Costunolide Inhibits Chronic Kidney Disease Development by Attenuating IKKβ/NF-κB Pathway

References

• Kidney Disease: Improving Global Outcomes (KDIGO) Diabetes Work Group. KDIGO 2020 clinical practice guideline for diabetes management in chronic kidney disease. Kidney Int. 2020;98(4S):S1–S115. doi:10.1016/j.kint.2020.06.019
   PubMedGoogle Scholar
• Ammirati AL. Chronic Kidney Disease. Rev Assoc Med Bras. 2020;66(Suppl 1):s03–s09. doi:10.1590/1806-9282.66.S1.3
   PubMed Web of Science ®Google Scholar
• Jha V, Garcia-Garcia G, Iseki K, et al. Chronic kidney disease: global dimension and perspectives. Lancet. 2013;382(9888):260–272. doi:10.1016/S0140-6736(13)60687-X
   PubMed Web of Science ®Google Scholar
• Wu P-H, Lin Y-T, Chiu Y-W, et al. The relationship of indoxyl sulfate and P-cresyl sulfate with target cardiovascular proteins in hemodialysis patients. Sci Rep. 2021;11(1):3786. doi:10.1038/s41598-021-83383-x
   PubMed Web of Science ®Google Scholar
• Dong Z, Sun Y, Wei G, Li S, Zhao Z. A nucleoside/nucleobase-rich extract from cordyceps sinensis inhibits the epithelial–mesenchymal transition and protects against renal fibrosis in diabetic nephropathy. Molecules. 2019;24(22):4119. doi:10.3390/molecules24224119
   PubMed Web of Science ®Google Scholar
• You Y-K, Luo Q, Wu W-F, et al. Petchiether A attenuates obstructive nephropathy by suppressing TGF-β/Smad3 and NF-κB signalling. J Cell & Mol Med. 2019;23(8):5576–5587. doi:10.1111/jcmm.14454
   PubMed Web of Science ®Google Scholar
• Zhang X, Ritter JK, Li N. Sphingosine-1-phosphate pathway in renal fibrosis. Am J Physiol Renal Physiol. 2018;315(4):F752–F756. doi:10.1152/ajprenal.00596.2017
   PubMed Web of Science ®Google Scholar
• Ren L, Guo X-Y, Gao F, Jin M-L, Song X-N. Identification of the perturbed metabolic pathways associating with renal fibrosis and evaluating metabolome changes of pretreatment with astragalus polysaccharide through liquid chromatography quadrupole time-of-flight mass spectrometry. Front Pharmacol. 2020;10:1623. doi:10.3389/fphar.2019.01623
   PubMed Web of Science ®Google Scholar
• Kim S, Kang S-W, Joo J, et al. Characterization of ferroptosis in kidney tubular cell death under diabetic conditions. Cell Death Dis. 2021;12(1):1–14. doi:10.1038/s41419-021-03452-x
   PubMedGoogle Scholar
• Zhang S, Wu J, Wang H, et al. Liposomal oxymatrine in hepatic fibrosis treatment: formulation. Asse AAPS Pharm. 2014;15(3):620–629. doi:10.1208/s12249-014-0086-y
   PubMed Web of Science ®Google Scholar
• Kadatane SP, Satariano M, Massey M, Mongan K, Raina R. The Role of Inflammation in CKD. Cells. 2023;12(1581):1581. doi:10.3390/cells12121581
   PubMedGoogle Scholar
• Mihai S, Codrici E, Popescu ID, et al. Inflammation-related mechanisms in chronic kidney disease prediction, progression, and outcome. J Immunol Res. 2018;2018:2180373. doi:10.1155/2018/2180373
   PubMed Web of Science ®Google Scholar
• Agharazii M, St-Louis R, Gautier-Bastien A, et al. Inflammatory cytokines and reactive oxygen species as mediators of chronic kidney disease-related vascular calcification. Am J Hypertens. 2015;28(6):746–755. doi:10.1093/ajh/hpu225
   PubMed Web of Science ®Google Scholar
• Luan J, Fu J, Jiao C, et al. IL-18 deficiency ameliorates the progression from AKI to CKD. Cell Death Dis. 2022;13(11):957. doi:10.1038/s41419-022-05394-4
