Development of a robust cell-based high-throughput screening assay to identify targets of HIV-1 viral protein R dimerization

References

• Tafforeau L Rabourdin-Combe C Lotteau V Virus-human cell interactomes Methods Mol Biol 2012 812 103 120 22218856
   PubMedGoogle Scholar
• de Chassey B Meyniel-Schicklin L Aublin-Gex A André P Lotteau V New horizons for antiviral drug discovery from virus-host protein interaction networks Curr Opin Virol 2012 2 5 606 613 23025912
   PubMed Web of Science ®Google Scholar
• Kar G Kuzu G Keskin O Gursoy A Protein-protein interfaces integrated into interaction networks: implications on drug design Curr Pharm Des 2012 18 30 4697 4705 22650259
   PubMed Web of Science ®Google Scholar
• Bultinck J Lievens S Tavernier J Protein-protein interactions: network analysis and applications in drug discovery Curr Pharm Des 2012 18 30 4619 4629 22650261
   PubMed Web of Science ®Google Scholar
• Gell DA Grant RP Mackay JP The detection and quantitation of protein oligomerization Adv Exp Med Biol 2012 747 19 41 22949109
   PubMed Web of Science ®Google Scholar
• Kerppola TK Design and implementation of bimolecular fluorescence complementation (BiFC) assays for the visualization of protein interactions in living cells Nat Protoc 2006 1 3 1278 1286 17406412
   PubMed Web of Science ®Google Scholar
• Zal T Visualization of protein interactions in living cells Self Nonself 2011 2 2 98 107 22299061
   PubMedGoogle Scholar
• Ventura S Bimolecular fluorescence complementation: illuminating cellular protein interactions Curr Mol Med 2011 11 7 582 598 21707513
   PubMed Web of Science ®Google Scholar
• Hollender CA Liu Z Bimolecular fluorescence complementation (BiFC) assay for protein-protein interaction in onion cells using the helios gene gun J Vis Exp 2010 40 pii 1963 20567209
   PubMedGoogle Scholar
• MacDonald ML Lamerdin J Owens S Identifying off-target effects and hidden phenotypes of drugs in human cells Nat Chem Biol 2006 2 6 329 337 16680159
   PubMed Web of Science ®Google Scholar
• Yerly S Rickenbach M Popescu M Taffe P Craig C Perrin L for Swiss HIV Cohort Study Drug resistance mutations in HIV-1-infected subjects during protease inhibitor-containing highly active antiretroviral therapy with nelfinavir or indinavir Antivir Ther 2001 6 3 185 189 11808753
   PubMed Web of Science ®Google Scholar
• Hirsch MS Conway B D’Aquila RT Antiretroviral drug resistance testing in adults with HIV infection: implications for clinical management. International AIDS Society – USA Panel JAMA 1998 279 24 1984 1991 9643863
   PubMed Web of Science ®Google Scholar
• Sarmati L Nicastri E Parisi SG Failure of stavudine-lamivudine combination therapy in antiretroviral-naive patients with AZT-like HIV-1 resistance mutations J Med Virol 2001 65 4 631 636 11745924
   PubMed Web of Science ®Google Scholar
• Aleman S Söderbärg K Visco-Comandini U Sitbon G Sönnerborg A Drug resistance at low viraemia in HIV-1-infected patients with antiretroviral combination therapy AIDS 2002 16 7 1039 1044 11953470
   PubMed Web of Science ®Google Scholar
• Hübner W Chen P Del Portillo A Liu Y Gordon RE Chen BK Sequence of human immunodeficiency virus type 1 (HIV-1) Gag localization and oligomerization monitored with live confocal imaging of a replication-competent, fluorescently tagged HIV-1 J Virol 2007 81 22 12596 12607 17728233
   PubMed Web of Science ®Google Scholar
• Ye H Choi HJ Poe J Smithgall TE Oligomerization is required for HIV-1 Nef-induced activation of the Src family protein-tyrosine kinase, Hck Biochemistry 2004 43 50 15775 15784 15595833
   PubMed Web of Science ®Google Scholar
• Liu LX Heveker N Fackler OT Mutation of a conserved residue (D123) required for oligomerization of human immunodeficiency virus type 1 Nef protein abolishes interaction with human thioesterase and results in impairment of Nef biological functions J Virol 2000 74 11 5310 5319 10799608
   PubMed Web of Science ®Google Scholar
• Srivastava S Sluis-Cremer N Tachedjian G Dimerization of human immunodeficiency virus type 1 reverse transcriptase as an antiviral target Curr Pharm Des 2006 12 15 1879 1894 16724954
   PubMed Web of Science ®Google Scholar
• Wapling J Moore KL Sonza S Mak J Tachedjian G Mutations that abrogate human immunodeficiency virus type 1 reverse transcriptase dimerization affect maturation of the reverse transcriptase heterodimer J Virol 2005 79 16 10247 10257 16051818
