References
- BuistAMcBurnieMVollmerWInternational variation in the prevalence of COPD (the BOLD study): a population-based prevalence studyLancet200737074175017765523
- MurrayCJLopezADMeasuring the global burden of diseaseN Engl J Med201336944845723902484
- HoggJCMacklemPTThurlbeckWMSite and nature of airway obstruction in chronic obstructive lung diseaseN Engl J Med1968278135513605650164
- CosioMGhezzoHHoggJCThe relations between structural changes in small airways and pulmonary-function testsN Engl J Med197829812771281651978
- HoggJCChuFUtokaparchSThe nature of small-airway obstruction in chronic obstructive pulmonary diseaseN Engl J Med20043502645265315215480
- McDonoughJEYuanRSuzukiMSmall-airway obstruction and emphysema in chronic obstructive pulmonary diseaseAm J Respir Crit Care Med201136515671575
- VestboJHurdSAgustìAGGlobal Strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease GOLD Executive SummaryAm J Respir Crit Care Med201318734736522878278
- SiafakasNMVermeirePPrideNBOptimal assessment and management of chronic obstructive pulmonary disease (COPD)Eur Respir J19958139814207489808
- BettoncelliGBlasiFBrusascoVThe clinical and integrated management of COPD. An official document of AIMAR, AIPO, SIMeR, SIMGSarcoidosis Vasc Diffuse Lung Dis201431Suppl 1321
- PellegrinoRViegiGBrusascoVInterpretative strategies for lung function testsEur Respir J20052694896816264058
- FletcherCPetoRTinkerCThe Natural History of Chronic Bronchitis and Emphysema An Eigth-Year Study of Early Chronic Obstructive Lung Disease in Working Men in LondonOxford, UKOxford University Press1976
- TantucciCModinaDLung function decline in COPDInt J COPD201279599
- MillerARaskinJMThe natural history of COPD: confirming and going beyond Fletcher and PetoEur Respir J20144428038325082904
- MacklemPTTherapeutic implications of the pathophysiology of COPDEur Respir J20103567668020190332
- HurstJRVestboJAnzuetoAEvaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) Investigators. Susceptibility to exacerbation in chronic obstructive pulmonary diseaseN Engl J Med20103631128113820843247
- HanMKKazerooniEALynchDAChronic obstructive pulmonary disease exacerbations in the COPD Gene Study: associated radiologic phenotypesRadiology201126127428221788524
- CazzolaMMateraMSantangeloGSalmeterol and formoterol in partially reversible severe chronic obstructive pulmonary disease: a dose-response studyRespir Med1995893573627638371
- VestboJTORCH Study GroupThe TORCH (TOwards a Revolution in COPD Health) survival study protocolEur Respir J20042420621015332386
- AugustiAFabbriLMInhaled steroids in COPD: when should they be used?Lancet2014286987125439566
- KaikGCombined administration of ipratropium bromide (SCH1000) and fenoterol in patients with chronic obstructive airway diseaseMed Klin Wochenschr197587653656
- American College of Chest PhysiciansIn chronic obstructive pulmonary disease, a combination of ipratropium and albuterol is more effective than either agent alone. An 85-day multicenter trial. COMBIVENT Inhalation Aerosol Study GroupChest1994105141114198181328
- BenayounSErnstPSuissaSThe impact of combined inhaled broncho-dilator therapy in the treatment of COPDChest2001119859211157588
- JonesPWDonohueJFNedelmanJPascoeSPinaultGLassenCCorrelating changes in lung function with patient outcomes in chronic ob struc tive pulmonary disease: a pooled analysisRespir Res20111216122206353
- CooperCBThe connection between chronic obstructive pulmonary disease symptoms and hyperinflation and its impact on exercise and functionAm J Med2006119Suppl 1213116996896
- CalverleyPMAAlbertPWalkerPPBronchodilator reversibility in chronic obstructive pulmonary diseaseLancet Respir Med2013156457324461617
- TantucciCDuguetASimilowskiTZelterMDerenneJ-PMilic-EmiliJEffect of salbutamol on dynamic hyperinflation in chronic obstructive pulmonary diseaseEur Respir J1998127998049817148
- O’DonnellDEVoducNFitzpatrickMWebbKAEffect of salmeterol on the ventilatory response to exercise in chronic obstructive pulmonary diseaseEur Respir J200424869415293609
- O’DonnellDEFlugeTGerkenAEffects of tiotropium on lung hyperinflation, dyspnoea, and exercise tolerance in COPDEur Respir J20042383284015218994
- RossiACentanniSCerveriIAcute effects of indacaterol on lung hyperinflation in moderate COPD: a comparison with tiotropiumRespir Med2012106849022035851
