NMDA receptors are important regulators of pancreatic cancer and are potential targets for treatment

William G North1 Department of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth College;2 Woomera Therapeutics Inc, Lebanon, NH, USACorrespondence[email protected]

Fuli Liu1 Department of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth College

Liz Z Lin1 Department of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth College

Ruiyang Tian2 Woomera Therapeutics Inc, Lebanon, NH, USA

Bonnie Akerman1 Department of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth College

Pages 79-86 | Published online: 17 Jul 2017

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References

American Cancer SocietyCancer Facts & Figures 2015 Available from: https://www.cancer.org/research/cancer-facts-statistics/all-cancer-facts-figures/cancer-facts-figures-2015.html
Google Scholar
HariharanDSaiedAKocherHMAnalysis of mortality rates for pancreatic cancer across the worldHPB (Oxford)2008101586218695761
PubMed Web of Science ®Google Scholar
BakkevoldKEArnesjøBKambestadBCarcinoma of the pancreas and papilla of Vater presenting symptoms, signs, and diagnosis related to stage and tumour site. A prospective multicenter trial in 472 patients. Norwegian Pancreatic Cancer TrialScand J Gastroenterol1992274317251589710
PubMed Web of Science ®Google Scholar
NeoptolemosJPStockenDDFriessHA randomized trial of chemoradiotherapy and chemotherapy after resection of pancreatic cancerN Engl J Med2004350121200121015028824
PubMed Web of Science ®Google Scholar
FesinmeyerMDAustinMALiCIDe RoosAJBowenDJDifferences in survival by histologic type of pancreatic cancerCancer Epidemiol Biomarkers Prev20051471766177316030115
PubMed Web of Science ®Google Scholar
Iacobuzio-DonahueCAMaitraAShen-OngGLDiscovery of novel tumor markers of pancreatic cancer using global gene expression technologyAm J Pathol200216041239124911943709
PubMed Web of Science ®Google Scholar
DemolsAPeetersMPolusMGemcitabine and oxaliplatin (GEMOX) in gemcitabine refractory advanced pancreatic adenocarcinoma: a phase II studyBr J Cancer200694448148516434988
PubMed Web of Science ®Google Scholar
EckelFSchneiderGSchmidRMPancreatic cancer: a review of recent advancesExpert Opin Investig Drugs2006151113951410
PubMed Web of Science ®Google Scholar
MimeaultMBrandRESassonAABatraSKRecent advances on the molecular mechanisms involved in pancreatic cancer progression and therapiesPancreas2005314306316
Web of Science ®Google Scholar
CarpenterDNMDA receptors and the molecular mechanisms of excitotoxicityJohnsonPBoldyrevAAOxidative stress at the molecular, cellular, and organ levelsTrivandrum, IndiaResearch Signpost20027788
Google Scholar
HinoiETakaradaTUeshimaTTsuchihashiYYonedaYGlutamate signaling in peripheral tissuesEur J Biochem2004271111314686914
PubMedGoogle Scholar
NorthWGFayMJDuJClearyMGallagherJDMcCannFVPresence of functional NMDA receptors in a human neuroblastoma cell lineMol Chem Neuropathol1997301–277949138430
PubMedGoogle Scholar
NorthWGGaoGMemoliVAPangRHLynchLBreast cancer expresses functional NMDA receptorsBreast Cancer Res Treat2010122230731419784770
PubMed Web of Science ®Google Scholar
NorthWGGaoGJensenAMemoliVADuJNMDA receptors are expressed by small-cell lung cancer and are potential targets for effective treatmentClin Pharmacol20102314022291485
PubMedGoogle Scholar
NorthWGLiuFTianRAbbasiHAkermanBNMDA receptor are expressed in human ovarian cancer tissues and ovarian cancer cell linesClin Pharmacol2015711111726566373
PubMedGoogle Scholar
TüzünEZhouLBaehringJMBannikhSResenfeldMRDalmauJEvidence for antibody-mediated pathogenesis in anti-NMDAR encephalitis associated with ovarian teratomaActa Neuropathol2009118673774319680671
PubMed Web of Science ®Google Scholar
DalmauJGleichmanAJHughesEGAnti-NMDA encephalitis:case series and analysis of the effects of antibodiesLancet Neurol20087121091109818851928
PubMed Web of Science ®Google Scholar
WillAAkalinMParaneoplastic limbic encephalitis with NMDA receptor (NR1) antibodies in breast cancerNeurology201278Meeting Abstracts 1S08.007
Google Scholar
SonkusareSKKaulCLRamaraoPDementia of Alzheimer’s disease and other neurodegenerative disorders-memantine, a new hopePharmacol Res200551111715519530
PubMed Web of Science ®Google Scholar
PloskerGLLyseng-WilliamsonKAMemantine: a pharmacoeconomic review of its use in moderate-to-severe Alzheimer’s diseasePharmacoecon2005232193206
Web of Science ®Google Scholar
SasakiTHashimotoKOkawadaKIfenprodil for the treatment of flashbacks in adolescent female posttraumatic stress disorder patients with a history of abusePsychother Psychosom201382534434523942427
PubMed Web of Science ®Google Scholar
DuringMJSymesCWLawlorPAAn oral vaccine against NMDAR1 with efficacy in experimental stroke and epilepsyScience20001453146010688787
PubMed Web of Science ®Google Scholar
MalsyMGebhardtKGruberMWieseKGrafBBundschererAEffect of ketamine, s-ketamine, and MK-801 on proliferation, apoptosis, and necrosis in pancreatic cancer cellsBMC Anesthesiol20151511112326219286
PubMed Web of Science ®Google Scholar
ChenXWuQYouLChenSZhuMMiaoCPropofol attenuates pancreatic cancer malignant potential via inhibition of NMDA receptorEur J Pharmacol201679515015927986626
PubMed Web of Science ®Google Scholar
TachibanaNShirakawaTIshiiKExpression of various glutamate receptors including N-methyl-D aspartate receptor (NMDAR) in ovarian teratoma removed from a young woman with anti-NMDAR encephalitisIntern Med201049192167217320930449
PubMed Web of Science ®Google Scholar
StepulakASifringerMRzeskiWNMDA antagonist inhibits the extracellular signal-regulated kinase pathway and suppresses cancer growthProc Natl Acad Sci USA200510243156051561016230611
PubMed Web of Science ®Google Scholar
StepulakALukschHGebhardtCExpression of glutamate receptor sub-units in human cancersHistochem Cell Biol2009132443544519526364
PubMed Web of Science ®Google Scholar
StepulakARolaRPolbergKIkonomidouCGlutamate and its receptors in cancerJ Neural Transm (Vienna)2014121893394424610491
PubMed Web of Science ®Google Scholar
MoralesMSpearLPThe effects of an acute challenge with the NMDA receptor antagonists, MK-801, PEAQX, and infenprodil, on social inhibition in adolescent and adult male ratsPsychopharmacology (Berl)201423181797180724043344
PubMed Web of Science ®Google Scholar

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