93
Views
0
CrossRef citations to date
0
Altmetric
ORIGINAL RESEARCH

Integrated Approaches Revealed the Therapeutic Mechanisms of Zuojin Pill Against Gastric Mucosa Injury in a Rat Model with Chronic Atrophic Gastritis

ORCID Icon, , , , , , , , , & show all
Pages 1651-1672 | Received 13 Dec 2023, Accepted 03 May 2024, Published online: 17 May 2024

References

  • Jayavelu ND, Bar NS. Metabolomic studies of human gastric cancer: review [J]. World J Gastroenterol. 2014;20(25):8092–8101. doi:10.3748/wjg.v20.i25.8092
  • Vannella L, Lahner E, Annibale B. Risk for gastric neoplasias in patients with chronic atrophic gastritis: a critical reappraisal [J]. World J Gastroenterol. 2012;18(12):1279–1285. doi:10.3748/wjg.v18.i12.1279
  • Bray F, Ferlay J, Soerjomataram I, et al. Global cancer statistics 2018: globocan estimates of incidence and mortality worldwide for 36 cancers in 185 countries [J]. CA Cancer J Clin. 2018;68(6):394–424. doi:10.3322/caac.21492
  • Zhenyukh O, Civantos E, Ruiz-Ortega M, et al. High concentration of branched-chain amino acids promotes oxidative stress, inflammation and migration of human peripheral blood mononuclear cells via mtorc1 activation [J]. Free Radic Biol Med. 2017;104:165–177. doi:10.1016/j.freeradbiomed.2017.01.009
  • Han L, Li T, Wang Y, et al. Weierning, a Chinese patent medicine, improves chronic atrophic gastritis with intestinal metaplasia [J]. J Ethnopharmacol. 2023;309:116345. doi:10.1016/j.jep.2023.116345
  • Li Z, Wu C, Li L, et al. Effect of long-term proton pump inhibitor administration on gastric mucosal atrophy: a meta-analysis [J]. Saudi J Gastroenterol. 2017;23(4):222–228. doi:10.4103/sjg.SJG_573_16
  • Donzelli A. Helicobacter pylori eradication? Gastroenterology. 2016;151(4):773–774. doi:10.1053/j.gastro.2016.05.059
  • Nazari M, Taghizadeh A, Orafaei H, et al. Nausea and vomiting in Iranian traditional medicine based on avicenna’s viewpoint. Elect Phys. 2015;7(2):1047–1053. doi:10.14661/2015.1047-1053
  • Hamidpour R, Hamidpour M, Hamidpour S, et al. Cinnamon from the selection of traditional applications to its novel effects on the inhibition of angiogenesis in cancer cells and prevention of Alzheimer’s disease, and a series of functions such as antioxidant, anticholesterol, antidiabetes, antibacterial, antifungal, nematicidal, acaracidal, and repellent activities. J Traditional Complementary Med. 2015;5(2):66–70. doi:10.1016/j.jtcme.2014.11.008
  • Liang F, Cooper EL, Wang H, et al. Acupuncture and immunity. Evid Based Complement Alternat Med. 2015;2015:260620. doi:10.1155/2015/260620
  • El Khoury D, Cuda C, Luhovyy BL, et al. Beta glucan: health benefits in obesity and metabolic syndrome. J Nutr Metab. 2012;2012:851362. doi:10.1155/2012/851362
  • Wei Y, Wang R, Ren S, et al. Zuojin pill ameliorates inflammation in indomethacin-induced gastric injury via inhibition of MAPK pathway [J]. J Ethnopharmacol. 2021;275:114103. doi:10.1016/j.jep.2021.114103
  • Wen J, Wu S, Ma X, et al. Zuojin pill attenuates helicobacter pylori-induced chronic atrophic gastritis in rats and improves gastric epithelial cells function in ges-1 cells. J Ethnopharmacol. 2022;285:114855. doi:10.1016/j.jep.2021.114855
  • Peng QX, Cai HB, Peng JL, et al. Extract of zuojin pill ([characters: see text]) induces apoptosis of sgc-7901 cells via mitochondria-dependent pathway. Chin J Integr Med. 2015;21(11):837–845. doi:10.1007/s11655-015-2043-3
