Hyperbaric oxygen therapy for the management of chronic wounds: patient selection and perspectives

References

• Hunt TK, Pai MP. The effect of varying ambient oxygen tensions on wound metabolism and collagen synthesis. Surg Gynecol Obstet. 1972;135(4):561–567.
   Google Scholar
• Hopf HW, Gibson JJ, Angeles AP, et al. Hyperoxia and angiogenesis. Wound Repair Regen. 2005;13(6):558–564. doi:10.1111/j.1524-475X.2005.00078.x
   Web of Science ®Google Scholar
• Knighton DR, Silver IA, Hunt TK. Regulation of wound-healing angiogenesis-effect of oxygen gradients and inspired oxygen concentration. Surgery. 1981;90(2):262–270.
   PubMed Web of Science ®Google Scholar
• LaVan FB, Hunt TK. Oxygen and wound healing. Clin Plast Surg. 1990;17(3):463–472.
   PubMed Web of Science ®Google Scholar
• Knighton DR, Hunt TK, Scheuenstuhl H, Halliday BJ, Werb Z, Banda MJ. Oxygen tension regulates the expression of angiogenesis factor by macrophages. Science. 1983;221(4617):1283–1285.
   Web of Science ®Google Scholar
• Knighton DR, Fiegel VD, Halverson T, Schneider S, Brown T, Wells CL. Oxygen as an antibiotic. The effect of inspired oxygen on bacterial clearance. Arch Surg. 1990;125(1):97–100.
   Google Scholar
• Knighton DR, Halliday B, Hunt TK. Oxygen as an antibiotic. The effect of inspired oxygen on infection. Arch Surg. 1984;119(2):199–204.
   Google Scholar
• Knighton DR, Halliday B, Hunt TK. Oxygen as an antibiotic. A comparison of the effects of inspired oxygen concentration and antibiotic administration on in vivo bacterial clearance. Arch Surg. 1986;121(2):191–195.
   Google Scholar
• Ruthenborg RJ, Ban JJ, Wazir A, Takeda N, Kim JW. Regulation of wound healing and fibrosis by hypoxia and hypoxia-inducible factor-1. Mol Cells. 2014;37(9):637–643. doi:10.14348/molcells.2014.0150
   PubMed Web of Science ®Google Scholar
• Janis JE, Harrison B. Wound healing: part I. Basic science. Plast Reconstr Surg. 2014;133(2):199e–207e. doi:10.1097/01.prs.0000437224.02985.f9
   PubMed Web of Science ®Google Scholar
• Heughan C, Grislis G, Hunt TK. The effect of anemia on wound healing. Ann Surg. 1974;179(2):163–167.
   PubMed Web of Science ®Google Scholar
• Knighton DR, Fiegel VD. Macrophage-derived growth factors in wound healing: regulation of growth factor production by the oxygen microenvironment. Am Rev Respir Dis. 1989;140(4):1108–1111. doi:10.1164/ajrccm/140.4.1108
   PubMed Web of Science ®Google Scholar
• Hohn DC, MacKay RD, Halliday B, Hunt TK. Effect of O2 tension on microbicidal function of leukocytes in wounds and in vitro. Surg Forum. 1976;27(62):18–20.
   Google Scholar
• Babior BM. Oxygen-dependent microbial killing by phagocytes (first of two parts). N Engl J Med. 1978;298(12):659–668. doi:10.1056/NEJM197803232981205
   PubMed Web of Science ®Google Scholar
• Babior BM. The respiratory burst of phagocytes. J Clin Invest. 1984;73(3):599–601. doi:10.1172/JCI111249
   PubMed Web of Science ®Google Scholar
• Tizard J. Destruction of foreign material - the myeloid system, neutrophils. In: Immunology: An Introduction. 3rd ed. Forth Worth (TX): Saunders College Publishing; 1992;26–37.
   Google Scholar
• Silver IA. Tissue PO2 changes in acute inflammation. Adv Exp Med Biol. 1978;94:769–774.
   Google Scholar
• Allen DB, Maguire JJ, Mahdavian M, et al. Wound hypoxia and acidosis limit neutrophil bacterial killing mechanisms. Arch Surg. 1997;132(9):991–996.
   PubMedGoogle Scholar
• Niinikoski J. Effect of oxygen supply on wound healing and formation of experimental granulation tissue. Acta Physiol Scand Suppl. 1969;334:1–72.
   PubMedGoogle Scholar
• Pai MP, Hunt TK. Effect of varying oxygen tensions on healing of open wounds. Surg Gynecol Obstet. 1972;135(5):756–758.
   Google Scholar
• Kivisaari J, Vihersaari T, Renvall S, Niinikoski J. Energy metabolism of experimental wounds at various oxygen environments. Ann Surg. 1975;181(6):823–828.
   Web of Science ®Google Scholar
• Udenfriend S. Formation of hydroxyproline in collagen. Science. 1966;152:1335.
   PubMed Web of Science ®Google Scholar
• Hunt TK, Ellison EC, Sen CK. Oxygen: at the foundation of wound healing–introduction. World J Surg. 2004;28(3):291–293. doi:10.1007/s00268-003-7405-x
   Web of Science ®Google Scholar
• Velazquez OC. Angiogenesis and vasculogenesis: inducing the growth of new blood vessels and wound healing by stimulation of bone marrow-derived progenitor cell mobilization and homing. J Vasc Surg. 2007;45(Suppl A):A39–47. doi:10.1016/j.jvs.2007.02.068
   Google Scholar
• Thom SR, Milovanova TN, Yang M, et al. Vasculogenic stem cell mobilization and wound recruitment in diabetic patients: increased cell number and intracellular regulatory protein content associated with hyperbaric oxygen therapy. Wound Repair Regen. 2011;19(2):149–161. doi:10.1111/j.1524-475X.2010.00660.x
   PubMed Web of Science ®Google Scholar
• Bullough WS, Johnson M. Epidermal mitotic activity and oxygen tension. Nature. 1957;167:488. doi:10.1038/167488a0
   Google Scholar
• Winter G, Perrins D Effects of hyperbaric oxygen treatment on epidermal regeneration. Paper presented at: Fourth International Congress on Hyperbaric Medicine 1970; Tokyo.
