555
Views
4
CrossRef citations to date
0
Altmetric
ORIGINAL RESEARCH

Development of Verapamil Hydrochloride-loaded Biopolymer-based Composite Electrospun Nanofibrous Mats: In vivo Evaluation of Enhanced Burn Wound Healing without Scar Formation

ORCID Icon, , , &
Pages 1211-1231 | Received 19 Sep 2022, Accepted 04 Mar 2023, Published online: 21 Apr 2023

References

  • Smith R, Russo J, Fiegel J, Brogden N. Antibiotic delivery strategies to treat skin infections when innate antimicrobial defense fails. Antibiotics. 2020;9:56.
  • Dong Y, Zheng Y, Zhang K, et al. Electrospun nanofibrous materials for wound healing. Adv Fiber Mater. 2020;2:212–227. doi:10.1007/s42765-020-00034-y
  • Azimi B, Maleki H, Zavagna L, et al. Bio-based electrospun fibers for wound healing. J Funct Biomater. 2020;11:67. doi:10.3390/jfb11030067
  • Taemeh MA, Shiravandi A, Korayem MA, Daemi H. Fabrication challenges and trends in biomedical applications of alginate electrospun nanofibers. Carbohydr Polym. 2020;15(228):115419. doi:10.1016/j.carbpol.2019.115419
  • Ji Y, Song W, Xu L, Yu DG, Bligh SWA. A review on electrospun poly(amino acid) nanofibers and their applications of hemostasis and wound healing. Biomolecules. 2022;12:794. doi:10.3390/biom12060794
  • Xue J, Xie J, Liu W, Xia Y. Electrospun nanofibers: new concepts, materials, and applications. Acc Chem Res. 2017;50(8):1976–1987. doi:10.1021/acs.accounts.7b00218
  • Zhou Y, Wang M, Yan C, Liu H, Yu DG. Advances in the application of electrospun drug-loaded nanofibers in the treatment of oral ulcers. Biomolecules. 2022;12:1254. doi:10.3390/biom12091254
  • Liu Y, Chen X, Liu Y, Gao Y, Liu P. Electrospun coaxial fibers to optimize the release of poorly water-soluble drug. Polymers. 2022;14(3):469.
  • Lv H, Yu DG, Wang M, Ning T. Nanofabrication of janus fibers through side-by-side electrospinning - a mini review. Mater Highlight. 2021;2(1–2):18. doi:10.2991/mathi.k.210212.001
  • Ghosal K, Augustine R, Zaszczynska A, et al. Novel drug delivery systems based on triaxial electrospinning based nanofibers. React Funct Polym. 2021;1(163):104895. doi:10.1016/j.reactfunctpolym.2021.104895
  • Nagiah N, Murdock CJ, Bhattacharjee M, Nair L, Laurencin CT. Development of tripolymeric triaxial electrospun fibrous matrices for dual drug delivery applications. Sci Rep. 2020;10(1). doi:10.1038/s41598-020-57412-0
  • Datta LP, Manchineella S, Govindaraju T. Biomolecules-derived biomaterials. Biomaterials. 2020;230:119633. doi:10.1016/j.biomaterials.2019.119633
  • Zhang B, Yan X, He HW, Yu M, Ning X, Long YZ. Solvent-free electrospinning: opportunities and challenges. Polym Chem. 2017;8:333. doi:10.1039/C6PY01898J
  • Fu R, Li C, Yu C, et al. A novel electrospun membrane based on moxifloxacin hydrochloride/poly(vinyl alcohol)/ sodium alginate for antibacterial wound dressings in practical application. Drug Deliv. 2016;23(3):818–829. doi:10.3109/10717544.2014.918676
  • Sun F, Guo J, Liu Y, Yu Y. Preparation, characterizations and properties of sodium alginate grafted acrylonitrile/polyethylene glycol electrospun nanofibers. Int J Biol Macromol. 2019;137:420–425. doi:10.1016/j.ijbiomac.2019.06.185
  • Fang D, Liu Y, Jiang S, Nie J, Ma G. Effect of intermolecular interaction on electrospinning of sodium alginate. Carbohydr Polym. 2011;85(1):276–279.
