76
Views
12
CrossRef citations to date
0
Altmetric
Review

New treatments for myasthenia: a focus on antisense oligonucleotides

, &
Pages 13-17 | Published online: 10 Jan 2013

References

  • Drachman DB Myasthenia gravis N Engl J Med 1994 330 25 1797 1810 8190158
  • Hoch W McConville J Helms S Newsom-Davis J Melms A Vincent A Auto-antibodies to the receptor tyrosine kinase MuSK in patients with myasthenia gravis without acetylcholine receptors antibodies Net Med 2001 7 3 365 368
  • Hughes BW Kusner LL Kaminski HJ Molecular architecture of the neuromuscular junction Muscle Nerve 2006 33 4 445 461 16228970
  • Howard JFJr Myasthenia Gravis: A Manual for the Health Care Provider St Paul, MN Myastehia Gravis Foundation of America 2008 Available from: http://www.myasthenia.org/LinkClick.aspx?fileticket=S472fPAE1ow%3D&tabid=69 Accessed November 18, 2008
  • Meshorer E Toiber D Zurel D Combinatorial complexity of 5 alternative acetylcholinesterase transcripts and protein products J Biol Chem 2004 279 29740 29751 15123727
  • Meshorer E Bryk B Toiber D SC35 promotes sustainable stress-induced alternative splicing of neuronal acetylcholinesterase mRNA Mol Psychiatry 2005 10 985 997 16116489
  • Meshorer E Soreq H Virtues and woes of AChE alternative splicing in stress-related neuropathologies Trends Neurosci 2006 29 4 216 224 16516310
  • Massoulié J The origin of the molecular diversity and functional anchoring of cholinesterases Neurosignals 2002 11 130 143 12138250
  • Li Y Camp S Rachinsky TL Getman D Taylor P Gene structure of mammalian acetylcholinesterase. Alternative exons dictate tissue-specific expression J Biol Chem 1991 266 23083 23090 1744105
  • Seidman S Sternfeld M Ben Aziz-Aloya R Timberg R Kaufer-Nachum D Soreq H Synaptic and epidermal accumulations of human acetylcholinesterase are encoded by alternative 3′-terminal exons Mol Cell Biol 1995 15 2993 3002 7760797
  • Kaufer D Soreq H Tracking cholinergic pathways from psychological and chemical stressors to variable neurodeterioration paradigms Curr Opin Neurol 1999 12 739 743 10676758
  • Brenner T Hamra-Amitay Y Evron T Boneva N Seidman S Soreq H The role of readthrough acetylcholinesterase in the pathophysiology of myasthenia gravis FASEB J 2003 17 214 222 12554700
  • Lev-Lehman E Evron T Broide RS Synaptogenesis and myopathy under acetylcholinesterase overexpression J Mol Neurosci 2000 14 93 105 10854041
  • Schwarz M Loewenstein-Lichtenstein Y Glick D Liao J Norgaard-Pedersen B Soreq H Successive organophosphate inhibition and oxime reactivation reveals distinct responses of recombinant human cholinesterase variants Brain Res Mol Brain Res 1995 31 101 110 7476018
  • Kaufer D Friedman A Seidman S Soreq H Acute stress facilitates long-lasting changes in cholinergic gene expression Nature 1998 393 373 377 9620801
  • Sussman JD Argov Z McKee D Hazum E Brawer S Soreq H Antisense treatment for myasthenia gravis: experience with monarsen Ann N Y Acad Sci 2008 1132 283 290 18567879
  • Dori A Soreq H Neuromuscular therapeutics by RNA-targeted suppression of ACHE gene expression Ann N Y Acad Sci 2006 1082 77 90 17145929
  • Soreq H Seidman S Acetylcholinesterase – new roles for an old actor Nat Rev Neurosci 2001 2 294 302 11283752
  • Soreq H Ben-Aziz R Prody CA Molecular cloning and construction of the coding region for human acetylcholinesterase reveals a G + C-rich attenuating structure Proc Natl Acad Sci U S A 1990 87 9688 9692 2263619
  • Evron T Moyal-Segal LB Lamm N Geffen A Soreq H RNA-targeted suppression of stress-induced allostasis in primate spinal cord neurons Neurodegener Dis 2005 2 1 16 27 16908999
  • Pollak Y Gilboa A Ben-Menachem O Ben-Hur T Soreq H Yirmiya R Acetylcholinesterase inhibitors reduce brain and blood interleukin-1beta production Ann Neurol 2005 57 5 741 745 15852394
  • Amarin: RNA therapy results announced to attract suitors [opinion] PharmaWatch: Monthly Review 2009 8 7 27 28
  • Borovikova LV Ivanova S Zhang M Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin Nature 2000 405 458 462 10839541
  • Huang D Shi FD Giscombe R Zhou Y Ljunggren HG Lefvert AK Disruption of the IL-1beta gene diminishes acetylcholine receptor-induced immune responses in a murine model of myasthenia gravis Eur J Immunol 2001 31 225 232 11265638
  • Martignago S Fanin M Albertini E Pegoraro E Angelini C Muscle histopathology in myasthenia gravis with antibodies against MuSK and AChR Neuropathol Appl Neurobiol 2009 35 1 103 110 19187062