   Google Scholar
• Utkina O. Regeneration of the skin epithelium in healing wounds under noral conditions and at reduced baroetric pressure. Biol Abs. 1964;45:78585.
   Google Scholar
• Broughton G 2nd, Janis JE, Attinger CE. Wound healing: an overview. Plast Reconstr Surg. 2006;117(7 Suppl):1e-S-32e-S. doi:10.1097/01.prs.0000222562.60260.f9
   Web of Science ®Google Scholar
• Chang N, Goodson WH 3rd, Gottrup F, Hunt TK. Direct measurement of wound and tissue oxygen tension in postoperative patients. Ann Surg. 1983;197(4):470–478.
   Web of Science ®Google Scholar
• Fife CE, Buyukcakir C, Otto G, Sheffield P, Love T, Warriner R 3rd. Factors influencing the outcome of lower-extremity diabetic ulcers treated with hyperbaric oxygen therapy. Wound Repair Regen. 2007;15(3):322–331. doi:10.1111/j.1524-475X.2007.00234.x
   Web of Science ®Google Scholar
• Fife CE, Buyukcakir C, Otto GH, et al. The predictive value of transcutaneous oxygen tension measurement in diabetic lower extremity ulcers treated with hyperbaric oxygen therapy: a retrospective analysis of 1,144 patients. Wound Repair Regen. 2002;10(4):198–207.
   PubMed Web of Science ®Google Scholar
• Fife CE, Smart DR, Sheffield PJ, Hopf HW, Hawkins G, Clarke D. Transcutaneous oximetry in clinical practice: consensus statements from an expert panel based on evidence. Undersea Hyperb Med. 2009;36(1):43–53.
   PubMed Web of Science ®Google Scholar
• Londahl M, Katzman P, Hammarlund C, Nilsson A, Landin-Olsson M. Relationship between ulcer healing after hyperbaric oxygen therapy and transcutaneous oximetry, toe blood pressure and ankle-brachial index in patients with diabetes and chronic foot ulcers. Diabetologia. 2011;54(1):65–68. doi:10.1007/s00125-010-1946-y
   PubMed Web of Science ®Google Scholar
• Heyboer M, Byrne J, Pons P, Wolner E, Seargent S, Wojcik SM. Use of in-chamber transcutaneous oxygen measurement to determine optimal treatment pressure in patients undergoing hyperbaric oxygen therapy. Undersea Hyperb Med. 2018;45(4):389–394.
   Web of Science ®Google Scholar
• Wormer BA, Huntington CR, Ross SW, et al. A prospective randomized double-blinded controlled trial evaluating indocyanine green fluorescence angiography on reducing wound complications in complex abdominal wall reconstruction. J Surg Res. 2016;202(2):461–472. doi:10.1016/j.jss.2016.01.029
   Web of Science ®Google Scholar
• Colavita PD, Wormer BA, Belyansky I, et al. Intraoperative indocyanine green fluorescence angiography to predict wound complications in complex ventral hernia repair. Hernia. 2016;20(1):139–149. doi:10.1007/s10029-015-1411-4
   Web of Science ®Google Scholar
• Furukawa H, Hayashi T, Oyama A, et al. Effectiveness of intraoperative indocyanine-green fluorescence angiography during inguinal lymph node dissection for skin cancer to prevent postoperative wound dehiscence. Surg Today. 2015;45(8):973–978. doi:10.1007/s00595-014-0996-z
   PubMed Web of Science ®Google Scholar
• Wang HD, Singh DP. The use of indocyanine green angiography to prevent wound complications in ventral hernia repair with open components separation technique. Hernia. 2013;17(3):397–402. doi:10.1007/s10029-012-0935-0
   Web of Science ®Google Scholar
• Kitai T, Kawashima M, Fujii H, Mashima S, Shimahara Y. Indocyanine green fluorescence monitoring of perineal wound contamination in abdominoperineal resection: a preliminary report. Surg Today. 2011;41(8):1037–1040. doi:10.1007/s00595-010-4417-7
   Web of Science ®Google Scholar
• Johnson-Arbor K, Falola R, Kelty J, Barbour J, Attinger C. Use of indocyanine green fluorescent angiography in a hyperbaric patient with soft tissue radiation necrosis: a case report. Undersea Hyperb Med. 2017;44(3):273–278.
   Web of Science ®Google Scholar
• Arnold J, Marmolejo V. Visulization of angiogenesis and vasculogenesis in a late tissue radiation injury of the chest wall treated with adjuvant hyperbaric oxygen therapy using fluorescence angiography. Undersea Hyperb Med. 2019;46(1):5.
   Web of Science ®Google Scholar
• Kim D, Rao A, Kaplan S, et al. The use of indocyanine green fluorescence angiography to assess perfusion of chronic wounds undergoing hyperbaric oxygen therapy. Undersea Hyperb Med. 2018;45(6):9.
