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Review

Is obesity in women protective against osteoporosis?

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Pages 273-282 | Published online: 04 Jul 2011

References

  • Kado DM Huang MH Karlamangla AS Barrett-Connor E Greendale GA Hyperkyphotic posture predicts mortality in older community-dwelling men and women: a prospective study J Am Geriatr Soc 2004 52 1662 1667 15450042
  • Rossner S Obesity: the disease of the twenty-first century Int J Obes Relat Metab Disord 2002 26 Suppl 4 S2 S4 12457290
  • Hu FB Overweight and obesity in women: health risks and consequences J Women Health (Larchmt) 2003 12 2 163 172
  • Obesity: preventing and managing the global epidemic. Report of a WHO consultation World Health Organ Tech Rep Ser 2000 894 1 253
  • Albala C Yanez M Devoto E Sostin C Zeballos L Santos JL Obesity as a protective factor for postmenopausal osteoporosis Int J Obes Relat Metab Disord 1996 20 1027 1032 8923160
  • Reid IR Relationships among body mass, its components, and bone Bone 2002 31 547 555 12477567
  • NIH Consensus development panel on osteoporosis JAMA 2001 285 785 795 11176917
  • Cagnacci A Zanin R Cannoletta M Generali M Caretto S Volpe A Menopause, estrogens, progestin, or their combination on body weight and anthropometric measurements Fertil Steril 2007 88 6 1603 1608 17481628
  • Lebovitz HE The relationship of obesity to the metabolic syndrome Int J Clin Pract Suppl 2003 134 18 27 12793594
  • Sowers JR Obesity as a cardiovascular risk factor Am J Med 2003 8 37S 41S 14678864
  • Zhao LJ Jiang H Papasian CJ Correlation of obesity and osteoporosis: effect of fat mass on the determination of osteoporosis J Bone Miner Res 2008 23 17 29 17784844
  • Johansson C Black D Johnell O Oden A Mellstrom D Bone mineral density is a predictor of survival Calcif Tissue Int 1998 63 190 196 9701621
  • Brown S Rosen CJ Osteoporosis Med Clin North Am 2003 87 1039 1063 14621330
  • Goulding A Jones IE Taylor RW Williams SM Manning PJ Bone mineral density and body composition in boys with distal forearm fractures: a dual-energy X-ray absorptiometry study J Pediatr 2001 139 509 515 11598596
  • Kveiborg M Flyvbjerg A Rattan SI Kassem M Changes in the insulin-lik growth factor-system may contribute to in vitro agerelate impaired osteoblast functions Exp Geronto 2000 35 1061 1074
  • Von der Recke P Hansen MA Hassager C The association between low bone mass at the menopause and cardiovascular mortality Am J Med 1999 106 273 278 10190374
  • Reid IR Plank LD Evans MC Fat mass is an important determinant of whole body bone density in premenopausal women but not in men J Clin Endoc Metab 1992 75 779 782
  • Eriksen EF Colvard DS Berg NJ Evidence of estrogen receptors in normal human osteoblast-like cells Science 1988 1 241 4861 84 86 3388021
  • Kim HJ New understanding of glucocorticoid action in bone cells BMB Rep 2010 43 8 524 529 20797313
  • Komm BS Terpening CM Benz DJ Estrogen binding, receptor mRNA, and biologic response in osteoblast-like osteosarcoma cells Science 1988 241 4861 81 84 3164526
  • Migliaccio S Davis VL Gibson MK Gray TK Korach KS Estrogens modulate the responsiveness of osteoblast-like cells (ROS 17/2.8) stably transfected with estrogen receptor Endocrinology 1992 130 5 2617 2624 1572285
  • Gomez-Ambrosi J Rodriguez A Catalan V Fruhbeck G The bone-adipose axis in obesity and weight loss Obes Surg 2008 18 1134 1143 18563500
  • Takeda S Effect of obesity on bone metabolism Clin Calcium 2008 18 632 637 18445881
  • Gimble JM Zvonic S Floyd ZE Kassem M Nuttall ME Playing with bone and fat J Cell Biochem 2006 98 251 266 16479589
  • Fukumoto S Martrin TJ Bone as an endocrine organ Trends Endocrinol Metab 2009 20 5 230 236 19546009
