References
- Bray F, Laversanne M, Sung H, et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. Ca a Cancer J Clinicians. 2024. doi:10.3322/caac.21834
- Mohamed K, Rzymski P, Islam MS, et al. COVID-19 vaccinations: the unknowns, challenges, and hopes. J med virol. 2022;94(4):1336–1349. doi:10.1002/jmv.27487
- Malik JA, Mulla AH, Farooqi T, Pottoo FH, Anwar S, Rengasamy KRR. Targets and strategies for vaccine development against SARS-CoV-2. Biomed Pharmacothe. 2021;137:111254. doi:10.1016/j.biopha.2021.111254
- Xue X, Lindstrom A, Qu H, Li Y. Recent advances on small-molecule nanomedicines for cancer treatment. Wiley Interdisciplinary Rev Nanomed Nanobiotechnol. 2020;12(3):e1607. doi:10.1002/wnan.1607
- Zhao PJ, Wang HX, Li GH, Li HD, Liu J, Shen YM. Secondary metabolites from endophytic Streptomyces sp. Lz531. Chem. Biodivers. 2007;4(5):899–904. doi:10.1002/cbdv.200790078
- Sang XN, Chen SF, Chen G, et al. Two pairs of enantiomeric α-pyrone dimers from the endophytic fungus Phoma sp YN02-P-3. RSC Adv. 2017;7(4):1943–1946. doi:10.1039/c6ra26319d
- Zhu Y, Zhang W, Chen J. Binary Nanodrug-Delivery System Designed for Leukemia Therapy: aptamer- and Transferrin-Codecorated Daunorubicin- and Luteolin-Coloaded Nanoparticles. Drug Des Devel Ther. 2023;17:1–13. doi:10.2147/dddt.S387246
- Zhao J, Lin E, Cai C, et al. Combined Treatment of Tanshinone I and Epirubicin Revealed Enhanced Inhibition of Hepatocellular Carcinoma by Targeting PI3K/AKT/HIF-1α. Drug Des Devel Ther. 2022;16:3197–3213. doi:10.2147/dddt.S360691
- Habibullah MM, Mohan S, Syed NK, et al. Human Growth Hormone Fragment 176-191 Peptide Enhances the Toxicity of Doxorubicin-Loaded Chitosan Nanoparticles Against MCF-7 Breast Cancer Cells. Drug Des Devel Ther. 2022;16:1963–1974. doi:10.2147/dddt.S367586
- Zhang S, Wu P, Liu J, Du Y, Yang Z. Roflumilast Attenuates Doxorubicin-Induced Cardiotoxicity by Targeting Inflammation and Cellular Senescence in Cardiomyocytes Mediated by SIRT1. Drug Des Devel Ther. 2021;15:87–97. doi:10.2147/dddt.S269029
- Liu J, Lane S, Lall R, et al. Circulating hemopexin modulates anthracycline cardiac toxicity in patients and in mice. Sci Adv. 2022;8(51):eadc9245. doi:10.1126/sciadv.adc9245
- Bosman M, Krüger D, Van Assche C, et al. Doxorubicin-induced cardiovascular toxicity: a longitudinal evaluation of functional and molecular markers. Cardiovascular Res. 2023;119(15):2579–2590. doi:10.1093/cvr/cvad136
- Ma A, Jiang K, Chen B, et al. Evaluation of the anticarcinogenic potential of the endophyte, Streptomyces sp. LRE541 isolated from Lilium davidii var. unicolor (Hoog) Cotton. Microb Cell Fact. 2021;20(1):217. doi:10.1186/s12934-021-01706-z
- Yang X, Shang P, Yu B, et al. Combination therapy with miR34a and doxorubicin synergistically inhibits Dox-resistant breast cancer progression via down-regulation of Snail through suppressing Notch/NF-κB and RAS/RAF/MEK/ERK signaling pathway. Acta pharmaceutica Sinica B. 2021;11(9):2819–2834. doi:10.1016/j.apsb.2021.06.003
- Wei J, Chen X, Li Y, et al. Cucurbitacin B-induced G2/M cell cycle arrest of conjunctival melanoma cells mediated by GRP78-FOXM1-KIF20A pathway. Acta pharmaceutica Sinica B. 2022;12(10):3861–3876. doi:10.1016/j.apsb.2022.05.021
- Kuerban K, Gao X, Zhang H, et al. Doxorubicin-loaded bacterial outer-membrane vesicles exert enhanced anti-tumor efficacy in non-small-cell lung cancer. Acta Pharmaceutica Sinica B. 2020;10(8):1534–1548. doi:10.1016/j.apsb.2020.02.002
- Chen S, Dong G, Wu S, Liu N, Zhang W, Sheng C. Novel fluorescent probes of 10-hydroxyevodiamine: autophagy and apoptosis-inducing anticancer mechanisms. Acta pharmaceutica Sinica B. 2019;9(1):144–156. doi:10.1016/j.apsb.2018.08.003