   Web of Science ®Google Scholar
• Huang E, Nichols T. Indocyanin green angriogaphy results pre- and post-hyperbaric oxygen exposure. Undersea Hyperb Med. 2016;43(6):1.
   Google Scholar
• Londahl M. Hyperbaric oxygen therapy as adjunctive treatment of diabetic foot ulcers. Med Clin North Am. 2013;97(5):957–980. doi:10.1016/j.mcna.2013.04.004
   Web of Science ®Google Scholar
• Huang ET, Mansouri J, Murad MH, et al. A clinical practice guideline for the use of hyperbaric oxygen therapy in the treatment of diabetic foot ulcers. Undersea Hyperb Med. 2015;42(3):205–247.
   Web of Science ®Google Scholar
• Margolis DJ, Gupta J, Hoffstad O, et al. Lack of effectiveness of hyperbaric oxygen therapy for the treatment of diabetic foot ulcer and the prevention of amputation: a cohort study. Diabetes Care. 2013;36(7):1961–1966. doi:10.2337/dc12-2160
   PubMed Web of Science ®Google Scholar
• Moon H, Strauss MB, La SS, Miller SS. The validity of transcutaneous oxygen measurements in predicting healing of diabetic foot ulcers. Undersea Hyperb Med. 2016;43(6):641–648.
   Web of Science ®Google Scholar
• Thom SR, Bhopale VM, Velazquez OC, Goldstein LJ, Thom LH, Buerk DG. Stem cell mobilization by hyperbaric oxygen. Am J Physiol Heart Circ Physiol. 2006;290(4):H1378–1386. doi:10.1152/ajpheart.00888.2005
   PubMed Web of Science ®Google Scholar
• Heyboer M 3rd, Milovanova TN, Wojcik S, et al. CD34+/CD45-dim stem cell mobilization by hyperbaric oxygen - changes with oxygen dosage. Stem Cell Res. 2014;12(3):638–645. doi:10.1016/j.scr.2014.02.005
   Web of Science ®Google Scholar
• Boerema I, Meyne NG, Brummelkamp WH, et al. [Life without blood]. Ned Tijdschr Geneeskd. 1960;104:949–954.
   Google Scholar
• Hopf HW, Rollins MD. Wounds: an overview of the role of oxygen. Antioxid Redox Signal. 2007;9(8):1183–1192. doi:10.1089/ars.2007.1641
   Web of Science ®Google Scholar
• Thom SR. Hyperbaric oxygen: its mechanisms and efficacy. Plast Reconstr Surg. 2011;127(Suppl 1):131S–141S. doi:10.1097/PRS.0b013e3181fbe2bf
   PubMed Web of Science ®Google Scholar
• Juttner B, Scheinichen D, Bartsch S, et al. Lack of toxic side effects in neutrophils following hyperbaric oxygen. Undersea Hyperb Med. 2003;30(4):305–311.
   Web of Science ®Google Scholar
• Thom SR, Mendiguren I, Hardy K, et al. Inhibition of human neutrophil beta2-integrin-dependent adherence by hyperbaric O2. Am J Physiol. 1997;272(3 Pt 1):C770–777. doi:10.1152/ajpcell.1997.272.3.C770
   Google Scholar
• Thom SR. Functional inhibition of leukocyte B2 integrins by hyperbaric oxygen in carbon monoxide-mediated brain injury in rats. Toxicol Appl Pharmacol. 1993;123(2):248–256. doi:10.1006/taap.1993.1243
   PubMed Web of Science ®Google Scholar
• Thom SR, Milavonova T. Hyperbaric oxygen therapy increases stem cell number and HIF-1 content in diabetics (Abstract). Undersea Hyperb Med. 2008;35(4):1.
   Google Scholar
• Berra E, Roux D, Richard DE, Pouyssegur J. Hypoxia-inducible factor-1 alpha (HIF-1 alpha) escapes O(2)-driven proteasomal degradation irrespective of its subcellular localization: nucleus or cytoplasm. EMBO Rep. 2001;2(7):615–620. doi:10.1093/embo-reports/kve130
   PubMed Web of Science ®Google Scholar
• Zhang Q, Chang Q, Cox RA, Gong X, Gould LJ. Hyperbaric oxygen attenuates apoptosis and decreases inflammation in an ischemic wound model. J Invest Dermatol. 2008;128(8):2102–2112. doi:10.1038/jid.2008.53
   Web of Science ®Google Scholar
• Thom SR. Oxidative stress is fundamental to hyperbaric oxygen therapy. J Appl Physiol (1985). 2009;106(3):988–995. doi:10.1152/japplphysiol.91004.2008
   PubMed Web of Science ®Google Scholar
• Schafer M, Werner S. Oxidative stress in normal and impaired wound repair. Pharmacol Res. 2008;58(2):165–171. doi:10.1016/j.phrs.2008.06.004
   PubMed Web of Science ®Google Scholar
• Dennog C, Gedik C, Wood S, Speit G. Analysis of oxidative DNA damage and HPRT mutations in humans after hyperbaric oxygen treatment. Mutat Res. 1999;431(2):351–359.
   Web of Science ®Google Scholar
• Dennog C, Hartmann A, Frey G, Speit G. Detection of DNA damage after hyperbaric oxygen (HBO) therapy. Mutagenesis. 1996;11(6):605–609.
   Web of Science ®Google Scholar
• Dennog C, Radermacher P, Barnett YA, Speit G. Antioxidant status in humans after exposure to hyperbaric oxygen. Mutat Res. 1999;428(1–2):83–89.