- O’DonnellDELavenezianaPOraJWebbKALamYMOfirDEvaluation of acute bronchodilator reversibility in patients with symptoms of GOLD stage I COPDThorax20096421622319052054
- O’DonnellDELavenezianaPLung hyperinflation in COPD: the impact of pharmacotherapyEur Respir Rev2006158589
- BeehKMWagnerFKhindriSDrollmannAFEffect of indacaterol on dynamic lung hyperinflation and breathlessness in hyperinflated patients with COPDCOPD2011834034521793716
- WedzichaJADecramerMSeemugalTAThe role of bronchodilator treatment in the prevention of exacerbations of COPDEur Respir J2012401545155422835613
- CazzolaMPageCPCalzettaLMateraMGPharmacology and therapeutics of bronchodilatorsPharmacol Rev20126445050422611179
- CazzolaMMolimardMThe scientific rationale for combining long-acting β2-agonists and muscarinic antagonists in COPDPulm Pharmacol Ther20102325726720381630
- CazzolaMCalzettaLMateraMGβ2-adrenoceptor agonists: current and future directionBr J Pharmacol201116341721232045
- MeursHOenemaTAKistemakerLEGosensRA new perspective on muscarinic receptor antagonism in obstructive airways diseasesCurr Opin Pharmacol20131331632323643733
- MeursHDekkersBGMaarsinghHHalaykoAJZaagsmaJGosensRMuscarinic receptors on airway mesenchymal cells: novel findings for an ancient targetPulm Pharmacol Ther20132614515522842340
- CazzolaMMateraMGThe effective treatment of COPD: anti-cholinergics and what else?Drug Discov Today Ther Strateg20063277286
- EastonPAJadueCDhingraSAnthonisenNRA comparison of the bronchodilating effect of a beta-2 adrenergic agent (albuterol) and an anticholinergic agent (ipratropium bromide) given by aerosol alone or in sequenceN Engl J Med19853157357392943994
- IngramRHMcFaddenERPredominantly large versus small airways responses in normal subjectsSadoulPMilic-EmiliJSimonssonBGClarkTJHSmall Airways in Health and DiseaseAmsterdam, The NetherlandsExcerpta Medica1979
- BarnesPJDistribution of receptors targets in the lungProc Am Thorac Soc2004134535116113456
- KeatingGMTiotropium bromide inhalation powder. A review of its use in the management of chronic obstructive pulmonary diseaseDrugs20127227330022217233
- KeatingMGTiotropium Respimat® Soft Mist™ inhaler: a review of its use in chronic obstructive pulmonary diseaseDrugs2014741801181625300412
- VogelmeierCHedereBGlaabTfor the POET-COPD investigatorsTiotropium versus salmeterol for prevention of exacerbations of COPDN Engl J Med20113641093110321428765
- DecramerMChapmanKRFrithPOnce daily indacaterol versus tiotropium for patients with severe chronic obstructive pulmonary disease (INVIGORATE): a randomized, blinded, parallel-group studyLancet Respir Med2013152453324461613
- WedzichaJACalverleyPMASeemugalTAThe prevention of chronic obstructive pulmonary disease exacerbations by salmeterol/fluticasone propionate or tiotropium bromideAm J Respir Crit Care Med2008177192617916806
- RossiAPoleseGIndacaterol: a comprehensive reviewInt J COPD20138353363
- TaskinDPFergusonGTCombination bronchodilator therapy in the management of chronic obstructive pulmonary diseaseRespir Res2013144923651244
- SinghDNew combination bronchodilators for COPD: current evidence and future perspectivesBr J Clin Pharmacol1162014 Epub ahead of print
- MahlerDAD’UrzoABatemanEDon behalf of the INTRUST-1 and INTRUST-2 Study InvestigatorsConcurrent use of indacaterol plus tiotropium in patients with COPD provides superior bronchodilation compared with tiotropium alone: a randomized, double-blind comparisonThorax20126778178822544891
- van NoordJABuhlRLaForceCQVA149 demonstrates superior bronchodilation compared with indacaterol or placebo in patients with chronic obstructive pulmonary diseaseThorax2010651086109120978028
- ZuWallackRAllenLHernandezGTingNAbrahamsREfficacy and safety of combining olodaterol Respimat(®) and tiotropium HandiHaler(®) in patients with COPD: results of two randomized, double-blind, active-controlled studiesInt J Chron Obstruct Pulmon Dis201491133114425342898
- BanerjiDFogelRBeehKMDual bronchodilation for the treatment of chronic obstructive pulmonary disease: a review of latest clinical dataClin Invest20144511533
- UlrikCSClinical benefit of fixed-dose dual bronchodilation with glycopyrronium and indacaterol once daily in patients with chronic obstructive pulmonary disease: a systematic reviewInt J COPD20149331338
- DecramerMAnzuetoAKerwinEEfficacy and safety of umeclidinium plus vilanterol versus tiotropium, vilanterol, or umeclidinium monotherapies over 24 weeks in patients with chronic obstructive pulmonary disease: results from two multicentre, blinded, randomised controlled trialsLancet Respir Med2014247248624835833
- MaltaisFSinghSDonaldACEffects of a combination of umeclidinium/villanterol on exercise endurance in patients with chronic obstructive pulmonary disease: two randomized, double-blind clinical trialsTher Adv Respir Dis2014816918125452426
- BlairHADeeksEDUmeclidinium/vilanterol: a review of its use as maintenance therapy in adults with chronic obstructive pulmonary diseaseDrugs201575617425398674
- VinkenWAumannJChenHHenleyMMcBryanDGoyalPEfficacy and safety of coadministration of once-daily indacaterol and glycopyrronium versus indacaterol alone in COPD patients: the GLOW6 studyInt J COPD20149215228
- BuhlRBanerjiDProfile of glycopyrronium for once-daily treatment of moderate-to-severe COPDInt J COPD20127729741
- DahlRJadeyelDAlagappanVKTChenHBanerjiDEfficacy and safety of QVA149 compared to the concurrent administration of its mono components indacaterol and glycopyrronium: the BEACON studyInt J COPD20138501508
- RenardDLoobyMKramerBLawrenceDMorrisDStanskiDRCharacterization of the bronchodilatory dose response to indacaterol in patients with chronic obstructive pulmonary disease using model-based approachesRespir Res2011125421518459
- CazzolaMCalzettaLSegretiAFaccioloFRoglianiPMateraMGTranslational study searching for synergy between glycopyrronium and indacaterolCOPD9152014 Epub ahead of print
- GlaabTVogelmeierCBuhlROutcome measures in chronic obstructive pulmonary disease (COPD): strengths and limitationsRespir Res2010117920565728
- FramptonJEQVA149 (indacaterol/glycopyrronium fixed-dose combination): a review of its use in patients with chronic obstructive pulmonary diseaseDrugs20147446548824604791
- CazzolaMMacNeeWMartinezFJOutcomes for COPD pharmacological trials: from lung function to biomarkersEur Respir J20083141646818238951
- MahalerDAMeasurement of dyspnea: clinical ratingsMahalerDADyspnea: Mechanisms, Measurement, and Management2nd edNew York, NY, USATaylor & Francis Inc2005
- MahlerDAWardJWatermannLAPatient-reported dyspnea in COPD reliability and association with stage of diseaseChest20091361473147919696126
- MahalerDAWardJFierro-CarrionGDevelopment of self-administered versions of modified baseline and transitional dyspnea indexes in COPDJ COPD2004118
- JonesPWQuality of life measurement for patients with diseases of the airwaysThorax1991466766821835178
- JonesPWQuirkFHBaveystockCMThe Saint George’s Respiratory QuestionnaireRespir Med199185Suppl B25311759018
- JonesPWBeehKMChapmanKRDecramerMMahalerDWedzichaJAMinimal clinically important differences in pharmacological trialsAm J Respir Crit Care Med201418925025524383418
- RodrigoGJPlazaVEfficacy and safety of a fixed-dose combination of indacaterol and glycopyrronium for the treatment of COPD. A systematic reviewChest201414630931724556877
- DahlRChapmanKRRudolfMSafety and efficacy of dual bronchodilation with QVA149 in COPD patients: the ENLIGHTEN studyRespir Med20131071558156723867808
- BatemanEDFergusonGTBarnesNDual bronchodilation with QVA149 versus single bronchodilator therapy: the SHINE studyEur Respir J2013421484149423722616
- VogelmeierCFBatemanEDPallanteJEfficacy and safety of once-daily QVA149 compared with twice-daily salmeterol-fluticasone in patients with chronic obstructive pulmonary disease (ILLUMINATE): a randomized, double-blind, parallel group studyLancet Respir Med20131516024321804
- WedzichaJADecramerMFickerJHAnalysis of chronic obstructive pulmonary disease exacerbations with the dual bronchodilator QVA149 compared with glycopyrronium and tiotropium (SPARK): a randomized, double-blind, parallel-group studyLancet Respir Med2013119920924429126
- ObaYLoneNAComparative effect of inhaled corticosteroid and long-acting beta agonist combinations in preventing COPD exacerbations: a Bayesian network meta-analysisInt J COPD20149469479
- MahalerDADecramerMD’UrzoADual bronchodilation with QVA149 reduces patient-reported dyspnea in COPD: the BLAZE studyEur Respir J2014431599160924176997
- RabeKFHurdSAnzuetoAGlobal strategy for the diagnosis management and prevention of chronic obstructive pulmonary disease. GOLD executive summaryAm J Respir Crit Care Med200717653255517507545
