References
- MonsóERosellABonetGRisk factors for lower airway bacterial colonization in chronic bronchitisEur Respir J199913233834210065678
- CabelloHTorresACelisRBacterial colonization of distal airways in healthy subjects and chronic lung disease: a bronchoscopic studyEur Respir J1997105113711449163659
- MurphyTFSethiSKlingmanKLBrueggemannABDoernGVSimultaneous respiratory tract colonization by multiple strains of nontypeable haemophilus influenzae in chronic obstructive pulmonary disease: implications for antibiotic therapyJ Infect Dis1999180240440910395856
- HillATCampbellEJHillSLBayleyDLStockleyRAAssociation between airway bacterial load and markers of airway inflammation in patients with stable chronic bronchitisAm J Med2000109428829510996579
- SethiSMaloneyJGroveLWronaCBerensonCSAirway inflammation and bronchial bacterial colonization in chronic obstructive pulmonary diseaseAm J Respir Crit Care Med2006173999199816474030
- BanerjeeDKhairOAHoneybourneDImpact of sputum bacteria on airway inflammation and health status in clinical stable COPDEur Respir J200423568569115176680
- PatelISSeemungalTAWilksMLloyd-OwenSJDonaldsonGCWedzichaJARelationship between bacterial colonisation and the frequency, character, and severity of COPD exacerbationsThorax200257975976412200518
- BafadhelMMcKennaSTerrySAcute exacerbations of chronic obstructive pulmonary disease: identification of biologic clusters and their biomarkersAm J Respir Crit Care Med2011184666267121680942
- SivaRBafadhelMMonteiroWBrightlingCEPavordIDEffect of levofloxacin on neutrophilic airway inflammation in stable COPD: a randomized, double-blind, placebo-controlled trialInt J Chron Obstruct Pulmon Dis2014917918624532969
- BafadhelMMcKennaSTerrySBlood eosinophils to direct corticosteroid treatment of exacerbations of chronic obstructive pulmonary disease: a randomized placebo-controlled trialAm J Respir Crit Care Med20121861485522447964
- MillerMRHankinsonJBrusascoVATS/ERS Task ForceStandardisation of spirometryEur Respir J200526231933816055882
- BrightlingCEMonterioWGreenRHInduced sputum and other outcome measures in chronic obstructive pulmonary disease: safety and repeatabilityRespir Med20019512999100211778799
- GuyattGMeasuring health status in chronic airflow limitationEur Respir J1988165605643049146
- JonesPWQuirkFHBaveystockCMThe St George’s Respiratory QuestionnaireRespir Med199185Suppl BS25S31 discussion S33–S37
- Health Protection AgencyUK Standards for Microbiology Investigations. Investigation of bronchoalveolar lavage, sputum and associated specimensBacteriology; B 57LondonHealth Protection Agency2009 Available from: http//www.hpa.org.uk/webc/HPAwebFile/HPAweb_C/1317132860548Accessed March 9, 2015
- PyeAStockleyRAHillSLSimple method for quantifying viable bacterial numbers in sputumJ Clin Pathol19954887197247560197
- BeldaJLeighRParameswaranKO’ByrnePMSearsMRHargreaveFEInduced sputum cell counts in healthy adultsAm J Respir Crit Care Med20001612 Pt 147547810673188
- GarchaDSThurstonSJPatelARChanges in prevalence and load of airway bacteria using quantitative PCR in stable and exacerbated COPDThorax201267121075108022863758
- BanerjeeDHoneybourneDKhairOAThe effect of oral clarithromycin on bronchial airway inflammation in moderate-to-severe stable COPD: a randomized controlled trialTreat Respir Med200431596515174894
- TaylorAEFinney-HaywardTKQuintJKDefective macrophage phagocytosis of bacteria in COPDEur Respir J20103551039104719897561
- MöllerLVTimensWvan der BijWHaemophilus influenzae in lung explants of patients with end-stage pulmonary diseaseAm J Respir Crit Care Med19981573 Pt 19509569517616
- DrömannDRuppJRohmannKThe TGF-beta-pseudoreceptor BAMBI is strongly expressed in COPD lungs and regulated by nontypeable Haemophilus influenzaeRespir Res2010116720513241
- KingPTLimSPickALung T-cell responses to nontypeable Haemophilus influenzae in patients with chronic obstructive pulmonary diseaseJ Allergy Clin Immunol2013131513141321. e1423142009
- BarkerBLHaldarKPatelHAssociation between pathogens detected using quantitative polymerase chain reaction with airway inflammation in COPD at stable state and exacerbationsChest20151471465525103335
- EssilfieATSimpsonJLDunkleyMLCombined Haemophilus influenzae respiratory infection and allergic airways disease drives chronic infection and features of neutrophilic asthmaThorax201267758859922387445
- MurphyTFBrauerALSchiffmacherATSethiSPersistent colonization by Haemophilus influenzae in chronic obstructive pulmonary diseaseAm J Respir Crit Care Med2004170326627215117742
- AlbertRKConnettJBaileyWCCOPD Clinical Research NetworkAzithromycin for prevention of exacerbations of COPDN Engl J Med2011365868969821864166
- HeZYOuLMZhangJQEffect of 6 months of erythromycin treatment on inflammatory cells in induced sputum and exacerbations in chronic obstructive pulmonary diseaseRespiration201080644545220881376
- SethiSMoxifloxacin for the treatment of acute exacerbations of chronic obstructive pulmonary diseaseClin Infect Dis200541Suppl 2S177S18515942884
- WaltonGMPurvisTChadwickCStockleyRASapeyES46 Phagocytosis by blood neutrophils is not attenuated in patients with chronic obstructive pulmonary diseaseThorax201469Suppl 2A26A27
- BafadhelMUmarIGuptaSThe role of CT scanning in multidimensional phenotyping of COPDChest2011140363464221454400
- HanMKAgustiACalverleyPMChronic obstructive pulmonary disease phenotypes: the future of COPDAm J Respir Crit Care Med2010182559860420522794