Plantar Fasciitis in Diabetic Foot Patients: Risk Factors, Pathophysiology, Diagnosis, and Management

References

• Cho NH, Shaw JE, Karuranga S, et al. IDF diabetes atlas: global estimates of diabetes prevalence for 2017 and projections for 2045. Diabetes Res Clin Pract. 2018;138:271–281. doi:10.1016/j.diabres.2018.02.023
   PubMed Web of Science ®Google Scholar
• Al-Homood IA. Rheumatic conditions in patients with diabetes mellitus. Clin Rheumatol. 2013;32(5):527–533. doi:10.1007/s10067-012-2144-8
   PubMedGoogle Scholar
• Ursini F, Arturi F, Nicolosi K, et al. Plantar fascia enthesopathy is highly prevalent in diabetic patients without peripheral neuropathy and correlates with retinopathy and impaired kidney function. PLoS One. 2017;12(3):e0174529. doi:10.1371/journal.pone.0174529
   PubMedGoogle Scholar
• Aydeniz A, Gursoy S, Guney E. Which musculoskeletal complications are most frequently seen in type 2 diabetes mellitus? J Int Med Res. 2008;36(3):505–511. doi:10.1177/147323000803600315
   PubMedGoogle Scholar
• Lavery LA, Armstrong DG, Wunderlich RP, Tredwell J, Boulton AJ. Predictive value of foot pressure assessment as part of a population-based diabetes disease management program. Diabetes Care. 2003;26(4):1069–1073. doi:10.2337/diacare.26.4.1069
   PubMed Web of Science ®Google Scholar
• Abate M, Schiavone C, Salini V, Andia I. Occurrence of tendon pathologies in metabolic disorders. Rheumatology (Oxford). 2013;52(4):599–608. doi:10.1093/rheumatology/kes395
   PubMed Web of Science ®Google Scholar
• Hernandez-Diaz C, Saavedra MA, Navarro-Zarza JE, et al. Clinical anatomy of the ankle and foot. Reumatol Clin. 2012;8(Suppl 2):46–52. doi:10.1016/j.reuma.2012.10.005
   PubMedGoogle Scholar
• D’Ambrogi E, Giurato L, D’Agostino MA, et al. Contribution of plantar fascia to the increased forefoot pressures in diabetic patients. Diabetes Care. 2003;26(5):1525–1529. doi:10.2337/diacare.26.5.1525
   PubMedGoogle Scholar
• Armstrong DG, Stacpoole-Shea S, Nguyen H, Harkless LB. Lengthening of the Achilles tendon in diabetic patients who are at high risk for ulceration of the foot. J Bone Joint Surg Am. 1999;81(4):535–538. doi:10.2106/00004623-199904000-00011
   PubMedGoogle Scholar
• Frykberg RG, Lavery LA, Pham H, Harvey C, Harkless L, Veves A. Role of neuropathy and high foot pressures in diabetic foot ulceration. Diabetes Care. 1998;21(10):1714–1719. doi:10.2337/diacare.21.10.1714
   PubMed Web of Science ®Google Scholar
• Gefen A. Plantar soft tissue loading under the medial metatarsals in the standing diabetic foot. Med Eng Phys. 2003;25(6):491–499. doi:10.1016/S1350-4533(03)00029-8
   PubMed Web of Science ®Google Scholar
• Riddle DL, Schappert SM. Volume of ambulatory care visits and patterns of care for patients diagnosed with plantar fasciitis: a national study of medical doctors. Foot Ankle Int. 2004;25(5):303–310. doi:10.1177/107110070402500505
   PubMed Web of Science ®Google Scholar
• Nahin RL. Prevalence and pharmaceutical treatment of plantar fasciitis in United States adults. J Pain. 2018;19(8):885–896. doi:10.1016/j.jpain.2018.03.003
   PubMed Web of Science ®Google Scholar
• Priesand SJ, Schmidt BM, Ang L, et al. Plantar fasciitis in patients with type 1 and type 2 diabetes: a contemporary cohort study. J Diabetes Complications. 2019;33(10):107399. doi:10.1016/j.jdiacomp.2019.06.004
   PubMedGoogle Scholar
• Taunton JE, Ryan MB, Clement DB, McKenzie DC, Lloyd-Smith DR, Zumbo BD. A retrospective case-control analysis of 2002 running injuries. Br J Sports Med. 2002;36(2):95–101. doi:10.1136/bjsm.36.2.95
   PubMed Web of Science ®Google Scholar
• Patel A, DiGiovanni B. Association between plantar fasciitis and isolated contracture of the gastrocnemius. Foot Ankle Int. 2011;32(1):5–8. doi:10.3113/FAI.2011.0005
   PubMed Web of Science ®Google Scholar
• Riddle DL, Pulisic M, Pidcoe P, Johnson RE. Risk factors for Plantar fasciitis: a matched case-control study. J Bone Joint Surg Am. 2003;85(5):872–877. doi:10.2106/00004623-200305000-00015
   PubMedGoogle Scholar
• van Leeuwen KD, Rogers J, Winzenberg T, van Middelkoop M. Higher body mass index is associated with plantar fasciopathy/’plantar fasciitis’: systematic review and meta-analysis of various clinical and imaging risk factors. Br J Sports Med. 2016;50(16):972–981. doi:10.1136/bjsports-2015-094695
   PubMedGoogle Scholar
• Kent MJ, Light ND, Bailey AJ. Evidence for glucose-mediated covalent cross-linking of collagen after glycosylation in vitro. Biochem J. 1985;225(3):745–752. doi:10.1042/bj2250745
   PubMed Web of Science ®Google Scholar
• Connizzo BK, Bhatt PR, Liechty KW, Soslowsky LJ. Diabetes alters mechanical properties and collagen fiber re-alignment in multiple mouse tendons. Ann Biomed Eng. 2014;42(9):1880–1888. doi:10.1007/s10439-014-1031-7
   PubMed Web of Science ®Google Scholar
• Ahmed N. Advanced glycation endproducts–role in pathology of diabetic complications. Diabetes Res Clin Pract. 2005;67(1):3–21. doi:10.1016/j.diabres.2004.09.004
   PubMed Web of Science ®Google Scholar
• Abate M, Schiavone C, Salini V, Andia I. Management of limited joint mobility in diabetic patients. Diabetes Metab Syndr Obes. 2013;6:197–207. doi:10.2147/DMSO.S33943
   PubMedGoogle Scholar
• Waltenberger J. Impaired collateral vessel development in diabetes: potential cellular mechanisms and therapeutic implications. Cardiovasc Res. 2001;49(3):554–560. doi:10.1016/S0008-6363(00)00228-5
   PubMedGoogle Scholar
• Grant WP, Sullivan R, Sonenshine DE, et al. Electron microscopic investigation of the effects of diabetes mellitus on the Achilles tendon. J Foot Ankle Surg. 1997;36(4):272–278; discussion 330. doi:10.1016/S1067-2516(97)80072-5
   PubMedGoogle Scholar
• Conde J, Gomez R, Bianco G, et al. Expanding the adipokine network in cartilage: identification and regulation of novel factors in human and murine chondrocytes. Ann Rheum Dis. 2011;70(3):551–559. doi:10.1136/ard.2010.132399
   PubMed Web of Science ®Google Scholar
• Lago R, Gomez R, Otero M, et al. A new player in cartilage homeostasis: adiponectin induces nitric oxide synthase type II and pro-inflammatory cytokines in chondrocytes. Osteoarthritis Cartilage. 2008;16(9):1101–1109. doi:10.1016/j.joca.2007.12.008
   PubMedGoogle Scholar
• Beason DP, Abboud JA, Kuntz AF, Bassora R, Soslowsky LJ. Cumulative effects of hypercholesterolemia on tendon biomechanics in a mouse model. J Orthop Res. 2011;29(3):380–383. doi:10.1002/jor.21255
   PubMedGoogle Scholar
• Li C, Hsieh MC, Chang SJ. Metabolic syndrome, diabetes, and hyperuricemia. Curr Opin Rheumatol. 2013;25(2):210–216. doi:10.1097/BOR.0b013e32835d951e
   PubMed Web of Science ®Google Scholar
• Schlesinger N, Thiele RG. The pathogenesis of bone erosions in gouty arthritis. Ann Rheum Dis. 2010;69(11):1907–1912. doi:10.1136/ard.2010.128454
   PubMed Web of Science ®Google Scholar
• Gill LH. Plantar fasciitis: diagnosis and conservative management. J Am Acad Orthop Surg. 1997;5(2):109–117. doi:10.5435/00124635-199703000-00006
   PubMedGoogle Scholar
• Flanigan RM, Nawoczenski DA, Chen L, Wu H, DiGiovanni BF. The influence of foot position on stretching of the plantar fascia. Foot Ankle Int. 2007;28(7):815–822. doi:10.3113/FAI.2007.0815
   PubMedGoogle Scholar
• Veves A, Murray HJ, Young MJ, Boulton AJ. The risk of foot ulceration in diabetic patients with high foot pressure: a prospective study. Diabetologia. 1992;35(7):660–663. doi:10.1007/BF00400259
   PubMed Web of Science ®Google Scholar
• Pataky Z, Assal JP, Conne P, Vuagnat H, Golay A. Plantar pressure distribution in Type 2 diabetic patients without peripheral neuropathy and peripheral vascular disease. Diabet Med. 2005;22(6):762–767. doi:10.1111/j.1464-5491.2005.01520.x
   PubMed Web of Science ®Google Scholar
• Pataky Z, Golay A, Faravel L, et al. The impact of callosities on the magnitude and duration of plantar pressure in patients with diabetes mellitus. A callus may cause 18,600 kilograms of excess plantar pressure per day. Diabetes Metab. 2002;28(5):356–361.
   PubMedGoogle Scholar
• Ctercteko GC, Dhanendran M, Hutton WC, Le Quesne LP. Vertical forces acting on the feet of diabetic patients with neuropathic ulceration. Br J Surg. 1981;68(9):608–614. doi:10.1002/bjs.1800680904
   PubMed Web of Science ®Google Scholar
• Shaw JE, van Schie CH, Carrington AL, Abbott CA, Boulton AJ. An analysis of dynamic forces transmitted through the foot in diabetic neuropathy. Diabetes Care. 1998;21(11):1955–1959. doi:10.2337/diacare.21.11.1955
   PubMedGoogle Scholar
• Gariani K, Uckay I, Lipsky BA. Managing diabetic foot infections: a review of the new guidelines. Acta Chir Belg. 2014;114(1):7–16. doi:10.1080/00015458.2014.11680970
   PubMed Web of Science ®Google Scholar
• Levy JC, Mizel MS, Clifford PD, Temple HT. Value of radiographs in the initial evaluation of nontraumatic adult heel pain. Foot Ankle Int. 2006;27(6):427–430. doi:10.1177/107110070602700607
   PubMedGoogle Scholar
• Osborne HR, Breidahl WH, Allison GT. Critical differences in lateral X-rays with and without a diagnosis of plantar fasciitis. J Sci Med Sport. 2006;9(3):231–237. doi:10.1016/j.jsams.2006.03.028
   PubMed Web of Science ®Google Scholar
• Alshami AM, Souvlis T, Coppieters MW. A review of plantar heel pain of neural origin: differential diagnosis and management. Man Ther. 2008;13(2):103–111. doi:10.1016/j.math.2007.01.014
   PubMedGoogle Scholar
• Zhou B, Zhou Y, Tao X, Yuan C, Tang K. Classification of calcaneal spurs and their relationship with plantar fasciitis. J Foot Ankle Surg. 2015;54(4):594–600. doi:10.1053/j.jfas.2014.11.009
   PubMedGoogle Scholar
• Chimutengwende-Gordon M, O’Donnell P, Singh D. Magnetic resonance imaging in plantar heel pain. Foot Ankle Int. 2010;31(10):865–870. doi:10.3113/FAI.2010.0865
   PubMed Web of Science ®Google Scholar
• Draghi F, