α-Mangostin Inhibited M1 Polarization of Macrophages/Monocytes in Antigen-Induced Arthritis Mice by Up-Regulating Silent Information Regulator 1 and Peroxisome Proliferators-Activated Receptor γ Simultaneously

References

• Fudenberg HH, Franklin EC. Rheumatoid factors and the etiology of rheumatoid arthritis. Ann NY Acad Sci. 1965;124(2):884–895. doi:10.1111/j.1749-6632.1965.tb19012.x
   PubMedGoogle Scholar
• Tu J, Huang W, Zhang W, Mei J, Zhu C. A tale of two immune cells in rheumatoid arthritis: the crosstalk between macrophages and T cells in the synovium. Front Immunol. 2021;12:655477. doi:10.3389/fimmu.2021.655477
   PubMedGoogle Scholar
• Tardito S, Martinelli G, Soldano S, et al. Macrophage M1/M2 polarization and rheumatoid arthritis: a systematic review. Autoimmun Rev. 2019;18(11):102397. doi:10.1016/j.autrev.2019.102397
   PubMed Web of Science ®Google Scholar
• Li J, Hsu H-C, Mountz JD. Managing macrophages in rheumatoid arthritis by reform or removal. Curr Rheumatol Rep. 2012;14(5):445–454. doi:10.1007/s11926-012-0272-4
   PubMed Web of Science ®Google Scholar
• Aletaha D, Smolen JS. Effectiveness profiles and dose dependent retention of traditional disease modifying antirheumatic drugs for rheumatoid arthritis. An observational study. J Rheumatol. 2002;29(8):1631–1638.
   PubMed Web of Science ®Google Scholar
• Saravanan V, Hamilton J. Advances in the treatment of rheumatoid arthritis: old versus new therapies. Expert Opin Pharmacother. 2002;3(7):845–856.
   PubMedGoogle Scholar
• Chung CP, Oeser A, Solus JF, et al. Prevalence of the metabolic syndrome is increased in rheumatoid arthritis and is associated with coronary atherosclerosis. Atherosclerosis. 2008;196(2):756–763.
   PubMed Web of Science ®Google Scholar
• Namgaladze D, Brüne B. Macrophage fatty acid oxidation and its roles in macrophage polarization and fatty acid-induced inflammation. Biochim Biophys Acta. 2016;1861(11):1796–1807.
   PubMed Web of Science ®Google Scholar
• Yan J, Horng T. Lipid metabolism in regulation of macrophage functions. Trends Cell Biol. 2020;30(12):979–989.
   PubMed Web of Science ®Google Scholar
• Marion-Letellier R, Savoye G, Ghosh S. Fatty acids, eicosanoids and PPAR gamma. Eur J Pharmacol. 2016;785:44–49. doi:10.1016/j.ejphar.2015.11.004
   PubMed Web of Science ®Google Scholar
• Kwon EJ, Park EJ, Choi S, Kim SR, Cho M, Kim J. PPARγ agonist rosiglitazone inhibits migration and invasion by downregulating Cyr61 in rheumatoid arthritis fibroblast-like synoviocytes. Int J Rheum Dis. 2017;20(10):1499–1509. doi:10.1111/1756-185X.12913
   PubMed Web of Science ®Google Scholar
• Kong S, McBurney MW, Fang D. Sirtuin 1 in immune regulation and autoimmunity. Immunol Cell Biol. 2012;90(1):6–13. doi:10.1038/icb.2011.102
   PubMed Web of Science ®Google Scholar
• Kotas ME, Gorecki MC, Gillum MP. Sirtuin-1 is a nutrient-dependent modulator of inflammation. Adipocyte. 2013;2(2):113–118. doi:10.4161/adip.23437
   PubMedGoogle Scholar
• Zuo J, Xia Y, Li X, Chen JW. Xanthones from Securidaca inappendiculata exert significant therapeutic efficacy on adjuvant-induced arthritis in mice. Inflammation. 2014;37(3):908–916. doi:10.1007/s10753-014-9810-8
   PubMed Web of Science ®Google Scholar
• Zuo J, Xia Y, Mao KJ, Li X, Chen JW. Xanthone-rich dichloromethane fraction of Securidaca inappendiculata, the possible antirheumatic material base with anti-inflammatory, analgesic, and immunodepressive effects. Pharm Biol. 2014;52(11):1367–1373. doi:10.3109/13880209.2014.892143