  • Cummings SR Black DM Nevitt MC Bone density at various sites for prediction of hip fractures. The Study of Osteoporotic Fractures Research Group Lancet 1993 341 72 75 8093403
  • Melton LJIII Atkinson EJ O’Fallon WM Wahner HW Riggs BL Long-term fracture prediction by bone mineral assessed at different skeletal sites J Bone Miner Res 1993 8 1227 1233 8256660
  • Mazess RB Barden HS Ettinger M Spine and femur density using dual-photon absorptiometry in US white women Bone Miner Res 1987 2 211 219
  • Felson DT Zhang Y Hannan MT Anderson JJ Effects of weight and body mass index on bone mineral density in men and women: The Framingham study J Bone Miner Res 1993 8 567 573 8511983
  • Marcus R Greendale G Blunt BA Correlates of bone mineral density in the postmenopausal estrogen/progestin interventions trial J Bone Miner Res 1994 9 1467 1476 7817832
  • Reid IR Ames R Evans MC Determinants of total body and regional bone mineral density in normal postmenopausal women – a key role for fat mass J Clin Endocrinol Metab 1992 75 45 51 1619030
  • Ravn P Cizza G Bjarnason NH Thompson D Low body mass index is an important risk factor for low bone mass and increased bone loss in early postmenopausal women. Early Postmenopausal Intervention Cohort (EPIC) study group J Bone Miner Res 1999 14 1622 1627 10469292
  • Khosla S Atkinson EJ Riggs BL Melton LJIII Relationship between body composition and bone mass in women J Bone Miner Res 1996 11 857 863 8725184
  • Pluijm SM Visser M Smit JH Popp-Snijders C Roos JC Lips P Determinants of bone mineral density in older men and women: Body composition as mediator J Bone Miner Res 2001 16 2142 2151 11697812
  • Hsu YH Venners SA Terwedow HA Relation of body composition, fat mass, and serum lipids to osteoporotic fractures and bone mineral density in Chinese men and women Am J Clin Nutr 2006 83 146 154 16400063
  • Greco EA Fornari R Rossi F Is obesity protective for osteoporosis? Evaluation of bone mineral density in individuals with high body mass index Int J Clin Pract 2010 64 6 817 820 20518955
  • Blum M Harris SS Must A Leptin, body composition and bone mineral density in premenopausal women Calcif Tissue Int 2003 73 27 32 14506951
  • Kim KC Shin DH Lee SY Relation between Obesity and Bone Mineral Density and Vertebral Fractures in Korean Postmenopausal Women Yonsei Med J 2010 51 6 857 863 20879051
  • Castro JP Joseph LA Shin JJ Differential effect of obesity on bone mineral density in White, Hispanic and African American women: A cross sectional study Nutr Metab (Lond) 2005 2 9 15817133
  • Afghani A Goran MI Racial differences in the association of subcutaneous and visceral fat on bone mineral content in prepubertal children Calcif Tissue Int 2006 79 383 388 17115240
  • Reid IR Legge M Stapleton JP Evans MC Grey AB Regular exercise dissociates fat mass and bone density in premenopausal women J Clin Endocrinol Metab 1995 80 1764 1768 7775619
  • Reid IR Therapy of osteoporosis: Calcium, vitamin D, and exercise Am J Med Sci 1996 312 278 286 8969617
  • Manson JE Martin KA Postmenopausal hormonereplacement therapy N Engl J Med 2001 345 34 40 11439947
  • Sorensen MB Rosenfalck AM Hojgaard L Ottesen B Obesity and sarcopenia after menopause are reversed by sex hormone replacement therapy Obes Res 2001 9 622 626 11595778
  • De Gregorio LH Lacativa PG Melazzi AC Russo LA Glucocorticoid-induced osteoporosis Arq Bras Endocrinol Metabol 2006 50 793 801 17117304
  • Steinbuch M Youket TE Cohen S Oral glucocorticoid use is associated with an increased risk of fracture Osteoporos Int 2004 15 323 328 14762652
  • Gaillard D Wabitsch M Pipy B Negrel R Control of terminal differentiation of adipose precursor cells by glucocorticoids J Lipid Res 1991 32 569 579 1649886
  • Livingstone DE Jones GC Smith K Understanding the role of glucocorticoids in obesity: Tissue-specific alterations of corticosterone metabolism in obese Zucker rats Endocrinology 2000 141 560 563 10650936
