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Original Research

Determination of the Permeation and Penetration of Flurbiprofen into Cadaveric Human Pharynx Tissue

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Pages 13-20 | Published online: 24 Mar 2020

References

  • EcclesR. Mechanisms of symptoms of the common cold and influenza. Br J Hosp Med (Lond). 2007;68(2):71–75. doi:10.12968/hmed.2007.68.2.2282417370703
  • RennerB, MuellerCA, ShephardA. Environmental and non-infectious factors in the aetiology of pharyngitis (sore throat). Inflamm Res. 2012;61(10):1041–1052. doi:10.1007/s00011-012-0540-922890476
  • SchachtelBP, FillingimJM, BeiterDJ, LaneAC, SchwartzLA. Subjective and objective features of sore throat. Arch Intern Med. 1984;144(3):497–500. doi:10.1001/archinte.1984.003501500810266703820
  • SchachtelB, ShephardA, SchachtelE, LortonMB, SheaT, AspleyS. Qualities of Sore Throat Index (QuaSTI): measuring descriptors of sore throat in a randomized, placebo-controlled trial. Pain Manag. 2018;8(2):85–94. doi:10.2217/pmt-2017-004129381110
  • ShojaeiAH. Buccal mucosa as a route for systemic drug delivery: a review. J Pharm Sci. 1998;1(1):15–30.
  • HarrisD, RobinsonJR. Drug delivery via the mucous membranes of the oral cavity. J Pharm Sci. 1992;81(1):1–10. doi:10.1002/jps.26008101021619560
  • NicolazzoJA, FinninBC. In vivo and in vitro models for assessing drug absorption across the buccal mucosa. In: EhrhardtC, KimKJ, editors. Drug Absorption Studies. Biotechnology: Pharmaceutical Aspects. Boston: Springer; 2008:89–111.
  • SquierCA, KremerMJ, Biology of oral mucosa and esophagus. J Natl Cancer Inst Monogr. 2001;29:7–15. doi:10.1093/oxfordjournals.jncimonographs.a00344311694559
  • SquierC, BrogdenKA. Human Oral Mucosa: Development, Structure and Function. Oxford: Wiley-Blackwell; 2011.
  • FunkCD. Prostaglandins and leukotrienes: advances in eicosanoid biology. Science. 2001;294(5548):1871–1875. doi:10.1126/science.294.5548.187111729303
  • RicciottiE, FitzGeraldGA. Prostaglandins and inflammation. Arterioscler Thromb Vasc Biol. 2011;31(5):986–1000. doi:10.1161/ATVBAHA.110.20744921508345
  • OxfordJS, LeuwerM. Acute sore throat revisited: clinical and experimental evidence for the efficacy of over-the-counter AMC/DCBA throat lozenges. Int J Clin Pract. 2011;65(5):524–530. doi:10.1111/j.1742-1241.2011.02644.x21489076
  • AspleyS, ShephardA, SchachtelE, SannerK, SavinoL, SchachtelB. Efficacy of flurbiprofen 8.75 mg lozenge in patients with a swollen and inflamed sore throat. Curr Med Res Opin. 2016;32(9):1529–1538. doi:10.1080/03007995.2016.118711927146963
  • SpinksA, GlasziouPP, Del MarCB. Antibiotics for sore throat. Cochrane Database Syst Rev. 2013;11:CD000023.
