-inflammatory efficacy of NAC in the treatment of COPD: discordant in vitro and in vivo dose-effects: a reviewPulm Pharmacol Ther200720192216458553
  • MoldeusPCotgreaveIABerggrenMLung protection by a thiol-containing antioxidant: N-acetylcysteineRespiration198650Suppl 131423809741
  • BridgemanMMMarsdenMMacNeeWFlenleyDCRyleAPCysteine and glutathione concentrations in plasma and bronchoalveolar lavage fluid after treatment with N-acetylcysteineThorax199146139421871695
  • KasielskiMNowakDLong-term administration of N-acetylcysteine decreases hydrogen peroxide exhalation in subjects with chronic obstructive pulmonary diseaseRespir Med200195644845611421501
  • BridgesRBProtective action of thiols on neutrophil functionEur J Respir Dis Suppl198513940483862610
  • DrostELannanSBridgemanMMLack of effect of N-acetylcysteine on the release of oxygen radicals from neutrophils and alveolar macrophagesEur Respir J1991467237291889500
  • JefferyPKRogersDFAyersMMEffect of oral acetylcysteine on tobacco smoke-induced secretory cell hyperplasiaEur J Respir Dis Suppl19851391171223862604
  • EklundAErikssonOHakanssonLOral N-acetylcysteine reduces selected humoral markers of inflammatory cell activity in BAL fluid from healthy smokers: correlation to effects on cellular variablesEur Respir J1988198328382852604
  • van OverveldFJVermeirePADe BackerWAInduced sputum of patients with chronic obstructive pulmonary disease (COPD) contains adhesion-promoting, therapy-sensitive factorsInflamm Res200049181310778915
  • BorgstromLKagedalBDose dependent pharmacokinetics of N-acetylcysteine after oral dosing to manBiopharm Drug Dispos19901121311362328298
  • CotgreaveIAMoldeusPLung protection by thiol-containing antioxidantsBull Eur Physiopathol Respir19872342752773318962
  • BridgemanMMMarsdenMSelbyCMorrisonDMacNeeWEffect of N-acetyl cysteine on the concentrations of thiols in plasma, bronchoalveolar lavage fluid, and lung tissueThorax19944976706758066561
  • De BenedettoFAcetoADraganiBLong-term oral N-acetylcysteine reduces exhaled hydrogen peroxide in stable COPDPulm Pharmacol Ther2005181414715607126
  • LundbackBLMAnderssonSPossible effect of acetylcysteine on lung functionEur Respir J19925Suppl 15895
  • DecramerMRutten-van MolkenMDekhuijzenPNEffects of N-acetylcysteine on outcomes in chronic obstructive pulmonary disease (Bronchitis Randomized on NAC Cost-Utility Study, BRONCUS): a randomised placebo-controlled trialLancet200536594701552156015866309
  • PoolePBlackPNCatesCJMucolytic agents for chronic bronchitis or chronic obstructive pulmonary diseaseCochrane Database Syst Rev20128CD00128722895919
  • RubioMLSanchez-CifuentesMVOrtegaMN-acetylcysteine prevents cigarette smoke induced small airways alterations in ratsEur Respir J200015350551110759444
  • TseHNRaiteriLWongKYHigh-dose N-acetylcysteine in stable COPD: the 1-year, double-blind, randomized, placebo-controlled HIACE studyChest2013144110611823348146
  • GoldmanMDSaadehCRossDClinical applications of forced oscillation to assess peripheral airway functionRespir Physiol Neurobiol20051481–217919415990365
  • GrimbyGTakishimaTGrahamWMacklemPMeadJFrequency dependence of flow resistance in patients with obstructive lung diseaseJ Clin Invest1968476145514655653219
  • BrochardLPelleGde PalmasJDensity and frequency dependence of resistance in early airway obstructionAm Rev Respir Dis198713535795843826883
  • FariaACCostaAALopesAJJansenJMMeloPLForced oscillation technique in the detection of smoking-induced respiratory alterations: diagnostic accuracy and comparison with spirometryClinics (Sao Paulo)201065121295130421340218
  • StavDRazMEffect of N-acetylcysteine on air trapping in COPD: a randomized placebo-controlled studyChest2009136238138619447919
  • HanaokaMDromaYChenYCarbocisteine protects against emphysema induced by cigarette smoke extract in ratsChest201113951101110820847042
  • RubioMLMartin-MosqueroMCOrtegaMPeces-BarbaGGonzalez-MangadoNOral N-acetylcysteine attenuates elastase-induced pulmonary emphysema in ratsChest200412541500150615078764
  • CaiSChenPZhangCChenJBWuJOral N-acetylcysteine attenuates pulmonary emphysema and alveolar septal cell apoptosis in smoking-induced COPD in ratsRespirology200914335435919341424
  • Long-term oral acetylcysteine in chronic bronchitis. a double-blind controlled studyEur J Respir Dis Suppl1980111931087011836