  • Lecka-Czernik B Moerman EJ Grant DF Lehmann JM Manolagas SC Jilka RL Divergent effects of selective peroxisome proliferator-activated receptor-gamma 2 ligands on adipocyte versus osteoblast differentiation Endocrinology 2002 143 2376 2384 12021203
  • Riche DM Travis King S Bone loss and fractures risk associated with thiazolidinedione therapy Endocrinology 2007 148 6 2669 2680 17332064
  • Kadowaki T Yamauchi T Adiponectin and adiponectin receptors Endocr Rev 2005 26 439 451 15897298
  • Steppan CM Crawford DT Chidsey-Frink KL Ke H Swick AG Leptin is a potent stimulator of bone growth in ob/ob mice Regul Pept 2000 92 73 78 11024568
  • Vendrell J Broch M Vilarrasa N Resistin, adiponectin, ghrelin, leptin, and proinflammatory cytokines: Relationships in obesity Obes Res 2004 12 962 971 15229336
  • Tilg H Moschen AR Inflammatory mechanisms in the regulation of insulin resistance Mol Med 2008 14 3–4 222 231 18235842
  • Magni P Dozio E Galliera E Ruscica M Corsi MM Molecular Aspects of Adipokine-Bone Interactions Curr Mol Med 2010 10 6 522 532 20642443
  • Wade GN Gray JM Bartness TJ Gonadal influences on adiposity Int J Obes Relat Metab Disord 1985 9 Suppl 1 83 92
  • Smith EP Boyd J Frank GR Estrogen resistance caused by a mutation in the estrogen receptor gene in a man N Engl J Med 1994 331 1056 1061 8090165
  • Morishima A Grumbach MM Simpson ER Fisher C Qin K Aromatase deficiency in male and female siblings caused by a novel mutation and the physiological role of estrogens J Clin Endocrinol Metab 1995 80 3689 3698 8530621
  • Heine PA Taylor JA Iwamoto GA Lubahn DB Cooke PS Increased adipose tissue in male and female estrogen receptor-alpha knockout mice Proc Natl Acad Sci U S A 2000 97 12729 12734 11070086
  • Cooke PS Heine PA Taylor JA Lubahn DB The role of estrogen and estrogen receptor-alpha in male adipose tissue Mol Cell Endocrinol 2001 178 147 154 11403904
  • Maffei L Murata Y Rochira V Dysmetabolic syndrome in a man with a novel mutation of the aromatase gene: Effects of testosterone, alendronate, and estradiol treatment J Clin Endocrinol Metab 2004 89 61 70 14715828
  • Tchernof A Calles-Escandon J Sites CK Poehlman ET Menopause, central body fatness, and insulin resistance: Effects of hormone-replacement therapy Coron Artery Dis 1998 9 503 511 9847982
  • Gambacciani M Ciaponi M Cappagli B De Simone L Orlandi R Genazzani AR Prospective evaluation of body weight and body fat distribution in early postmenopausal women with and without hormonal replacement therapy Maturitas 2001 39 125 132 11514111
  • Jensen LB Vestergaard P Hermann AP Hormone replacement therapy dissociates fat mass and bone mass, and tends to reduce weight gain in early postmenopausal women: A randomized controlled 5-year clinical trial of the Danish Osteoporosis Prevention Study J Bone Miner Res 2003 18 333 342 12568411
  • Rossouw JE Anderson GL Prentice RL Risks and benefits of estrogen plus progestin in healthy postmenopausal women: Principal results From the Women’s Health Initiative randomized controlled trial JAMA 2002 288 321 333 12117397
  • Justesen J Stenderup K Ebbesen EN Mosekilde L Steiniche T Kassem M Adipocyte tissue volume in bone marrow is increased with aging and in patients with osteoporosis Biogerontology 2001 2 165 171 11708718
  • Zhang Y Proenca R Maffei M Barone M Leopold L Friedman JM Positional cloning of the mouse obese gene and its human homologue Nature 1994 372 425 432 7984236
  • Mantzoros CS The role of leptin in human obesity and disease: A review of current evidence Ann Intern Med 1999 130 671 680 10215564
  • Ducy P Amling M Takeda S Leptin inhibits bone formation through a hypothalamic relay: A central control of bone mass Cell 2000 100 197 207 10660043
  • Takeda S Elefteriou F Levasseur R Leptin regulates bone formation via the sympathetic nervous system Cell 2002 111 305 317 12419242
