Shensong Yangxin Capsule Reduces the Susceptibility of Arrhythmia in db/db Mice via Inhibiting the Inflammatory Response Induced by Endothelium Dysfunction

References

• Zeng Z, Zhuang Z, He Y, et al. Efficacy and safety of Shen-Song-Yang-Xin capsule for treating arrhythmia in the elderly patients with coronary heart disease: protocol for a systematic review and meta-analysis. Medicine. 2018;97(51):e13599. doi:10.1097/MD.0000000000013599
   PubMed Web of Science ®Google Scholar
• Driessen HE, van Veen TAB, Boink GJJ. Emerging molecular therapies targeting myocardial infarction-related arrhythmias. Europace. 2017;19(4):518–528. doi:10.1093/europace/euw198
   PubMed Web of Science ®Google Scholar
• Roubille F, Tardif JC. New therapeutic targets in cardiology: heart failure and arrhythmia: HCN channels. Circulation. 2013;127(19):1986–1996. doi:10.1161/CIRCULATIONAHA.112.000145
   PubMed Web of Science ®Google Scholar
• Yang KC, Nerbonne JM. Mechanisms contributing to myocardial potassium channel diversity, regulation and remodeling. Trends Cardiovasc Med. 2016;26(3):209–218. doi:10.1016/j.tcm.2015.07.002
   PubMed Web of Science ®Google Scholar
• Burchfield JS, Xie M, Hill JA. Pathological ventricular remodeling: mechanisms: part 1 of 2. Circulation. 2013;128(4):388–400. doi:10.1161/CIRCULATIONAHA.113.001878
   PubMed Web of Science ®Google Scholar
• Abrams D, Schilling R. Mechanism and mapping of atrial arrhythmia in the modified Fontan circulation. Heart Rhythm. 2005;2(10):1138–1144. doi:10.1016/j.hrthm.2005.07.009
   PubMed Web of Science ®Google Scholar
• Corban MT, Toya T, Ahmad A, et al. Atrial fibrillation and endothelial dysfunction: a potential link? Mayo Clin Proc. 2021;96(6):1609–1621. doi:10.1016/j.mayocp.2020.11.005
   PubMed Web of Science ®Google Scholar
• Corban MT, Lerman LO, Lerman A. Endothelial dysfunction. Arterioscler Thromb Vasc Biol. 2019;39(7):1272–1274. doi:10.1161/ATVBAHA.119.312836
   PubMed Web of Science ®Google Scholar
• Grune J, Yamazoe M, Nahrendorf M. Electroimmunology and cardiac arrhythmia. Nat Rev Cardiol. 2021;18(8):547–564. doi:10.1038/s41569-021-00520-9
   PubMed Web of Science ®Google Scholar
• Nicolás-ávila JA, Lechuga-Vieco AV, Esteban-Martínez L, et al. A network of macrophages supports mitochondrial homeostasis in the heart. Cell. 2020;183(1):94–109.e23. doi:10.1016/j.cell.2020.08.031
   PubMed Web of Science ®Google Scholar
• Hulsmans M, Clauss S, Xiao L, et al. Macrophages facilitate electrical conduction in the heart. Cell. 2017;169(3):510–522.e20. doi:10.1016/j.cell.2017.03.050
   PubMed Web of Science ®Google Scholar
• Fei YD, Wang Q, Hou JW, et al. Macrophages facilitate post myocardial infarction arrhythmias: roles of gap junction and KCa3.1. Theranostics. 2019;9(22):6396–6411. doi:10.7150/thno.34801
   PubMed Web of Science ®Google Scholar
• Jungen C, Scherschel K, Flenner F, et al. Increased arrhythmia susceptibility in type 2 diabetic mice related to dysregulation of ventricular sympathetic innervation. Am J Physiol Heart Circ Physiol. 2019;317(6):H1328–H1341. doi:10.1152/ajpheart.00249.2019
   PubMed Web of Science ®Google Scholar
• Staerk L, Sherer JA, Ko D, et al. Atrial fibrillation: epidemiology, pathophysiology, and clinical outcomes. Circ Res. 2017;120(9):1501–1517. doi:10.1161/CIRCRESAHA.117.309732
   PubMed Web of Science ®Google Scholar
• Russo S, Kwiatkowski M, Govorukhina N, et al. Meta-inflammation and metabolic reprogramming of macrophages in diabetes and obesity: the importance of metabolites. Front Immunol. 2021;12(12):746151. doi:10.3389/fimmu.2021.746151
   PubMedGoogle Scholar
• Rendra E, Riabov V, Mossel DM, et al. Reactive oxygen species (ROS) in macrophage activation and function in diabetes. Immunobiology. 2019;224(2):242–253. doi:10.1016/j.imbio.2018.11.010
   PubMed Web of Science ®Google Scholar
• Shi Y, Vanhoutte PM. Macro- and microvascular endothelial dysfunction in diabetes. J Diabetes. 2017;9(5):434–449. doi:10.1111/1753-0407.12521
   PubMed Web of Science ®Google Scholar
• Jiang C, Wang X, Dang S, et al. Chinese Medicine Shensong Yangxin capsule () ameliorates myocardial microcirculation dysfunction in rabbits with chronic myocardial infarction. Chin J Integr Med. 2021;27(1):24–30. doi:10.1007/s11655-018-2578-1
   PubMed Web of Science ®Google Scholar
• Dang S, Huang CX, Wang X, et al. Shensong Yangxin (SSYX) ameliorates disordered excitation transmission by suppressing cardiac collagen hyperplasia in rabbits with chronic myocardial infarction. J Huazhong Univ Sci Technol Med Sci. 2016;36(2):162–167. doi:10.1007/s11596-016-1560-4