  • AddeyD, ShephardA. Incidence, causes, severity and treatment of throat discomfort: a four-region online questionnaire survey. BMC Ear Nose Throat Disord. 2012;12:9. doi:10.1186/1472-6815-12-922883470
  • SchachtelB, AspleyS, ShephardA, et al. Onset of action of a lozenge containing flurbiprofen 8.75 mg: a randomized, double-blind, placebo-controlled trial with a new method for measuring onset of analgesic activity. Pain. 2014;155(2):422–428. doi:10.1016/j.pain.2013.11.00124231654
  • EssackS, BellJ, ShephardA. Community pharmacists – leaders for antibiotic stewardship in respiratory tract infection. J Clin Pharm Ther. 2018;43(2):302–307. doi:10.1111/jcpt.2018.43.issue-229205419
  • VealeD, ShephardA, AdamsV, LidsterC. Comparison of the characteristics and performance of flurbiprofen 8.75 mg spray for sore throat. Curr Drug Deliv. 2017;14(5):725–733. doi:10.2174/156720181366616120515583027919213
  • de LoozeF, RussoM, BlochM, et al. Efficacy of flurbiprofen 8.75 mg spray in patients with sore throat due to an upper respiratory tract infection: a randomised controlled trial. Eur J Gen Pract. 2016;22(2):111–118. doi:10.3109/13814788.2016.114565027028316
  • RadkovaE, BurovaN, BychkovaV, DeVitoR. Efficacy of flurbiprofen 8.75 mg delivered as a spray or lozenge in patients with sore throat due to upper respiratory tract infection: a randomized, non-inferiority trial in the Russian Federation. J Pain Res. 2017;10:1591–1600. doi:10.2147/JPR28740426
  • SchachtelB, AspleyS, ShephardA, SchachtelE, LortonMB, SheaT. Onset of analgesia by a topically administered flurbiprofen lozenge: a randomised controlled trial using the double stopwatch method. Br J Pain. 2018;12(4):208–216. doi:10.1177/204946371875615230349694
  • SefiaE, MannA, LambkinR, et al. Flurbiprofen lozenges rapidly reduce levels of the inflammatory mediator prostaglandin E in human respiratory cells in vitro. Poster presented at: Annual Scientific Meeting of the British Pain Society; 424–27, 2007; Glasgow, UK.
  • de LoozeF, ShephardA, SmithAB. Locally delivered flurbiprofen 8.75 mg for treatment and prevention of sore throat: a narrative review of clinical studies. J Pain Res. 2019;12:3477–3509. doi:10.2147/JPR.S22170631920372
  • MuderrisT, GulF, YalcinerG, BabademezMA, BercinS, KirisM. Oral flurbiprofen spray for posttonsillectomy pain. Otolaryngol Head Neck Surg. 2016;155:166–172. doi:10.1177/019459981663786526980919
  • MuderrisT, TezcanG, SancakM, GulF, UgurG. Oral flurbiprofen spray for postoperative sore throat and hoarseness: a prospective, randomized, double-blind, placebo-controlled study. Minerva Anestesiol. 2019;85(1):21–27. doi:10.23736/S0375-9393.18.12703-929756749
  • TürkB, AkpinarM, ErolZN, KayaKS, ÜnsalO, CoşkumBU. The effect of flurbiprofen oral spray and ibuprofen vs ibuprofen alone on postoperative tonsillectomy pain: an open, randomised, controlled trial. Clin Otolaryngol. 2018;43:835–840. doi:10.1111/coa.1305829288561
  • BarkinRL. The pharmacology of topical analgesics. Postgrad Med. 2013;125(4Suppl. 1):7–18. doi:10.1080/00325481.2013.1110566911
  • ImbertiR, De GregoriS, LisiL, NavarraP. Influence of the oral dissolution time on the absorption rate of locally administered solid formulations for oromucosal use: the flurbiprofen lozenges paradigm. Pharmacology. 2014;94(3–4):143–147. doi:10.1159/00036766325277061
  • BarsuhnCL, OlanoffLS, GleasonDD, AdkinsEL, HoNF. Human buccal absorption of flurbiprofen. Clin Pharmacol Ther. 1988;44(2):225–231. doi:10.1038/clpt.1988.1413293876
  • Gonzalez-YounesI, WagnerJG, GainesDA, FerryJJ, HagemanJM. Absorption of flurbiprofen through human buccal mucosa. J Pharm Sci. 1991;80(9):820–823. doi:10.1002/jps.26008009031800701
  • AzziC, ZhangJ, PurdonCH, et al. Permeation and reservoir formation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and benzo[a]pyrene (B[a]P) across porcine esophageal tissue in the presence of ethanol and menthol. Carcinogenesis. 2006;27(1):137–145. doi:10.1093/carcin/bgi17316000402
  • NgSF, RouseJJ, SandersonFD, MeidanV, EcclestonGM. Validation of a static Franz diffusion cell system for in vitro permeation studies. AAPS PharmSciTech. 2010;11(3):1432–1441. doi:10.1208/s12249-010-9522-920842539
  • FranzTJ. Percutaneous absorption on the relevance of in vitro data. J Invest Dermatol. 1975;64(3):190–195. doi:10.1111/1523-1747.ep12533356123263
  • IngramRJ, BartlettA, BrownMB, MarriottC, WhitfieldPJ. Penetration of human skin by the cercariae of Schistosoma mansoni: an investigation of the effect of multiple cercarial applications. J Helminthol. 2003;77(1):27–31. doi:10.1079/JOH200215712590661
  • TurnerR, WevrettSR, EdmundsS, BrownM, AtkinsonR, SheaT. Validation of an analytical method to quantify the permeation and penetration of flurbiprofen into human pharynx tissue. Biomed Chromatogr. 2019;33:e4499. doi:10.1002/bmc.449930667527
  • International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use. ICH Harmonised tripartite guideline. pharmaceutical quality system Q10. Available from:https://www.ich.org/fileadmin/Public_Web_Site/ICH_Products/Guidelines/Quality/Q10/Step4/Q10_Guideline.pdf. Accessed 41, 2019..
