An Exosome-Based Therapeutic Strategy Targeting Neuroinflammation in Alzheimer’s Disease with Berberine and Palmatine

References

• Webers A, Heneka MT, Gleeson PA. The role of innate immune responses and neuroinflammation in amyloid accumulation and progression of Alzheimer’s disease. Immunol Cell Biol. 2020;98(1):28–41. doi:10.1111/imcb.12301
   PubMed Web of Science ®Google Scholar
• Vay SU, Flitsch LJ, Rabenstein M, et al. The plasticity of primary microglia and their multifaceted effects on endogenous neural stem cells in vitro and in vivo. J Neuroinflamm. 2018;15(1):226. doi:10.1186/s12974-018-1261-y
   PubMedGoogle Scholar
• Ismail R, Parbo P, Madsen LS, et al. The relationships between neuroinflammation, beta-amyloid and tau deposition in Alzheimer’s disease: a longitudinal PET study. J Neuroinflamm. 2020;17(1):151. doi:10.1186/s12974-020-01820-6
   PubMed Web of Science ®Google Scholar
• Roddan R, Subrizi F, Broomfield J, et al. Chemoenzymatic cascades toward methylated tetrahydroprotoberberine and protoberberine alkaloids. Org Lett. 2021;23(16):6342–6347. doi:10.1021/acs.orglett.1c02110
   PubMed Web of Science ®Google Scholar
• Tao C, S-q H, Chen J, et al. Highly efficient synthesis and monoamine oxidase B inhibitory profile of demethyleneberberine, columbamine and palmatine. Neurochem Int. 2020;139:104807. doi:10.1016/j.neuint.2020.104807
   PubMed Web of Science ®Google Scholar
• Wang S, Lee DY-W, Shang Y, et al. The bioactive alkaloids identified from cortex phellodendri ameliorate benign prostatic hyperplasia via LOX-5/COX-2 pathways. Phytomedicine. 2021;93:153813. doi:10.1016/j.phymed.2021.153813
   PubMed Web of Science ®Google Scholar
• Akbar M, Shabbir A, Rehman K, et al. Neuroprotective potential of berberine in modulating Alzheimer’s disease via multiple signaling pathways. J Food Biochem. 2021;45(10):e13936. doi:10.1111/jfbc.13936
   PubMed Web of Science ®Google Scholar
• Kiris I, Kukula-Koch W, Karayel-Basar M, et al. Proteomic alterations in the cerebellum and hippocampus in an Alzheimer’s disease mouse model: alleviating effect of palmatine. Biomed Pharmacother. 2023;158:114111. doi:10.1016/j.biopha.2022.114111
   PubMed Web of Science ®Google Scholar
• Mak S, Luk WWK, Cui W, et al. Synergistic inhibition on acetylcholinesterase by the combination of berberine and palmatine originally isolated from Chinese medicinal herbs. J Mol Neurosci. 2014;53(3):511–516. doi:10.1007/s12031-014-0288-5
   PubMed Web of Science ®Google Scholar
• Han L, Jiang C. Evolution of blood-brain barrier in brain diseases and related systemic nanoscale brain-targeting drug delivery strategies. Acta Pharmaceutica Sinica B. 2021;11(8):2306–2325. doi:10.1016/j.apsb.2020.11.023
   PubMed Web of Science ®Google Scholar
• Liao J, Fan L, Li Y, et al. Recent advances in biomimetic nanodelivery systems: new brain-targeting strategies. J Control Release. 2023;358:439–464. doi:10.1016/j.jconrel.2023.05.009
   PubMed Web of Science ®Google Scholar
• Arshaghi TE, Clifford J, Davies S, et al. Mesenchymal stem cell exosome characterisation and high-throughput quantification by fluorescence polarisation spectroscopy. Cytotherapy. 2020;22(5):S48. doi:10.1016/j.jcyt.2020.03.057
   Web of Science ®Google Scholar
• Zhu S, Huang H, Liu D, et al. Augmented cellular uptake and homologous targeting of exosome-based drug loaded IOL for posterior capsular opacification prevention and biosafety improvement. Bioact Mater. 2022;15:469–481. doi:10.1016/j.bioactmat.2022.02.019
   PubMed Web of Science ®Google Scholar
• Tang B, Zeng W, Song LL, et al. Extracellular vesicle delivery of neferine for the attenuation of neurodegenerative disease proteins and motor deficit in an Alzheimer disease mouse model. Pharmaceuticals. 2022;15(1):83. doi:10.3390/ph15010083