   Web of Science ®Google Scholar
• Rothfuss A, Dennog C, Speit G. Adaptive protection against the induction of oxidative DNA damage after hyperbaric oxygen treatment. Carcinogenesis. 1998;19(11):1913–1917.
   Web of Science ®Google Scholar
• Speit G, Dennog C, Eichhorn U, Rothfuss A, Kaina B. Induction of heme oxygenase-1 and adaptive protection against the induction of DNA damage after hyperbaric oxygen treatment. Carcinogenesis. 2000;21(10):1795–1799.
   PubMed Web of Science ®Google Scholar
• Speit G, Dennog C, Lampl L. Biological significance of DNA damage induced by hyperbaric oxygen. Mutagenesis. 1998;13(1):85–87.
   Web of Science ®Google Scholar
• Speit G, Dennog C, Radermacher P, Rothfuss A. Genotoxicity of hyperbaric oxygen. Mutat Res. 2002;512(2–3):111–119.
   PubMed Web of Science ®Google Scholar
• Boykin JV Jr., Baylis C. Hyperbaric oxygen therapy mediates increased nitric oxide production associated with wound healing: a preliminary study. Adv Skin Wound Care. 2007;20(7):382–388. doi:10.1097/01.ASW.0000280198.81130.d5
   Google Scholar
• Sheikh AY, Gibson JJ, Rollins MD, Hopf HW, Hussain Z, Hunt TK. Effect of hyperoxia on vascular endothelial growth factor levels in a wound model. Arch Surg. 2000;135(11):1293–1297.
   PubMedGoogle Scholar
• Kang TS, Gorti GK, Quan SY, Ho M, Koch RJ. Effect of hyperbaric oxygen on the growth factor profile of fibroblasts. Arch Facial Plast Surg. 2004;6(1):31–35. doi:10.1001/archfaci.6.1.31
   PubMedGoogle Scholar
• Lin S, Shyu KG, Lee CC, et al. Hyperbaric oxygen selectively induces angiopoietin-2 in human umbilical vein endothelial cells. Biochem Biophys Res Commun. 2002;296(3):710–715.
   Web of Science ®Google Scholar
• Sander AL, Henrich D, Muth CM, Marzi I, Barker JH, Frank JM. In vivo effect of hyperbaric oxygen on wound angiogenesis and epithelialization. Wound Repair Regen. 2009;17(2):179–184. doi:10.1111/j.1524-475X.2009.00455.x
   PubMed Web of Science ®Google Scholar
• Bonomo SR, Davidson JD, Yu Y, Xia Y, Lin X, Mustoe TA. Hyperbaric oxygen as a signal transducer: upregulation of platelet derived growth factor-beta receptor in the presence of HBO2 and PDGF. Undersea Hyperb Med. 1998;25(4):211–216.
   Google Scholar
• Godman CA, Chheda KP, Hightower LE, Perdrizet G, Shin DG, Giardina C. Hyperbaric oxygen induces a cytoprotective and angiogenic response in human microvascular endothelial cells. Cell Stress Chaperones. 2010;15(4):431–442. doi:10.1007/s12192-009-0159-0
   PubMed Web of Science ®Google Scholar
• Chvapil M, Hurych J, Mirejovska E. Effect of long-term hypoxia on protein synthesis in granuloma and in some organs in rats. Proc Soc Exp Biol Med. 1970;135(3):613–617.
   Web of Science ®Google Scholar
• Worth ER, Tettelbach W, Hopf HW. Enhancement of Healing in Selected Problem Wounds. North Palm Beach (FL): Undersea and Hyperbaric Medical Society; 2014.
   Google Scholar
• Kranke P, Bennett MH, Martyn-St James M, Schnabel A, Debus SE, Weibel S. Hyperbaric oxygen therapy for chronic wounds. Cochrane Database Syst Rev. 2015;(6):CD004123.
   Google Scholar
• Dinh TL, Veves A. A review of the mechanisms implicated in the pathogenesis of the diabetic foot. Int J Low Extrem Wounds. 2005;4(3):154–159. doi:10.1177/1534734605280130
   PubMedGoogle Scholar
• Gallagher KA, Liu ZJ, Xiao M, et al. Diabetic impairments in NO-mediated endothelial progenitor cell mobilization and homing are reversed by hyperoxia and SDF-1 alpha. J Clin Invest. 2007;117(5):1249–1259. doi:10.1172/JCI29710
   PubMed Web of Science ®Google Scholar
• Goldstein LJ, Gallagher KA, Bauer SM, et al. Endothelial progenitor cell release into circulation is triggered by hyperoxia-induced increases in bone marrow nitric oxide. Stem Cells. 2006;24(10):2309–2318. doi:10.1634/stemcells.2006-0010
   PubMed Web of Science ®Google Scholar
• Liu ZJ, Velazquez OC. Hyperoxia, endothelial progenitor cell mobilization, and diabetic wound healing. Antioxid Redox Signal. 2008;10(11):1869–1882. doi:10.1089/ars.2008.2121
   PubMed Web of Science ®Google Scholar
• Camporesi EM, Bosco G. Mechanisms of action of hyperbaric oxygen therapy. Undersea Hyperb Med. 2014;41(3):247–252.
   PubMed Web of Science ®Google Scholar
• Huang E, Heyboer M. Adjunctive hyperbaric oxygen therapy for diabetic foot ulcers. In: Whelan H, Kindwall E, editors. Hyperbaric Medicine Practice. 4th ed. North Palm Beach (FL): Best Publishing; 2018;591–622.
   Google Scholar
• Huang E, Heyboer M, Savaser D. Enhancement of Healing in Selected Problem Wounds. North Palm Beach (FL): Undersea and Hyperbaric Medical Society; In press.
