136
Views
0
CrossRef citations to date
0
Altmetric
ORIGINAL RESEARCH

Identification of cholest-4-ene-3,6-dione as a Novel Neuroprotectant in Ischemic Stroke and Its Lipidomics

, ORCID Icon, , , , , , & show all
Pages 3709-3722 | Received 11 Apr 2023, Accepted 15 Nov 2023, Published online: 10 Dec 2023

References

  • Zhou M, Wang H, Zeng X, et al. Mortality, morbidity, and risk factors in China and its provinces, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet. 2019;394(10204):1145–1158. doi:10.1016/s0140-6736(19)30427-1
  • Su Z, Ye Y, Shen C, et al. Pathophysiology of ischemic stroke: noncoding RNA role in oxidative stress. Oxid Med Cell Longev. 2022;2022:5815843. doi:10.1155/2022/5815843
  • Liu S, Lin F, Wang J, Pan X, Sun L, Wu W. Polyphenols for the treatment of ischemic stroke: new applications and insights. Molecules. 2022;27(13). doi:10.3390/molecules27134181
  • Tang H, Li Y, Tang W, Zhu J, Parker GC, Zhang JH. Endogenous neural stem cell-induced neurogenesis after ischemic stroke: processes for brain repair and perspectives. Transl Stroke Res. 2022. doi:10.1007/s12975-022-01078-5
  • Gu Y, Zhou C, Piao Z, et al. Cerebral edema after ischemic stroke: pathophysiology and underlying mechanisms. Front Neurosci. 2022;16:988283. doi:10.3389/fnins.2022.988283
  • Kopach O, Rusakov DA, Sylantyev S. Multi-target action of β-alanine protects cerebellar tissue from ischemic damage. Cell Death Dis. 2022;13(8):747. doi:10.1038/s41419-022-05159-z
  • Sillapachaiyaporn C, Rangsinth P, Nilkhet S, Ung AT, Chuchawankul S, Tencomnao T. Neuroprotective effects against glutamate-induced HT-22 hippocampal cell damage and caenorhabditis elegans lifespan/healthspan enhancing activity of auricularia polytricha mushroom extracts. Pharmaceuticals. 2021;14(10):1001. doi:10.3390/ph14101001
  • Zhou MH, Yang G, Jiao S, Hu CL, Mei YA. Cholesterol enhances neuron susceptibility to apoptotic stimuli via cAMP/PKA/CREB-dependent up-regulation of Kv2.1. J Neurochem. 2012;120(4):502–514. doi:10.1111/j.1471-4159.2011.07593.x
  • Borozdenko DA, Ezdoglian AA, Shmigol TA, et al. A novel phenylpyrrolidine derivative: synthesis and effect on cognitive functions in rats with experimental ishemic stroke. Molecules. 2021;26(20):6124. doi:10.3390/molecules26206124
  • Hu H, Zhou Y, Leng T, et al. The major cholesterol metabolite cholestane-3β,5α,6β-triol functions as an endogenous neuroprotectant. J Neurosci. 2014;34(34):11426–11438. doi:10.1523/jneurosci.0344-14.2014
  • Qi J, Ojika M, Sakagami Y. Linckosides A and B, two new neuritogenic steroid glycosides from the Okinawan starfish Linckia laevigata. Bioorg Med Chem. 2002;10(6):1961–1966. doi:10.1016/s0968-0896(02)00006-8
  • Wu L, Xiong X, Wu X, et al. Targeting Oxidative Stress and Inflammation to Prevent Ischemia-Reperfusion Injury. Front Mol Neurosci. 2020;13:28. doi:10.3389/fnmol.2020.00028
  • Wang B, Huang X, Pan X, et al. Minocycline prevents the depressive-like behavior through inhibiting the release of HMGB1 from microglia and neurons. Brain Behav Immun. 2020;88:132–143. doi:10.1016/j.bbi.2020.06.019
  • Blumrich EM, Dringen R. Metformin accelerates glycolytic lactate production in cultured primary cerebellar granule neurons. Neurochem Res. 2019;44(1):188–199. doi:10.1007/s11064-017-2346-1
  • Fang Y, Chen X, Tan Q, Zhou H, Xu J, Gu Q. Inhibiting ferroptosis through disrupting the NCOA4-FTH1 interaction: a new mechanism of action. ACS Cent Sci. 2021;7(6):980–989. doi:10.1021/acscentsci.0c01592
  • Bieber M, Gronewold J, Scharf AC, et al. Validity and reliability of neurological scores in mice exposed to middle cerebral artery occlusion. Stroke. 2019;50(10):2875–2882. doi:10.1161/strokeaha.119.026652
