Unveiling the Pharmacological Mechanisms of Davidiin’s Anti-Diabetic Efficacy in Streptozotocin-Treated Rats: A Comprehensive Analysis of Serum Metabolome

References

• Hu J, Ye M, Zhou Z. Aptamers: novel diagnostic and therapeutic tools for diabetes mellitus and metabolic diseases. J Mol Med. 2017;95:249–256. doi:10.1007/s00109-016-1485-1
   PubMed Web of Science ®Google Scholar
• Wang X, Lv S, Huang D, Chen W, Sun L. Hypoglycemic activity of extracts from leaves of Terminalia catappa. Chinese Traditional Patent Med. 2018;40:2531–2535. doi:10.3969/j.issn.1001-1528.2018.11.032
   Google Scholar
• Zhou B, Lu Y, Hajifathalian K; NCD Risk Factor Collaboration (NCD-RisC). Worldwide trends in diabetes since 1980: a pooled analysis of 751 population-based studies with 4.4 million participants. Lancet. 2016;387:1513–1530. doi:10.1016/S0140-6736(16)00618-8
   PubMed Web of Science ®Google Scholar
• Zheng L, Lu Y, Cao X, et al. Evaluation of the impact of Polygonum capitatum, a traditional Chinese herbal medicine, on rat hepatic cytochrome P450 enzymes by using a cocktail of probe drugs. J Ethnopharmacol. 2014;158:Pt A:276–82. PMID: 25446640. doi:10.1016/j.jep.2014.10.031
   Web of Science ®Google Scholar
• Zhou F, Chen X. Status of Traditional Chinese Medicine Constitutional Theory in Diabetes Mellitus. China J Chin Med. 2015;30:343–345+348. doi:10.16368/j.issn.1674-8999.2015.03.115
   Google Scholar
• Chen B, Li C, Chang X, Kang W. Inhibitory activity of polygonum capitatum to α-Glucosidase. Chin J Exp Traditional Med Formulae. 2010;16:151–153. doi:10.13422/j.cnki.syfjx.2010.08.055
   Google Scholar
• Tong N, Wu M, Wang J, Chen P, Huang S. Study on in vitro hypoglycemic effect and mechanism of Polygonum capitatum. Chin Traditional Herbal Drugs. 2017;48:3401–3407. doi:10.7501/j.issn.0253-2670.2017.16.024
   Google Scholar
• Liu B, Tong N, Li Y, Huang S. Hypoglycemic mechanism of polygonum capitatum extract on spontaneous model of type 2 Diabetic db/db Mice. Chin Pharm J. 2017;52:384–390. doi:10.11669/cpj.2017.05.011
   Google Scholar
• Ma J. Studies on Metabolism of FR429, a Bioactive Ellagitannin from Miao Herb Polygonum Capitatum. Peking Union Medical College; 2013.
   Google Scholar
• Yang Y, Hong Q, Zhu B, Zhou Z, Yang J. Quality standard for Polygonum capitatum. Chinese Traditional Patent Med. 2020;42(2):408–415.
   Google Scholar
• Wang Y, Ma J, Chow SC, et al. A potential antitumor ellagitannin, davidiin, inhib-ited hepatocellular tumor growth by targeting EZH2. Tumour Biol. 2014;35(1):205–212. doi:10.1007/s13277-013-1025-3
   PubMedGoogle Scholar
• Takemoto M, Kawamura Y, Hirohama M, et al. Inhibition of protein SUMOylation by davidiin, an ellagitannin from Davidia involucrata. J Antibiot. 2014;67(4):335–338. doi:10.1038/ja.2013.142
   PubMed Web of Science ®Google Scholar
• Zhu M, Phillipson JD, Greengrass PM, Bowery NE, Cai Y. Plant polyphenols: biologically active compounds or non-selective binders to protein? Phytochemistry. 1997;44(3):441–447. doi:10.1016/s0031-9422(96)00598-5
   PubMed Web of Science ®Google Scholar
• Sun L, Huang D, Han J, et al. Application of beta-1,6-hexa-hydroxydibenzoyl-2,3,4-trigallate-D-glucose compound in medicine preparation, CN201610663093.5; 2018.
