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Review

New developments in the combination treatment of COPD: focus on umeclidinium/vilanterol

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Pages 1201-1208 | Published online: 10 Oct 2013

References

  • Qaseem A Wilt TJ Weinberger SE American College of Physicians American College of Chest Physicians American Thoracic Society European Respiratory Society Diagnosis and management of stable chronic obstructive pulmonary disease: a clinical practice guideline update from the American College of Physicians, American College of Chest Physicians, American Thoracic Society, and European Respiratory Society Ann Intern Med 2011 155 179 191 21810710
  • Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Pulmonary Disease Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2013 Available from: http://www.goldcopd.org/guidelines-global-strategy-for-diagnosis-management.html Accessed June 20, 2013
  • Cazzola M Page CP Calzetta L Matera MG Pharmacology and therapeutics of bronchodilators Pharmacol Rev 2012 64 450 504 22611179
  • Cazzola M Brusasco V Centanni S Project PriMo: sharing principles and practices of bronchodilator therapy monitoring in COPD: a consensus initiative for optimizing therapeutic appropriateness among Italian specialists Pulm Pharmacol Ther 2013 26 218 228 23147424
  • Cazzola M Tashkin DP Combination of formoterol and tiotropium in the treatment of COPD: effects on lung function COPD 2009 6 404 415 19863370
  • van der Molen T Cazzola M Beyond lung function in COPD management: effectiveness of LABA/LAMA combination therapy on patient-centred outcomes Prim Care Respir J 2012 21 101 108 22222945
  • Wedzicha JA Decramer M Ficker JH Analysis of chronic obstructive pulmonary disease exacerbations with the dual bronchodilator QVA149 compared with glycopyrronium and tiotropium (SPARK): a randomised, double-blind, parallel-group study Lancet Respir Med 2013 1 199 209
  • Donohue JF Combination therapy for chronic obstructive pulmonary disease: clinical aspects Proc Am Thorac Soc 2005 2 272 281 16267348
  • Cazzola M Molimard M The scientific rationale for combining long-acting β2-agonists and muscarinic antagonists in COPD Pulm Pharmacol Ther 2010 23 257 267 20381630
  • Cazzola M Calzetta L Matera MG β2-adrenoceptor agonists: current and future direction Br J Pharmacol 2011 163 4 17 21232045
  • Meurs H Oenema TA Kistemaker LE Gosens R A new perspective on muscarinic receptor antagonism in obstructive airways diseases Curr Opin Pharmacol 2013 13 316 323 23643733
  • Meurs H Dekkers BG Maarsingh H Halayko AJ Zaagsma J Gosens R Muscarinic receptors on airway mesenchymal cells: novel findings for an ancient target Pulm Pharmacol Ther 2013 26 145 155 22842340
  • Ahmedat AS Warnken M Juergens UR Paul Pieper M Racké K β2-adrenoceptors and muscarinic receptors mediate opposing effects on endothelin-1 expression in human lung fibroblasts Eur J Pharmacol 2012 691 218 224 22796455
  • Profita M Bonanno A Montalbano AM β2 long-acting and anticholinergic drugs control TGF-β1-mediated neutrophilic inflammation in COPD Biochim Biophys Acta 2012 1822 1079 1089 22440430
  • Tashkin DP Ferguson GT Combination bronchodilator therapy in the management of chronic obstructive pulmonary disease Respir Res 2013 14 49 23651244
  • Matera MG Page CP Cazzola M Novel bronchodilators for the treatment of chronic obstructive pulmonary disease Trends Pharmacol Sci 2011 32 495 506 21683458
  • Cazzola M Rogliani P Segreti A Matera MG An update on bronchodilators in Phase I and II clinical trials Expert Opin Investig Drugs 2012 21 1489 1501
  • Cazzola M Page CP Rogliani P Matera MG β2-agonist therapy in lung disease Am J Respir Crit Care Med 2013 187 690 696 23348973
  • Cazzola M Rogliani P Matera MG Aclidinium bromide/formoterol fumarate fixed-dose combination for the treatment of chronic obstructive pulmonary disease Expert Opin Pharmacother 2013 14 775 781 23472632
  • Salmon M Luttmann MA Foley JJ Pharmacological characterization of GSK573719 (umeclidinium): a novel, long-acting, inhaled antagonist of the muscarinic cholinergic receptors for treatment of pulmonary diseases J Pharmacol Exp Ther 2013 345 260 270 23435542