  • Kontogianni MD Dafni UG Routsias JG Skopouli FN Blood leptin and adiponectin as possible mediators of the relation between fat mass and BMD in perimenopausal women J Bone Miner Res 2004 19 546 551 15005840
  • Goulding A Taylor RW Plasma leptin values in relation to bone mass and density and to dynamic biochemical markers of bone resorption and formation in postmenopausal women Calcif Tissue Int 1998 63 456 458 9817937
  • Yamauchi M Sugimoto T Yamaguchi T Plasma leptin concentrations are associated with bone mineral density and the presence of vertebral fractures in postmenopausal women Clin Endocrinol (Oxf) 2001 55 341 347 11589677
  • Pasco JA Henry MJ Kotowicz MA Serum leptin levels are associated with bone mass in nonobese women J Clin Endocrinol Metab 2001 86 1884 1887 11344177
  • Thomas T Burguera B Is leptin the link between fat and bone mass? J Bone Miner Res 2002 17 1563 1569 12211425
  • Thomas T Leptin: A potential mediator for protective effects of fat mass on bone tissue Joint Bone Spine 2003 70 18 21 12639613
  • Thomas T The complex effects of leptin on bone metabolism through multiple pathways Curr Opin Pharmacol 2004 4 295 300 15140423
  • Martin A de Vittoris R David V Leptin modulate both resorption and formation while preventing disuse-induced bone loss in tail-suspended female rats Endocrinology 2005 146 8 3652 3659 15845621
  • Cornish J Callon KE Bava U Leptin directly regulates bone cell function in vitro and reduces bone fragility in vivo J Endocrinol 2001 175 405 415 12429038
  • Thomas T Gori F Khosla S Jensen MD Burguera B Riggs BL Leptin acts on human marrow stromal cells to enhance differentiation to osteoblasts and to inhibit differentiation to adipocytes Endocrinology 1999 140 1630 1638 10098497
  • Fu L Patel MS Bradley A Wagner EF Karsenty G The molecular clock mediates leptin-regulated bone formation Cell 2005 122 803 815 16143109
  • Elefteriou F Ahn JD Takeda S Leptin regulation of bone resorption by the sympathetic nervous system and CART Nature 2005 434 514 520 15724149
  • Karsenty G Convergence between bone and energy homeostases: Leptin regulation of bone mass Cell Metab 2006 4 341 348 17084709
  • Friedman JM Halaas JL Leptin and the regulation of body weight in mammals Nature 1998 395 763 770 9796811
  • Wisse BE Schwartz MW Role of melanocortins in control of obesity Lancet 2001 358 857 859 11567697
  • Herzog H Neuropeptide Y and energy homeostasis: Insights from Y receptor knockout models Eur J Pharmacol 2003 480 21 29 14623347
  • Liu YJ Araujo S Recker RR Deng HW Molecular and genetic mechanisms of obesity: Implications for future management Curr Mol Med 2003 3 325 340 12776988
  • Sainsbury A Schwarzer C Couzens M Important role of hypothalamic Y2 receptors in body weight regulation revealed in conditional knockout mice Proc Natl Acad Sci U S A 2002 99 8938 8943 12072562
  • Baldock PA Sainsbury A Couzens M Hypothalamic Y2 receptors regulate bone formation J Clin Invest 2002 109 915 921 11927618
  • Combs TP Berg AH Obici S Scherer PE Rossetti L Endogenous glucose production is inhibited by the adiposederived protein Acrp30 J Clin Invest 2001 108 1875 1881 11748271
  • Berg AH Combs TP Du X Brownlee M Scherer PE The adipocyte-secreted protein Acrp30 enhances hepatic insulin action Nat Med 2001 7 947 953 11479628
  • Berner HS Lyngstadaas SP Spahr A Adiponectin and its receptors are expressed in bone-forming cells Bone 2004 35 842 849 15454091
  • Oshima K Nampei A Matsuda M Adiponectin increases bone mass by suppressing osteoclast and activating osteoblast Biochem Biophys Res Commun 2005 331 520 526 15850790
  • Luo XH Guo LJ Yuan LQ Adiponectin stimulates human osteoblasts proliferation and differentiation via the MAPK signaling pathway Exp Cell Res 2005 309 99 109 15963981