   PubMedGoogle Scholar
• Yang HJ, Kong B, Shuai W, et al. Shensong Yangxin protects against metabolic syndrome-induced ventricular arrhythmias by inhibiting electrical remodeling. Front Pharmacol. 2020;11:993. doi:10.3389/fphar.2020.00993
   PubMed Web of Science ®Google Scholar
• Shen DF, Wu QQ, Ni J, et al. Shensongyangxin protects against pressure overload-induced cardiac hypertrophy. Mol Med Rep. 2016;13(1):980–988. doi:10.3892/mmr.2015.4598
   PubMed Web of Science ®Google Scholar
• Shen N, Li X, Zhou T, et al. Shensong Yangxin capsule prevents diabetic myocardial fibrosis by inhibiting TGF-β1/Smad signaling. J Ethnopharmacol. 2014;157:161–170. doi:10.1016/j.jep.2014.09.035
   PubMed Web of Science ®Google Scholar
• Ma J, Yin C, Ma S, et al. Shensong Yangxin capsule reduces atrial fibrillation susceptibility by inhibiting atrial fibrosis in rats with post-myocardial infarction heart failure. Drug Des Devel Ther. 2018;12:3407–3418. doi:10.2147/DDDT.S182834
   PubMed Web of Science ®Google Scholar
• Zhao HY, Zhang SD, Zhang K, et al. Effect of Shensong Yangxin on the progression of paroxysmal atrial fibrillation is correlated with regulation of autonomic nerve activity. Chin Med J. 2017;130(2):171–178. doi:10.4103/0366-6999.197997
   PubMed Web of Science ®Google Scholar
• Li N, Ma KJ, Wu XF, et al. Effects of Chinese herbs on multiple ion channels in isolated ventricular myocytes. Chin Med J. 2007;120(12):1068–1074. doi:10.1097/00029330-200706020-00008
   PubMed Web of Science ®Google Scholar
• Yang HJ, Kong B, Shuai W, et al. Shensong Yangxin attenuates metabolic syndrome-induced atrial fibrillation via inhibition of ferroportin-mediated intracellular iron overload. Phytomedicine. 2022;101:154086. doi:10.1016/j.phymed.2022.154086
   PubMed Web of Science ®Google Scholar
• Lubberding AF, Pereira L, Xue J, et al. Aberrant sinus node firing during β-adrenergic stimulation leads to cardiac arrhythmias in diabetic mice. Acta Physiol. 2020;229(1):e13444. doi:10.1111/apha.13444
   PubMed Web of Science ®Google Scholar
• Bohne LJ, Jansen HJ, Daniel I, et al. Electrical and structural remodeling contribute to atrial fibrillation in type 2 diabetic db/db mice. Heart Rhythm. 2021;18(1):118–129. doi:10.1016/j.hrthm.2020.08.019
   PubMed Web of Science ®Google Scholar
• Selthofer-Relatic K, Mihalj M, Kibel A, et al. Coronary microcirculatory dysfunction in human cardiomyopathies: a pathologic and pathophysiologic review. Cardiol Rev. 2017;25(4):165–178. doi:10.1097/CRD.0000000000000140
   PubMed Web of Science ®Google Scholar
• Fanning AS, Jameson BJ, Jesaitis LA, et al. The tight junction protein ZO-1 establishes a link between the transmembrane protein occludin and the actin cytoskeleton. J Biol Chem. 1998;273(45):29745–29753. doi:10.1074/jbc.273.45.29745
   PubMed Web of Science ®Google Scholar
• Feldman GJ, Mullin JM, Ryan MP. Occludin: structure, function and regulation. Adv Drug Deliv Rev. 2005;57(6):883–917. doi:10.1016/j.addr.2005.01.009
   PubMed Web of Science ®Google Scholar
• Couto GK, Britto LR, Mill JG, et al. Enhanced nitric oxide bioavailability in coronary arteries prevents the onset of heart failure in rats with myocardial infarction. J Mol Cell Cardiol. 2015;86:110–120. doi:10.1016/j.yjmcc.2015.07.017
   PubMed Web of Science ®Google Scholar
• Regal-McDonald K, Somarathna M, Lee T, et al. Assessment of ICAM-1 N-glycoforms in mouse and human models of endothelial dysfunction. PLoS One. 2020;15(3):e0230358. doi:10.1371/journal.pone.0230358
   PubMed Web of Science ®Google Scholar
• Liu J, Zhang Y, Sheng H, et al. Hyperoside suppresses renal inflammation by regulating macrophage polarization in mice with type 2 diabetes mellitus. Front Immunol. 2021;12:733808. doi:10.3389/fimmu.2021.733808
   PubMed Web of Science ®Google Scholar
• Lim AK, Tesch GH. Inflammation in diabetic nephropathy. Mediators Inflamm. 2012;2012:146154. doi:10.1155/2012/146154
   PubMed Web of Science ®Google Scholar
• Epifantseva I, Shaw RM. Intracellular trafficking pathways of Cx43 gap junction channels. Biochim Biophys Acta Biomembr. 2018;1860(1):40–47. doi:10.1016/j.bbamem.2017.05.018
   PubMed Web of Science ®Google Scholar
• Sjöblom B, Salmazo A, Djinović-Carugo K. Alpha-actinin structure and regulation. Cell Mol Life Sci. 2008;65(17):2688–2701. doi:10.1007/s00018-008-8080-8
   PubMed Web of Science ®Google Scholar