  • Wang QS, Zhu XN, Jiang HL, et al. Protective effects of alginate-chitosan microspheres loaded with alkaloids from coptis chinensis franch. And evodia rutaecarpa (juss.) benth. (zuojin pill) against ethanol-induced acute gastric mucosal injury in rats. Drug Des Devel Ther. 2015;9:6151–6165. doi:10.2147/DDDT.S96056
  • Ma X, Xie S, Wang R, et al. Metabolomics profiles associated with the treatment of zuojin pill on patients with chronic nonatrophic gastritis. Front Pharmacol. 2022;13:898680. doi:10.3389/fphar.2022.898680
  • Li S, Zhang B. Traditional Chinese medicine network pharmacology: theory, methodology and application. Chinese J Nat Med. 2013;11(2):110–120. doi:10.1016/S1875-5364(13)60037-0
  • Li Q, Lan T, He S, et al. A network pharmacology-based approach to explore the active ingredients and molecular mechanism of lei-gong-gen formula granule on a spontaneously hypertensive rat model. Chin Med. 2021;16(1):99. doi:10.1186/s13020-021-00507-1
  • Xiang SY, Zhao J, Lu Y, et al. Network pharmacology-based identification for therapeutic mechanism of ling-gui-zhu-gan decoction in the metabolic syndrome induced by antipsychotic drugs. Comput Biol Med 2019;110:1–7. doi:10.1016/j.compbiomed.2019.05.007
  • Guo W, Huang J, Wang N, et al. Integrating network pharmacology and pharmacological evaluation for deciphering the action mechanism of herbal formula zuojin pill in suppressing hepatocellular carcinoma. Front Pharmacol. 2019;10:1185. doi:10.3389/fphar.2019.01185
  • Cui J, Liu Y, Hu Y, et al. NMR-based metabonomics and correlation analysis reveal potential biomarkers associated with chronic atrophic gastritis. J Pharm Biomed Anal. 2017;132:77–86. doi:10.1016/j.jpba.2016.09.044
  • Tong Y, Wang R, Liu X, et al. Zuojin pill ameliorates chronic atrophic gastritis induced by mnng through tgf-beta1/pi3k/akt axis. J Ethnopharmacol. 2021;271:113893. doi:10.1016/j.jep.2021.113893
  • Kangwan N, Pintha K, Lekawanvijit S, et al. Rosmarinic acid enriched fraction from perilla frutescens leaves strongly protects indomethacin-induced gastric ulcer in rats. Biomed Res Int 2019;2019:9514703. doi:10.1155/2019/9514703
  • Hu Y, Liu T, Zheng G, et al. Mechanism exploration of 6-gingerol in the treatment of atherosclerosis based on network pharmacology, molecular docking and experimental validation. Phytomedicine. 2023;115:154835. doi:10.1016/j.phymed.2023.154835
  • Sun Y, Wang S, Qi M, et al. Psychological distress in patients with chronic atrophic gastritis: the risk factors, protection factors, and cumulative effect. Psychol Health Med. 2018;23(7):797–803. doi:10.1080/13548506.2018.1428756
  • Wang J, Zhang T, Zhu L, et al. Anti-ulcerogenic effect of zuojin pill against ethanol-induced acute gastric lesion in animal models. J Ethnopharmacol. 2015;173:459–467. doi:10.1016/j.jep.2015.04.017
  • Guo K, Li Z, Qiu B, et al. Analysis of gastric diseases and their symptoms based on indexes of pepsinogen i (pgi) and pepsinogen ii (pgii): take 1106 patients as samples. Cellular Microbiology. 2022;2022:1–6. doi:10.1155/2022/8393351
  • Cuomo P, Papaianni M, Capparelli R, et al. The role of formyl peptide receptors in permanent and low-grade inflammation: helicobacter pylori infection as a model. Int J Mol Sci. 2021;22(7):3706.