- BeehKMKornSBeierJEffect of QVA149 on lung volumes and exercise tolerance in COPD patients; the BRIGHT studyRespir Med201410858459224534204
- OraJLavenezianaPOfirDDeesomchokAWebbKO’DonnellDECombined effects of obesity and chronic obstructive pulmonary disease on dyspnea and exercise toleranceAm J Respir Crit Care Med200918096497119897773
- OfirDLavenezianaPWebbKLamYMO’DonnellDEMechanisms of dyspnea during cycle exercise in symptomatic patients with GOLD I stage chronic obstructive pulmonary diseaseAm J Respir Crit Care Med200817762262918006885
- GuenetteJAChinRCChengSMechanisms of exercise intolerance in global initiative for chronic obstructive lung disease grade 1 COPDEur Respir J2014441177118725142487
- O’DonnellDELavenezianaPPhysiology and consequences of lung hyperinflation in COPDEur Respir Rev2006156167
- BuhlRGessnerCSchuermannWEfficacy and safety of once-daily QVA1448 compared with the free combination of one-daily tiotropium plus twice-daily formoterol in patients with moderate-to-severe COPD (QUANTIFY): a randomized, non-inferiority studyThorax20157031131925677679
- CazzolaMMateraMGBronchodilators: current and futureClin Chest Med20143519120124507846
- National Clinical Guideline CentreChronic obstructive pulmonary disease: management of chronic obstructive pulmonary disease in adults in primary and secondary careLondon, UKNational Clinical Guideline Centre2010 Available from: http://guidance.nice.org.uk/CG101/Guidance/pdf/EnglishAccessed April 24, 2015
- TashkinDPCelliBSennSUPLIFT Study InvestigatorsA 4-year trial of tiotropium in chronic obstructive pulmonary diseaseN Engl J Med20083591543155418836213
- WiseRAAnzuetoACalverleyPThe Tiotropium Safety and Performance in Respimat Trial (TIOSPIR): a large scale, randomized, controlled, parallel-group trial design and rationaleRespir Res2013144023547660
- CalverleyPPauwelsRVestboJTrial of Inhaled Steroids and Long-Acting Beta2 Agonists Study GroupCombined salmeterol and fluticasone in the treatment of chronic obstructive pulmonary disease: a randomised controlled trialLancet200336144945612583942
- CalverleyPMAndersonJACelliBTORCH InvestigatorsSalmeterol and fluticasone propionate and survival in chronic obstructive pulmonary diseaseN Engl J Med200735677578917314337
- CorradoARossiAHow far is real life from COPD therapy guidelines? An Italian observational studyRespir Med2012106e989e997
- RossiAGuerrieroMCorradoAOPTIMO/AIPO Study GroupWithdrawal of inhaled corticosteroids can be safe in COPD patients at low risk of exacerbation: a real-life study on the appropriateness of treatment in moderate COPD patients (OPTIMO)Respir Res2014157725005873
- ErnstPSaadNSuissaSInhaled corticosteroids in COPD: the clinical evidenceEur Respir J20154552553725537556
- WedzichaJADecramerMVestboJA novel study design for the comparison between once-daily QVA149 and twice-daily salmeterol/fluticasone on the reduction of COPD exacerbations: the FLAME studyEur Respir J201342Suppl 57P696
- ChapmanKRFogartyCMPeckittCDelivery characteristics and patients’ handling of two single-dose dry-powder inhalers used in COPDInt J Chron Obstruct Pulmon Dis2011635336321760722
- PavkovRMuellerSFiebichKCharacteristics of a capsule based dry powder inhaler for the delivery of indacaterolCurr Med Res Opin2010262527253320843166
- HamiltonMPrimeDBogalo HuescarMIn vitro delivery performance of umeclidinium and umeclidinium/vilanterol from a dry powder inhaler using the Electronic Lung breathing simulator to replicate inhalation profiles from patients with varying COPD severityAm J Respir Crit Care Med2013187A4281
- SvedsaterHDalePGarrillKQualitative assessment of attributes and ease of use of the Ellipta™ dry powder inhaler for delivery of maintenance therapy for asthma and COPDBMC Pulm Med2013137224314123
- DalbyRSpallekMVoshaarTA review of the development of Respimat Soft Mist inhalerInt J Pharm20042831915363496
- HodderRPriceDPatient preferences for inhaler devices in chronic obstructive pulmonary disease: experience with Respimat Soft Mist inhalerInt J Chron Obstruct Pulmon Dis2009438139019888356
- WedzichaJADahlRBuhlRPooled safety analysis of the fixed-dose combination of indacaterol and glycopyrronium (QVA149), its monocomponents, and tiotropium versus placebo in COPD patientsRespir Med20141081498150725135743