   Google Scholar
• Baroni G, Porro T, Faglia E, et al. Hyperbaric oxygen in diabetic gangrene treatment. Diabetes Care. 1987;10(1):81–86.
   Web of Science ®Google Scholar
• Faglia E, Favales F, Aldeghi A, et al. Change in major amputation rate in a center dedicated to diabetic foot care during the 1980s: prognostic determinants for major amputation. J Diabetes Complications. 1998;12(2):96–102.
   PubMed Web of Science ®Google Scholar
• Faglia E, Favales F, Aldeghi A, et al. Adjunctive systemic hyperbaric oxygen therapy in treatment of severe prevalently ischemic diabetic foot ulcer. A randomized study. Diabetes Care. 1996;19(12):1338–1343.
   PubMed Web of Science ®Google Scholar
• Oriani G, Meazza D, Favales F, Pizzi G, Aldeghi A, Faglia E. Hyperbaric oxygen therapy in diabetic gangrene. J Hyperbaric Med. 1990;5(3):171–175.
   Google Scholar
• Doctor N, Pandya S, Supe A. Hyperbaric oxygen therapy in diabetic foot. J Postgrad Med. 1992;38(3):112–114.
   PubMedGoogle Scholar
• Londahl M, Katzman P. Comments on Margolis et al. Lack of effectiveness of hyperbaric oxygen therapy for the treatment of diabetic foot ulcer and the prevention of amputation. Int Wound J. 2015;12(2):232. doi:10.1111/iwj.12093
   Web of Science ®Google Scholar
• Abidia A, Laden G, Kuhan G, et al. The role of hyperbaric oxygen therapy in ischaemic diabetic lower extremity ulcers: a double-blind randomised-controlled trial. Eur J Vasc Endovasc Surg. 2003;25(6):513–518. doi:10.1053/ejvs.2002.1911
   PubMed Web of Science ®Google Scholar
• Duzgun AP, Satir HZ, Ozozan O, Saylam B, Kulah B, Coskun F. Effect of hyperbaric oxygen therapy on healing of diabetic foot ulcers. J Foot Ankle Surg. 2008;47(6):515–519. doi:10.1053/j.jfas.2008.08.002
   PubMed Web of Science ®Google Scholar
• Ma L, Li P, Shi Z, Hou T, Chen X, Du J. A prospective, randomized, controlled study of hyperbaric oxygen therapy: effects on healing and oxidative stress of ulcer tissue in patients with a diabetic foot ulcer. Ostomy Wound Manage. 2013;59(3):18–24.
   Google Scholar
• Strauss MB, Bryant BJ, Hart GB. Transcutaneous oxygen measurements under hyperbaric oxygen conditions as a predictor for healing of problem wounds. Foot Ankle Int. 2002;23(10):933–937. doi:10.1177/107110070202301008
   Web of Science ®Google Scholar
• Game FL, Attinger C, Hartemann A, et al. IWGDF guidance on use of interventions to enhance the healing of chronic ulcers of the foot in diabetes. Diabetes Metab Res Rev. 2016;32(Suppl 1):75–83. doi:10.1002/dmrr.2700
   PubMedGoogle Scholar
• Game FL, Hinchliffe RJ, Apelqvist J, et al. A systematic review of interventions to enhance the healing of chronic ulcers of the foot in diabetes. Diabetes Metab Res Rev. 2012;28(Suppl 1):119–141. doi:10.1002/dmrr.2246
   Web of Science ®Google Scholar
• Game F. Classification of diabetic foot ulcers. Diabetes Metab Res Rev. 2016;32(Suppl 1):186–194. doi:10.1002/dmrr.2746
   Google Scholar
• Carter MJ, Fife CE, Bennett M. Comment on: Margolis et al. Lack of effectiveness of hyperbaric oxygen therapy for the treatment of diabetic foot ulcer and the prevention of amputation: a cohort study. Diabetes Care. 2013;36:1961–1966. doi:10.2337/dc12-2160
   Web of Science ®Google Scholar
• Fedorko L, Bowen JM, Jones W, et al. Hyperbaric oxygen therapy does not reduce indications for amputation in patients with diabetes with nonhealing ulcers of the lower limb: a prospective, double-blind, randomized controlled clinical trial. Diabetes Care. 2016. doi:10.2337/dc15-2001
   Web of Science ®Google Scholar
• Santema KTB, Stoekenbroek RM, Koelemay MJW, et al. Hyperbaric oxygen therapy in the treatment of ischemic lower- extremity ulcers in patients with diabetes: results of the DAMO2CLES multicenter randomized clinical trial. Diabetes Care. 2018;41(1):112–119. doi:10.2337/dc17-0654
   PubMed Web of Science ®Google Scholar
• Huang ET. Comment on Fedorko et al. Hyperbaric oxygen therapy does not reduce indications for amputation in patients with diabetes with nonhealing ulcers of the lower limb: a prospective, double-blind, randomized controlled clinical trial. Diabetes Care. 2016;39:392–399. doi:10.2337/dc15-2001
   Web of Science ®Google Scholar
• Londahl M, Fagher K, Katzman P. Comment on Fedorko et al. Hyperbaric oxygen therapy does not reduce indications for amputation in patients with diabetes with nonhealing ulcers of the lower limb: a prospective, double-blind, randomized controlled clinical trial. Diabetes Care. 2016;39:392–399. doi:10.2337/dc15-2001
   Web of Science ®Google Scholar
