References
- Alison M NCATS launches drug repurposing program Nat Biotechnol 2012 30 7 571 572 22781662
- National Center for Advancing Translational Sciences Rescuing and repurposing drugs Available from: http://www.ncats.nih.gov/research/reengineering/rescue-repurpose/rescue-repurpose.html Accessed March 21, 2013
- Philippidis A NCATS MRC take aim at teaching old drug new tricks 2012 Available from: http://www.genengnews.com/insight-and-intelligenceand153/ncats-mrc-take-aim-at-teaching-old-drugs-new-tricks/77899618 Accessed June 16, 2013
- Medical Research Council Alzheimer’s, cancer and rare disease research to benefit from landmark MRC-AstraZeneca compound collaboration [press release] London MRC 2012 [Oct 31]. Available from: http://www.mrc.ac.uk/Newspublications/News/MRC008918 Accessed March 21, 2013
- Padhy BM Gupta YK Drug repositioning: re-investigating existing drugs for new therapeutic indications J Postgrad Med 2011 57 2 153 160 21654146
- Zhu S Stavrovskaya IG Drozda M Minocycline inhibits cytochrome c release and delays progression of amyotrophic lateral sclerosis in mice Nature 2002 417 6684 74 78 11986668
- Gao Z Li H Zhang H PDTD: a web-accessible protein database for drug target identification BMC Bioinformatics 2008 9 104 18282303
- Günther S Kuhn M Dunkel M SuperTarget and Matador: resources for exploring drug-target relationships Nucleic Acids Res 2008 36 Database issue D919 D922 17942422
- Knox C Law V Jewison T DrugBank 3.0: a comprehensive resource for ‘omics’ research on drugs Nucleic Acids Res 2011 39 Database issue D1035 D1041 21059682
- Ashburn TT Thor KB Drug repositioning: identifying and developing new uses for existing drugs Nat Rev Drug Discov 2004 3 8 673 683 15286734
- Ma’ayan A Jenkins SL Goldfarb J Iyengar R Network analysis of FDA approved drugs and their targets Mt Sinai J Med 2007 74 1 27 32 17516560
- Poh A Breathing new life into old drugs 2008 Available from: http://www.bio-itworld.com/issues/2008/nov-dec/chantest.html Accessed July 19, 2013
- Ha S Seo YJ Kwon MS Chang BH Han CK Yoon JH IDMap: facilitating the detection of potential leads with therapeutic targets Bioinformatics 2008 24 11 1413 1415 18417489
- Open PHACTS [website on the Internet] Available from: http://www.openphacts.org Accessed March 21, 2013
- Wu Z Wang Y Chen L Network-based drug repositioning Mol Biosyst 2013 9 6 1268 1281 23493874
- Emig D Ivliev A Pustovalova O Drug target prediction and repositioning using an integrated network-based approach PLoS One 2013 8 4 e60618 23593264
- von Eichborn J Murgueitio MS Dunkel M Koerner S Bourne PE Preissner R PROMISCUOUS: a database for network-based drug-repositioning Nucleic Acids Res 2011 39 Database issue D1060 D1066 21071407
- Giacomotto J Ségalat L High-throughput screening and small animal models, where are we? Br J Pharmacol 2010 160 2 204 216 20423335
- National Institutes of Health NIH and Lilly to generate public resource of approved and investigational medicines [press release] Bethesda(MD) NIH 2012 [Mar 13]. Available from: http://www.nih.gov/news/health/mar2012/ncats-13.htm Accessed March 21, 2013
- Thayer AM Drug repurposing Chem Eng News 2012 90 40 15 25
- Genetic Engineering and Biotechnology News Roche, Broad Institute seek new uses for old drugs 2012 Available from: http://www.genengnews.com/gen-news-highlights/roche-broad-institute-seek-new-uses-for-old-drugs/81247689 Accessed June 16, 2013
- Chong CR Chen X Shi L Liu OJ Sullivan DJJr A clinical drug library screen identifies astemizole as an antimalarial agent Nat Chem Biol 2006 2 8 415 416 16816845
- Huang R Southall N Wang Y The NCGC Pharmaceutical Collection: a comprehensive resource of clinically approved drugs enabling repurposing and chemical genomics Sci Transl Med 2011 3 80 80ps16
- Muthyala R Orphan/rare drug discovery through drug repositioning Drug Discov Today Ther Strateg 2011 8 3–4 71 76
- International Rare Diseases Research Consortium [website on the Internet] Available from: http://www.irdirc.org Accessed March 21, 2013