   Google Scholar
• Wu J, Yan LJ. Streptozotocin-induced type 1 diabetes in rodents as a model for studying mitochondrial mechanisms of diabetic β cell glucotoxicity. Diabetes Metab Syndr Obes. 2015;8:181–188. PMID: 25897251; PMCID: PMC4396517. doi:10.2147/DMSO.S82272
   PubMed Web of Science ®Google Scholar
• Guo Y, Xiao Z, Wang Y, et al. Sodium Butyrate Ameliorates Streptozotocin-Induced Type 1 Diabetes in Mice by Inhibiting the HMGB1 Expression. Front Endocrinol. 2018;9:630. PMID: 30410469; PMCID: PMC6209660. doi:10.3389/fendo.2018.00630
   PubMed Web of Science ®Google Scholar
• Ghadge A, Harsulkar A, Karandikar M, Pandit V, Kuvalekar A. Comparative anti-inflammatory and lipid-normalizing effects of metformin and omega-3 fatty acids through modulation of transcription factors in diabetic rats. Genes Nutr. 2016;11:10. PMID: 27551311; PMCID: PMC4968436. doi:10.1186/s12263-016-0518-4
   PubMed Web of Science ®Google Scholar
• Xuan W. Study on Metabolomics of Davidiin Based on Diabetic Rat Model. Fujian University of Traditional Chinese Medicine; 2019.
   Google Scholar
• Han H, Song F, Shu Z, Liu Z, Ren Y, Pi Z. An untargeted urinary metabolomics strategy for investigation of therapeutical mechanism of schisandra chinensis on complications of diabetes rats. Chin J Anal Chem. 2017;45:389–399. doi:10.11895/j.issn.0253-3820.160753
   Web of Science ®Google Scholar
• Zhao Y. Study on the preparation process of polyphenols from Polygonum capitatum and its metabolite identification in diabetes model. Naval Medical University. 2021. doi:10.26998/d.cnki.gjuyu.2020.000272
   Google Scholar
• Zhang C, Xie G, Jiang Y, et al. Studying ofstreptozotocin in-ducing type2 diabetes rat mode. Anhui Med Pharm J. 2012;16(9):1241–1244.
   Google Scholar
• Zhang B, Quan A, Fei M, et al. Studying ofstreptozotocin inducing type2 diabetesratmode. J Hubei Univer Sci Technol. 2012;26(6):468–469.
   Google Scholar
• Srinivasan K, Viswanad B, Asrat L, Kaul CL, Ramarao P. Combination of high-fat diet-fed and low-dose streptozotocin-treated rat: a model for type 2 diabetes and pharmacological screening. Pharmacol Res. 2005;52(4):313–320. doi:10.1016/j.phrs.2005.05.004
   PubMed Web of Science ®Google Scholar
• Yang Y, Huang G, Wu Z, Han J, Liang F, Cheng W. Effect of Polygonum Capitatum Extract on Hypoglycemic Drugs. China: Inventor; Naval Medical University, assignee; 2015.
   Google Scholar
• Xiang L, Wu Q, Osada H, Yoshida M, Pan W, Qi J. Peanut skin extract ameliorates the symptoms of type 2 diabetes mellitus in mice by alleviating inflammation and maintaining gut microbiota homeosta-sis. Aging. 2020;12(14):13991–14018. doi:10.18632/aging.103521
   PubMedGoogle Scholar
• Xiang L, Li J, Wang Y, et al. Tetradecyl 2,3-dihydroxybenzoate improves the symptoms of diabetic mice by modulation of insulin and adiponectin signaling pathways. Front Pharmacol. 2017;8:806. doi:10.3389/fphar.2017.00806
   PubMed Web of Science ®Google Scholar
• Yang J, Zhao X, Lu X, Lin X, Xu G. A data preprocessing strategy for metabolomics to reduce the mask effect in data analysis. Front Mol Biosci. 2015;2. doi:10.3389/fmolb.2015.00004
   Web of Science ®Google Scholar
• Xia J, Sinelnikov IV, Han B, Wishart DS. MetaboAnalyst 3.0--making metabolomics more meaningful. Nucleic Acids Res. 2015;43:W251–257. doi:10.1093/nar/gkv380
   PubMed Web of Science ®Google Scholar
• Gotoh N, Nagao K, Ishida H, et al. Metabolism of natural highly unsaturated fatty acid, tetracosahexaenoic acid (24:6n-3), in C57BL/KsJ-db/db Mice. J Oleo Sci. 2018;67:1597–1607. doi:10.5650/jos.ess18167
   PubMed Web of Science ®Google Scholar
• Jia W, Xie G, Jia W. Bile acid-microbiota crosstalk in gastrointestinal inflammation and carcinogenesis. Nat Rev Gastroenterol Hepatol. 2018;15:111–128. doi:10.1038/nrgastro.2017.119
   PubMed Web of Science ®Google Scholar
• Tianyue Xu. Research progress on the rat model of experimental type 2 diabetes induced by high-fat and high-sugar diet combined with streptozotocin. Diet Science. 2019;1(18):205.
