Effect of Remimazolam on Postoperative Delirium in Older Adult Patients Undergoing Orthopedic Surgery: A Prospective Randomized Controlled Clinical Trial

References

• Inouye SK, Westendorp RGJ, Saczynski JS. Delirium in elderly people. Lancet. 2014;383(9920):911–922. doi:10.1016/S0140-6736(13)60688-1
   PubMed Web of Science ®Google Scholar
• Mattison MLP. Delirium. Ann Intern Med. 2020;173(7):ITC49–ITC64.3. doi:10.7326/AITC202010060
   PubMed Web of Science ®Google Scholar
• Saczynski JS, Marcantonio ER, Quach L, et al. Cognitive trajectories after postoperative delirium. N Engl J Med. 2012;367(1):30–39. doi:10.1056/NEJMoa1112923
   PubMed Web of Science ®Google Scholar
• Goldberg TE, Chen C, Wang Y, et al. Association of delirium with long-term cognitive decline: a meta-analysis. JAMA Neurol. 2020;77(11):1373–1381. doi:10.1001/jamaneurol.2020.2273
   PubMed Web of Science ®Google Scholar
• Jin Z, Hu J, Ma D. Postoperative delirium: perioperative assessment, risk reduction, and management. Br J Anaesth. 2020;125(4):492–504. doi:10.1016/j.bja.2020.06.063
   PubMed Web of Science ®Google Scholar
• Duprey MS, Devlin JW, Griffith JL, et al. Association between perioperative medication use and postoperative delirium and cognition in older adults undergoing elective noncardiac surgery. Anesth Analg. 2022;134(6):1154–1163. doi:10.1213/ANE.0000000000005959
   PubMed Web of Science ®Google Scholar
• Masui K. Remimazolam besilate, a benzodiazepine, has been approved for general anesthesia. J Anesth. 2020;34(4):479–482. doi:10.1007/s00540-020-02755-1
   PubMed Web of Science ®Google Scholar
• Lohmer LL, Schippers F, Petersen KU, Stoehr T, Schmith VD. Time-to-event modeling for remimazolam for the indication of induction and maintenance of general anesthesia. J Clin Pharmacol. 2020;60(4):505–514. doi:10.1002/jcph.1552
   PubMed Web of Science ®Google Scholar
• Keam SJ. Remimazolam: first Approval. Drugs. 2020;80(6):625–633. doi:10.1007/s40265-020-01299-8
   PubMed Web of Science ®Google Scholar
• Sneyd JR, Gambus PL, Rigby-Jones AE. Current status of perioperative hypnotics, role of benzodiazepines, and the case for remimazolam: a narrative review. Br J Anaesth. 2021;127(1):41–55. doi:10.1016/j.bja.2021.03.028
   PubMed Web of Science ®Google Scholar
• Zhou J, Leonowens C, Ivaturi VD, et al. Population pharmacokinetic/pharmacodynamic modeling for remimazolam in the induction and maintenance of general anesthesia in healthy subjects and in surgical subjects. J Clin Anesth. 2020;66:109899. doi:10.1016/j.jclinane.2020.109899
   PubMed Web of Science ®Google Scholar
• Kudoh A, Takase H, Takahira Y, Takazawa T. Postoperative confusion increases in elderly long-term benzodiazepine users. Anesth Analg. 2004;99(6):1674–1678. doi:10.1213/01.ANE.0000136845.24802.19
   PubMed Web of Science ®Google Scholar
• Memtsoudis S, Cozowicz C, Zubizarreta N, et al. Risk factors for postoperative delirium in patients undergoing lower extremity joint arthroplasty: a retrospective population-based cohort study. Reg Anesth Pain Med. 2019;44:934–943. doi:10.1136/rapm-2019-100700
   Web of Science ®Google Scholar
• Pandharipande PP, Pun BT, Herr DL, et al. Effect of sedation with dexmedetomidine vs lorazepam on acute brain dysfunction in mechanically ventilated patients: the MENDS randomized controlled trial. JAMA. 2007;298(22):2644–2653. doi:10.1001/jama.298.22.2644
   PubMed Web of Science ®Google Scholar
• By the American Geriatrics Society Beers Criteria Update Expert P. American geriatrics society 2019 updated AGS beers criteria(R) for potentially inappropriate medication use in older adults. J Am Geriatr Soc. 2019;67(4):674–694. doi:10.1111/jgs.15767
   PubMed Web of Science ®Google Scholar
• Hughes CG, Boncyk CS, Culley DJ, et al. American society for enhanced recovery and perioperative quality initiative joint consensus statement on postoperative delirium prevention. Anesth Analg. 2020;130(6):1572–1590. doi:10.1213/ANE.0000000000004641
   PubMed Web of Science ®Google Scholar
• Aldecoa C, Bettelli G, Bilotta F, et al. European Society of Anaesthesiology evidence-based and consensus-based guideline on postoperative delirium. Eur J Anaesthesiol. 2017;34(4):192–214. doi:10.1097/EJA.0000000000000594
   PubMed Web of Science ®Google Scholar
• Aoki Y, Kurita T, Nakajima M, et al. Association between remimazolam and postoperative delirium in older adults undergoing elective cardiovascular surgery: a prospective cohort study. J Anesth. 2022;2022:1.
