Unexpected effects of peripherally administered kynurenic acid on cortical spreading depression and related blood–brain barrier permeability

References

• Gardner-Medwin AR Possible roles of vertebrate neuroglia in potassium dynamics, spreading depression and migraine J Exp Biol 1981 95 111 127 7334315
   PubMed Web of Science ®Google Scholar
• Kraig RP Nicholson C Extracellular ionic variations during spreading depression Neuroscience 1978 3 11 1045 1059 745780
   PubMed Web of Science ®Google Scholar
• Somjen GG Mechanisms of spreading depression and hypoxic spreading depression-like depolarization Physiol Rev 2001 81 3 1065 1096 11427692
   PubMed Web of Science ®Google Scholar
• Fabricius M Jensen LH Lauritzen M Microdialysis of interstitial amino acids during spreading depression and anoxic depolarization in rat neocortex Brain Res 1993 612 1–2 61 69 8330214
   PubMed Web of Science ®Google Scholar
• Jander S Schroeter M Peters O Witte OW Stoll G Cortical spreading depression induces proinflammatory cytokine gene expression in the rat brain J Cereb Blood Flow Metab 2001 21 3 218 225 11295876
   PubMed Web of Science ®Google Scholar
• András IE Deli MA Veszelka S Hayashi K Hennig B Toborek M The NMDA and AMPA/KA receptors are involved in glutamate-induced alterations of occludin expression and phosphorylation in brain endothelial cells J Cereb Blood Flow Metab 2007 27 8 1431 1443 17245419
   PubMed Web of Science ®Google Scholar
• Gursoy-Ozdemir Y Qiu J Matsuoka N Cortical spreading depression activates and upregulates MMP-9 J Clin Invest 2004 113 10 1447 1455 15146242
   PubMed Web of Science ®Google Scholar
• Brennan KC Beltrán-Parrazal L López-Valdés HE Theriot J Toga AW Charles AC Distinct vascular conduction with cortical spreading depression J Neurophysiol 2007 97 6 4143 4151 17329631
   PubMed Web of Science ®Google Scholar
• Dohmen C Sakowitz OW Fabricius M Spreading depolarizations occur in human ischemic stroke with high incidence Ann Neurol 2008 63 6 720 728 18496842
   PubMed Web of Science ®Google Scholar
• Santos E Sánchez-Porras R Dohmen C Hertle D Unterberg AW Sakowitz OW Spreading depolarizations in a case of migraine-related stroke Cephalalgia 2012 32 5 433 436 22407661
   PubMed Web of Science ®Google Scholar
• Zhang X Levy D Noseda R Kainz V Jakubowski M Burstein R Activation of meningeal nociceptors by cortical spreading depression: implications for migraine with aura J Neurosci 2010 30 26 8807 8814 20592202
   PubMed Web of Science ®Google Scholar
• Knyihár-Csillik E Toldi J Krisztin-Péva B Prevention of electrical stimulation-induced increase of c-fos immunoreaction in the caudal trigeminal nucleus by kynurenine combined with probenecid Neurosci Lett 2007 418 2 122 126 17382471
   PubMed Web of Science ®Google Scholar
• Knyihár-Csillik E Toldi J Mihály A Kynurenine in combination with probenecid mitigates the stimulation-induced increase of c-fos immunoreactivity of the rat caudal trigeminal nucleus in an experimental migraine model J Neural Transm 2007 114 4 417 421 16897600
   PubMed Web of Science ®Google Scholar
• Vámos E Párdutz A Varga H l-kynurenine combined with probenecid and the novel synthetic kynurenic acid derivative attenuate nitroglycerin-induced nNOS in the rat caudal trigeminal nucleus Neuropharmacology 2009 57 4 425 429 19580819
   PubMed Web of Science ®Google Scholar
• Chauvel V Vamos E Párdutz A Vecsei L Schoenen J Multon S Effect of systemic kynurenine on cortical spreading depression and its modulation by sex hormones in rat Exp Neurol 2012 236 2 207 214 22587906
   PubMed Web of Science ®Google Scholar
• Fukui S Schwarcz R Rapoport SI Takada Y Smith QR Blood-brain barrier transport of kynurenines: implications for brain synthesis and metabolism J Neurochem 1991 56 6 2007 2017 1827495