  • Wongkanya R, Chuysinuan P, Pengsuk C, et al. Electrospinning of alginate/soy protein isolated nanofibers and their release characteristics for biomedical applications. J Sci Adv Mater Dev. 2017;2(3):309–316.
  • Teboho M, Jacobs N, Adriaan L. Electrospun alginate nanofibres as potential bio-sorption agent of heavy metals in water treatment. Express Polym Lett. 2017;11:652–663. doi:10.3144/expresspolymlett.2017.63
  • Vigani B, Rossi S, Milanesi G, et al. Electrospun alginate fibers: mixing of two different poly(ethylene oxide) grades to improve fiber functional properties. Nanomaterials. 2018;8(12):971. doi:10.3390/nano8120971
  • Li W, Li X, Chen Y, et al. Poly(vinyl alcohol)/sodium alginate/layered silicate based nanofibrous mats for bacterial inhibition. Carbohydr Polym. 2013;92(2):2232–2238. doi:10.1016/j.carbpol.2012.12.004
  • Labib G. Overview on zein protein: a promising pharmaceutical excipient in drug delivery systems and tissue engineering. Expert Opin Drug Deliv. 2018;15(1):65–75. doi:10.1080/17425247.2017.1349752
  • Fan X, Wang Y, Zheng M, et al. Morphology engineering of protein fabrics for advanced and sustainable filtration †. J Mater Chem A. 2018;6:21585–21595. doi:10.1039/C8TA08717B
  • Singh N, Georget DM, Belton PS, Barker SA. Zein-iodine complex studied by FTIR spectroscopy and dielectric and dynamic rheometry in films and precipitates. J Agric Food Chem. 2009;57(10):4334–4341. doi:10.1021/jf900436q
  • Dashdorj U, Reyes MK, Unnithan AR, et al. Fabrication and characterization of electrospun zein/Ag nanocomposite mats for wound dressing applications. Int J Biol Macromol. 2015;1(80):1–7. doi:10.1016/j.ijbiomac.2015.06.026
  • Wang Y, Padua GW. Nanoscale characterization of zein self-assembly. Langmuir. 2012;28(5):2429–2435. doi:10.1021/la204204j
  • Miyoshi T, Toyohara K, Minematsu H. Preparation of ultrafine fibrous zein membranes via electrospinning. Polym Int. 2005;54:1187–1190. doi:10.1002/pi.1829
  • Kanjanapongkul K, Wongsasulak S, Yoovidhya T. Investigation and prevention of clogging during electrospinning of zein solution. J Appl Polym Sci. 2010;118:1821–1829.
