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Drug Design, Development and Therapy Volume 7, 2013 - Issue
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Original Research

In vitro and in vivo characterization of the antimalarial lead compound SSJ-183 in Plasmodium models

Sarah Schleiferböck1 Swiss Tropical and Public Health Institute, Basel, Switzerland;2 University of Basel, Basel, Switzerland
,
Christian Scheurer1 Swiss Tropical and Public Health Institute, Basel, Switzerland;2 University of Basel, Basel, Switzerland
,
Masataka Ihara3 Drug Discovery Science Research Center, Hoshi University, Shinagawa, Tokyo, Japan;4 Synstar Japan Co, Ltd, Odawara, Japan
,
Isamu Itoh3 Drug Discovery Science Research Center, Hoshi University, Shinagawa, Tokyo, Japan;4 Synstar Japan Co, Ltd, Odawara, Japan
,
Ian Bathurst5 Medicines for Malaria Venture, Geneva, Switzerland
,
Jeremy N Burrows5 Medicines for Malaria Venture, Geneva, Switzerland
,
Pascal Fantauzzi5 Medicines for Malaria Venture, Geneva, Switzerland
,
Julie Lotharius5 Medicines for Malaria Venture, Geneva, Switzerland
,
Susan A Charman6 Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Parkville, VIC, Australia
,
Julia Morizzi6 Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Parkville, VIC, Australia
,
David M Shackleford6 Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Parkville, VIC, Australia
,
Karen L White6 Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Parkville, VIC, Australia
,
Reto Brun1 Swiss Tropical and Public Health Institute, Basel, Switzerland;2 University of Basel, Basel, Switzerland
&
Sergio Wittlin1 Swiss Tropical and Public Health Institute, Basel, Switzerland;2 University of Basel, Basel, SwitzerlandCorrespondence[email protected]
 show all
Pages 1377-1384 | Published online: 15 Nov 2013

References

  • World Health Organization World Malaria Report 2011 Summary and Keypoints. Available from: http://www.who.int/malaria/world_malaria_report_2011/wmr2011_summary_keypoints.pdf Accessed September 8, 2012
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  • Ge J-F Arai C Yang M Discovery of novel benzo[a]phenoxazine SSJ-183 as a drug candidate for malaria ACS Med Chem Lett 2010 1 7 360 364
  • Lu J Arai C Md AB Ihara M Plasmodium berghei proteome changes in response to SSJ-183 treatment Bioorg Med Chem 2011 19 13 4144 4147 21622001
  • Burrows JN Hooft van Huijsduijnen R Möhrle JJ Oeuvray C Wells TN Designing the next generation of medicines for malaria control and eradication Malar J 2013 12 187 23742293
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  • Maerki S Brun R Charman S Dorn A Matile H Wittlin S In vitro assessment of the pharmacodynamic properties and the partitioning of OZ277/RBx-11160 in cultures of Plasmodium falciparum J Antimicrob Chemother 2006 58 52 58 16735432
  • Fivelman QL Adagu IS Warhurst DC Fixed-ratio isobologram method for studying in vitro interactions between atovaquone and proguanil or dihydroartemisinin against drug-resistant strains of Plasmodium falciparum Antimicrob Agents Chemother 2004 48 11 4097 4102 15504827
  • Charman SA Arbe-Barnes S Bathurst IC Synthetic ozonide drug candidate OZ439 offers new hope for a single-dose cure of uncomplicated malaria Proc Natl Acad Sci U S A 2011 108 11 4400 4405 21300861
  • Akoachere M Buchholz K Fischer E In vitro assessment of methylene blue on chloroquine-sensitive and -resistant Plasmodium falciparum strains reveals synergistic action with artemisinins Antimicrob Agents Chemother 2005 49 11 4592 4597 16251300
  • White NJ Qinghaosu (artemisinin): the price of success Science 2008 320 5874 330 334 18420924
  • Saralamba S Pan-Ngum W Maude RJ Intrahost modeling of artemisinin resistance in Plasmodium falciparum Proc Natl Acad Sci U S A 2011 108 1 397 402 21173254
  • Dondorp AM Yeung S White L Artemisinin resistance: current status and scenarios for containment Nat Rev Microbiol 2010 8 4 272 280 20208550
  • Witkowski B Khim N Chim P Reduced artemisinin susceptibility of Plasmodium falciparum ring stages in western Cambodia Antimicrob Agents Chemother 2013 57 2 914 923 23208708
  • Brunner R Aissaoui H Boss C Identification of a new chemical class of antimalarials J Infect Dis 2012 206 5 735 743 22732921

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