   PubMed Web of Science ®Google Scholar
• Narasimhan S, Maheshwaran S, Abu-Yousef IA, et al. Anti-bacterial and anti-fungal activity of xanthones obtained via semi-synthetic modification of α-mangostin from garcinia mangostana. Molecules. 2017;22(2):275. doi:10.3390/molecules22020275
   PubMed Web of Science ®Google Scholar
• Yang K, Yin Q, Mao Q, et al. Metabolomics analysis reveals therapeutic effects of α-mangostin on collagen-induced arthritis in rats by down-regulating nicotinamide phosphoribosyltransferase. Inflammation. 2019;42(2):741–753. doi:10.1007/s10753-018-0932-2
   PubMed Web of Science ®Google Scholar
• Zuo J, Yin Q, Wang YW, et al. Inhibition of NF-κB pathway in fibroblast-like synoviocytes by α-mangostin implicated in protective effects on joints in rats suffering from adjuvant-induced arthritis. Int Immunopharmacol. 2018;56:78–89. doi:10.1016/j.intimp.2018.01.016
   PubMed Web of Science ®Google Scholar
• Yang Z, Yin Q, Olatunji OJ, et al. Activation of cholinergic anti-inflammatory pathway involved in therapeutic actions of α-mangostin on lipopolysaccharide-induced acute lung injury in rats. Int J Immunopathol Pharmacol. 2020;34:2058738420954941. doi:10.1177/2058738420954941
   Web of Science ®Google Scholar
• Chen WG, Zhang SS, Pan S, et al. α-mangostin treats early-stage adjuvant-induced arthritis of rat by regulating the CAP-SIRT1 pathway in macrophages. Drug Des Devel Ther. 2022;16:509–520. doi:10.2147/DDDT.S348836
   PubMed Web of Science ®Google Scholar
• Choi YH, Bae JK, Chae H-S, et al. α-mangostin regulates hepatic steatosis and obesity through SirT1-AMPK and PPARγ pathways in high-fat diet-induced obese mice. J Agric Food Chem. 2015;63(38):8399–8406. doi:10.1021/acs.jafc.5b01637
   PubMed Web of Science ®Google Scholar
• Liu Y, Grimm M, Dai W-T, Hou M-C, Xiao Z-X, Cao Y. CB-Dock: a web server for cavity detection-guided protein–ligand blind docking. Acta Pharmacol Sin. 2020;41(1):138–144. doi:10.1038/s41401-019-0228-6
   PubMed Web of Science ®Google Scholar
• Liu Y, Yang X, Gan J, Chen S, Xiao Z-X, Cao Y. CB-Dock2: improved protein–ligand blind docking by integrating cavity detection, docking and homologous template fitting. Nucleic Acids Res. 2022;50(W1):W159–W164. doi:10.1093/nar/gkac394
   PubMed Web of Science ®Google Scholar
• Ohashi M, Gamo K, Oyama T, Miyachi H. Peroxisome proliferator-activated receptor gamma (PPARγ) has multiple binding points that accommodate ligands in various conformations: structurally similar PPARγ partial agonists bind to PPARγ LBD in different conformations. Bioorg Med Chem Lett. 2015;25(14):2758–2762. doi:10.1016/j.bmcl.2015.05.025
   PubMed Web of Science ®Google Scholar
• Lazić Mosler E, Lukač N, Flegar D, et al. Fas receptor induces apoptosis of synovial bone and cartilage progenitor populations and promotes bone loss in antigen-induced arthritis. FASEB J. 2019;33(3):3330–3342. doi:10.1096/fj.201801426R
   PubMed Web of Science ®Google Scholar
• Shu J-L, Zhang X-Z, Han L, et al. Paeoniflorin-6′-O-benzene sulfonate alleviates collagen-induced arthritis in mice by downregulating BAFF-TRAF2-NF-κB signaling: comparison with biological agents. Acta Pharmacol Sin. 2019;40(6):801–813. doi:10.1038/s41401-018-0169-5
   PubMed Web of Science ®Google Scholar
