Dexmedetomidine’s Effects on the Livers and Kidneys of Rats with Pancreatic Ischemia-Reperfusion Injury

References

• Maglione M, Ploeg RJ, Friend PJ. Donor risk factors, retrieval technique, preservation and ischemia/reperfusion injury in pancreas transplantation. Current Opin Organ Transpl. 2013;18:83–88. doi:10.1097/MOT.0b013e32835c29ef
   PubMed Web of Science ®Google Scholar
• Prudhomme T, Mulvey JF, Young LAJ, et al. Ischemia-reperfusion injuries assessment during pancreas preservation. Int J Mol Sci. 2021;22. doi:10.3390/ijms22105172
   PubMed Web of Science ®Google Scholar
• Abelha FJ, Botelho M, Fernandes V, Barros H. Determinants of postoperative acute kidney injury. Critical Care. 2009;13:1–10. doi:10.1186/cc7894
   Web of Science ®Google Scholar
• Causey MW, Maykel JA, Hatch Q, Miller S, Steele SR. Identifying risk factors for renal failure and myocardial infarction following colorectal surgery. J Surg Res. 2011;170:32–37. doi:10.1016/j.jss.2011.03.027
   PubMed Web of Science ®Google Scholar
• Kheterpal S, Tremper KK, Englesbe MJ, et al. Predictors of postoperative acute renal failure after noncardiac surgery in patients with previously normal renal function. J Am Soc Anesthesiologists. 2007;107:892–902.
   PubMed Web of Science ®Google Scholar
• Neeff H, Mariaskin D, Spangenberg H-C, Hopt UT, Makowiec F. Perioperative mortality after non-hepatic general surgery in patients with liver cirrhosis: an analysis of 138 operations in the 2000s Using Child and MELD scores. J Gastrointestinal Surg. 2011;15:1–11. doi:10.1007/s11605-010-1366-9
   PubMed Web of Science ®Google Scholar
• Grochowiecki T, Gałązka Z, Madej K, et al. Surgical complications related to transplanted pancreas after simultaneous pancreas and kidney transplantation. In: Transplantation Proceedings Elsevier; 2014:2818–2821.
   Google Scholar
• Rydenfelt K, Kjøsen G, Horneland R, et al. Local postoperative graft inflammation in pancreas transplant patients with early graft thrombosis. Transplant Direct. 2024;10:e1567. doi:10.1097/TXD.0000000000001567
   PubMed Web of Science ®Google Scholar
• Herrero-Martínez J, Lumbreras C, Manrique A, et al. Epidemiology, risk factors and impact on long-term pancreatic function of infection following pancreas-kidney transplantation. Clin Microbiol Infect. 2013;19:1132–1139. doi:10.1111/1469-0691.12165
   PubMed Web of Science ®Google Scholar
• Lee S. Dexmedetomidine: present and future directions. Kja. 2019;72:323–330.
   Google Scholar
• Carollo DS, Nossaman BD, Ramadhyani U. Dexmedetomidine: a review of clinical applications. Curr Opin Anesthesiol. 2008;21:457–461. doi:10.1097/ACO.0b013e328305e3ef
   PubMed Web of Science ®Google Scholar
• Cheng M, Gao T, Xi F, et al. Dexmedetomidine ameliorates muscle wasting and attenuates the alteration of hypothalamic neuropeptides and inflammation in endotoxemic rats. PLoS One. 2017;12:e0174894. doi:10.1371/journal.pone.0174894
   PubMed Web of Science ®Google Scholar
• Liang H, Liu H-Z, Wang H-B, Zhong J-Y, Yang C-X, Zhang B. Dexmedetomidine protects against cisplatin-induced acute kidney injury in mice through regulating apoptosis and inflammation. Inflammation Res. 2017;66:399–411. doi:10.1007/s00011-017-1023-9
   PubMed Web of Science ®Google Scholar
• Liu Z, Wang Y, Wang Y, et al. Dexmedetomidine attenuates inflammatory reaction in the lung tissues of septic mice by activating cholinergic anti-inflammatory pathway. Int Immunopharmacol. 2016;35:210–216. doi:10.1016/j.intimp.2016.04.003
   PubMed Web of Science ®Google Scholar
• C-l T, Li J, Zhao B, Shi S, Shen H, Z-y X. Effects of dexmedetomidine combined with sodium creatine phosphate on inflammation, oxidative stress, and neurological function recovery in patients undergoing intracranial hematoma evacuation: study protocol for a multi-center, prospective randomized parallel-cohort controlled trial. Asia Pacif J Clin Trials. 2017;2:1.
   Google Scholar
• Dong A, Zhang Y, Lu S, Yu W. Influence of dexmedetomidine on myocardial injury in patients with simultaneous pancreas-kidney transplantation. Evid Based Complement Alternat Med. 2022;2022:1–8. doi:10.1155/2022/7196449
   Web of Science ®Google Scholar
• Zhang X-Y, Liu Z-M, Wen S-H, et al. Dexmedetomidine administration before, but not after, ischemia attenuates intestinal injury induced by intestinal ischemia-reperfusion in rats. J Am Soc Anesthesiologists. 2012;116:1035–1046.