   Web of Science ®Google Scholar
• Qi YY, Heng X, Yao ZY, et al. Involvement of Huanglian Jiedu decoction on microglia with abnormal sphingolipid metabolism in Alzheimer’s disease. Drug Des Dev Ther. 2022;16:931–950. doi:10.2147/DDDT.S357061
   PubMed Web of Science ®Google Scholar
• Vorhees CV, Williams MT. Morris water maze: procedures for assessing spatial and related forms of learning and memory. Nat Protoc. 2006;1(2):848–858. doi:10.1038/nprot.2006.116
   PubMed Web of Science ®Google Scholar
• Bevins RA, Besheer J. Object recognition in rats and mice: a one-trial non-matching-to-sample learning task to study ‘recognition memory’. Nat Protoc. 2006;1(3):1306–1311. doi:10.1038/nprot.2006.205
   PubMed Web of Science ®Google Scholar
• Spina S, La Joie R, Petersen C, et al. Comorbid neuropathological diagnoses in early versus late-onset Alzheimer’s disease. Brain. 2021;144(7):2186–2198. doi:10.1093/brain/awab099
   PubMedGoogle Scholar
• Feldman RA. Microglia orchestrate neuroinflammation. eLife. 2022;11:e81890. doi:10.7554/eLife.81890
   PubMed Web of Science ®Google Scholar
• Ottoy J, Bezgin G, Savard M, et al. Microglia activation predicts tau positivity beyond Aβ in Alzheimer’s disease. Alzheimers Dement. 2021;17(S1):e054667. doi:10.1002/alz.053125
   Google Scholar
• Hausner L, Frölich L. Medikamentöse therapie der Alzheimer-Demenz mit antidementiva [Antidementia drug therapy of Alzheimer’s Dementia: status 2018 and outlook]. Dtsch Med Wochenschr. 2019;144(03):156–160. German. doi:10.1055/a-0658-6720
   PubMedGoogle Scholar
• Bachurin SO, Bovina EV, Ustyugov AA. Drugs in clinical trials for Alzheimer’s disease: the major trends. Med Res Rev. 2017;37(5):1186–1225. doi:10.1002/med.21434
   PubMed Web of Science ®Google Scholar
• Hung S-Y, Fu W-M. Drug candidates in clinical trials for Alzheimer’s disease. J Biomed Sci. 2017;24(1):47. doi:10.1186/s12929-017-0355-7
   PubMed Web of Science ®Google Scholar
• Iqbal K. Thinking beyond the aducanumab controversy. Ann Neurol. 2021;90(6):1003–1004. doi:10.1002/ana.26252
   PubMed Web of Science ®Google Scholar
• Haghighijoo Z, Akrami S, Saeedi M, et al. N-Cyclohexylimidazo[1,2-a]pyridine derivatives as multi-target-directed ligands for treatment of Alzheimer’s disease. Bioorg Chem. 2020;103:104146. doi:10.1016/j.bioorg.2020.104146
   PubMed Web of Science ®Google Scholar
• Weinstein JD. A unique and promising combination of medications for the treatment of Alzheimer’s disease. Med Hypotheses. 2017;109:53–55. doi:10.1016/j.mehy.2017.09.021
   PubMed Web of Science ®Google Scholar
• Ahmad A, Tandon S, Xuan TD, et al. A review on phytoconstituents and biological activities of cuscuta species. Biomed Pharmacother. 2017;92:772–795. doi:10.1016/j.biopha.2017.05.124
   PubMed Web of Science ®Google Scholar
• Haque A, Brazeau D, Amin AR. Perspectives on natural compounds in chemoprevention and treatment of cancer: an update with new promising compounds. Eur J Cancer. 2021;149:165–183. doi:10.1016/j.ejca.2021.03.009
   PubMed Web of Science ®Google Scholar
• Liu N, Li Y, Liu L, et al. Administration of silver nasal spray leads to nanoparticle accumulation in rat brain tissues. Environ Sci Technol. 2022;56(1):403–413. doi:10.1021/acs.est.1c02532
   PubMed Web of Science ®Google Scholar
• Katekar R, Thombre G, Riyazuddin M, et al. Pharmacokinetics and brain targeting of trans-resveratrol loaded mixed micelles in rats following intravenous administration. Pharm Dev Technol. 2020;25(3):300–307. doi:10.1080/10837450.2019.1680690
   PubMed Web of Science ®Google Scholar