  • Weyer C Funahashi T Tanaka S Hypoadiponectinemia in obesity and type 2 diabetes: Close association with insulin resistance and hyperinsulinemia J Clin Endocrinol Metab 2001 86 1930 1935 11344187
  • Lenchik L Register TC Hsu FC Adiponectin as a novel determinant of bone mineral density and visceral fat Bone 2003 33 646 651 14555270
  • Jurimae J Rembel K Jurimae T Rehand M Adiponectin is associated with bone mineral density in perimenopausal women Horm Metab Res 2005 37 297 302 15971153
  • Thommesen L Stunes AK Monjo M Expression and regulation of resistin in osteoblasts and osteoclasts indicate a role in bone metabolism J Cell Biochem 2006 99 3 824 834 16721825
  • Fain JN Madan AK Hiler ML Cheema P Bahouth SW Comparison of the release of adipokines by adipose tissue, adipose tissue matrix, and adipocytes from visceral and subcutaneous abdominal adipose tissues of obese humans Endocrinology 2004 145 2273 2282 14726444
  • Fernandez-Real JM Ricart W Insulin resistance and chronic cardiovascular inflammatory syndrome Endocr Rev 2003 24 278 301 12788800
  • Das UN Is obesity an inflammatory condition? Nutrition 2001 17 953 966 11744348
  • Berthier MT Paradis AM Tchernof A The interleukin 6-174G/C polymorphism is associated with indices of obesity in men J Hum Genet 2003 48 14 19 12560873
  • Kershaw EE Flier JS Adipose tissue as an endocrine organ J Clin Endocrinol Metab 2004 89 2548 2556 15181022
  • Richards CD Langdon C Deschamps P Pennica D Shaughnessy SG Stimulation of osteoclast differentiation in vitro by mouse oncostatin M, leukaemia inhibitory factor, cardiotrophin-1 and interleukin 6: Synergy with dexamethasone Cytokine 2000 12 613 621 10843736
  • Rodan GA Introduction to bone biology Bone 1992 13 Suppl 1 S3 S6 1581117
  • Dodds RA Merry K Littlewood A Gowen M Expression of mRNA for IL1 beta, IL6 and TGF beta 1 in developing human bone and cartilage J Histochem Cytochem 1994 42 733 744 8189035
  • Taguchi Y Yamamoto M Yamate T Interleukin-6-type cytokines stimulate mesenchymal progenitor differentiation toward the osteoblastic lineage Proc Assoc Am Physicians 1998 110 559 574 9824538
  • Franchimont N Wertz S Malaise M 2005 Interleukin-6: An osteotropic factor influencing bone formation Bone 37 601 606 16112634 Sims NA Jenkins BJ Quinn JM Nakamura A Glatt M Gillespie MT Ernst M Martin TJ 2004 Glycoprotein 130 regulates bone turnover and bone size by distinct downstream signaling pathways J Clin Invest 113 379 389 14755335
  • Sims NA Jenkins BJ Quinn JM Glycoprotein 130 regulates bone turnover and bone size by distinct downstream signaling pathways J Clin Invest 2004 113 379 389 14755335
  • Suganami T Nishida J Ogawa Y A paracrine loop between adipocytes and macrophages aggravates inflammatory changes: Role of free fatty acids and tumor necrosis factor α Arterioscler Thromb Vasc Biol 2005 25 10 2062 2068 16123319
  • Nishimura S Manabe I Nagai R Adipose tissue inflammation in obesity and metabolic syndrome Discov Med 2009 8 8 41 55 60 19788868
  • Akune T Ohba S Kamekura S PPARγ insufficiency enhances osteogenesis through osteoblast formation from bone marrow progenitors J Clin Invest 2004 113 846 855 15067317
  • Gimble JM Robinson CE Wu X Peroxisome proliferator-activated receptor-gamma activation by thiazolidinediones induces adipogenesis in bone marrow stromal cells Mol Pharmacol 1996 50 1087 1094 8913339
  • Rodriguez JP Montecinos L Rios S Reyes P Martinez J Mesenchymal stem cells from osteoporotic patients produce a type I collagen-deficient extracellular matrix favoring adipogenic differentiation J Cell Biochem 2000 79 557 565 10996846
  • Sekiya I Larson BL Vuoristo JT Cui JG Prockop DJ Adipogenic differentiation of human adult stem cells from bone marrow stroma (MSCs) J Bone Miner Res 2004 19 256 264 14969395
  • Aubin JE Bone stem cells J Cell Biochem 1998 Suppl 30–31 73 82 19594448