   Google Scholar
• Wang Z, Yang Y, Xiang X, Zhu Y, Men J, He M. Estimation of the normal range of blood glucose in rats. Wei Sheng Yan Jiu. 2010;39(2):133–7, 142.
   PubMedGoogle Scholar
• Li Y, Lu Zhang Q, Hu W, Qu G, Hong Y. Roles and regulation of phosphatidic acid phosphatase in lipid metabolism and signaling. Plant Physiol J. 2017;53:897–904. doi:10.13592/j.cnki.ppj.2017.1010
   Google Scholar
• Schlame M, Greenberg ML. Biosynthesis, remodeling and turnover of mitochondrial cardiolipin. Biochim Biophys Acta Mol Cell Biol Lipids. 2017;1862(1):3–7. PMID: 27556952; PMCID: PMC5125896. doi:10.1016/j.bbalip.2016.08.010
   PubMed Web of Science ®Google Scholar
• van der Veen JN, Kennelly JP, Wan S, Vance JE, Vance DE, Jacobs RL. The critical role of phosphatidylcholine and phosphatidylethanolamine metabolism in health and disease. Biochim Biophys Acta Biomembr. 2017;1859(9):1558–1572. PMID: 28411170. doi:10.1016/j.bbamem.2017.04.006
   PubMed Web of Science ®Google Scholar
• Xiaoke Z. Biochemistry. Beijing: People ‘s Health Publishing House; 2020:178–179.
   Google Scholar
• Sampath H, Ntambi JM. The fate and intermediary metabolism of stearic acid. Lipids. 2005;40(12):1187–1191. PMID: 16477801. doi:10.1007/s11745-005-1484-z
   PubMed Web of Science ®Google Scholar
• D’Souza K, Paramel GV, Kienesberger PC. Lysophosphatidic acid signaling in obesity and insulin resistance. Nutrients. 2018;10(4):399. PMID: 29570618; PMCID: PMC5946184. doi:10.3390/nu10040399
   PubMed Web of Science ®Google Scholar
• El-Magd NF A, Ramadan NM, Eraky SM. The ameliorative effect of bromelain on STZ-induced type 1 diabetes in rats through Oxi-LDL/LPA/LPAR1 pathway. Life Sci. 2021;285:119982. PMID: 34592232. doi:10.1016/j.lfs.2021.119982
   PubMed Web of Science ®Google Scholar
• Bornfeldt KE. Adipocyte phosphatidylinositol biosynthesis via the Lands cycle protects against insulin resistance. J Lipid Res. 2023;64(6):100383. PMID: 37127068; PMCID: PMC10239062. doi:10.1016/j.jlr.2023.100383
   PubMed Web of Science ®Google Scholar
• Zhang X, Zhang J, Sun H, et al. Defective phosphatidylglycerol remodeling causes hepatopathy, linking mitochondrial dysfunction to hepatosteatosis. Cell Mol Gastroenterol Hepatol. 2019;7(4):763–781. PMID: 30831319; PMCID: PMC6463126. doi:10.1016/j.jcmgh.2019.02.002
   PubMed Web of Science ®Google Scholar
• He Q, Bo J, Shen R, et al. S1P Signaling Pathways in Pathogenesis of Type 2 Diabetes. J Diabetes Res. 2021;2021:1341750. PMID: 34751249; PMCID: PMC8571914. doi:10.1155/2021/1341750
   PubMed Web of Science ®Google Scholar
• Gundala NKV, Naidu VGM, Das UN. Amelioration of streptozotocin-induced type 2 diabetes mellitus in Wistar rats by arachidonic acid. Biochem Biophys Res Commun. 2018;496(1):105–113. PMID: 29309791. doi:10.1016/j.bbrc.2018.01.007
   PubMed Web of Science ®Google Scholar
• Wei C, Wang M, Wang X-J. Evolutionary conservation analysis of human arachidonic acid metabolism pathway genesJ. Life Medicine. 2023;2(2):9. doi:10.1093/lifemedi/lnad004
   Google Scholar