• Comoglu T, Arisoy S, Akkus BZ. Nanocarriers for effective brain drug delivery. Curr Top Med Chem. 2017;17(13):1490–1506. doi:10.2174/1568026616666161222101355
   PubMed Web of Science ®Google Scholar
• Lin Y, Lu Y, Li X. Biological characteristics of exosomes and genetically engineered exosomes for the targeted delivery of therapeutic agents. J Drug Target. 2020;28(2):129–141. doi:10.1080/1061186X.2019.1641508
   PubMed Web of Science ®Google Scholar
• Pi Y-N, Xia B-R, Jin M-Z, et al. Exosomes: powerful weapon for cancer nano-immunoengineering. Biochem Pharmacol. 2021;186:114487. doi:10.1016/j.bcp.2021.114487
   PubMed Web of Science ®Google Scholar
• Happel C, Peñalber-Johnstone C, Tagle DA. Pivoting novel exosome-based technologies for the detection of SARS-CoV-2. Viruses. 2022;14(5):1083. doi:10.3390/v14051083
   PubMed Web of Science ®Google Scholar
• Salarpour S, Barani M, Pardakhty A, et al. The application of exosomes and exosome-nanoparticle in treating brain disorders. J Mol Liq. 2022;350:118549. doi:10.1016/j.molliq.2022.118549
   Web of Science ®Google Scholar
• Crivelli SM, Giovagnoni C, Visseren L, et al. Sphingolipids in Alzheimer’s disease, how can we target them? Adv Drug Deliv Rev. 2020;159:214–231. doi:10.1016/j.addr.2019.12.003
   PubMed Web of Science ®Google Scholar
• Puig N, Estruch M, Jin L, et al. The role of distinctive sphingolipids in the inflammatory and apoptotic effects of electronegative LDL on monocytes. Biomolecules. 2019;9(8):300. doi:10.3390/biom9080300
   PubMed Web of Science ®Google Scholar
• Torretta E, Arosio B, Barbacini P, et al. Particular CSF sphingolipid patterns identify iNPH and AD patients. Sci Rep. 2018;8(1):13639. doi:10.1038/s41598-018-31756-0
   PubMedGoogle Scholar
• Brodowicz J, Przegaliński E, Müller CP, et al. Ceramide and its related neurochemical networks as targets for some brain disorder therapies. Neurotox Res. 2018;33(2):474–484. doi:10.1007/s12640-017-9798-6
   PubMed Web of Science ®Google Scholar
• Liu Y, Du T, Zhang W, et al. Modified Huang-Lian-Jie-Du decoction ameliorates Aβ synaptotoxicity in a murine model of Alzheimer’s disease. Oxid Med Cell Longev. 2019;2019:8340192. doi:10.1155/2019/8340192
   PubMed Web of Science ®Google Scholar
• Zhu B, Cao H, Sun L, et al. Metabolomics-based mechanisms exploration of Huang-Lian Jie-Du decoction on cerebral ischemia via UPLC-Q-TOF/MS analysis on rat serum. J Ethnopharmacol. 2018;216:147–156. doi:10.1016/j.jep.2018.01.015
   PubMed Web of Science ®Google Scholar
• Chen J, Huang Y, Bian X, et al. Berberine ameliorates inflammation in acute lung injury via NF-κB/Nlrp3 signaling pathway. Oxid Med Cell Longev. 2022;9:851255.
   Google Scholar
• Zhao Z, Qu L, Shuang T, et al. Low-intensity ultrasound radiation increases exosome yield for efficient drug delivery. J Drug Deliv Sci Technol. 2020;57:101713. doi:10.1016/j.jddst.2020.101713
   Web of Science ®Google Scholar
• Gao M, Cai J, Zitkovsky HS, et al. Comparison of yield, purity, and functional properties of large-volume exosome isolation using ultrafiltration and polymer-based precipitation. Plast Reconstr Surg. 2022;149(3):638–649. doi:10.1097/PRS.0000000000008830
   PubMed Web of Science ®Google Scholar
• Li M, Li S, Du C, et al. Exosomes from different cells: characteristics, modifications, and therapeutic applications. Eur J Med Chem. 2020;207:112784. doi:10.1016/j.ejmech.2020.112784
   PubMed Web of Science ®Google Scholar
• Zhu Z, Zhai Y, Hao Y, et al. Specific anti-glioma targeted-delivery strategy of engineered small extracellular vesicles dual-functionalised by Angiopep-2 and TAT peptides. J Extracell Vesicles. 2022;11(8):e12255. doi:10.1002/jev2.12255
   PubMed Web of Science ®Google Scholar