   PubMed Web of Science ®Google Scholar
• Huang D-Y, Li Q, Shi C-Y, Hou C-Q, Miao Y, Shen H-B. Dexmedetomidine attenuates inflammation and pancreatic injury in a rat model of experimental severe acute pancreatitis via cholinergic anti-inflammatory pathway. Chinese Med J. 2020;133:1073–1079. doi:10.1097/CM9.0000000000000766
   PubMed Web of Science ®Google Scholar
• Li Y, Pan Y, Gao L, et al. Dexmedetomidine attenuates pancreatic injury and inflammatory response in mice with pancreatitis by possible reduction of NLRP3 activation and up-regulation of NET expression. Biochem Biophys Res Commun. 2018;495:2439–2447. doi:10.1016/j.bbrc.2017.12.090
   PubMed Web of Science ®Google Scholar
• Şengel N, Köksal Z, Dursun AD, et al. Effects of dexmedetomidine administered through different routes on kidney tissue in rats with spinal cord ischaemia–reperfusion injury. Drug Des Devel Ther;2022. 2229–2239. doi:10.2147/DDDT.S361618
   PubMed Web of Science ®Google Scholar
• Dembinski A, Warzecha Z, Ceranowicz P, et al. Pancreatic damage and regeneration in the course of ischemia-reperfusion induced pancreatitis in rats. J Physiol Pharmacol. 2001;52:1.
   PubMed Web of Science ®Google Scholar
• Von Dobschuetz E, Schmidt R, Scholtes M, et al. Protective role of heme oxygenase-1 in pancreatic microcirculatory dysfunction after ischemia/reperfusion in rats. Pancreas. 2008;36:377–384. doi:10.1097/MPA.0b013e31815ceb0e
   PubMed Web of Science ®Google Scholar
• Van Ye TM, Roza AM, Pieper GM, Henderson J, Johnson CP, Adams MB. Inhibition of intestinal lipid peroxidation does not minimize morphologic damage. J Surg Res. 1993;55:553–558. doi:10.1006/jsre.1993.1183
   PubMed Web of Science ®Google Scholar
• Aebi H. Catalase. Method Enzym Anal Elsev. 1974;1974:673–684.
   Google Scholar
• Habig WH, Pabst MJ, Jakoby WB. Glutathione S-transferases: the first enzymatic step in mercapturic acid formation. J Biol Chem. 1974;249:7130–7139. doi:10.1016/S0021-9258(19)42083-8
   PubMed Web of Science ®Google Scholar
• Lowry O, Rosebrough N, Farr AL, Randall R. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951;193:265–275. doi:10.1016/S0021-9258(19)52451-6
   PubMed Web of Science ®Google Scholar
• Abdel‐Wahhab M, Nada S, Arbid M. Ochratoxicosis: prevention of developmental toxicity by L‐methionine in rats. J Appl Toxicol. 1999;19:7–12. doi:10.1002/(SICI)1099-1263(199901/02)19:1<7::AID-JAT529>3.0.CO;2-G
   PubMed Web of Science ®Google Scholar
• Gobut H, Erel S, Ozdemir C, et al. Effects of cerium oxide on liver tissue in liver ischemia‑reperfusion injury in rats undergoing sevoflurane anesthesia. Exp Ther Med. 2023;25:1–8. doi:10.3892/etm.2023.11863
   PubMed Web of Science ®Google Scholar
• Bostan H, Kalkan Y, Tomak Y, et al. Reversal of rocuronium-induced neuromuscular block with sugammadex and resulting histopathological effects in rat kidneys. Renal Failure. 2011;33:1019–1024. doi:10.3109/0886022X.2011.618972
   PubMed Web of Science ®Google Scholar
• Basile D P, Yoder M C. Renal endothelial dysfunction in acute kidney ischemia reperfusion injury. Cardiov Haematol Disord Drug Targ. 2014;14:3–14. doi:10.2174/1871529X1401140724093505
   PubMedGoogle Scholar
• Ho CK, Kleeff J, Friess H, Büchler MW. Complications of pancreatic surgery. HPB. 2005;7:99–108. doi:10.1080/13651820510028936
   PubMedGoogle Scholar
• Benz S, Pfeffer F, Adam U, Schareck W, Hopt U. Impairment of pancreatic microcirculation in the early reperfusion period during simultaneous pancreas-kidney transplantation. Transplant Int. 1998;11:S433–S435. doi:10.1111/j.1432-2277.1998.tb01175.x
   PubMedGoogle Scholar
• Muñoz‐Casares FC, Padillo FJ, Briceño J, et al. Melatonin reduces apoptosis and necrosis induced by ischemia/reperfusion injury of the pancreas. J Pineal Res. 2006;40:195–203. doi:10.1111/j.1600-079X.2005.00291.x
   PubMed Web of Science ®Google Scholar
• Baertschiger RM, Berney T, Morel P. Organ preservation in pancreas and islet transplantation. Current Opin Organ Transplant. 2008;13:59–66. doi:10.1097/MOT.0b013e3282f44a63
   PubMed Web of Science ®Google Scholar
• Arcangeli A, D’alo C, Gaspari R. Dexmedetomidine use in general anaesthesia. Curr Drug Targ. 2009;10:687–695. doi:10.2174/138945009788982423
   PubMed Web of Science ®Google Scholar
• Chen R, Dou X-K, Dai M-S, Sun Y, Sun S-J, Wu Y. The role of dexmedetomidine in immune tissue and inflammatory diseases: a narrative review. Eur Rev Med Pharmacol Sci. 2022;26:1.
