346
Views
1
CrossRef citations to date
0
Altmetric
ORIGINAL RESEARCH

Effectiveness and Safety of a Fixed-Dose Combination of Valsartan and Rosuvastatin (Rovatitan® Tablet) in Patients with Concomitant Hypertension and Hyperlipidemia: An Observational Study

ORCID Icon, , , , ORCID Icon, , , , & show all
Pages 1047-1062 | Received 17 Oct 2022, Accepted 23 Feb 2023, Published online: 06 Apr 2023

References

  • World Health Organization. Cardiovascular diseases (CVDs) Fact sheet. Available from: https://www.who.int/en/newsroom/fact-sheets/detail/cardiovascular-diseases-(cvds). Accessed March 14, 2023.
  • Johnson ML, Pietz K, Battleman DS, et al. Prevalence of comorbid hypertension and dyslipidemia and associated cardiovascular disease. Am J Manag Care. 2004;10(12):926–932.
  • Lim S, Shin H, Song JH, et al. Increasing prevalence of metabolic syndrome in Korea: the Korean National Health and Nutrition Examination Survey for 1998–2007. Diabetes Care. 2011;34(6):1323–1328. doi:10.2337/dc10-2109
  • Stamler J, Wentworth D, Neaton D. Prevalence and prognostic significance of hypercholesterolemia in men with hypertension: prospective data on the primary screenees of the Multiple Risk Factor Intervention Trial. Am J Med. 1986;80:33–39. doi:10.1016/0002-9343(86)90158-0
  • Castelli P, Anderson K. A population at risk: prevalence of high cholesterol levels in hypertensive patients in the Framingham Study. Am J Med. 1986;80:23–32.
  • Satoh M, Ohkubo T, Asayama K, et al. Evidence for Cardiovascular Prevention From Observational Cohorts in Japan (EPOCH-Japan) Research Group*. Combined effect of blood pressure and total cholesterol levels on long-term risks of subtypes of cardiovascular death: evidence for Cardiovascular Prevention from Observational Cohorts in Japan. Hypertension. 2015;65(3):517–524. doi:10.1161/HYPERTENSIONAHA.114.04639
  • National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). Third report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III) final report. Circulation. 2002;106(25):3143–3421. doi:10.1161/circ.106.25.3143
  • Kannel WB, Castelli WP, Gordon T, et al. Serum cholesterol, lipoproteins, and the risk of coronary heart disease. The Framingham study. Ann Int Med. 1971;74:1–12. doi:10.7326/0003-4819-74-1-1
  • Borghi C. Interactions between hypercholesterolemia and hypertension: implications for therapy. Curr Opin Nephrol Hypertens. 2002;11:489–496. doi:10.1097/00041552-200209000-00003
  • Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Executive summary of the third report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III). JAMA. 2001;285(19):2486–2497. doi:10.1001/jama.285.19.2486
  • Spannella F, Giulietti F, Di Pentima C, et al. Prevalence and control of dyslipidemia in patients referred for high blood pressure: the disregarded “Double-Trouble” lipid profile in overweight/obese. Adv Ther. 2019;36(6):1426–1437. doi:10.1007/s12325-019-00941-6
  • Petrella RJ, Merikle E. A retrospective analysis of the prevalence and treatment of hypertension and dyslipidemia in southwestern Ontario, Canada. Clin Ther. 2008;30(6):1145–1154. doi:10.1016/j.clinthera.2008.06.004
  • Bangalore S, Kamalakkannan G, Parkar S, et al. Fixed-dose combinations improve medication compliance: a meta-analysis. Am J Med. 2007;120(8):713–719. doi:10.1016/j.amjmed.2006.08.033
  • Mancia G, Fagard R, Narkiewicz K. 2013 ESH/ESC guidelines for the management of arterial hypertension: the task force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). J Hypertens. 2013;31(7):1281–1357. doi:10.1097/01.hjh.0000431740.32696.cc
  • Choi JM, Lee SH, Jang YJ, Kang M, Choi JH. Medication adherence and clinical outcome of fixed-dose combination vs. free combination of angiotensin receptor blocker and statin. Circ J. 2021;85(5):595–603. doi:10.1253/circj.CJ-20-0966
  • Dresser GK, Nelson SA, Mahon JL, et al. Simplified therapeutic intervention to control hypertension and hypercholesterolemia: a cluster randomized controlled trial (STITCH2). J Hypertens. 2013;31(8):1702–1713. doi:10.1097/HJH.0b013e3283619d6a
  • Kotseva K, Wood D, De Bacquer D, et al.; EUROASPIRE Investigators. EUROASPIRE IV: a European Society of Cardiology survey on the lifestyle, risk factor and therapeutic management of coronary patients from 24 European countries. Eur J Prev Cardiol. 2016;23(6):636–648. doi:10.1177/2047487315569401
  • Blank R, LaSalle J, Reeves R, et al. Single-pill therapy in the treatment of concomitant hypertension and dyslipidemia (the amlodipine/atorvastatin Gemini study). J Clin Hypertens. 2005;7(5):264–273. doi:10.1111/j.1524-6175.2005.04533.x
  • Flack JM, Victor R, Watson K, et al. Improved attainment of blood pressure and cholesterol goals using single-pill amlodipine/atorvastatin in African Americans: the CAPABLE trial. Mayo Clin Proc. 2008;83(1):35–45. doi:10.4065/83.1.35
