Influence of FTO rs9939609 polymorphism on appetite, ghrelin, leptin, IL6, TNFα levels, and food intake of women with morbid obesity

References

• GBD 2015 Obesity Collaborators Afshin A Forouzanfar MH Reitsma MB Health effects of overweight and obesity in 195 Countries over 25 years N Engl J Med 2017 377 1 13 27 28604169
   PubMed Web of Science ®Google Scholar
• WHO. World Health Organization Obesity and overweight 2016 Available from: http://www.who.int/mediacentre/factsheets/fs311/en/ Accessed June 26, 2017
   Google Scholar
• Withrow D Alter DA The economic burden of obesity worldwide: a systematic review of the direct costs of obesity Obes Rev 2011 12 2 131 141 20122135
   PubMed Web of Science ®Google Scholar
• IMHA. Institute for Metrics and Health Assessment Available from: http://www.OverweightandObesityViz/ 2015 Accessed June 17, 2017
   Google Scholar
• Ng M Fleming T Robinson M Global, regional, and national prevalence of overweight and obesity in children and adults during 1980-2013: a systematic analysis for the Global Burden of Disease Study 2013 Lancet 2014 384 9945 766 781 24880830
   PubMed Web of Science ®Google Scholar
• Cesare MD Bentham Jm Stevens GA Trends in adult body-mass index in 200 countries from 1975 to 2014: a pooled analysis of 1698 population-based measurement studies with 19.2 million participants Lancet 2016 387 10026 1377 1396 27115820
   PubMed Web of Science ®Google Scholar
• BRASIL VIGITEL – Fatores de risco e proteção para doenças crônicas não transmissíveis obtidos por inquérito telefônico 2016 Available from: http://portalarquivos.saude.gov.br/images/pdf/2017/junho/07/vigitel_2016_jun17.pdf Accessed June 16, 2017
   Google Scholar
• de Oliveira ML Santos LM da Silva EN Direct healthcare cost of obesity in Brazil: an application of the cost-of-illness method from the perspective of the public health system in 2011 PLoS One 2015 10 4 e0121160 25830909
   PubMed Web of Science ®Google Scholar
• Swinburn BA Sacks G Hall KD The global obesity pandemic: shaped by global drivers and local environments Lancet 2011 378 9793 804 814 21872749
   PubMed Web of Science ®Google Scholar
• Xia Q Grant SFA The genetics of human obesity Ann N Y Acad Sci 2013 1281 1 178 190 23360386
   PubMed Web of Science ®Google Scholar
• Fall T Ingelsson E Genome-wide association studies of obesity and metabolic syndrome Mol Cell Endocrinol 2014 382 1 740 757 22963884
   PubMed Web of Science ®Google Scholar
• Speliotes EK Willer CJ Berndt SI Association analyses of 249,796 individuals reveal eighteen new loci associated with body mass index Nat Genet 2010 42 11 937 948 20935630
   PubMed Web of Science ®Google Scholar
• Jia G Fu Y Zhao X N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO Nat Chem Biol 2011 7 12 885 887 22002720
   PubMed Web of Science ®Google Scholar
• Gerken T Girard CA Tung Y-CL The obesity-associated FTO gene encodes a 2-oxoglutarate–dependent nucleic acid demethylase Science 2007 318 5855 1469 1472 17991826
   PubMed Web of Science ®Google Scholar
• Ben-Haim MS Moshitch-Moshkovitz S Rechavi G FTO: linking m6A demethylation to adipogenesis Cell Res 2015 25 1 3 4 25475057
   PubMed Web of Science ®Google Scholar
• Fruhbeck G Gomez-Ambrosi J Muruzabal FJ Burrell MA The adipocyte: a model for integration of endocrine and metabolic signaling in energy metabolism regulation Am J Physiol Endocrinol Metab 2001 280 6 827 847
   PubMed Web of Science ®Google Scholar
• Fredriksson R Hagglund M Olszewski PK The obesity gene, FTO, is of ancient origin, up-regulated during food deprivation and expressed in neurons of feeding-related nuclei of the brain Endocrinology 2008 149 5 2062 2071 18218688
   PubMed Web of Science ®Google Scholar