• Murad MH. Comment on Fedorko et al. Hyperbaric oxygen therapy does not reduce indications for amputation in patients with diabetes with nonhealing ulcers of the lower limb: a prospective, double-blind, randomized controlled clinical trial. Diabetes Care. 2016;39:392–399. doi:10.2337/dc15-2001
   Web of Science ®Google Scholar
• Huang E. Comment on Santema et al. Hyperbaric oxygen therapy in the treatment of ischemic lower-extremity ulcers in patients with diabetes: results of the DAMO2CLES multicenter randomized clinical trial. Diabetes Care. 2018;41:112–119. doi:10.2337/dc17-0654
   Web of Science ®Google Scholar
• Mutluoglu M. Comment on Santema et al. Hyperbaric oxygen therapy in the treatment of ischemic lower-extremity ulcers in patients with diabetes: results of the DAMO2CLES multicenter randomized clinical trial. Diabetes Care. 2018;41:112–119. doi:10.2337/dc17-0654
   Web of Science ®Google Scholar
• Londahl M, Katzman P, Nilsson A, Hammarlund C. Hyperbaric oxygen therapy facilitates healing of chronic foot ulcers in patients with diabetes. Diabetes Care. 2010;33(5):998–1003. doi:10.2337/dc09-1754
   PubMed Web of Science ®Google Scholar
• Ennis W, Huang E, Gordon H. Impact of hyperbaric oxygen on more advanced wagner grades 3 and 4 diabetic foot ulcers: matching therapy to specific wound conditions. Adv Wound Care. 2018;7(12):11. doi:10.1089/wound.2018.0855
   Web of Science ®Google Scholar
• Guo S, Counte MA, Gillespie KN, Schmitz H. Cost-effectiveness of adjunctive hyperbaric oxygen in the treatment of diabetic ulcers. Int J Technol Assess Health Care. 2003;19(4):731–737.
   PubMed Web of Science ®Google Scholar
• Chuck AW, Hailey D, Jacobs P, Perry DC. Cost-effectiveness and budget impact of adjunctive hyperbaric oxygen therapy for diabetic foot ulcers. Int J Technol Assess Health Care. 2008;24(2):178–183. doi:10.1017/S0266462308080252
   PubMed Web of Science ®Google Scholar
• Hailey D, Jacobs P, Perry D, Chuck A, Morrison A, Boudreau R. Adjunctive hyperbaric oxygen therapy for diabetic foot ulcer: an economic analysis. Can Agency Drugs Technol Health. March 2007;2007.
   Google Scholar
• Cianci P, Petrone G, Drager S, Lueders H, Lee H, Shapiro R. Salvage of the problem wound and potential amputation with wound care and adjunctive hyperbaric oxygen therapy: an economic analysis. J Hyperbaric Med. 1988;3(3):127–141.
   Google Scholar
• Eggert JV, Worth ER, Van Gils CC. Cost and mortality data of a regional limb salvage and hyperbaric medicine program for Wagner grade 3 or 4 diabetic foot ulcers. Undersea Hyperb Med. 2016;43(1):1–8.
   Web of Science ®Google Scholar
• Huang ET. Hyperbaric medicine today: an historically noble discipline challenged by loss of critical access and overutilization – an introduction to invited commentary. Undersea Hyperb Med. 2017;44(1):1–3.
   Web of Science ®Google Scholar
• Rosamond W, Flegal K, Furie K, et al. Heart disease and stroke statistics–2008 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation. 2008;117(4):e25–146. doi:10.1161/CIRCULATIONAHA.107.187998
   PubMed Web of Science ®Google Scholar
• Thomas DR. Managing peripheral arterial disease and vascular ulcers. Clin Geriatr Med. 2013;29(2):425–431. doi:10.1016/j.cger.2013.01.010
   Web of Science ®Google Scholar
• Marston WA, Davies SW, Armstrong B, et al. Natural history of limbs with arterial insufficiency and chronic ulceration treated without revascularization. J Vasc Surg. 2006;44(1):108–114. doi:10.1016/j.jvs.2006.03.026
   PubMed Web of Science ®Google Scholar
• Tautenhahn J, Lobmann R, Koenig B, Halloul Z, Lippert H, Buerger T. The influence of polymorbidity, revascularization, and wound therapy on the healing of arterial ulceration. Vasc Health Risk Manag. 2008;4(3):683–689.
   PubMedGoogle Scholar
• Heyboer M 3rd, Grant WD, Byrne J, et al. Hyperbaric oxygen for the treatment of nonhealing arterial insufficiency ulcers. Wound Repair Regen. 2014;22(3):351–355. doi:10.1111/wrr.12176
   Web of Science ®Google Scholar
• Hopf HW, Ueno C, Aslam R, et al. Guidelines for the treatment of arterial insufficiency ulcers. Wound Repair Regen. 2006;14(6):693–710. doi:10.1111/j.1524-475X.2006.00177.x
   PubMed Web of Science ®Google Scholar
• Angelis M, Wong LL, Myers SA, Wong LM. Calciphylaxis in patients on hemodialysis: a prevalence study. Surgery. 1997;122(6):1083–1089; discussion 1089–1090.
   Web of Science ®Google Scholar
• Podymow T, Wherrett C, Burns KD. Hyperbaric oxygen in the treatment of calciphylaxis: a case series. Nephrol Dial Transplant. 2001;16(11):2176–2180.
   Web of Science ®Google Scholar
• Bhambri A, Del Rosso JQ. Calciphylaxis: a review. J Clin Aesthet Dermatol. 2008;1(2):38–41.