  • Ceriello A, Assaloni R, Da Ros R, et al. Effect of atorvastatin and irbesartan, alone and in combination, on postprandial endothelial dysfunction, oxidative stress, and inflammation in type 2 diabetic patients. Circulation. 2005;111(19):2518–2524. doi:10.1161/01.CIR.0000165070.46111.9F
  • Ihm SH, Shin J, Park CG, et al. Efficacy of a fixed dose combination of irbesartan and atorvastatin (Rovelito®) in Korean adults with hypertension and hypercholesterolemia. Drug Des Devel Ther. 2019;13:633–645. doi:10.2147/DDDT.S191973
  • Jang JY, Lee SH, Kim BS, et al. Additive beneficial effects of valsartan combined with rosuvastatin in the treatment of hypercholesterolemic hypertensive patients [Published correction appears in Korean Circ J. 2015;45(4):349]. Korean Circ J. 2015;45(3):225–233. doi:10.4070/kcj.2015.45.3.225
  • Kim SH, Jo SH, Lee SC, et al. Blood pressure and cholesterol-lowering efficacy of a fixed-dose combination with irbesartan and atorvastatin in patients with hypertension and hypercholesterolemia: a randomized, double-blind, factorial, multicenter Phase III study. Clin Ther. 2016;38(10):2171–2184. doi:10.1016/j.clinthera.2016.09.005
  • Cho KI, Kim BH, Park YH, et al. Efficacy and safety of a fixed-dose combination of candesartan and rosuvastatin on blood pressure and cholesterol in patients with hypertension and hypercholesterolemia: a multicenter, randomized, double-blind, parallel phase III clinical study. Clin Ther. 2019;41(8):1508–1521. doi:10.1016/j.clinthera.2019.05.007
  • Park JS, Shin JH, Hong TJ, et al. Efficacy and safety of fixed-dose combination therapy with olmesartan medoxomil and rosuvastatin in Korean patients with mild to moderate hypertension and dyslipidemia: an 8-week, multicenter, randomized, double-blind, factorial-design study (OLSTA-D RCT: oLmesartan rosuvaSTAtin from Daewoong). Drug Des Devel Ther. 2016;10:2599–2609. doi:10.2147/DDDT.S112873
  • Oh GC, Han JK, Han KH, et al. Efficacy and safety of fixed-dose combination therapy with telmisartan and rosuvastatin in Korean patients with hypertension and dyslipidemia: TELSTA-YU (TELmisartanrosuvaSTAtin from YUhan), a multicenter, randomized, 4-arm, double-blind, placebo-controlled, phase III study. Clin Ther. 2018;40(5):676–691. doi:10.1016/j.clinthera.2018.03.010
  • Potier L, Roussel R, Elbez Y, et al. REACH Registry Investigators*. Angiotensin-converting enzyme inhibitors and angiotensin receptor blockers in high vascular risk. Heart. 2017;103(17):1339–1346. doi:10.1136/heartjnl-2016-310705
  • Elliott WJ, Meyer PM. Incident diabetes in clinical trials of antihypertensive drugs: a network meta-analysis. Lancet. 2007;369(9557):201–207. doi:10.1016/S0140-6736(07)60108-1
  • Lee S-H. Update on familial hypercholesterolemia: diagnosis, cardiovascular risk, and novel therapeutics. Endocrinol Metab. 2017;32(1):36–40. doi:10.3803/EnM.2017.32.1.36
  • Oesterle A, Laufs U, Liao JK. Pleiotropic effects of statins on the cardiovascular system. Circ Res. 2017;120(1):229–243. doi:10.1161/CIRCRESAHA.116.308537
  • Mancia G, De Backer G, Dominiczak A, et al. 2007 guidelines for the management of arterial hypertension: the task force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). J Hypertens. 2007;25:1105–1187. doi:10.1097/HJH.0b013e3281fc975a
  • Graham I, Atar D, Borch-Johnsen K, et al. European guidelines on cardiovascular disease prevention in clinical practice: executive summary. Eur Heart J. 2007;28:2375–2414. doi:10.1093/eurheartj/ehm316
  • Tuomilehto J, Leiter LA, Kallend D. A review of the efficacy of rosuvastatin in patients with type 2 diabetes. Int J Clin Pract Suppl. 2004;143:30–40. doi:10.1111/j.1368-504X.2004.00390.x
  • Taylor AA, Siragy H, Nesbitt S. Angiotensin receptor blockers: pharmacology, efficacy, and safety. J Clin Hypertens. 2011;13(9):677–686. doi:10.1111/j.1751-7176.2011.00518.x
  • Korean guidelines for the management of dyslipidemia IV. Available from: https://www.lipid.or.kr/file/guidlines.pdf. Accessed March 14, 2023.
  • Chobanian AV, Bakris GL, Black HR, et al.; Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure; National Heart, Lung, and Blood Institute; National High Blood Pressure Education Program Coordinating Committee. Seventh report of the Joint National Committee on prevention, detection, evaluation, and treatment of high blood pressure. Hypertension. 2003;42(6):1206–1252. doi:10.1161/01.HYP.0000107251.49515.c2
  • James PA, Oparil S, Carter BL, et al. 2014 evidence-based guideline for the management of high blood pressure in adults: report from the panel members appointed to the eighth Joint National Committee (JNC 8). JAMA. 2014;311(5):507–520. doi:10.1001/jama.2013.284427
  • Leggio M, Lombardi M, Caldarone E, et al. The relationship between obesity and hypertension: an updated comprehensive overview on vicious twins. Hypertens Res. 2017;40:947–963. doi:10.1038/hr.2017.75
  • Chopra I, Kamal KM, Candrilli SD, et al. Association between obesity and therapeutic goal attainment in patients with concomitant hypertension and dyslipidemia. Postgrad Med. 2014;126(1):66–77. doi:10.3810/pgm.2014.01.2726