  • Tal-Singer R Cahn A Mehta R Initial assessment of single and repeat doses of inhaled umeclidinium in patients with chronic obstructive pulmonary disease: two randomised studies Eur J Pharmacol 2013 701 40 48 23276660
  • Cahn A Tal-Singer R Pouliquen IJ Safety, tolerability, pharmacokinetics and pharmacodynamics of single and repeat inhaled doses of umeclidinium in healthy subjects: two randomized studies Clin Drug Investig 2013 33 477 488
  • Decramer M Maltais F Feldman G Bronchodilation of umeclidinium, a new long-acting muscarinic antagonist, in COPD patients Respir Physiol Neurobiol 2013 185 393 399 23026438
  • Donohue JF Anzueto A Brooks J Mehta R Kalberg C Crater G A randomized, double-blind dose-ranging study of the novel LAMA GSK573719 in patients with COPD Respir Med 2012 106 970 979 22498110
  • Slack RJ Barrett VJ Morrison VS In vitro pharmacological characterization of vilanterol, a novel long-acting β2-adrenoceptor agonist with 24-hour duration of action J Pharmacol Exp Ther 2013 344 218 230 23131596
  • Harrell AW Siederer SK Bal J Metabolism and disposition of vilanterol, a long-acting β2-adrenoceptor agonist for inhalation use in humans Drug Metab Dispos 2013 41 89 100 23043183
  • Kempsford R Norris V Siederer S Vilanterol trifenatate, a novel inhaled long-acting beta2 adrenoceptor agonist, is well tolerated in healthy subjects and demonstrates prolonged bronchodilation in subjects with asthma and COPD Pulm Pharmacol Ther 2013 26 256 264 23232038
  • Hanania NA Feldman G Zachgo W The efficacy and safety of the novel long-acting β2 agonist vilanterol in patients with COPD: a randomized placebo-controlled trial Chest 2012 142 119 127 22241764
  • Kelleher DL Mehta RS Jean-Francois BM Safety, tolerability, pharmacodynamics and pharmacokinetics of umeclidinium and vilanterol alone and in combination: a randomized crossover trial PLoS One 2012 7 e50716 23284643
  • Kelleher D Tombs L Crater G Preece A Brealey N Mehta R A placebo- and moxifloxacin-controlled thorough QT study of umeclidinium monotherapy and umeclidinium/vilanterol combination in healthy subjects Am J Respir Crit Care Med 2013 187 A1487
  • Feldman G Walker RR Brooks J Mehta R Crater G 28-day safety and tolerability of umeclidinium in combination with vilanterol in COPD: a randomized placebo-controlled trial Pulm Pharmacol Ther 2012 25 465 471 22955035
  • Donohue JF Maleki-Yazdi M Kilbride S Mehta R Kalberg CJ Church A ride S Mehta R Kalberg C Church A Efficacy and safety of once-daily umeclidinium/vilanterol 62.5/25 mcg in COPD Respir Med 2013 7 2 [Epub ahead of print]
  • Celli BR Crater G Kilbride S A 24-week randomized, doubleblind, placebo-controlled study of the efficacy and safety of once-daily umeclidinium/vilanterol 125/25 mcg in COPD Am J Respir Crit Care Med 2013 187 A2435
  • Anzueto A Decramer M Kaelin T The efficacy and safety of umeclidinium/vilanterol compared with tiotropium or vilanterol over 24 weeks in subjects with COPD Am J Respir Crit Care Med 2013 187 A4268
  • Cazzola M Page C Matera MG Long-acting muscarinic receptor antagonists for the treatment of respiratory disease Pulm Pharmacol Ther 2013 26 307 317 23274274
  • Charlton SJ Agonist efficacy and receptor desensitization: from partial truths to a fuller picture Br J Pharmacol 2009 158 165 168 19719779
  • D’Urzo AD De Salvo MC Ramirez-Rivera A In patients with COPD, treatment with a combination of formoterol and ipratropium is more effective than a combination of salbutamol and ipratropium: a 3-week, randomized, double-blind, within-patient, multicenter study Chest 2001 119 1347 1356 11348938
  • Restrepo RD Alvarez MT Wittnebel LD Medication adherence issues in patients treated for COPD Int J Chron Obstruct Pulmon Dis 2008 3 371 384 18990964
  • Wu K Looby M Pillai G Pinault G Drollman AF Pascoe S Population pharmacodynamic model of the longitudinal FEV1 response to an inhaled long-acting anti-muscarinic in COPD patients J Pharmacokinet Pharmacodyn 2011 38 105 119 21104005
  • Church A Kalberg C Shah P Beerahee M Donohue J An analysis of the dose response of umeclidinium (GSK573719) administered once or twice daily in patients with COPD Chest 2012 142 672A
  • Sterling R Lim J Frith L Snowise NG Jacques L Haumann B Efficacy and optimal dosing interval of the long-acting beta2 agonist, vilanterol, in persistent asthma: a randomised trial Respir Med 2012 106 1110 1115 22520084