  • Booth AL, Gonzalez RS. Helicobacter pylori colonisation of duodenal foveolar metaplasia requires concurrent gastric infection. J Clin Pathol. 2021;74(8):537–539. doi:10.1136/jclinpath-2020-206844
  • Chen X, Zhang J, Wang R, et al. UPLC-Q-TOF/MS-based serum and urine metabonomics study on the ameliorative effects of palmatine on helicobacter pylori-induced chronic atrophic gastritis. Front Pharmacol. 2020;11:586954. doi:10.3389/fphar.2020.586954
  • Koivurova OP, Koskela R, Blomster T, et al. Serological biomarker panel in diagnosis of atrophic gastritis and helicobacter pylori infection in gastroscopy referral patients: clinical validation of the new-generation gastropanel(®) test. Anticancer Res. 2021;41(11):5527–5537. doi:10.21873/anticanres.15366
  • Kim YJ, Chung WC, Kim DB. Efficacy of bismuth added to standard triple therapy as the first-line eradication regimen for helicobacter pylori infection. Helicobacter. 2021;26(3):e12792. doi:10.1111/hel.12792
  • Zagari RM, Rabitti S, Greenwood DC, et al. Systematic review with meta-analysis: diagnostic performance of the combination of pepsinogen, gastrin-17 and anti- helicobacter pylori antibodies serum assays for the diagnosis of atrophic gastritis. Aliment Pharmacol Ther. 2017;46(7):657–667. doi:10.1111/apt.14248
  • Antonisamy P, Arasu MV, Dhanasekaran M, et al. Protective effects of trigonelline against indomethacin-induced gastric ulcer in rats and potential underlying mechanisms. Food Funct. 2016;7(1):398–408. doi:10.1039/C5FO00403A
  • Tong Y, Zhao X, Wang R, et al. Therapeutic effect of berberine on chronic atrophic gastritis based on plasma and urine metabolisms. Eur J Pharmacol. 2021;908:174335. doi:10.1016/j.ejphar.2021.174335
  • Wang B, Zhou W, Zhang H, et al. Exploring the effect of weifuchun capsule on the toll-like receptor pathway mediated hes6 and immune regulation against chronic atrophic gastritis. J Ethnopharmacol. 2023;303:115930. doi:10.1016/j.jep.2022.115930
  • Tong Y, Liu L, Wang R, et al. Berberine attenuates chronic atrophic gastritis induced by mnng and its potential mechanism. Front Pharmacol. 2021;12:644638. doi:10.3389/fphar.2021.644638
  • Beales IL, Calam J. Interleukin 1 beta and tumour necrosis factor alpha inhibit acid secretion in cultured rabbit parietal cells by multiple pathways. Gut. 1998;42(2):227–234. doi:10.1136/gut.42.2.227
  • Unver N, McAllister F. Il-6 family cytokines: key inflammatory mediators as biomarkers and potential therapeutic targets. Cytokine Growth Factor Rev. 2018;41:10–17. doi:10.1016/j.cytogfr.2018.04.004
  • Tang X, Chen X, Li X, et al. The tlr4 mediated inflammatory signal pathway might be involved in drug resistance in drug-resistant epileptic rats. J Neuroimmunol. 2022;365:577802. doi:10.1016/j.jneuroim.2021.577802
  • Li H, Tang D, Qi C, et al. Forsythiaside inhibits bacterial adhesion on titanium alloy and attenuates ti-induced activation of nuclear factor-κb signaling-mediated macrophage inflammation. J Orthopaedic Surg Res. 2018;13(1):139. doi:10.1186/s13018-018-0834-x
  • Zhou X, Zhang L, Lie L, et al. Mxa suppresses tak1-ikkα/β-nf-κb mediated inflammatory cytokine production to facilitate mycobacterium tuberculosis infection. J Infect. 2020;81(2):231–241. doi:10.1016/j.jinf.2020.05.030
  • Jing C, Sun Z, Xie X, et al. Network pharmacology-based identification of the key mechanism of qinghuo rougan formula acting on uveitis. Biomed Pharmacother. 2019;120:109381. doi:10.1016/j.biopha.2019.109381
  • Qiu W, Leibowitz B, Zhang L, et al. Growth factors protect intestinal stem cells from radiation-induced apoptosis by suppressing puma through the pi3k/akt/p53 axis. Oncogene. 2010;29(11):1622–1632. doi:10.1038/onc.2009.451
  • Tiemin P, Fanzheng M, Peng X, et al. Muc13 promotes intrahepatic cholangiocarcinoma progression via egfr/pi3k/akt pathways. J Hepatol. 2020;72(4):761–773. doi:10.1016/j.jhep.2019.11.021
  • Kim SH, Kim JY, Park SY, et al. Activation of the egfr-pi3k-cam pathway by prl-1-overexpressing placenta-derived mesenchymal stem cells ameliorates liver cirrhosis via er stress-dependent calcium. Stem Cell Res Ther. 2021;12(1):551. doi:10.1186/s13287-021-02616-y