   PubMed Web of Science ®Google Scholar
• Ma L-J, Corsa BA, Zhou J, et al. Angiotensin Type 1 Receptor Modulates Macrophage Polarization and Renal Injury in Obesity. Am J Physiol Renal Physiol. 2011;300(5):F1203–1213. doi:10.1152/ajprenal.00468.2010
   PubMed Web of Science ®Google Scholar
• Tseng K-F, Tsai P-H, Wang J-S, Chen F-Y, Shen M-Y. Sesamol attenuates renal inflammation and arrests reactive-oxygen-species-mediated IL-1β secretion via the HO-1-induced inhibition of the ikkα/nfκb pathway in vivo and in vitro. Antioxidants. 2022;11(12):2461. doi:10.3390/antiox11122461
   Web of Science ®Google Scholar
• Li J, Cao F, Yin H-L, et al. Ferroptosis: past, present and future. Cell Death Dis. 2020;11(2):88. doi:10.1038/s41419-020-2298-2
   PubMed Web of Science ®Google Scholar
• Yang WS, Stockwell BR. Synthetic lethal screening identifies compounds activating iron-dependent, nonapoptotic cell death in oncogenic-RAS-harboring cancer cells. Chem Biol. 2008;15(3):234–245. doi:10.1016/j.chembiol.2008.02.010
   PubMedGoogle Scholar
• Takada Y, Itoh H, Paudel A, et al. Discovery of gramicidin a analogues with altered activities by multidimensional screening of a one-bead-one-compound library. Nat Commun. 2020;11(1):4935. doi:10.1038/s41467-020-18711-2
   PubMed Web of Science ®Google Scholar
• Rasul A, Bao R, Malhi M, et al. Induction of apoptosis by costunolide in bladder cancer cells is mediated through ROS generation and mitochondrial dysfunction. Molecules. 2013;18(2):1418–1433. doi:10.3390/molecules18021418
   PubMed Web of Science ®Google Scholar
• Wei M, Li J, Qiu J, et al. Costunolide induces apoptosis and inhibits migration and invasion in H1299 lung cancer cells. Oncol Rep. 2020;43(6):1986–1994. doi:10.3892/or.2020.7566
   PubMed Web of Science ®Google Scholar
• Hu M, Liu L, Yao W. Activation of P53 by costunolide blocks glutaminolysis and inhibits proliferation in human colorectal cancer cells. Gene. 2018;678:261–269. doi:10.1016/j.gene.2018.08.048
   PubMed Web of Science ®Google Scholar
• Zhuge W, Chen R, Vladimir K, et al. Costunolide specifically binds and inhibits thioredoxin reductase 1 to induce apoptosis in colon cancer. Cancer Lett. 2018;412:46–58. doi:10.1016/j.canlet.2017.10.006
   PubMed Web of Science ®Google Scholar
• Inan MS, Razzaque MS, Taguchi T. Pathological significance of renal expression of NF-kappa B. Contrib Nephrol. 2003;139:90–101. doi:10.1159/000071738
   PubMed Web of Science ®Google Scholar
• Ren N, Wang W-F, Zou L, Zhao Y-L, Miao H, Zhao -Y-Y. The nuclear factor kappa b signaling pathway is a master regulator of renal fibrosis. Front Pharmacol. 2023;14:1335094. doi:10.3389/fphar.2023.1335094
   PubMed Web of Science ®Google Scholar
• He Y, Moqbel SAA, Xu L, et al. Costunolide inhibits matrix metalloproteinases expression and osteoarthritis via the NF‑κB and Wnt/Β‑catenin signaling pathways. Mol Med Rep. 2019;20(1):312–322. doi:10.3892/mmr.2019.10239
   PubMed Web of Science ®Google Scholar
• Liu B, Rong Y, Sun D, et al. Costunolide inhibits pulmonary fibrosis via regulating NF-kB and TGF-Β1/Smad2/Nrf2-NOX4 signaling pathways. Biochem Biophys Res Commun. 2019;510(2):329–333. doi:10.1016/j.bbrc.2019.01.104
   PubMed Web of Science ®Google Scholar
• Ren Y, Du C, Yan L, et al. CTGF siRNA ameliorates tubular cell apoptosis and tubulointerstitial fibrosis in obstructed mouse kidneys in a sirt1-independent manner. Drug Des Devel Ther. 2015;9:4155–4171. doi:10.2147/DDDT.S86748