  • [No authors listed]Oral N-acetylcysteine and exacerbation rates in patients with chronic bronchitis and severe airways obstruction. British Thoracic Society Research CommitteeThorax198540118328352866607
  • BomanGBackerULarssonSMelanderBWahlanderLOral acetylcysteine reduces exacerbation rate in chronic bronchitis: report of a trial organized by the Swedish Society for Pulmonary DiseasesEur J Respir Dis19836464054156350033
  • GrassiCMorandiniGCA controlled trial of intermittent oral acetylcysteine in the long-term treatment of chronic bronchitisEur J Clin Pharmacol197695–6393396786665
  • HansenNCSkriverABrorsen-RiisLOrally administered N-acetylcysteine may improve general well-being in patients with mild chronic bronchitisRespir Med19948875315357972979
  • PelaRCalcagniAMSubiacoSIsidoriPTubaldiASanguinettiCMN-acetylcysteine reduces the exacerbation rate in patients with moderate to severe COPDRespiration199966649550010575333
  • RasmussenJBGlennowCReduction in days of illness after long-term treatment with N-acetylcysteine controlled-release tablets in patients with chronic bronchitisEur Respir J1988143513553294038
  • SchermerTChavannesNDekhuijzenRFluticasone and N-acetylcysteine in primary care patients with COPD or chronic bronchitisRespir Med2009103454255119138505
  • ZhengJPWenFQBaiCXTwice daily N-acetylcysteine 600 mg for exacerbations of chronic obstructive pulmonary disease (PANTHEON): a randomised, double-blind placebo-controlled trialLancet Respir Med20142318719424621680
  • GerritsCMHeringsRMLeufkensHGLammersJWN-acetylcysteine reduces the risk of re-hospitalisation among patients with chronic obstructive pulmonary diseaseEur Respir J200321579579812765423
  • GrandjeanEMBerthetPRuffmannRLeuenbergerPEfficacy of oral long-term N-acetylcysteine in chronic bronchopulmonary disease: a meta-analysis of published double-blind, placebo-controlled clinical trialsClin Ther200022220922110743980
  • SteyCSteurerJBachmannSMediciTCTramerMRThe effect of oral N-acetylcysteine in chronic bronchitis: a quantitative systematic reviewEur Respir J200016225326210968500
  • NiedermanMSRaffertyTDSasakiCTMerrillWWMatthayRAReynoldsHYComparison of bacterial adherence to ciliated and squamous epithelial cells obtained from the human respiratory tractAm Rev Respir Dis1983127185906401417
  • SuerESayracSSarinayEVariation in the attachment of Streptococcus pneumoniae to human pharyngeal epithelial cells after treatment with S-carboxymethylcysteineJ Infect Chemother200814433333618709541
  • Radomska-LesniewskaDMSadowskaAMVan OverveldFJDemkowUZielinskiJDe BackerWAInfluence of N-acetylcysteine on ICAM-1 expression and IL-8 release from endothelial and epithelial cellsJ Physiol Pharmacol200657Suppl 432533417072061
  • SinojiaRShaikhMKodguleRPriming of beta-2 agonist and antimuscarinic induced physiological responses induced by 1200 mg/day NAC in moderate to severe COPD patients: a pilot studyRespir Physiol Neurobiol2014191525924211316
  • LindenMWieslanderEEklundALarssonKBrattsandREffects of oral N-acetylcysteine on cell content and macrophage function in bronchoalveolar lavage from healthy smokersEur Respir J1988176456502846345
  • RiiseGCQvarfordtILarssonSEliassonVAnderssonBAInhibitory effect of N-acetylcysteine on adherence of Streptococcus pneumoniae and Haemophilus influenzae to human oropharyngeal epithelial cells in vitroRespiration200067555255811070462
  • WuWPatelKBBoothJLZhangWMetcalfJPCigarette smoke extract suppresses the RIG-I-initiated innate immune response to influenza virus in the human lungAm J Physiol Lung Cell Mol Physiol20113006L821L83021335520
  • TseHNRaiteriLWongKYNgLYYeeKSTsengCZBenefits of high dose N-acetylcysteine to exacerbation-prone COPD patientsChest5152014 [Epub ahead of print.]
  • ZhouYWangXZengXPositive benefits of theophylline in a randomized, double-blind, parallel-group, placebo-controlled study of low-dose, slow-release theophylline in the treatment of COPD for 1 yearRespirology200611560361016916334
  • McGavinCRMacfarlaneJTPrescottRJElmesPFergusonANarimanSStableforthDOral N-acetylcysteine and exacerbation rates in patients with chronic bronchitis and severe airways obstructionThorax1985408328352866607
  • BaboliniHCharpinJGermoutyJMulticenter study group. Long term oral acetylcysteine in chronic bronchitis. A double-blind controlled studyEur J Respir Dis Suppl198061Suppl 11193108