   Web of Science ®Google Scholar
• Arslan M. Effect of dexmedetomidine on ischemia-reperfusion injury of liver and kidney tissues in experimental diabetes and hepatic ischemia-reperfusion injury induced rats. Anaesth Pain Intensive Care. 2019;2019:1.
   Google Scholar
• Wang Y, Wu S, Yu X, et al. Dexmedetomidine protects rat liver against ischemia-reperfusion injury partly by the α2A-adrenoceptor subtype and the mechanism is associated with the TLR4/NF-κB pathway. Int J Mol Sci. 2016;17:995. doi:10.3390/ijms17070995
   PubMed Web of Science ®Google Scholar
• Bao N, Tang B. Organ-protective effects and the underlying mechanism of dexmedetomidine. Mediators Inflammation. 2020;2020. doi:10.1155/2020/6136105
   Web of Science ®Google Scholar
• Smith GS, Walter GL, Walker RM. Clinical pathology in non-clinical toxicology testing. Haschek and Rousseaux’s Handbook of Toxicologic Pathology Elsevier. 2013;2013:565–594.
   Google Scholar
• Vasseur P, Devaure I, Sellier J, et al. High plasma levels of the pro-inflammatory cytokine IL-22 and the anti-inflammatory cytokines IL-10 and IL-1ra in acute pancreatitis. Pancreatology. 2014;14:465–469. doi:10.1016/j.pan.2014.08.005
   PubMed Web of Science ®Google Scholar
• Maduzia D, Ceranowicz P, Cieszkowski J, et al. Administration of warfarin accelerates the recovery in ischemia/reperfusion-induced acute pancreatitis. J Physiol Pharmacol. 2020;71:417–427.
   Web of Science ®Google Scholar
• Frossard J-L, Pastor CM. Experimental acute pancreatitis: new insights into the pathophysiology. Front Biosci. 2002;7:257.
   Web of Science ®Google Scholar
• Huang Y-Q, Wen R-T, X-T L, Zhang J, Yu Z-Y, Feng Y-F. The protective effect of dexmedetomidine against ischemia-reperfusion injury after hepatectomy: a meta-analysis of randomized controlled trials. Front Pharmacol. 2021;12:747911. doi:10.3389/fphar.2021.747911
   PubMed Web of Science ®Google Scholar
• Fayed NA, Sayed EI, Saleh SM, Ehsan NA, Elfert AY. Effect of dexmedetomidine on hepatic ischemia–reperfusion injury in the setting of adult living donor liver transplantation. Clin Transplant. 2016;30:470–482. doi:10.1111/ctr.12713
   PubMed Web of Science ®Google Scholar
• Cakir M, Polat A, Tekin S, et al. The effect of dexmedetomidine against oxidative and tubular damage induced by renal ischemia reperfusion in rats. Renal Failure. 2015;37:704–708. doi:10.3109/0886022X.2015.1011550
   PubMed Web of Science ®Google Scholar
• Şahin T, Begeç Z, Toprak Hİ, et al. The effects of dexmedetomidine on liver ischemia–reperfusion injury in rats. J Surg Res. 2013;183:385–390. doi:10.1016/j.jss.2012.11.034
   PubMed Web of Science ®Google Scholar
• Scheinin M, Kallio A, Koulu M, Viikari J, Scheinin H. Sedative and cardiovascular effects of medetomidine, a novel selective alpha 2‐adrenoceptor agonist, in healthy volunteers. Br J Clin Pharmacol. 1987;24:443–451. doi:10.1111/j.1365-2125.1987.tb03196.x
   PubMed Web of Science ®Google Scholar
• Jaionen J, Hynynen M, Kuitunen A, et al. Dexmedetomidine as an anesthetic adjunct in coronary artery bypass grafting. J Am Soc Anesthesiologists. 1997;86:331–345.
   PubMed Web of Science ®Google Scholar
• van Duijl TT, Ruhaak LR, de Fijter JW, Cobbaert CM. Kidney injury biomarkers in an academic hospital setting: where are we now? Clin Biochem Rev. 2019;40:79–97.
   PubMedGoogle Scholar