   PubMed Web of Science ®Google Scholar
• Zhang Q-F. Ulinastatin inhibits renal tubular epithelial apoptosis and interstitial fibrosis in rats with unilateral ureteral obstruction. Mol Med Rep. 2017;16(6):8916–8922. doi:10.3892/mmr.2017.7692
   PubMed Web of Science ®Google Scholar
• Kang D-H, Nakagawa T, Feng L, Johnson RJ. Nitric oxide modulates vascular disease in the remnant kidney model. Am J Pathol. 2002;161(1):239–248. doi:10.1016/S0002-9440(10)64175-2
   PubMed Web of Science ®Google Scholar
• Yang R, Xu X, Li H, et al. P53 Induces miR199a-3p to Suppress SOCS7 for STAT3 activation and renal fibrosis in UUO. Sci Rep. 2017;7(1):43409. doi:10.1038/srep43409
   PubMedGoogle Scholar
• Li J, Bai L, Wei F, et al. Therapeutic mechanisms of herbal medicines against insulin resistance: a review. Front Pharmacol. 2019;10:661. doi:10.3389/fphar.2019.00661
   PubMed Web of Science ®Google Scholar
• Zheng H, Chen Y, Zhang J, et al. Evaluation of protective effects of costunolide and dehydrocostuslactone on ethanol-induced gastric ulcer in mice based on multi-pathway regulation. Chem Biol Interact. 2016;250:68–77. doi:10.1016/j.cbi.2016.03.003
   PubMed Web of Science ®Google Scholar
• Fu D, Wu D, Cheng W, et al. Costunolide induces autophagy and apoptosis by activating ROS/MAPK signaling pathways in renal cell carcinoma. Front Oncol. 2020;10:582273. doi:10.3389/fonc.2020.582273
   PubMed Web of Science ®Google Scholar
• Yan Q, Luo H, Wang B, et al. Correlation between PKB/Akt, GSK-3β expression and tubular epithelial-mesenchymal transition in renal allografts with chronic active antibody-mediated rejection. Exp Ther Med. 2017;13(5):2217–2224. doi:10.3892/etm.2017.4261
   PubMed Web of Science ®Google Scholar
• Xing Q, Yates K, Tahtinen M, Shearier E, Qian Z, Zhao F. Decellularization of fibroblast cell sheets for natural extracellular matrix scaffold preparation. Tissue Eng Part C Methods. 2015;21(1):77–87. doi:10.1089/ten.tec.2013.0666
   PubMed Web of Science ®Google Scholar
• Aoki K, Teshima Y, Kondo H, et al. Role of indoxyl sulfate as a predisposing factor for atrial fibrillation in renal dysfunction. J Am Heart Assoc. 2015;4(10):e002023. doi:10.1161/JAHA.115.002023
   PubMed Web of Science ®Google Scholar
• Chambers SM, Boles NC, Lin K-YK, et al. Hematopoietic fingerprints: an expression database of stem cells and their progeny. Cell Stem Cell. 2007;1(5):578–591. doi:10.1016/j.stem.2007.10.003
   PubMedGoogle Scholar
• Panzer U, Kurts C. T cell cross-talk with kidney dendritic cells in glomerulonephritis. J Mol Med. 2010;88(1):19–26. doi:10.1007/s00109-009-0541-5
   PubMed Web of Science ®Google Scholar
• Sood P, Hariharan S. Anti-CD20 Blocker Rituximab in Kidney Transplantation. Transplantation. 2018;102(1):44–58. doi:10.1097/TP.0000000000001849
   PubMed Web of Science ®Google Scholar
• Wang J, Huang L, Mou C, et al. Mucosal immune responses induced by oral administration recombinant Bacillus subtilis expressing the COE antigen of PEDV in newborn piglets. Biosci Rep. 2019;39(3):BSR20182028. doi:10.1042/BSR20182028
   PubMedGoogle Scholar
• Xie F, Zhang H, Zheng C, Shen X-F. Costunolide improved dextran sulfate sodium-induced acute ulcerative colitis in mice through NF-κB, STAT1/3, and Akt signaling pathways. Int Immunopharmacol. 2020;84:106567. doi:10.1016/j.intimp.2020.106567