   PubMed Web of Science ®Google Scholar
• Koh Y Matreyek KA Engelman A Differential sensitivities of retroviruses to integrase strand transfer inhibitors J Virol 2011 85 7 3677 3682 21270168
   PubMed Web of Science ®Google Scholar
• Wang Y Liu Z Brunzelle JS The higher barrier of darunavir and tipranavir resistance for HIV-1 protease Biochem Biophys Res Commun 2011 412 4 737 742 21871444
   PubMed Web of Science ®Google Scholar
• Kogan M Rappaport J HIV-1 accessory protein Vpr: relevance in the pathogenesis of HIV and potential for therapeutic intervention Retrovirology 2011 8 25 21489275
   PubMed Web of Science ®Google Scholar
• Majumder B Venkatachari NJ Srinivasan A Ayyavoo V HIV-1 mediated immune pathogenesis: spotlight on the role of viral protein R (Vpr) Curr HIV Res 2009 7 2 169 177 19275586
   PubMed Web of Science ®Google Scholar
• Ong EB Watanabe N Saito A Vipirinin, a coumarin-based HIV-1 Vpr inhibitor, interacts with a hydrophobic region of VPR J Biol Chem 2011 286 16 14049 14056 21357691
   PubMed Web of Science ®Google Scholar
• Hagiwara K Murakami T Xue G Identification of a novel Vpr-binding compound that inhibits HIV-1 multiplication in macrophages by chemical array Biochem Biophys Res Commun 2010 403 1 40 45 21036153
   PubMed Web of Science ®Google Scholar
• Suzuki T Yamamoto N Nonaka M Inhibition of human immunodeficiency virus type 1 (HIV-1) nuclear import via Vpr-Importin alpha interactions as a novel HIV-1 therapy Biochem Biophys Res Commun 2009 380 4 838 843 19338763
   PubMed Web of Science ®Google Scholar
• Schafer EA Venkatachari NJ Ayyavoo V Antiviral effects of mifepristone on human immunodeficiency virus type-1 (HIV-1): targeting Vpr and its cellular partner, the glucocorticoid receptor (GR) Antiviral Res 2006 72 3 224 232 16889838
   PubMed Web of Science ®Google Scholar
• Kamata M Wu RP An DS Cell-based chemical genetic screen identifies damnacanthal as an inhibitor of HIV-1 Vpr induced cell death Biochem Biophys Res Commun 2006 348 3 1101 1106 16904642
   PubMed Web of Science ®Google Scholar
• Morellet N Bouaziz S Petitjean P Roques BP NMR structure of the HIV-1 regulatory protein VPR J Mol Biol 2003 327 1 215 227 12614620
   PubMed Web of Science ®Google Scholar
• Wecker K Morellet N Bouaziz S Roques BP NMR structure of the HIV-1 regulatory protein Vpr in H2O/trifluoroethanol. Comparison with the Vpr N-terminal (1–51) and C-terminal (52–96) domains Eur J Biochem 2002 269 15 3779 3788 12153575
   PubMedGoogle Scholar
• Zhao LJ Wang L Mukherjee S Narayan O Biochemical mechanism of HIV-1 Vpr function. Oligomerization mediated by the N-terminal domain J Biol Chem 1994 269 51 32131 32137 7798208
   PubMed Web of Science ®Google Scholar
• Singh SP Tomkowicz B Lai D Functional role of residues corresponding to helical domain II (amino acids 35 to 46) of human immunodeficiency virus type 1 Vpr J Virol 2000 74 22 10650 10657 11044109
   PubMed Web of Science ®Google Scholar
• Poon B Chang MA Chen IS Vpr is required for efficient Nef expression from unintegrated human immunodeficiency virus type 1 DNA J Virol 2007 81 19 10515 10523 17652391
   PubMed Web of Science ®Google Scholar
• Majumder B Janket ML Schafer EA Human immunodeficiency virus type 1 Vpr impairs dendritic cell maturation and T-cell activation: implications for viral immune escape J Virol 2005 79 13 7990 8003 15956545
   PubMed Web of Science ®Google Scholar
• Arokium H Kamata M Chen I Virion-associated Vpr of human immunodeficiency virus type 1 triggers activation of apoptotic events and enhances fas-induced apoptosis in human T cells J Virol 2009 83 21 11283 11297 19692467
   PubMed Web of Science ®Google Scholar
• Fritz JV Didier P Clamme JP Direct Vpr-Vpr interaction in cells monitored by two photon fluorescence correlation spectroscopy and fluorescence lifetime imaging Retrovirology 2008 5 87 18808682
   PubMed Web of Science ®Google Scholar
• Jenkins Y Pornillos O Rich RL Myszka DG Sundquist WI Malim MH Biochemical analyses of the interactions between human immunodeficiency virus type 1 Vpr and p6(Gag) J Virol 2001 75 21 10537 10542 11581428
   PubMed Web of Science ®Google Scholar