- Wei T, Xiaojun X, Peilong C. Magnoflorine improves sensitivity to doxorubicin (DOX) of breast cancer cells via inducing apoptosis and autophagy through AKT/mTOR and p38 signaling pathways. Biomed Pharmacothe. 2020;121:109139. doi:10.1016/j.biopha.2019.109139
- Kciuk M, Gielecińska A, Mujwar S, et al. Doxorubicin-An Agent with Multiple Mechanisms of Anticancer Activity. Cells. 2023;12(4):659. doi:10.3390/cells12040659
- Wang X, Hua P, He C, Chen M. Non-apoptotic cell death-based cancer therapy: molecular mechanism, pharmacological modulators, and nanomedicine. Acta pharmaceutica Sinica B. 2022;12(9):3567–3593. doi:10.1016/j.apsb.2022.03.020
- Chen J, Kos R, Garssen J, Redegeld F. Molecular Insights into the Mechanism of Necroptosis: the Necrosome As a Potential Therapeutic Target. Cells. 2019;8(12):1486. doi:10.3390/cells8121486
- Lopez A, Reyna DE, Gitego N, et al. Co-targeting of BAX and BCL-XL proteins broadly overcomes resistance to apoptosis in cancer. Nat Commun. 2022;13(1):1199. doi:10.1038/s41467-022-28741-7
- Chaudhry GE, Md Akim A, Sung YY, Sifzizul TMT. Cancer and apoptosis: the apoptotic activity of plant and marine natural products and their potential as targeted cancer therapeutics. Front Pharmacol. 2022;13:842376. doi:10.3389/fphar.2022.842376
- Morana O, Wood W, Gregory CD. The Apoptosis Paradox in Cancer. Int J Mol Sci. 2022;23(3):1328. doi:10.3390/ijms23031328
- He GW, Günther C, Thonn V, et al. Regression of apoptosis-resistant colorectal tumors by induction of necroptosis in mice. J Exp Med. 2017;214(6):1655–1662. doi:10.1084/jem.20160442
- Hannes S, Karlowitz R, van Wijk SJL. The Smac mimetic BV6 cooperates with STING to induce necroptosis in apoptosis-resistant pancreatic carcinoma cells. Cell Death Dis. 2021;12(9):816. doi:10.1038/s41419-021-04014-x
- Meier P, Legrand AJ, Adam D, Silke J. Immunogenic cell death in cancer: targeting necroptosis to induce antitumour immunity. Nat Rev Cancer. 2024;24(5):299–315. doi:10.1038/s41568-024-00674-x
- Sun Y, Liu Y, Ma X, Hu H. The Influence of Cell Cycle Regulation on Chemotherapy. Int J Mol Sci. 2021;22(13):6923. doi:10.3390/ijms22136923
- Hao G, Zhai J, Jiang H, et al. Acetylshikonin induces apoptosis of human leukemia cell line K562 by inducing S phase cell cycle arrest, modulating ROS accumulation, depleting Bcr-Abl and blocking NF-κB signaling. Biomed Pharmacothe. 2020;122:109677. doi:10.1016/j.biopha.2019.109677
- Wang Y, Wu H, Dong N, et al. Sulforaphane induces S-phase arrest and apoptosis via p53-dependent manner in gastric cancer cells. Sci Rep. 2021;11(1):2504. doi:10.1038/s41598-021-81815-2
- Navarro-Hortal MD, Varela-López A, Romero-Márquez JM, et al. Role of flavonoids against Adriamycin toxicity. Food Chem Toxicol. 2020;146:111820. doi:10.1016/j.fct.2020.111820
- Aljobaily N, Viereckl MJ, Hydock DS, et al. Creatine Alleviates Doxorubicin-Induced Liver Damage by Inhibiting Liver Fibrosis, Inflammation, Oxidative Stress, and Cellular Senescence. Nutrients. 2020;13(1):41. doi:10.3390/nu13010041
- Du W, Lu Q, Zhang M, Cao H, Zhang S. Synthesis and Characterization of Folate-Modified Cell Membrane Mimetic Copolymer Micelles for Effective Tumor Cell Internalization. ACS Appl. Bio Mater. 2021;4(4):3246–3255. doi:10.1021/acsabm.0c01612
- Christidi E, Brunham LR. Regulated cell death pathways in doxorubicin-induced cardiotoxicity. Cell Death Dis. 2021;12(4):339. doi:10.1038/s41419-021-03614-x
- Wu L, Wang L, Du Y, Zhang Y, Ren J. Mitochondrial quality control mechanisms as therapeutic targets in doxorubicin-induced cardiotoxicity. Trends Pharmacol Sci. 2023;44(1):34–49. doi:10.1016/j.tips.2022.10.003