- Xu K Coté TR Database identifies FDA-approved drugs with potential to be repurposed for treatment of orphan diseases Brief Bioinform 2011 12 4 341 345 21357612
- US Food and Drug Administration A valuable resource for drug developers: the Rare Disease Repurposing Database (RDRD) 2011 Available from: http://www.fda.gov/ForIndustry/DevelopingProductsforRareDiseasesConditions/HowtoapplyforOrphanProductDesignation/ucm216147.htm Accessed March 21, 2013
- Marusina K Welsch DJ Lynn R Brock D Bahr N The CTSA Pharmaceutical Assets Portal – a public-private partnership model for drug repositioning Drug Discov Today Ther Strateg 2011 8 3–4 77 83 22768020
- World Intellectual Property Organization Re:Search [website on the Internet] Available from: http://www.wipo.int/research/en Accessed March 21, 2013
- Johns Hopkins Clinical Compound Screening Initiative [website on the Internet] Available from: http://www.jhccsi.org/background.html Accessed March 21, 2013
- Cures Within Reach [website on the Internet] Available from: http://www.cureswithinreach.org/about-us Accessed March 21, 2013
- Weir SJ DeGennaro LJ Austin C P Repurposing approved and abandoned drugs for the treatment and prevention of cancer through public-private partnerships Cancer Res 2012 72 5 1055 1058 22246671
- Hassig CA Smith LH Jackson M Creating the world’s most comprehensive drug repurposing library 2012 Available from: http://www.americanlaboratory.com/913-Technical-Articles/114059-Creating-the-World-s-Most-Comprehensive-Drug-Repurposing-Library Accessed June 16, 2013
- Arbanas C Washington University, Pfizer announce groundbreaking research collaboration 2010 Available from: http://news.wustl.edu/news/Pages/20770.aspx Accessed June 16, 2013
- Boston’s Children Hospital Children’s Hospital Boston and Pfizer enter into novel collaborative research agreement for muscular dystrophy therapeutics 2011 Available from: http://childrenshospital.org/newsroom/Site1339/mainpageS1339P795.html Accessed June 16, 2013
- Seoane-Vazquez E Rodriguez-Monguio R Szeinbach SL Visaria J Incentives for orphan drug research and development in the United States Orphanet J Rare Dis 2008 3 33 19087348
- Wellman-Labadie O Zhou Y The US Orphan Drug Act: rare disease research stimulator or commercial opportunity? Health Policy 2010 95 2–3 216 228 20036435
- Tambuyzer E Rare diseases, orphan drugs and their regulation: questions and misconceptions Nat Rev Drug Discov 2010 9 12 921 929 21060315
- Peabody J W Ruby A Cannon P The economics of orphan drug policy in the US. Can the legislation be improved? Pharmacoeconomics 1995 8 5 374 384 10160072
- Allarakhia M Evolving concept of openness in the health commons: engaging global stakeholders in technology development for malaria 2011 Available from: http://www.bioendeavor.net/CommonData/Resources/ECHC.pdf Accessed March 21, 2013
- Agres T New life for old drugs 2011 Available from: http://www.dddmag.com/articles/2011/07/new-life-old-drugs Accessed June 16, 2013
- Oprea TI Bauman JE Bologa CG Drug repurposing from an academic perspective Drug Discov Today Ther Strateg 2011 8 3–4 61 69 22368688
- Muthyala R Orphan/rare drug discovery through drug repositioning Drug Discovery Today 2011 8 3–4 71 76
- Scott C Núñez M Grid computing guiding malaria drug discovery 2009 Available from: http://www.scidev.net/en/news/grid-computing-guiding-malaria-drug-discovery.html Accessed June 16, 2013
- Indiana University-Purdue University Indianapolis Molecules made by IUPUI students may have potential to cure diseases 2011 Available from: http://newscenter.iupui.edu/4997/Molecules-Made-by-IUPUI-Students-May-Have-Potential-To-Cure-Diseases110124 Accessed June 16, 2013
- American Type Culture Collection What we offer Available from: http://www.atcc.org/About/About_ATCC/What_We_Offer.aspx Accessed June 16, 2013
- Wu Y Fairfield AS Oduola A Cypess RH The Malaria Research and Reference Reagent Resource (MR4) Center – creating African opportunities Afr J Med Sci 2001 30 Suppl 52 54
- Allarakhia M Ajuwon L Understanding and creating value from open source drug discovery for neglected tropical diseases Expert Opin Drug Discov 2012 7 8 643 657 22657529