   PubMed Web of Science ®Google Scholar
• Zhou B, Zhang J-Y, Liu X-S, et al. Tom20 senses iron-activated ROS signaling to promote melanoma cell pyroptosis. Cell Res. 2018;28(12):1171–1185. doi:10.1038/s41422-018-0090-y
   PubMed Web of Science ®Google Scholar
• Zhang Y, Zhang Z, Huang L, et al. Augmenter of liver regeneration knockout aggravates tubular ferroptosis and macrophage activation by regulating carnitine palmitoyltransferase-1A-induced lipid metabolism in diabetic nephropathy. Acta Physiol. 2024;2024:e14159. doi:10.1111/apha.14159
   Google Scholar
• Wang Y, Shen Z, Mo S, et al. Crosstalk among proximal tubular cells, macrophages, and fibroblasts in acute kidney injury: single-cell profiling from the perspective of ferroptosis. Hum Cell. 2024;37(4):1039–1055. doi:10.1007/s13577-024-01072-z
   Web of Science ®Google Scholar
• An G, Wu F, Huang S, et al. Effects of CCL5 on the biological behavior of breast cancer and the mechanisms of its interaction with tumor‑associated macrophages. Oncol Rep. 2019;42(6):2499–2511. doi:10.3892/or.2019.7344
   PubMed Web of Science ®Google Scholar
• Yuan J-L, Tao -Y-Y, Wang Q-L, Shen L, Liu C-H. Fuzheng huayu formula () prevents rat renal interstitial fibrosis induced by HgCl2 via antioxidative stress and down-regulation of nuclear factor-kappa b activity. Chin J Integr Med. 2017;23(8):598–604. doi:10.1007/s11655-016-2540-z
   PubMed Web of Science ®Google Scholar
• Luo L-P, Suo P, Ren -L-L, Liu H-J, Zhang Y, Zhao -Y-Y. Shenkang injection and its three anthraquinones ameliorates renal fibrosis by simultaneous targeting IƙB/NF-ƙB and Keap1/Nrf2 signaling pathways. Front Pharmacol. 2021;12:800522. doi:10.3389/fphar.2021.800522
   PubMed Web of Science ®Google Scholar
• Zhang L, Wang X-Z, Li Y-S, Zhang L, Hao L-R. Icariin ameliorates IgA nephropathy by inhibition of nuclear factor kappa b/Nlrp3 Pathway. FEBS Open Bio. 2017;7(1):54–63. doi:10.1002/2211-5463.12161
   PubMed Web of Science ®Google Scholar
• Hu X, Zhang X, Jin G, Shi Z, Sun W, Chen F. Geniposide reduces development of streptozotocin-induced diabetic nephropathy via regulating nuclear factor-Kappa B signaling pathways. Fundam Clin Pharmacol. 2017;31(1):54–63. doi:10.1111/fcp.12231
   PubMed Web of Science ®Google Scholar
• Chen J, Tang Y, Zhong Y, et al. P2Y12 inhibitor clopidogrel inhibits renal fibrosis by blocking macrophage-to-myofibroblast transition. Mol Ther. 2022;30(9):3017–3033. doi:10.1016/j.ymthe.2022.06.019
   PubMed Web of Science ®Google Scholar
• Chen M, Menon MC, Wang W, et al. HCK induces macrophage activation to promote renal inflammation and fibrosis via suppression of autophagy. Nat Commun. 2023;14(1):4297. doi:10.1038/s41467-023-40086-3
   PubMed Web of Science ®Google Scholar
• Antonios JK, Yao Z, Li C, Rao AJ, Goodman SB. Macrophage polarization in response to wear particles in vitro. Cell Mol Immunol. 2013;10(6):471–482. doi:10.1038/cmi.2013.39
   PubMed Web of Science ®Google Scholar
• Tong WW, Zhang C, Hong T, et al. Silibinin alleviates inflammation and induces apoptosis in human rheumatoid arthritis fibroblast-like synoviocytes and has a therapeutic effect on arthritis in rats. Sci Rep. 2018;8(1):3241. (). doi:10.1038/s41598-018-21674-6
   PubMed Web of Science ®Google Scholar