  • Strefen® Direct (flurbiprofen 8.75 mg) Oromucosal Spray [summary of product characteristics]. Reckitt Benckiser; 2014.
  • LimbM, ConnorA, PickfordM, et al. Scintigraphy can be used to compare delivery of sore throat formulations. Int J Clin Pract. 2009;63(4):606–612. doi:10.1111/ijcp.2009.63.issue-419222617
  • GeisslingerG, LotschJ, MenzelS, KobalG, BruneK. Stereoselective disposition of flurbiprofen in healthy subjects following administration of the single enantiomers. Br J Clin Pharmacol. 1994;37(4):392–394. doi:10.1111/j.1365-2125.1994.tb04295.x8018462
  • WalshJH, LeighMS, PaduchA, et al. Evaluation of pharyngeal shape and size using anatomical optical coherence tomography in individuals with and without obstructive sleep apnoea. J Sleep Res. 2008;17(2):230–238. doi:10.1111/j.1365-2869.2008.00647.x18422508
  • PeresJC, RouquetteJL, MiočevićO, WarnerMC, SloweyPD, ShirtcliffEA. New techniques for augmenting saliva collection: bacon rules and lozenge drools. Clin Ther. 2015;37(3):515–522. doi:10.1016/j.clinthera.2015.02.01525773460
  • RathboneMJ, HadgraftJ. Absorption of drugs from the human oral cavity. Int J Pharmaceutics. 1991;74(1):9–24. doi:10.1016/0378-5173(91)90403-B
  • DesimoniE, BrunettiB. About estimating the limit of detection by the signal to noise approach. Pharm Anal Acta. 2015;6:355.
  • TakeuchiH, ManoY, TerasakaS, et al. Usefulness of rat skin as a substitute for human skin in the in vitro skin permeation study. Exp Anim. 2011;60(4):373–384. doi:10.1538/expanim.60.37321791877
  • AyoubRK, MurtazaG, ImranM, et al. Formulation and permeation kinetic studies of flurbiprofen gel. Trop J Pharm Res. 2015;14(2):195–203. doi:10.4314/tjpr.v14i2.2
  • HussainA, KhanGM, JanSU, et al. Effect of olive oil on transdermal penetration of flurbiprofen from topical gel as enhancer. Pak J Pharm Sci. 2012;25(2):365–369.22459463
  • YilmazB, ErdemAF. Determination of flurbiprofen in human plasma by high-performance liquid chromatography. J Chromatogr Sci. 2015;53(9):1443–1448. doi:10.1093/chromsci/bmv03225820260
  • AkhlaqM, KhanGM, WahabA, et al. A simple high-performance liquid chromatographic practical approach for determination of flurbiprofen. J Adv Pharm Technol Res. 2011;2(3):151–155. doi:10.4103/2231-4040.8552922171311
  • ManoN, NaruiT, NikaidoA, GotoJ. Separation and determination of diastereomeric flurbiprofen acyl glucuronides in human urine by LC/ESI-MS with a simple column-switching technique. Drug Metab Pharmacokinet. 2002;17(2):142–149. doi:10.2133/dmpk.17.14215618663