   Google Scholar
• Budisavljevic MN, Cheek D, Ploth DW. Calciphylaxis in chronic renal failure. J Am Soc Nephrol. 1996;7(7):978–982.
   Web of Science ®Google Scholar
• An J, Devaney B, Ooi KY, Ford S, Frawley G, Menahem S. Hyperbaric oxygen in the treatment of calciphylaxis: a case series and literature review. Nephrology (Carlton). 2015;20(7):444–450. doi:10.1111/nep.12433
   Web of Science ®Google Scholar
• Basile C, Montanaro A, Masi M, Pati G, De Maio P, Gismondi A. Hyperbaric oxygen therapy for calcific uremic arteriolopathy: a case series. J Nephrol. 2002;15(6):676–680.
   Web of Science ®Google Scholar
• Arenas MD, Gil MT, Gutierrez MD, et al. Management of calcific uremic arteriolopathy (calciphylaxis) with a combination of treatments, including hyperbaric oxygen therapy. Clin Nephrol. 2008;70(3):261–264.
   PubMed Web of Science ®Google Scholar
• Don BR, Chin AI. A strategy for the treatment of calcific uremic arteriolopathy (calciphylaxis) employing a combination of therapies. Clin Nephrol. 2003;59(6):463–470.
   Web of Science ®Google Scholar
• Dean SM, Werman H. Calciphylaxis: a favorable outcome with hyperbaric oxygen. Vasc Med. 1998;3(2):115–120. doi:10.1177/1358836X9800300205
   Google Scholar
• Vassa N, Twardowski ZJ, Campbell J. Hyperbaric oxygen therapy in calciphylaxis-induced skin necrosis in a peritoneal dialysis patient. Am J Kidney Dis. 1994;23(6):878–881.
   PubMed Web of Science ®Google Scholar
• McCulloch N, Wojcik SM, Heyboer M 3rd. Patient outcomes and factors associated with healing in calciphylaxis patients undergoing adjunctive hyperbaric oxygen therapy. J Am Coll Clin Wound Spec. 2015;7(1–3):8–12. doi:10.1016/j.jccw.2016.08.004
   Google Scholar
• Baldwin C, Farah M, Leung M, et al. Multi-intervention management of calciphylaxis: a report of 7 cases. Am J Kidney Dis. 2011;58(6):988–991. doi:10.1053/j.ajkd.2011.06.022
   Web of Science ®Google Scholar
• Moran ME. Scleroderma and evidence based non-pharmaceutical treatment modalities for digital ulcers: a systematic review. J Wound Care. 2014;23(10):510–516. doi:10.12968/jowc.2014.23.10.510
   Web of Science ®Google Scholar
• Rollins MD, Gibson JJ, Hunt TK, Hopf HW. Wound oxygen levels during hyperbaric oxygen treatment in healing wounds. Undersea Hyperb Med. 2006;33(1):17–25.
   PubMedGoogle Scholar
• Tibbles PM, Edelsberg JS. Hyperbaric-oxygen therapy. N Engl J Med. 1996;334(25):1642–1648. doi:10.1056/NEJM199606203342506
   PubMed Web of Science ®Google Scholar
• Gassas A, Wayne Evans A, Armstrong C, Doyle JJ. Open wound chronic skin graft-vs-host disease. Are these wounds ischemic? Pediatr Transplant. 2007;11(1):101–104. doi:10.1111/j.1399-3046.2006.00582.x
   Web of Science ®Google Scholar
• Al-Waili NS, Butler GJ. Effects of hyperbaric oxygen on inflammatory response to wound and trauma: possible mechanism of action. ScientificWorldJournal. 2006;6:425–441. doi:10.1100/tsw.2006.78
   Google Scholar
• Dowling GB, Copeman PW, Ashfield R. Raynaud‘s phenomenon in scleroderma treated with hyperbaric oxygen. Proc R Soc Med. 1967;60(12):1268–1269.
   Google Scholar
• Chun W, Kim S, Seong H, Chong T. Hyperbaric oxygen therapy in systemic scleroderma. Korean J Dermatol. 1974;12(1):4.
   Google Scholar
• Slade B. The Effect of hyperbaric oxygen therapy (HBO) on wound healing in patients with collagen-vascular disease: a retrospective analysis. Undersea Biomed Res. 1991;18(Suppl):1.
   Google Scholar
• Markus YM, Bell MJ, Evans AW. Ischemic scleroderma wounds successfully treated with hyperbaric oxygen therapy. J Rheumatol. 2006;33(8):1694–1696.
   Web of Science ®Google Scholar
• Gerodimos C, Stefanidou S, Kotsiou M, Melekos T, Mesimeris T. Hyperbaric oxygen treatment of intractable ulcers in a systemic sclerosis patient. Aristotle Univ Med J. 2013;40(3):4.
   Google Scholar
• Li Y, Pang J, Miao L, Yu M. The long-term effect of hyperbaric oxygen therapy on systemic sclerosis. Guide of China Medicine. 2013. Available from: http://en.cnki.com.cn/Article_en/CJFDTotal-YYXK201317339.htm. Accessed May 06, 2019.