- Allarakhia M Developing a framework for understanding and enabling open source drug discovery Expert Opin Drug Discov 2010 5 8 709 714 22827795
- Kinnings SL Liu N Buchmeier N Tonge PJ Xie L Bourne PE Drug discovery using chemical systems biology: repositioning the safe medicine Comtan to treat multi-drug and extensively drug resistant tuberculosis PLoS Comput Biol 2009 5 e1000423 19578428
- Gloeckner C Garner AL Mersha F Repositioning of an existing drug for the neglected tropical disease onchocerciasis Proc Natl Acad Sci U S A 2010 107 8 3424 3429 20142509
- Lim LE Vilchèze C Ng C Jacobs WRJr Ramón-García S Thompson CJ Anthelmintic avermectins kill Mycobacterium tuberculosis, including multidrug-resistant clinical strains Antimicrob Agents Chemother 2013 57 2 1040 1046 23165468
- Sundar S Jha TK Thakur C P Bhattacharya SK Rai M Oral miltefosine for the treatment of Indian visceral leishmaniasis Trans R Soc Trop Med Hyg 2006 100 Suppl 1 S26 S33 16730038
- Miguel DC Yokoyama-Yasunaka JK Andreoli WK Mortara RA Uliana SR Tamoxifen is effective against Leishmania and induces a rapid alkalinization of parasitophorous vacuoles harbouring Leishmania (Leishmania) amazonensis amastigotes J Antimicrob Chemother 2007 60 3 526 534 17584801
- Freitas-Junior LH Chatelain E Kim HA Siqueira-Neto JL Visceral leishmaniasis treatment: what do we have, what do we need and how to deliver it? Int J Parasitol Drugs Drug Resist 2012 2 11 19
- [No authors listed] One world problem, one world solution? Nature Rev Drug Discov 2005 4 701
- Sardana D Zhu C Zhang M Gudivada RC Yang L Jegga AG Drug repositioning for orphan diseases Brief Bioinform 2011 12 4 346 356 21504985
- Pollastri MP Campbell RK Target repurposing for neglected diseases Future Med Chem 2011 3 10 1307 1315 21859304
- Robertson SA Renslo AR Drug discovery for neglected tropical diseases at the Sandler Center Future Med Chem 2011 3 10 1279 1288 21859302
- Bhardwaj A Scaria V Raghava GP Open source drug discovery – a new paradigm of collaborative research in tuberculosis drug development Tuberculosis (Edinb) 2011 91 5 479 486 21782516
- Open Source Drug Discovery [website on the Internet] Available from: http://www.osdd.net Accessed February 15, 2012
- Sreelata M Open source TB megaproject yields first fruits 2010 Available from: http://www.scidev.net/en/news/open-source-tb-mega-project-yields-first-fruits.html Accessed June 16, 2013
- Nelson R National Innovation Systems: A Comparative Analysis Oxford Oxford University Press 1993
- Freeman C Technology and Economic Performance: Lessons from Japan London Pinter 1987
- Coles LD Cloyd JC The role of academic institutions in the development of drugs for rare and neglected diseases Clin Pharmacol Ther 2012 92 2 193 202 22760003
- Ekins S Williams AJ Krasowski MD Freundlich JS In silico repositioning of approved drugs for rare and neglected diseases Drug Discov Today 2011 16 7–8 298 310 21376136
- Sardana D Zhu C Zhang M Gudivada RC Yang L Jegga AG Drug repositioning for orphan diseases Brief Bioinform 2011 12 4 346 356 21504985
- Allarakhia M Walsh S Managing knowledge assets under conditions of radical change: The case of the pharmaceutical industry Technovation 2011 31 2 105 117
- Metcalfe S The economic foundations of technology policy: equilibrium and evolutionary perspectives Stoneman P Handbook of the Economics of Innovation and Technological Change Oxford Blackwell 1995
- Hess C Ostrom E Understanding Knowledge as a Commons: From Theory to Practice Cambridge (MA) Blackwell 2006
- Organisation for Economic Co-operation and Development National systems of innovation 1997 Available from: http://www.oecd.org/science/inno/2101733.pdf Accessed March 21, 2013
- PR Newswire Transparency Life Sciences launches Indication Finder crowdsourcing tool for drug repurposing 2012 Available from: http://www.prnewswire.com/news-releases/transparency-life-sciences-launches-indication-finder-crowdsourcing-tool-for-drug-repurposing-175572351.html Accessed April 2, 2013