  • Vogt L, Liverani L, Roether JA, Boccaccini AR. Electrospun zein fibers incorporating poly(glycerol sebacate) for soft tissue engineering. Nanomaterials. 2018;8(3):150. doi:10.3390/nano8030150
  • Akhmetova A, Lanno GM, Kogermann K, Malmsten M, Rades T, Heinz A. Highly elastic and water stable zein microfibers as a potential drug delivery system for wound healing. Pharmaceutics. 2020;12(5):458. doi:10.3390/pharmaceutics12050458
  • Sotiropoulou G, Zingkou E, Pampalakis G. Redirecting drug repositioning to discover innovative cosmeceuticals. Exp Dermatol. 2021;30:628–644. doi:10.1111/exd.14299
  • Spampinato SF, Caruso GI, de Pasquale R, Sortino MA, Merlo S. The treatment of impaired wound healing in diabetes: looking among old drugs. Pharmaceuticals. 2020;13(4). doi:10.3390/ph13040060
  • Pillaiyar T, Meenakshisundaram S, Manickam M, Sankaranarayanan M. A medicinal chemistry perspective of drug repositioning: recent advances and challenges in drug discovery. Eur J Med Chem. 2020;1(195):112275. doi:10.1016/j.ejmech.2020.112275
  • Boggio RF, Boggio LF, Galvão BL, Machado-Santelli GM. Topical verapamil as a scar modulator. Aesthetic Plast Surg. 2014;38(5):968–975. doi:10.1007/s00266-014-0400-9
  • Yoshida MI, Cassiana E, Gomes L, et al. Thermal analysis applied to verapamil hydrochloride characterization in pharmaceutical formulations. Molecules. 2010;15:2439–2452. doi:10.3390/molecules15042439
  • Priya KS, Gnanamani A, Radhakrishnan N, Babu M. Healing potential of Datura alba on burn wounds in albino rats. J Ethnopharmacol. 2002;83(3):193–199. doi:10.1016/S0378-8741(02)00195-2
  • El-Refaie WM, Elnaggar YS, El-Massik MA, Abdallah OY. Novel curcumin-loaded gel-core hyaluosomes with promising burn-wound healing potential: development, in-vitro appraisal and in-vivo studies. Int J Pharm. 2015;486(1–2):88–98. doi:10.1016/j.ijpharm.2015.03.052
  • Gong C, Wu Q, Wang Y, et al. A biodegradable hydrogel system containing curcumin encapsulated in micelles for cutaneous wound healing. Biomaterials. 2013;34(27):6377–6387. doi:10.1016/j.biomaterials.2013.05.005
  • Hothorn T, Hornik K, Wien W, van de Wiel MA, Zeileis A. Implementing a class of permutation tests: the coin package. J Stat Softw. 2008;28(8):1–23. doi:10.18637/jss.v028.i08
  • Shalumon KT, Anulekha KH, Nair SV, Chennazhi KP, Jayakumar R. Sodium alginate/poly(vinyl alcohol)/nano ZnO composite nanofibers for antibacterial wound dressings. Int J Biol Macromol. 2011;49(3):247–254. doi:10.1016/j.ijbiomac.2011.04.005
  • Nie H, He A, Zheng J, Xu S, Li J, Han CC. Effects of chain conformation and entanglement on the electrospinning of pure alginate. Biomacromolecules. 2008;9(5):1362–1365. doi:10.1021/bm701349j
  • Fong H, Chun I, Reneker DH. Beaded nanofibers formed during electrospinning. Polymer. 1999;40(16):4585–4592. doi:10.1016/S0032-3861(99)00068-3
  • Islam MS, Karim MR. Fabrication and characterization of poly(vinyl alcohol)/alginate blend nanofibers by electrospinning method. Colloids Surf a Physicochem Eng. 2010;366(1–3):135–140. doi:10.1016/j.colsurfa.2010.05.038
  • Kataria K, Gupta A, Rath G, Mathur RB, Dhakate SR. In vivo wound healing performance of drug loaded electrospun composite nanofibers transdermal patch. Int J Pharm. 2014;469(1):102–110. doi:10.1016/j.ijpharm.2014.04.047
  • Zhang M, Liu Y, Yi H, Luan J, Zhang Y. Electrospun zein/PVA fibrous mats as three-dimensional surface for embryonic stem cell culture. J Text Inst. 2014;105(3):246–255. doi:10.1080/00405000.2013.835902
  • Liu FX, Liu YJ, Cai HL, Luan JS, Zhang M. Preparation and mechanical properties of zein/PVA nanofibrous membranes. Adv Mater Res. 2012;466:391–395.
  • Lin J, Li C, Zhao Y, Hu J, Zhang LM. Co-electrospun nanofibrous membranes of collagen and zein for wound healing. ACS Appl Mater Interfaces. 2012;4(2):1050–1057. doi:10.1021/am201669z
  • Wang X, Mousavi S. Encapsulation of Lidocaine into Zein Nanofibers; 2018.