• Frayling TM Genome-wide association studies provide new insights into type 2 diabetes aetiology Nat Rev Genet 2007 8 9 657 662 17703236
   PubMed Web of Science ®Google Scholar
• Scuteri A Sanna S Chen WM Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits PLoS Genet 2007 10 1 43 47
   Google Scholar
• Illangasekera YA Kumarasiri RP Fernando DJ Dalton CF Association of FTO and near MC4R variants with obesity measures in urban and rural dwelling Sri Lankans Obes Res Clin Pract 2016 10 Suppl 1 S117 S124 26948330
   PubMed Web of Science ®Google Scholar
• Gulati P Yeo GS The biology of FTO: from nucleic acid demethylase to amino acid sensor Diabetologia 2013 56 10 2113 2121 23896822
   PubMed Web of Science ®Google Scholar
• Speakman JR Rance KA Johnstone AM Polymorphisms of the FTO gene are associated with variation in energy intake, but not energy expenditure Obesity (Silver Spring) 2008 16 8 1961 1965 18551109
   PubMed Web of Science ®Google Scholar
• Speakman JR The “Fat Mass and Obesity Related” (FTO) gene: mechanisms of impact on obesity and energy balance Curr Obes Rep 2015 4 1 73 91 26627093
   PubMed Web of Science ®Google Scholar
• Oyeyemi BF Ologunde CA Olaoye AB Alamukii NA FTO gene associates and interacts with obesity risk, physical activity, energy intake, and time spent sitting: pilot study in a Nigerian population J Obes 2017 2017 3245270 28607773
   PubMed Web of Science ®Google Scholar
• WHO. World Health Organization Waist Circumference and Waist-Hip Ratio 2011 Available from: http://apps.who.int/iris/bitstream/10665/44583/1/9789241501491_eng.pdf Accessed August 7, 2017
   Google Scholar
• Sampaio LR Silva MdCMd Roriz AKC Leite VR Inquérito Alimentar [Food Inquiry] Sampaio LR Avaliação Nutricional 1 EDUFBA 2012 Portuguese
   Google Scholar
• Matsudo S Araujo T Matsudo V Questionário Internacional de Atividade Física (IPAQ): Estudo de validade e reprodutibilidade no Brasil [International Physical Activity Questionnaire (IPAQ): Study of validity and reproducibility in Brazil] Revista Brasileira de Atividade Física e Saúde 2001 6 2 5 18 Portuguese
   Google Scholar
• Freitas S Lopes CS Coutinho W Appolinario JC Tradução e adaptação para o português da Escala de Compulsão Alimentar Periódica Revista Brasileira de Psiquiatria 2001 23 4 215 220 Portuguese
   Google Scholar
• Flint A Raben A Blundell JE Astrup A Reproducibility, power and validity of visual analogue scales in assessment of appetite sensations in single test meal studies Int J Obes Relat Metab Disord 2000 24 1 38 48 10702749
   PubMed Web of Science ®Google Scholar
• Hardy GH Mendelian proportions in a mixed population Science 1908 28 706 49 50 17779291
   PubMedGoogle Scholar
• Weinberg W Über den Nachweis der Vererbung beim Menschen 64 Jahresh Wuertt Ver vaterl Natkd 1908
   Google Scholar
• Loos RJ Yeo GS The bigger picture of FTO – the first GWAS-identified obesity gene Nat Rev Endocrinol 2014 10 1 51 61 24247219
   PubMed Web of Science ®Google Scholar
• De Luis DA Aller R Izaola O Primo D Romero E Association of the rs9939609 gene variant in FTO with insulin resistance, cardiovascular risk factor and serum adipokine levels in obese patients Nutr Hosp 2016 33 5 573 27759977
   PubMed Web of Science ®Google Scholar
• Shahid A Rana S Saeed S Imran M Afzal N Mahmood S Common variant of FTO gene, rs9939609, and obesity in Pakistani females Biomed Res Int 2013 2013 324093 24102053
   PubMed Web of Science ®Google Scholar
• Muc M Padez C Manco L Influence of physical activity on the association between the FTO variant rs9939609 and adiposity in young adults Am J Human Biol 2015 27 5 734 738 25809737
   PubMed Web of Science ®Google Scholar
• Kilpelainen TO Qi L Brage S Physical activity attenuates the influence of FTO variants on obesity risk: a meta-analysis of 218,166 adults and 19,268 children PLoS Med 2011 8 11 e1001116 22069379