• Pace-Asciak CR, Martin JM, Corey EJ. Hepoxilins, potential endogenous mediators of insulin release. Prog Lipid Res. 1986;25(1–4):625–628. PMID: 3321096. doi:10.1016/0163-7827(86)90127-x
   PubMedGoogle Scholar
• Khan H, Gupta A, Singh TG, Kaur A. Mechanistic insight on the role of leukotriene receptors in ischemic-reperfusion injury. Pharmacol Rep. 2021;73(5):1240–1254. PMID: 33818747. doi:10.1007/s43440-021-00258-8
   PubMed Web of Science ®Google Scholar
• Chakrabarti SK, Cole BK, Wen Y, Keller SR, Nadler JL. 12/15-lipoxygenase products induce inflammation and impair insulin signaling in 3T3-L1 adipocytes. Obesity (Silver Spring). 2009;17(9):1657–1663. PMID: 19521344; PMCID: PMC2887741. doi:10.1038/oby.2009.192
   PubMed Web of Science ®Google Scholar
• Qureshi S, Ali G, Muhammad T, et al. Thiadiazine-thione derivatives ameliorate STZ-induced diabetic neuropathy by regulating insulin and neuroinflammatory signaling. Int Immunopharmacol. 2022;113(Pt B):109421. PMID: 36403520. doi:10.1016/j.intimp.2022.109421
   PubMedGoogle Scholar
• Han PC, Hsiao FC, Chang HM, Wabitsch M, Hsieh PS. Importance of adipocyte cyclooxygenase-2 and prostaglandin E2-prostaglandin E receptor 3 signaling in the development of obesity-induced adipose tissue inflammation and insulin resistance. FASEB J. 2016;30(6):2282–2297. PMID: 26932930. doi:10.1096/fj.201500127
   PubMed Web of Science ®Google Scholar
• Chan PC, Liao MT, Hsieh PS. The Dualistic Effect of COX-2-mediated signaling in obesity and insulin resistance. Int J Mol Sci. 2019;20(13):3115. PMID: 31247902; PMCID: PMC6651192. doi:10.3390/ijms20133115
   PubMed Web of Science ®Google Scholar
• Abadpour S, Tyrberg B, Schive SW, et al. Inhibition of the prostaglandin D2-GPR44/DP2 axis improves human islet survival and function. Diabetologia. 2020;63(7):1355–1367. PMID: 32350565; PMCID: PMC7286861. doi:10.1007/s00125-020-05138-z
   PubMed Web of Science ®Google Scholar
• Maggi LB, Sadeghi H, Weigand C, Scarim AL, Heitmeier MR, Corbett JA. Anti-inflammatory actions of 15-deoxy-delta 12,14-prostaglandin J2 and troglitazone: evidence for heat shock-dependent and -independent inhibition of cytokine-induced inducible nitric oxide synthase expression. Diabetes. 2000;49(3):346–355. PMID: 10868955. doi:10.2337/diabetes.49.3.346
   PubMed Web of Science ®Google Scholar
• Souza SC, Yamamoto MT, Franciosa MD, Lien P, Greenberg AS. BRL 49653 blocks the lipolytic actions of tumor necrosis factor-alpha: a potential new insulin-sensitizing mechanism for thiazolidinediones. Diabetes. 1998;47(4):691–695. PMID: 9568706. doi:10.2337/diabetes.47.4.691
   PubMed Web of Science ®Google Scholar
• Thieringer R, Fenyk-Melody JE, Le Grand CB, et al. Activation of peroxisome proliferator-activated receptor gamma does not inhibit IL-6 or TNF-alpha responses of macrophages to lipopolysaccharide in vitro or in vivo. J Immunol. 2000;164(2):1046–1054. PMID: 10623855. doi:10.4049/jimmunol.164.2.1046
   PubMed Web of Science ®Google Scholar