• Pandey RC Datta D Mukerjee R Srinivasan A Mahalingam S Sawaya BE HIV-1 Vpr: a closer look at the multifunctional protein from the structural perspective Curr HIV Res 2009 7 2 114 128 19275580
   PubMed Web of Science ®Google Scholar
• Venkatachari NJ Walker LA Tastan O Human immunodeficiency virus type 1 Vpr: oligomerization is an essential feature for its incorporation into virus particles Virol J 2010 7 119 20529298
   PubMed Web of Science ®Google Scholar
• Thotala D Schafer EA Tungaturthi PK Structure-functional analysis of human immunodeficiency virus type 1 (HIV-1) Vpr: role of leucine residues on Vpr-mediated transactivation and virus replication Virology 2004 328 1 89 100 15380361
   PubMed Web of Science ®Google Scholar
• Zhang JH Chung TD Oldenburg KR A simple statistical parameter for use in evaluation and validation of high throughput screening assays J Biomol Screen 1999 4 2 67 73 10838414
   PubMed Web of Science ®Google Scholar
• Shun TY Lazo JS Sharlow ER Johnston PA Identifying actives from HTS data sets: practical approaches for the selection of an appropriate HTS data-processing method and quality control review J Biomol Screen 2011 16 1 1 14 21160066
   PubMedGoogle Scholar
• Kerppola TK Bimolecular fluorescence complementation (BiFC) analysis as a probe of protein interactions in living cells Annu Rev Biophys 2008 37 465 487 18573091
   PubMed Web of Science ®Google Scholar
• Roumier T Vieira HL Castedo M The C-terminal moiety of HIV-1 Vpr induces cell death via a caspase-independent mitochondrial pathway Cell Death Differ 2002 9 11 1212 1219 12404120
   PubMed Web of Science ®Google Scholar
• Arunagiri C Macreadie I Hewish D Azad A A C-terminal domain of HIV-1 accessory protein Vpr is involved in penetration, mitochondrial dysfunction and apoptosis of human CD4+ lymphocytes Apoptosis 1997 2 1 69 76 14646566
   PubMed Web of Science ®Google Scholar
• Christ F Voet A Marchand A Rational design of small-molecule inhibitors of the LEDGF/p75-integrase interaction and HIV replication Nat Chem Biol 2010 6 6 442 448 20473303
   PubMed Web of Science ®Google Scholar
• Cen S Peng ZG Li XY Small molecular compounds inhibit HIV-1 replication through specifically stabilizing APOBEC3G J Biol Chem 2010 285 22 16546 16552 20363737
   PubMed Web of Science ®Google Scholar
• Kodama Y Hu CD Bimolecular fluorescence complementation (BiFC): a 5-year update and future perspectives Biotechniques 2012 53 5 285 298 23148879
   PubMed Web of Science ®Google Scholar
• Bannwarth L Rose T Dufau L Dimer disruption and monomer sequestration by alkyl tripeptides are successful strategies for inhibiting wild-type and multidrug-resistant mutated HIV-1 proteases Biochemistry 2009 48 2 379 387 19105629
   PubMed Web of Science ®Google Scholar
• Camarasa MJ Velázquez S San-Félix A Pérez-Pérez MJ Gago F Dimerization inhibitors of HIV-1 reverse transcriptase, protease and integrase: a single mode of inhibition for the three HIV enzymes? Antiviral Res 2006 71 2–3 260 267 16872687
   PubMed Web of Science ®Google Scholar
• DiMattia MA Watts NR Stahl SJ Implications of the HIV-1 Rev dimer structure at 3.2 A resolution for multimeric binding to the Rev response element Proc Natl Acad Sci U S A 2010 107 13 5810 5814 20231488
   PubMed Web of Science ®Google Scholar
• Doménech R Abian O Bocanegra R Dendrimers as potential inhibitors of the dimerization of the capsid protein of HIV-1 Biomacromolecules 2010 11 8 2069 2078 20690715
   PubMed Web of Science ®Google Scholar
• Frankel AD Chen L Cotter RJ Pabo CO Dimerization of the tat protein from human immunodeficiency virus: a cysteine-rich peptide mimics the normal metal-linked dimer interface Proc Natl Acad Sci U S A 1988 85 17 6297 6300 2842763
   PubMed Web of Science ®Google Scholar
• Hayouka Z Rosenbluh J Levin A Inhibiting HIV-1 integrase by shifting its oligomerization equilibrium Proc Natl Acad Sci U S A 2007 104 20 8316 8321 17488811
   PubMed Web of Science ®Google Scholar
• Miller JH Presnyak V Smith HC The dimerization domain of HIV-1 viral infectivity factor Vif is required to block virion incorporation of APOBEC3G Retrovirology 2007 4 81 18036235
   PubMed Web of Science ®Google Scholar
• Mason JM Müller KM Arndt KM Positive aspects of negative design: simultaneous selection of specificity and interaction stability Biochemistry 2007 46 16 4804 4814 17402748
   PubMed Web of Science ®Google Scholar