- Ahmed A, Tait SWG. Targeting immunogenic cell death in cancer. Mol Oncol. 2020;14(12):2994–3006. doi:10.1002/1878-0261.12851
- Ma X, Yang S, Zhang T, et al. Bioresponsive immune-booster-based prodrug nanogel for cancer immunotherapy. Acta Pharmaceutica Sinica B. 2022;12(1):451–466. doi:10.1016/j.apsb.2021.05.016
- Fucikova J, Kepp O, Kasikova L, et al. Detection of immunogenic cell death and its relevance for cancer therapy. Cell Death Dis. 2020;11(11):1013. doi:10.1038/s41419-020-03221-2
- Zheng D, Liu J, Xie L, et al. Enzyme-instructed and mitochondria-targeting peptide self-assembly to efficiently induce immunogenic cell death. Acta pharmaceutica Sinica B. 2022;12(6):2740–2750. doi:10.1016/j.apsb.2021.07.005
- Yu Z, Guo J, Hu M, Gao Y, Huang L. Icaritin Exacerbates Mitophagy and Synergizes with Doxorubicin to Induce Immunogenic Cell Death in Hepatocellular Carcinoma. ACS nano. 2020;14(4):4816–4828. doi:10.1021/acsnano.0c00708
- Liang Q, Lan Y, Li Y, Cao Y, Li J, Liu Y. Crizotinib prodrug micelles co-delivered doxorubicin for synergistic immunogenic cell death induction on breast cancer chemo-immunotherapy. Eur j Pharm Biopharmaceutics. 2022;177:260–272. doi:10.1016/j.ejpb.2022.07.006
- Kim M, Lee JS, Kim W, et al. Aptamer-conjugated nano-liposome for immunogenic chemotherapy with reversal of immunosuppression. J Controlled Release. 2022;348:893–910. doi:10.1016/j.jconrel.2022.06.039
- Cheng K, Cai N, Zhu J, Yang X, Liang H, Zhang W. Tumor-associated macrophages in liver cancer: from mechanisms to therapy. Cancer commun. 2022;42(11):1112–1140. doi:10.1002/cac2.12345
- Xiang X, Wang J, Lu D, Xu X. Targeting tumor-associated macrophages to synergize tumor immunotherapy. Signal Transduction Targeted Therapy. 2021;6(1):75. doi:10.1038/s41392-021-00484-9
- Cruceriu D, Baldasici O, Balacescu O, Berindan-Neagoe I. The dual role of tumor necrosis factor-alpha (TNF-α) in breast cancer: molecular insights and therapeutic approaches. Cellular Oncology. 2020;43(1):1–18. doi:10.1007/s13402-019-00489-1
- Pan Y, Yu Y, Wang X, Zhang T. Tumor-Associated Macrophages in Tumor Immunity. Front Immunol. 2020;11:583084. doi:10.3389/fimmu.2020.583084
- Munir MT, Kay MK, Kang MH, et al. Tumor-Associated Macrophages as Multifaceted Regulators of Breast Tumor Growth. Int J Mol Sci. 2021;22(12):6526. doi:10.3390/ijms22126526
- Fang J, Ou Q, Wu B, et al. TcpC Inhibits M1 but Promotes M2 Macrophage Polarization via Regulation of the MAPK/NF-κB and Akt/STAT6 Pathways in Urinary Tract Infection. Cells. 2022;11(17):2674. doi:10.3390/cells11172674
- Luo G, Wang X, Cui Y, Cao Y, Zhao Z, Zhang J. Metabolic reprogramming mediates hippocampal microglial M1 polarization in response to surgical trauma causing perioperative neurocognitive disorders. J Neuroinflammation. 2021;18(1):267. doi:10.1186/s12974-021-02318-5
- Arabpour M, Saghazadeh A, Rezaei N. Anti-inflammatory and M2 macrophage polarization-promoting effect of mesenchymal stem cell-derived exosomes. Int Immunopharmacol. 2021;97:107823. doi:10.1016/j.intimp.2021.107823
- Wen J, Wang S, Guo R, Liu D. CSF1R inhibitors are emerging immunotherapeutic drugs for cancer treatment. Eur. J. Med. Chem. 2023;245(Pt 1):114884. doi:10.1016/j.ejmech.2022.114884
- Ramesh A, Brouillard A, Kumar S, Nandi D, Kulkarni A. Dual inhibition of CSF1R and MAPK pathways using supramolecular nanoparticles enhances macrophage immunotherapy. Biomaterials. 2020;227:119559. doi:10.1016/j.biomaterials.2019.119559
- Wang S, Sun J, Dastgheyb RM, Li Z. Tumor-derived extracellular vesicles modulate innate immune responses to affect tumor progression. Front Immunol. 2022;13:1045624. doi:10.3389/fimmu.2022.1045624