   Google Scholar
• Poirier E, Wind H, Cordel N. [Efficacy of hyperbaric oxygen therapy in the treatment of ischemic toe ulcer in a patient presenting systemic sclerosis]. Ann Dermatol Venereol. 2017;144(1):55–59. doi:10.1016/j.annder.2016.06.007
   Web of Science ®Google Scholar
• Mirasoglu B, Bagli BS, Aktas S. Hyperbaric oxygen therapy for chronic ulcers in systemic sclerosis - case series. Int J Dermatol. 2017;56(6):636–640. doi:10.1111/ijd.13570
   Web of Science ®Google Scholar
• Hymes SR, Alousi AM, Cowen EW. Graft-versus-host disease: part I. Pathogenesis and clinical manifestations of graft-versus-host disease. J Am Acad Dermatol. 2012;66(4):515e511-518; quiz 533–514. doi:10.1016/j.jaad.2011.11.960
   Web of Science ®Google Scholar
• Stussi G, Tsakiris DA. Late effects on haemostasis after haematopoietic stem cell transplantation. Hamostaseologie. 2012;32(1):63–66. doi:10.5482/ha-1184
   Web of Science ®Google Scholar
• Biedermann BC, Sahner S, Gregor M, et al. Endothelial injury mediated by cytotoxic T lymphocytes and loss of microvessels in chronic graft versus host disease. Lancet. 2002;359(9323):2078–2083.
   PubMed Web of Science ®Google Scholar
• Song XY, Sun LN, Zheng NN, Zhang HP. Effect of hyperbaric oxygen on acute graft-versus-host disease after allogeneic bone marrow transplantation. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2008;16(3):623–626.
   Google Scholar
• Heyboer M 3rd, Taylor J, Morgan M, Mariani P, Jennings S. The use of hyperbaric oxygen therapy in the treatment of non-healing ulcers secondary to graft-versus-host disease. J Am Coll Clin Wound Spec. 2013;5(1):14–18. doi:10.1016/j.jccw.2014.04.001
   Google Scholar
• Hurwitz RM, Haseman JH. The evolution of pyoderma gangrenosum. A clinicopathologic correlation. Am J Dermatopathol. 1993;15(1):28–33.
   Web of Science ®Google Scholar
• Fakhar F, Memon S, Deitz D, Abramowitz R, Alpert DR. Refractory postsurgical pyoderma gangrenosum in a patient with Beckwith Wiedemann syndrome: response to multimodal therapy. BMJ Case Rep. 2013;2013.
   Google Scholar
• Tutrone WD, Green K, Weinberg JM, Caglar S, Clarke D. Pyoderma gangrenosum: dermatologic application of hyperbaric oxygen therapy. J Drugs Dermatol. 2007;6(12):1214–1219.
   Google Scholar
• Niezgoda JA, Cabigas EB, Allen HK, Simanonok JP, Kindwall EP, Krumenauer J. Managing pyoderma gangrenosum: a synergistic approach combining surgical debridement, vacuum-assisted closure, and hyperbaric oxygen therapy. Plast Reconstr Surg. 2006;117(2):24e–28e. doi:10.1097/01.prs.0000200776.13868.02
   Web of Science ®Google Scholar
• Campton-Johnston S, Wilson J, Ramundo JM. Treatment of painful lower extremity ulcers in a patient with sickle cell disease. J Wound Ostomy Continence Nurs. 1999;26(2):98–104.
   Google Scholar
• Wethers DL, Ramirez GM, Koshy M, et al. Accelerated healing of chronic sickle-cell leg ulcers treated with RGD peptide matrix. RGD Study Group. Blood. 1994;84(6):1775–1779.
   Web of Science ®Google Scholar
• Laszlo J, Obenour W Jr., Saltzman HA. Effects of hyperbaric oxygenation on sickle syndromes. South Med J. 1969;62(4):453–456.
   Web of Science ®Google Scholar
• Desforges JF, Wang MY. Sickle cell anemia. Med Clin North Am. 1966;50(6):1519–1532.
   Web of Science ®Google Scholar
• Rudge FW. Hyperbaric oxygen therapy in the treatment of sickle cell ulcers. J Hyperbaric Med. 1991;6(1):1–4.
   Google Scholar
• Reynolds JD. Painful sickle cell crisis. Successful treatment with hyperbaric oxygen therapy. JAMA. 1971;216(12):1977–1978.
   Web of Science ®Google Scholar
• Stirnemann J, Letellier E, Aras N, Borne M, Brinquin L, Fain O. Hyperbaric oxygen therapy for vaso-occlusive crises in nine patients with sickle-cell disease. Diving Hyperb Med. 2012;42(2):82–84.
   Web of Science ®Google Scholar
• Azik FM, Atay A, Kurekci AE, Ay H, Kibar Y, Ozcan O. Treatment of priapism with automated red cell exchange and hyperbaric oxygen in an 11-year-old patient with sickle cell disease. Turk J Haematol. 2012;29(3):270–273. doi:10.5505/tjh.2012.78553
   Web of Science ®Google Scholar
• Canan H, Ulas B, Altan-Yaycioglu R. Hyperbaric oxygen therapy in combination with systemic treatment of sickle cell disease presenting as central retinal artery occlusion: a case report. J Med Case Rep. 2014;8:370. doi:10.1186/1752-1947-8-370
   Google Scholar
• Hammarlund C, Sundberg T. Hyperbaric oxygen reduced size of chronic leg ulcers: a randomized double-blind study. Plast Reconstr Surg. 1994;93(4):829–33; discussion 834.
   Google Scholar
• Thistlethwaite KR, Finlayson KJ, Cooper PD, et al. The effectiveness of hyperbaric oxygen therapy for healing chronic venous leg ulcers: A randomized, double-blind, placebo-controlled trial. Wound Repair Regen. 2018;26(4):324–331. doi:10.1111/wrr.12657
   Web of Science ®Google Scholar
• Andrade SM, Santos IC. Hyperbaric oxygen therapy for wound care. Rev Gaucha Enferm. 2016;37(2):e59257.
   PubMedGoogle Scholar