   PubMed Web of Science ®Google Scholar
• Hudson JI Hiripi E Pope HGJr Kessler RC The prevalence and correlates of eating disorders in the National Comorbidity Survey Replication Biol Psychiatry 2007 61 3 348 358 16815322
   PubMed Web of Science ®Google Scholar
• Wardle J Carnell S Haworth CMA Farooqi IS O’Rahilly S Plomin R Obesity associated genetic variation in FTO is associated with diminished satiety J Clin Endocrinol Metab 2008 93 9 3640 3643 18583465
   PubMed Web of Science ®Google Scholar
• Jonassaint CR Szatkiewicz JP Bulik CM Specific common variants of the obesity-associated FTO gene are not associated with psychological and behavioral eating disorder phenotypes Am J Med Genet 2011 156 4 454 461
   Web of Science ®Google Scholar
• Castellini G Franzago M Bagnoli S Fat mass and obesity-associated gene (FTO) is associated to eating disorders susceptibility and moderates the expression of psychopathological traits PLoS One 2017 12 3 e0173560 28282466
   PubMed Web of Science ®Google Scholar
• Arrizabalaga M Larrarte E Margareto J Maldonado-Martin S Barrenechea L Labayen I Preliminary findings on the influence of FTO rs9939609 and MC4R rs17782313 polymorphisms on resting energy expenditure, leptin and thyrotropin levels in obese non-morbid pre-menopausal women J Physiol Biochem 2014 70 1 255 262 24307561
   PubMed Web of Science ®Google Scholar
• Karra E O’Daly OG Choudhury AI A link between FTO, ghrelin, and impaired brain food-cue responsivity J Clin Invest 2013 123 8 3539 3551 23867619
   PubMed Web of Science ®Google Scholar
• Olza J Ruperez AI Gil-Campos M Influence of FTO variants on obesity, inflammation and cardiovascular disease risk biomarkers in Spanish children: a case-control multicentre study BMC Med Genet 2013 14 123 24289790
   PubMed Web of Science ®Google Scholar
• Labayen I Margareto J Maldonado-Martin S Independent and combined influence of the FTO rs9939609 and MC4Rrs17782313 polymorphisms on hypocaloric diet induced changes in body mass and composition and energy metabolism in non-morbid obese premenopausal women Nutr Hosp 2015 31 5 2025 2032 25929371
   PubMed Web of Science ®Google Scholar
• Zimmermann E Skogstrand K Hougaard DM Influences of the common FTO rs9939609 variant on inflammatory markers throughout a broad range of body mass index PLoS One 2011 6 1 e15958 21246032
   PubMed Web of Science ®Google Scholar
• de Luis DA Aller R Conde R Relation of the rs9939609 gene variant in FTO with cardiovascular risk factor and serum adipokine levels in morbid obese patients Nutr Hosp 2012 27 4 1184 1189 Spanish 23165561
   PubMed Web of Science ®Google Scholar
• Douglas A Yaqoob P Givens DI Reynolds CK Minihane AM The impact of obesity-related SNP on appetite and energy intake Br J Nutr 2013 110 6 1151 1156 23433430
   PubMed Web of Science ®Google Scholar
• den Hoed M Westerterp-Plantenga MS Bouwman FG Mariman EC Westerterp KR Postprandial responses in hunger and satiety are associated with the rs9939609 single nucleotide polymorphism in FTO Am J Clin Nutr 2009 90 5 1426 1432 19793853
   PubMed Web of Science ®Google Scholar
• Gustavsson J Mehlig K Leander K FTO gene variation, macronutrient intake and coronary heart disease risk: a gene-diet interaction analysis Eur J Nutr 2016 55 1 247 255 25644180
   PubMed Web of Science ®Google Scholar
• Qi Q Kilpeläinen TO Downer MK FTO genetic variants, dietary intake and body mass index: insights from 177 330 individuals Hum Mol Genet 2014 23 25 6961 6972 25104851
   PubMed Web of Science ®Google Scholar
• Church C Moir L McMurray F Overexpression of Fto leads to increased food intake and results in obesity Nat Genet 2010 42 12 1086 1092 21076408
   PubMed Web of Science ®Google Scholar