  • Matei N, Camara J, McBride D, et al. Intranasal wnt3a attenuates neuronal apoptosis through Frz1/PIWIL1a/FOXM1 pathway in MCAO rats. J Neurosci. 2018;38(30):6787–6801. doi:10.1523/jneurosci.2352-17.2018
  • Zhang B, Zhang HX, Shi ST, et al. Interleukin-11 treatment protected against cerebral ischemia/reperfusion injury. Biomed Pharmacother. 2019;115(17):108816. doi:10.1016/j.biopha.2019.108816
  • Lee DH, Park JS, Lee YS, et al. SQSTM1/p62 activates NFE2L2/NRF2 via ULK1-mediated autophagic KEAP1 degradation and protects mouse liver from lipotoxicity. Autophagy. 2020;16(11):1949–1973. doi:10.1080/15548627.2020.1712108
  • Kushairi N, Phan CW, Sabaratnam V, David P, Naidu M. Lion’s Mane Mushroom, Hericium erinaceus (Bull.: fr.) Pers. Suppresses H(2)O(2)-induced oxidative damage and LPS-induced inflammation in HT22 hippocampal neurons and BV2 microglia. Antioxidants. 2019;8(8):261. doi:10.3390/antiox8080261
  • Sun J, He F, Gao Y, et al. Lipidomics-based study on the neuroprotective effect of geissoschizine methyl ether against oxidative stress-induced cytotoxicity. J Ethnopharmacol. 2020;253(20):112636. doi:10.1016/j.jep.2020.112636
  • Liu YN, Hu Y, Wang J, et al. Development of a UPLC-MS/MS method for the determination of orelabrutinib in rat plasma and its application in pharmacokinetics. Front Pharmacol. 2022;13:991281. doi:10.3389/fphar.2022.991281
  • Sun R, Gu J, Chang X, et al. Metabonomics study on orthotopic transplantion mice model of colon cancer treated with Astragalus membranaceus-Curcuma wenyujin in different proportions via UPLC-Q-TOF/MS. J Pharm Biomed Anal. 2021;193(22):113708. doi:10.1016/j.jpba.2020.113708
  • García-Santos G, Herrera F, Martín V, et al. Antioxidant activity and neuroprotective effects of zolpidem and several synthesis intermediates. Free Radic Res. 2004;38(12):1289–1299. doi:10.1080/10715760400017343
  • Tobaben S, Grohm J, Seiler A, Conrad M, Plesnila N, Culmsee C. Bid-mediated mitochondrial damage is a key mechanism in glutamate-induced oxidative stress and AIF-dependent cell death in immortalized HT-22 hippocampal neurons. Cell Death Differ. 2011;18(2):282–292. doi:10.1038/cdd.2010.92
  • Chompoo J, Upadhyay A, Gima S, Fukuta M, Tawata S. Antiatherogenic properties of acetone extract of Alpinia zerumbet seeds. Molecules. 2012;17(6):6237–6248. doi:10.3390/molecules17066237
  • Lee H, Selvaraj B, Lee JW. Anticancer effects of seaweed-derived bioactive compounds. Appl Sci. 2021;11(23):11261. doi:10.3390/app112311261
  • Sali VK, Mani S, Meenaloshani G, Velmurugan Ilavarasi A, Vasanthi HR. Type 5 17-hydroxysteroid dehydrogenase/prostaglandin F synthase (AKR1C3) inhibition and potential anti-proliferative activity of cholest-4-ene-3,6-dione in MCF-7 breast cancer cells. Steroids. 2020;159(27):108638. doi:10.1016/j.steroids.2020.108638
  • Tayade AB, Dhar P, Kumar J, et al. Chemometric profile of root extracts of Rhodiola imbricata Edgew. with hyphenated gas chromatography mass spectrometric technique. PLoS One. 2013;8(1):e52797. doi:10.1371/journal.pone.0052797
  • Tuo QZ, Zhang ST, Lei P. Mechanisms of neuronal cell death in ischemic stroke and their therapeutic implications. Med Res Rev. 2022;42(1):259–305. doi:10.1002/med.21817
  • Suzuki K, Shimizu T, Nakata T. The cholesterol metabolite cholest-4-en-3-one and its 3-oxo derivatives suppress body weight gain, body fat accumulation and serum lipid concentration in mice. Bioorg Med Chem Lett. 1998;8(16):2133–2138. doi:10.1016/s0960-894x(98)00362-x
  • Zhao B, Fei Y, Zhu J, Yin Q, Fang W, Li Y. PAF receptor inhibition attenuates neuronal pyroptosis in cerebral ischemia/reperfusion injury. Mol Neurobiol. 2021;58(12):6520–6539. doi:10.1007/s12035-021-02537-0