  • Cohen PG Aromatase, adiposity, aging and disease. The hypogonadal-metabolic-atherogenicdisease and aging connection Med Hypotheses 2001 56 702 708 11399122
  • Martin RB Zissimos SL Relationships between marrow fat and bone turnover in ovariectomized and intact rats Bone 1991 12 123 131 2064840
  • Martin RB Chow BD Lucas PA Bone marrow fat content in relation to bone remodeling and serum chemistry in intact and ovariectomized dogs Calcif Tissue Int 1990 46 189 194 2106378
  • Cheleuitte D Mizuno S Glowacki J In vitro secretion of cytokines by human bone marrow: Effects of age and estrogen status J Clin Endocrinol Metab 1998 83 2043 2051 9626137
  • Moerman EJ Teng K Lipschitz DA Lecka-Czernik B Aging activates adipogenic and suppresses osteogenic programs in mesenchymal marrow stroma/stem cells: The role of PPAR-gamma2 transcription factor and TGF-beta/BMP signaling pathways Aging Cell 2004 3 379 389 15569355
  • Kajkenova O Lecka-Czernik B Gubrij I Increased adipogenesis and myelopoiesis in the bone marrow of SAMP6: a murine model of defective osteoblastogenesis and low turnover osteopenia J Bone Miner Res 1997 12 1772 1779 9383681
  • Duque G Macoritto M Kremer R Vitamin D treatment of senescence accelerated mice (SAM-P/6) induces several regulators of stromal cell plasticity Biogerontology 2004 5 421 429 15609106
  • Logan CY Nusse R The Wnt signaling pathway in development and disease Annu Rev Cell Dev Biol 2004 20 781 810 15473860
  • Ross SE Erickson RL Gerin I Microarray analyses during adipogenesis: Understanding the effects of Wnt signaling on adipogenesis and the roles of liver X receptor {alpha} in adipocyte metabolism Mol Cell Biol 2002 22 5989 5999 12138207
  • Bennett CN Ross SE Longo KA Regulation of Wnt signaling during adipogenesis J Biol Chem 2002 277 30998 31004 12055200
  • Gong Y Slee RB Fukai N LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development Cell 2001 107 513 523 11719191
  • Boyden LM Mao J Belsky J High bone density due to a mutation in LDL-receptor-related protein 5 N Engl J Med 2002 346 1513 1521 12015390
  • Kato M Patel MS Levasseur R Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor J Cell Biol 2002 157 303 314 11956231
  • Little RD Carulli JP Del Mastro RG A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait Am J Hum Genet 2002 70 11 19 11741193
  • Bennett CN Longo KA Wright WS Regulation of osteoblastogenesis and bone mass by Wnt10b Proc Natl Acad Sci U S A 2005 102 3324 3329 15728361
  • Liu J Farmer SR Regulating the balance between peroxisome proliferator-activated receptor gamma and beta-catenin signaling during adipogenesis. A glycogen synthase kinase 3beta phosphorylation-defective mutant of beta-catenin inhibits expression of a subset of adipogenic genes J Biol Chem 2004 279 45020 45027 15308623
  • Zhou S Eid K Glowacki J Cooperation between TGFbeta and Wnt pathways during chondrocyte and adipocyte differentiation of human marrow stromal cells J Bone Miner Res 2004 19 463 470 15040835
  • Abdallah BM Jensen CH Gutierrez G Leslie RG Jensen TG Kassem M Regulation of human skeletal stem cells differentiation by Dlk1/Pref-1 J Bone Miner Res 2004 19 841 852 15068508
  • Kindblom JM Gevers EF Skrtic SM Increased adipogenesis in bone marrow but decreased bone mineral density in mice devoid of thyroid hormone receptors Bone 2005 36 607 616 15780976
  • Kajkenova O Lecka-Czernik B Gubrij I Increased adipogenesis and myelopoiesis in the bone marrow of SAMP6, a murine model of defective osteoblastogenesis and low turnover osteopenia J Bone Miner Res 1997 12 1772 1779 9383681
  • Duque G Macoritto M Dion N Ste-Marie LG Kremer R 1,25(OH)2D3 acts as a bone-forming agent in the hormone-independent senescence-accelerated mouse (SAM-P/6) Am J Physiol Endocrinol Metab 2005 288 E723 E730 15572658