  • Diedericks H. C release of an antimicrobial substance from polymeric matrices. Controlled release of antimicrobial substances from polymer matrices. European Patent Office Publ. of Application with search report EP20040386006; 2016.
  • Gönen S, Taygun ME, Küçükbayrak S. Evaluation of the factors influencing the resultant diameter of the electrospun gelatin/sodium alginate nanofibers via Box-Behnken design. Mater Sci Eng C Mater Biol Appl. 2016;58:709–723. doi:10.1016/j.msec.2015.09.024
  • Ghitescu RE, Popa AM, Popa VI, Rossi RM, Fortunato G. Encapsulation of polyphenols into pHEMA e-spun fibers and determination of their antioxidant activities. Int J Pharm. 2015;494(1):278–287. doi:10.1016/j.ijpharm.2015.08.020
  • Song TY, Yao C, Li XS. Electrospinning of zein/chitosan composite fibrous membranes. Chinese J Polym Sci. 2010;28:171–179. doi:10.1007/s10118-010-8239-2
  • de Oliveira Mori CLS, Dos Passos NA, Oliveira JE, et al. Electrospinning of zein/tannin bio-nanofibers. Ind Crops Prod. 2014;52:298–304. doi:10.1016/j.indcrop.2013.10.047
  • Motealleh B, Zahedi P, Rezaeian I, Moghimi M, Abdolghaffari AH, Zarandi MA. Morphology, drug release, antibacterial, cell proliferation, and histology studies of chamomile-loaded wound dressing mats based on electrospun nanofibrous poly(E-caprolactone)/polystyrene blends. J Biomed Mater Res Part B Appl Biomater. 2013;102:977–987. doi:10.1002/jbm.b.33078
  • Zong X, Kim K, Fang D, Ran S, Hsiao BS, Chu B. Structure and process relationship of electrospun bioabsorbable nanofiber membranes. Polymer. 2002;43(16):4403–4412. doi:10.1016/S0032-3861(02)00275-6
  • Johnson CDL, D’amato AR, Gilbert RJ. Electrospun fibers for drug delivery after spinal cord injury and the effects of drug incorporation on fiber properties. Cells Tissues Organs. 2016;202(1–2):116–135. doi:10.1159/000446621
  • Bao J, Lv W, Sun Y, Deng Y. Electrospun antimicrobial microfibrous scaffold for annulus fibrosus tissue engineering. J Mater Sci. 2013;48:4223–4232. doi:10.1007/s10853-013-7235-7
  • Toncheva A, Paneva D, Manolova N, Rashkov I. Electrospun poly(L-lactide) membranes containing a single drug or multiple drug system for antimicrobial wound dressings. Macromol Res. 2011;19(12):1310–1319. doi:10.1007/s13233-011-1206-0
  • Huang W, Zou T, Li S, Jing J, Xia X, Liu X. Drug-loaded zein nanofibers prepared using a modified coaxial electrospinning process. AAPS PharmSciTech. 2013;14(2):675–681. doi:10.1208/s12249-013-9953-1
  • Kyzioł A, Michna J, Moreno I, Gamez E, Irusta S. Preparation and characterization of electrospun alginate nanofibers loaded with ciprofloxacin hydrochloride. Eur Polym J. 2017;1(96):350–360. doi:10.1016/j.eurpolymj.2017.09.020
  • Shukla R, Cheryan M. Zein: the industrial protein from corn. Ind Crops Prod. 2001;13(3):171–192. doi:10.1016/S0926-6690(00)00064-9
  • Ghalei S, Asadi H, Ghalei B, Ghalei S. Zein nanoparticle-embedded electrospun PVA nanofibers as wound dressing for topical delivery of anti-inflammatory diclofenac. J Appl Polym Sci. 2018;135:46643. doi:10.1002/app.46643
  • Idriss N, Maibach HI. Scar assessment scales: a dermatologic overview. Skin Res Technol. 2009;15:1–5. doi:10.1111/j.1600-0846.2008.00327.x