• Lu L, Fan Z, Chai Y. Antipyretic effect and mechanism of relinqing granules on rats induced by dry yeast. J Hubei Minzu University. 2022. doi:10.13501/j.cnki.42-1590/r.2022.04.016
   Google Scholar
• Chi PL, Liu CJ, Lee IT, Chen YW, Hsiao LD, Yang CM. HO-1 induction by CO-RM2 attenuates TNF-α-induced cytosolic phospholipase A2 expression via inhibition of PKCα-dependent NADPH oxidase/ROS and NF-κB. Mediators Inflamm. 2014;2014:279171. PMID: 24616552; PMCID: PMC3927740. doi:10.1155/2014/279171
   PubMed Web of Science ®Google Scholar
• Chen J, Zhao KN, Chen C. The role of CYP3A4 in the biotransformation of bile acids and therapeutic implication for cholestasis. Ann Transl Med. 2014;2(1):7. PMID: 25332983; PMCID: PMC4200650. doi:10.3978/j.issn.2305-5839.2013.03.02
   PubMedGoogle Scholar
• Chiang JYL, Ferrell JM. Up to date on cholesterol 7 alpha-hydroxylase (CYP7A1) in bile acid synthesis. Liver Res. 2020;4(2):47–63. PMID: 34290896; PMCID: PMC8291349. doi:10.1016/j.livres.2020.05.001
   PubMedGoogle Scholar
• Yan Y, Niu Z, Sun C, et al. Hepatic thyroid hormone signalling modulates glucose homeostasis through the regulation of GLP-1 production via bile acid-mediated FXR antagonism. Nat Commun. 2022;13(1):6408. PMID: 36302774; PMCID: PMC9613917. doi:10.1038/s41467-022-34258-w
   PubMed Web of Science ®Google Scholar
• Modica S, Gadaleta RM, Moschetta A. Deciphering the nuclear bile acid receptor FXR paradigm. Nucl Recept Signal. 2010;8:e005. PMID: 21383957; PMCID: PMC3049226. doi:10.1621/nrs.08005
   PubMedGoogle Scholar
• Müllenbach R, Weber SN, Lammert F. Nuclear receptor variants in liver disease. J Lipids. 2012;2012:934707. PMID: 22523693; PMCID: PMC3317184. doi:10.1155/2012/934707
   PubMedGoogle Scholar
• Chiang JY. Bile acid metabolism and signaling. Compr Physiol. 2013;3(3):1191–1212. PMID: 23897684; PMCID: PMC4422175. doi:10.1002/cphy.c120023
   PubMed Web of Science ®Google Scholar
• He L. Metformin and Systemic Metabolism. Trends Pharmacol Sci. 2020;41(11):868–881. doi:10.1016/j.tips.2020.09.001
   PubMed Web of Science ®Google Scholar
• Zhu H, Jia Z, Li YR, Danelisen I. Molecular mechanisms of action of metformin: latest advances and therapeutic implications. Clin Exp Med. 2023;23(7):2941–2951. doi:10.1007/s10238-023-01051-y
   PubMed Web of Science ®Google Scholar
• Agius L, Ford BE, Chachra SS. The metformin mechanism on gluconeogenesis and AMPK activation: the metabolite perspective. Int J Mol Sci. 2020;21(9):3240. doi:10.3390/ijms21093240
   PubMed Web of Science ®Google Scholar
• Galicia-Garcia U, Benito-Vicente A, Jebari S, et al. Pathophysiology of type 2 diabetes mellitus. Int J Mol Sci. 2020;21(17):6275. doi:10.3390/ijms21176275
   PubMed Web of Science ®Google Scholar
• Ojo OA, Ibrahim HS, Rotimi DE, Ogunlakin AD, Ojo AB. Diabetes mellitus: from molecular mechanism to pathophysiology and pharmacology. Med Novel Technol Dev. 2023;19:100247. doi:10.1016/j.medntd.2023.100247
   Google Scholar
• Banday MZ, Sameer AS, Nissar S. Pathophysiology of diabetes: an overview. Avicenna J Med. 2020;10(4):174–188. doi:10.4103/ajm.ajm_53_20
   PubMedGoogle Scholar