   PubMed Web of Science ®Google Scholar
• Heyes MP Quearry BJ Quantification of kynurenic acid in cerebrospinal fluid: effects of systemic and central L-kynurenine administration J Chromatogr 1990 530 1 108 115 2177481
   PubMed Web of Science ®Google Scholar
• Scharfman HE Goodman JH Effects of central and peripheral administration of kynurenic acid on hippocampal evoked responses in vivo and in vitro Neuroscience 1998 86 3 751 764 9692715
   PubMed Web of Science ®Google Scholar
• Koroleva VI Vinogradova LV [Ischemic and hypoxic depolarization in the rat neocortex.] Zh Vyssh Nerv Deiat Im I P Pavlova 2000 50 4 612 623 Russian [with English abstract] 10984906
   PubMed Web of Science ®Google Scholar
• Lauritzen M Hansen AJ The effect of glutamate receptor blockade on anoxic depolarization and cortical spreading depression J Cereb Blood Flow Metab 1992 12 2 223 229 1312539
   PubMed Web of Science ®Google Scholar
• Fejes A Párdutz A Toldi J Vécsei L Kynurenine metabolites and migraine: experimental studies and therapeutic perspectives Curr Neuropharmacol 2011 9 2 376 387 22131946
   PubMed Web of Science ®Google Scholar
• Roussel S Pinard E Seylaz J Kynurenate does not reduce infarct size after middle cerebral artery occlusion in spontaneously hypertensive rats Brain Res 1990 518 1–2 353 355 2390725
   PubMed Web of Science ®Google Scholar
• Schwarcz R Pellicciari R Manipulation of brain kynurenines: glial targets, neuronal effects, and clinical opportunities J Pharmacol Exp Ther 2002 303 1 1 10 12235226
   PubMed Web of Science ®Google Scholar
• Turski WA Schwarcz R On the disposition of intrahippocampally injected kynurenic acid in the rat Exp Brain Research 1988 71 3 563 567
   PubMed Web of Science ®Google Scholar
• Longoni M Ferrarese C Inflammation and excitotoxicity: role in migraine pathogenesis Neurol Sci 2006 27 Suppl 2 S107 S110 16688611
   PubMed Web of Science ®Google Scholar
• Ramadan NM The link between glutamate and migraine CNS Spectr 2003 8 6 446 449 12858134
   PubMed Web of Science ®Google Scholar
• Andreou AP Goadsby PJ Therapeutic potential of novel glutamate receptor antagonists in migraine Expert Opin Investig Drugs 2009 18 6 789 803
   PubMed Web of Science ®Google Scholar
• Gniel HM Martin RL Changes in membrane potential and the intracellular calcium concentration during CSD and OGD in layer V and layer II/III mouse cortical neurons J Neurophysiol 2010 104 6 3203 3212 20810684
   PubMed Web of Science ®Google Scholar
• Chen Y McCarron RM Azzam N Endothelin-1 and nitric oxide affect human cerebromicrovascular endothelial responses and signal transduction Acta Neurochir Suppl 2000 76 131 135 11449992
   PubMedGoogle Scholar
• Thiel VE Audus KL Nitric oxide and blood-brain barrier integrity Antioxid Redox Signal 2001 3 2 273 278 11396481
   PubMed Web of Science ®Google Scholar
• Hilmas C Pereira EF Alkondon M Rassoulpour A Schwarcz R Albuquerque EX The brain metabolite kynurenic acid inhibits alpha7 nicotinic receptor activity and increases non-alpha7 nicotinic receptor expression: physiopathological implications J Neurosci 2001 21 19 7463 7473 11567036
   PubMed Web of Science ®Google Scholar
• Stone TW Forrest CM Mackay GM Stoy N Darlington LG Tryptophan, adenosine, neurodegeneration and neuroprotection Metab Brain Dis 2007 22 3–4 337 352 17712616
   PubMed Web of Science ®Google Scholar
• Konradsson-Geuken A Wu HQ Gash CR Cortical kynurenic acid bi-directionally modulates prefrontal glutamate levels as assessed by microdialysis and rapid electrochemistry Neuroscience 15 169 4 1848 1859
   Web of Science ®Google Scholar
• Tajti J Szok D Párdutz A Where does a migraine attack originate? In the brainstem J Neural Transm 2012 119 5 557 568 22426834
   PubMed Web of Science ®Google Scholar