• Han L, Zhang X-Z, Wang C, et al. IgD-Fc-Ig fusion protein, a new biological agent, inhibits T cell function in CIA rats by inhibiting IgD-IgDR-Lck-NF-κB signaling pathways. Acta Pharmacol Sin. 2020;41(6):800–812. doi:10.1038/s41401-019-0337-2
   PubMed Web of Science ®Google Scholar
• Cai X-Y, Ge J-R, Xu L, et al. Paeoniflorin-6′-o-benzene sulfonate (CP −25) improves vasculitis through inhibiting IL-17A / JAK / STAT3 signaling pathway in endothelial cells of HFD CIA rats. Phytother Res. 2021;35(2):1033–1047. doi:10.1002/ptr.6870
   PubMed Web of Science ®Google Scholar
• Lei M, Tao M-Q, Wu Y-J, et al. Metabolic enzyme triosephosphate isomerase 1 and nicotinamide phosphoribosyltransferase, two independent inflammatory indicators in rheumatoid arthritis: evidences from collagen-induced arthritis and clinical samples. Front Immunol. 2022;12:795626. doi:10.3389/fimmu.2021.795626
   PubMed Web of Science ®Google Scholar
• Cai X-Y, Zhu Y, Wang C, et al. Etanercept inhibits B cell differentiation by regulating TNFRII/TRAF2/NF-κB signaling pathway in rheumatoid arthritis. Front Pharmacol. 2020;11:676. doi:10.3389/fphar.2020.00676
   PubMed Web of Science ®Google Scholar
• Cutolo M, Campitiello R, Gotelli E, Soldano S. The role of M1/M2 macrophage polarization in rheumatoid arthritis synovitis. Front Immunol. 2022;13:867260. doi:10.3389/fimmu.2022.867260
   PubMed Web of Science ®Google Scholar
• Dai X, Lu L, Deng S, et al. USP7 targeting modulates anti-tumor immune response by reprogramming tumor-associated macrophages in lung cancer. Theranostics. 2020;10(20):9332–9347. doi:10.7150/thno.47137
   PubMed Web of Science ®Google Scholar
• Zhao W, Ma L, Cai C, Gong X. Caffeine inhibits NLRP3 inflammasome activation by suppressing MAPK/NF-κB and A2aR signaling in LPS-induced THP-1 macrophages. Int J Biol Sci. 2019;15(8):1571–1581. doi:10.7150/ijbs.34211
   PubMed Web of Science ®Google Scholar
• Yin Q, Wu Y-J, Pan S, et al. Activation of cholinergic anti-inflammatory pathway in peripheral immune cells involved in therapeutic actions of α-mangostin on collagen-induced arthritis in rats. Drug Des Devel Ther. 2020;14:1983–1993. doi:10.2147/DDDT.S249865
   PubMed Web of Science ®Google Scholar
• Daïen CI, Sellam J. Obesity and inflammatory arthritis: impact on occurrence, disease characteristics and therapeutic response. RMD Open. 2015;1(1):e000012. doi:10.1136/rmdopen-2014-000012
   PubMed Web of Science ®Google Scholar
• Qiang L, Wang L, Kon N, et al. Brown remodeling of white adipose tissue by SirT1-dependent deacetylation of Pparγ. Cell. 2012;150(3):620–632. doi:10.1016/j.cell.2012.06.027
   PubMed Web of Science ®Google Scholar
• Kauppinen A, Suuronen T, Ojala J, Kaarniranta K, Salminen A. Antagonistic crosstalk between NF-κB and SIRT1 in the regulation of inflammation and metabolic disorders. Cell Signal. 2013;25(10):1939–1948. doi:10.1016/j.cellsig.2013.06.007
   PubMed Web of Science ®Google Scholar
• Bouhlel MA, Derudas B, Rigamonti E, et al. PPARγ activation primes human monocytes into alternative M2 macrophages with anti-inflammatory properties. Cell Metab. 2007;6(2):137–143. doi:10.1016/j.cmet.2007.06.010
   PubMed Web of Science ®Google Scholar
• Wu Y-J, Fang W-J, Pan S, et al. Regulation of Sirt1 on energy metabolism and immune response in rheumatoid arthritis. Int Immunopharmacol. 2021;101(Pt A):108175. doi:10.1016/j.intimp.2021.108175
   PubMedGoogle Scholar
• Olefsky JM, Glass CK. Macrophages, inflammation, and insulin resistance. Annu Rev Physiol. 2010;72(1):219–246. doi:10.1146/annurev-physiol-021909-135846
   PubMed Web of Science ®Google Scholar
• Han L, Zhou R, Niu J, McNutt MA, Wang P, Tong T. SIRT1 is regulated by a PPARγ–SIRT1 negative feedback loop associated with senescence. Nucleic Acids Res. 2010;38(21):7458–7471. doi:10.1093/nar/gkq609
   PubMed Web of Science ®Google Scholar
• Obolskiy D, Pischel I, Siriwatanametanon N, Heinrich M. Garcinia mangostana L.: a phytochemical and pharmacological review. Phytother Res. 2009;23(8):1047–1065. doi:10.1002/ptr.2730
   PubMed Web of Science ®Google Scholar
• Hu Y-H, Han J, Wang L, et al. α-mangostin alleviated inflammation in rats with adjuvant-induced arthritis by disrupting adipocytes-mediated metabolism-immune feedback. Front Pharmacol. 2021;12:692806. doi:10.3389/fphar.2021.692806
   PubMed Web of Science ®Google Scholar
• Scherer HU, Häupl T, Burmester GR. The etiology of rheumatoid arthritis. J Autoimmun. 2020;110:102400. doi:10.1016/j.jaut.2019.102400
   PubMed Web of Science ®Google Scholar
• Davignon J-L, Hayder M, Baron M, et al. Targeting monocytes/macrophages in the treatment of rheumatoid arthritis. Rheumatology. 2013;52(4):590–598. doi:10.1093/rheumatology/kes304
   PubMed Web of Science ®Google Scholar
• McGrath CM, Young SP. Lipid and metabolic changes in rheumatoid arthritis. Curr Rheumatol Rep. 2015;17(9):57. doi:10.1007/s11926-015-0534-z
   PubMed Web of Science ®Google Scholar
• Leone RD, Powell JD. Metabolism of immune cells in cancer. Nat Rev Cancer. 2020;20(9):516–531.
   PubMed Web of Science ®Google Scholar
• Shen P, Deng X, Chen Z, et al. SIRT1: a potential therapeutic target in autoimmune diseases. Front Immunol. 2021;12:779177.
   PubMed Web of Science ®Google Scholar
• Ahmadian M, Suh JM, Hah N, et al. PPARγ signaling and metabolism: the good, the bad and the future. Nat Med. 2013;19(5):557–566.
   PubMed Web of Science ®Google Scholar
• Harmon GS, Lam MT, Glass CK. PPARs and lipid ligands in inflammation and metabolism. Chem Rev. 2011;111(10):6321–6340.
   PubMed Web of Science ®Google Scholar
• Roszkowski L, Ciechomska M. Tuning monocytes and macrophages for personalized therapy and diagnostic challenge in rheumatoid arthritis. Cells. 2021;10(8):1860.
   PubMed Web of Science ®Google Scholar
• Funes SC, Rios M, Escobar-Vera J, Kalergis AM. Implications of macrophage polarization in autoimmunity. Immunology. 2018;154(2):186–195.
   PubMed Web of Science ®Google Scholar
• Ross EA, Devitt A, Johnson JR. Macrophages: the good, the bad, and the gluttony. Front Immunol. 2021;12:708186.
   PubMed Web of Science ®Google Scholar
• Di Benedetto P, Ruscitti P, Vadasz Z, Toubi E, Giacomelli R. Macrophages with regulatory functions, a possible new therapeutic perspective in autoimmune diseases. Autoimmun Rev. 2019;18(10):102369.
   PubMed Web of Science ®Google Scholar
• Loftus RM, Finlay DK. Immunometabolism: cellular metabolism turns immune regulator. J Biol Chem. 2016;291(1):1–10.
   PubMed Web of Science ®Google Scholar
• Mahali SK, Verma N, Manna SK. Advanced glycation end products induce lipogenesis: regulation by natural xanthone through inhibition of ERK and NF-κB. J Cell Physiol. 2014;229(12):1972–1980.
   PubMed Web of Science ®Google Scholar
• Wahli W, Michalik L. PPARs at the crossroads of lipid signaling and inflammation. Trends Endocrinol Metab. 2012;23(7):351–363.
   PubMed Web of Science ®Google Scholar