  • Jiang R, Tang J, Zhang X, et al. Ccn1 promotes inflammation by inducing il-6 production via alpha6beta1/pi3k/akt/nf-kappab pathway in autoimmune hepatitis. Front Immunol. 2022;13:810671. doi:10.3389/fimmu.2022.810671
  • Miao Z, Miao Z, Wang S, et al. Quercetin antagonizes imidacloprid-induced mitochondrial apoptosis through PTEN/PI3K/AKT in grass carp hepatocytes. Environ Pollut 2021;290:118036. doi:10.1016/j.envpol.2021.118036
  • Pappalardo F, Russo G, Candido S, et al. Computational modeling of pi3k/akt and MAPK signaling pathways in melanoma cancer. PLoS One. 2016;11(3):e0152104. doi:10.1371/journal.pone.0152104
  • Tsai HF, Hsu PN. Modulation of tumor necrosis factor-related apoptosis-inducing ligand (trail)-mediated apoptosis by helicobacter pylori in immune pathogenesis of gastric mucosal damage. J Microbiol Immunol Infect. 2017;50(1):4–9. doi:10.1016/j.jmii.2016.01.002
  • He H, Feng M, Xu H, et al. Total triterpenoids from the fruits of Chaenomeles speciosa exerted gastroprotective activities on indomethacin-induced gastric damage via modulating microRNA-423-5p-mediated tff/nag-1 and apoptotic pathways. Food Funct. 2020;11(1):662–679. doi:10.1039/C9FO02322D
  • Han B, Jiang P, Li Z, et al. Coptisine-induced apoptosis in human colon cancer cells (hct-116) is mediated by pi3k/akt and mitochondrial-associated apoptotic pathway. Phytomedicine. 2018;48:152–160. doi:10.1016/j.phymed.2017.12.027
  • Wang J, Hu S, Wang J, et al. Fucoidan from acaudina molpadioides protects pancreatic islet against cell apoptosis via inhibition of inflammation in type 2 diabetic mice. Food Sci Biotechnol. 2016;25(1):293–300. doi:10.1007/s10068-016-0042-6
  • Wang L, Liu X, Kang Q, et al. Nrf2 overexpression decreases vincristine chemotherapy sensitivity through the pi3k-akt pathway in adult b-cell acute lymphoblastic leukemia. Front Oncol. 2022;12:876556. doi:10.3389/fonc.2022.876556
  • Wang J, Wang A, He H, et al. Trametenolic acid b protects against cerebral ischemia and reperfusion injury through modulation of microRNA-10a and pi3k/akt/mtor signaling pathways. Biomed Pharmacother. 2019;112:108692. doi:10.1016/j.biopha.2019.108692
  • Zhang Y, Xu H, He H, et al. Total triterpenes from the fruits of Chaenomeles speciosa (sweet) nakai protects against indomethacin-induced gastric mucosal injury: involvement of tff1-mediated egf/egfr and apoptotic pathways. J Pharm Pharmacol. 2020;72(3):409–423. doi:10.1111/jphp.13207
  • Kim B, Srivastava SK, Kim SH. Caspase-9 as a therapeutic target for treating cancer. Expert Opin Ther Targets. 2015;19(1):113–127. doi:10.1517/14728222.2014.961425
  • Meyer AR, Goldenring JR. Injury, repair, inflammation and metaplasia in the stomach. J Physiol. 2018;596(17):3861–3867. doi:10.1113/JP275512
  • Ye HY, Shang ZZ, Zhang FY, et al. Dendrobium huoshanense stem polysaccharide ameliorates alcohol-induced gastric ulcer in rats through nrf2-mediated strengthening of gastric mucosal barrier. Int J Biol Macromol. 2023;236:124001. doi:10.1016/j.ijbiomac.2023.124001
  • Schulzke J, Fromm M. Tight junctions: molecular structure meets function. Ann NY Acad Sci 2009;1165(1):1–6. doi:10.1111/j.1749-6632.2009.04925.x
  • Gao A, Xia T, Peng Z, et al. The ethanolic extract of peanut shell attenuates the depressive-like behaviors of mice through modulation of inflammation and gut microbiota. Food Res Int. 2023;168:112765. doi:10.1016/j.foodres.2023.112765
  • Ren L, Feng W, Shao J, et al. Diethyldithiocarbamate-copper nanocomplex reinforces disulfiram chemotherapeutic efficacy through light-triggered nuclear targeting. Theranostics. 2020;10(14):6384–6398. doi:10.7150/thno.45558
  • Müller SL, Portwich M, Schmidt A, et al. The tight junction protein occludin and the adherens junction protein alpha-catenin share a common interaction mechanism with zo-1. J Biol Chem. 2005;280(5):3747–3756. doi:10.1074/jbc.M411365200
  • Derk J, Como C, Jones H, et al. Formation and function of the meningeal arachnoid barrier around the developing mouse brain. Dev Cell. 2023;58(8):635–44.e4. doi:10.1016/j.devcel.2023.03.005