   Google Scholar
• Kaneko S, Morimoto T, Ichinomiya T, Murata H, Yoshitomi O, Hara T. Effect of remimazolam on the incidence of delirium after transcatheter aortic valve implantation under general anesthesia: a retrospective exploratory study. J Anesth. 2022. doi:10.1007/s00540-022-03148-2
   Web of Science ®Google Scholar
• Li H, Jia J, Mini-Mental State YZ. Examination in elderly Chinese: a population-based normative study. J Alzheimers Dis. 2016;53(2):487–496. doi:10.3233/JAD-160119
   PubMed Web of Science ®Google Scholar
• Inouye SK, van Dyck CH, Alessi CA, Balkin S, Siegal AP, Horwitz RI. Clarifying confusion: the confusion assessment method. A new method for detection of delirium. Ann Intern Med. 1990;113(12):941–948. doi:10.7326/0003-4819-113-12-941
   PubMed Web of Science ®Google Scholar
• Riker RR, Picard JT, Fraser GL. Prospective evaluation of the Sedation-Agitation Scale for adult critically ill patients. Crit Care Med US. 1999;27:1325–1329. doi:10.1097/00003246-199907000-00022
   PubMed Web of Science ®Google Scholar
• Mei X, Zheng HL, Li C, et al. The effects of propofol and sevoflurane on postoperative delirium in older patients: a randomized clinical trial study. J Alzheimers Dis. 2020;76(4):1627–1636. doi:10.3233/JAD-200322
   PubMed Web of Science ®Google Scholar
• Hong N, Park JY. The motoric types of delirium and estimated blood loss during perioperative period in orthopedic elderly patients. Biomed Res Int. 2018;2018:9812041. doi:10.1155/2018/9812041
   PubMed Web of Science ®Google Scholar
• Pandharipande P, Shintani A, Peterson J. Lorazepam is an independent risk factor for transitioning to delirium in intensive care unit patients. Anesthesiology. 2006;104:121. doi:10.1097/00000542-200601000-00005
   Web of Science ®Google Scholar
• Zaal IJ, Devlin JW, Hazelbag M, et al. Benzodiazepine-associated delirium in critically ill adults. Intensive Care Med. 2015;41(12):2130–2137. doi:10.1007/s00134-015-4063-z
   PubMed Web of Science ®Google Scholar
• Casault C, Soo A, Lee CH, et al. Sedation strategy and ICU delirium: a multicentre, population-based propensity score-matched cohort study. BMJ Open. 2021;11(7):e045087. doi:10.1136/bmjopen-2020-045087
   PubMed Web of Science ®Google Scholar
• Marcantonio ER, Juarez G, Goldman L, et al. The relationship of postoperative delirium with psychoactive medications. JAMA. 1994;272(19):1518–1522. doi:10.1001/jama.1994.03520190064036
   PubMed Web of Science ®Google Scholar
• Poeran J, Cozowicz C, Zubizarreta N, et al. Modifiable factors associated with postoperative delirium after Hip fracture repair: an age-stratified retrospective cohort study. Eur J Anaesthesiol. 2020;37(8):649–658. doi:10.1097/EJA.0000000000001197
   PubMed Web of Science ®Google Scholar
• Sheng XY, Liang Y, Yang XY, et al. Safety, pharmacokinetic and pharmacodynamic properties of single ascending dose and continuous infusion of remimazolam besylate in healthy Chinese volunteers. Eur J Clin Pharmacol. 2020;76(3):383–391. doi:10.1007/s00228-019-02800-3
   PubMed Web of Science ®Google Scholar
• Wang J, Li Z, Yu Y, Li B, Shao G, Wang Q. Risk factors contributing to postoperative delirium in geriatric patients post orthopedic surgery. Asia Pac Psychiatry. 2015;7(4):375–382. doi:10.1111/appy.12193
   PubMed Web of Science ®Google Scholar
• Park SA, Tomimaru Y, Shibata A, Miyagawa S, Noguchi K, Dono K. Incidence and risk factors for postoperative delirium in patients after hepatectomy. World J Surg. 2017;41(11):2847–2853. doi:10.1007/s00268-017-4079-3
   PubMed Web of Science ®Google Scholar
• Tomimaru Y, Park SA, Shibata A, et al. Predictive Factors of Postoperative Delirium in Patients After Pancreaticoduodenectomy. J Gastrointest Surg. 2020;24(4):849–854. doi:10.1007/s11605-019-04212-1
   PubMed Web of Science ®Google Scholar
• Gerlach LB, Wiechers IR, Maust DT. prescription benzodiazepine use among older adults: a critical review. Harv Rev Psychiatry. 2018;26(5):264–273. doi:10.1097/HRP.0000000000000190
   PubMed Web of Science ®Google Scholar
• Attard A, Ranjith G, Taylor D. Delirium and its treatment. CNS Drugs. 2008;22(8):631–644. doi:10.2165/00023210-200822080-00002
   PubMed Web of Science ®Google Scholar
• Yang M, Liu X, Yang D, et al. Effect of remimazolam besylate compared with propofol on the incidence of delirium after cardiac surgery: study protocol for a randomized trial. Trials. 2021;22(1):717. doi:10.1186/s13063-021-05691-x
   PubMed Web of Science ®Google Scholar
• Evered LA, Chan MTV, Han R, et al. Anaesthetic depth and delirium after major surgery: a randomised clinical trial. Br J Anaesth. 2021;127(5):704–712. doi:10.1016/j.bja.2021.07.021
   PubMed Web of Science ®Google Scholar
• Wachtendorf LJ, Azimaraghi O, Santer P, et al. Association between intraoperative arterial hypotension and postoperative delirium after noncardiac surgery: a retrospective multicenter cohort study. Anesth Analg. 2022;134(4):822–833. doi:10.1213/ANE.0000000000005739
   PubMed Web of Science ®Google Scholar
• Mueller A, Spies CD, Eckardt R, et al. Anticholinergic burden of long-term medication is an independent risk factor for the development of postoperative delirium: a clinical trial. J Clin Anesth. 2020;61:109632. doi:10.1016/j.jclinane.2019.109632
   PubMed Web of Science ®Google Scholar
• Mao Y, Guo J, Yuan J, Zhao E, Yang J. Quality of recovery after general anesthesia with remimazolam in patients’ undergoing urologic surgery: a randomized controlled trial comparing remimazolam with propofol. Drug Des Devel Ther. 2022;16:1199–1209. doi:10.2147/DDDT.S359496
   PubMed Web of Science ®Google Scholar
• Hu AM, Qiu Y, Zhang P, et al. Higher versus lower mean arterial pressure target management in older patients having non-cardiothoracic surgery: a prospective randomized controlled trial. J Clin Anesth. 2021;69:110150. doi:10.1016/j.jclinane.2020.110150
   PubMed Web of Science ®Google Scholar
• Doi M, Morita K, Takeda J, Sakamoto A, Yamakage M, Suzuki T. Efficacy and safety of remimazolam versus propofol for general anesthesia: a multicenter, single-blind, randomized, parallel-group, phase IIb/III trial. J Anesth. 2020;34(4):543–553. doi:10.1007/s00540-020-02788-6
   PubMed Web of Science ®Google Scholar
• Chen X, Sang N, Song K, et al. Psychomotor recovery following remimazolam-induced sedation and the effectiveness of flumazenil as an antidote. Clin Ther. 2020;42(4):614–624. doi:10.1016/j.clinthera.2020.02.006
   PubMed Web of Science ®Google Scholar
• Schulz KF, Altman DG, Moher D. CONSORT 2010 Statement: updated guidelines for reporting parallel group randomised trials. BMJ. 2010;340:c332. doi:10.1136/bmj.c332
   PubMed Web of Science ®Google Scholar
• Hari Y, Satomi S, Murakami C, et al. Remimazolam decreased the incidence of early postoperative nausea and vomiting compared to desflurane after laparoscopic gynecological surgery. J Anesth. 2022;36(2):265–269. doi:10.1007/s00540-022-03041-y
   PubMed Web of Science ®Google Scholar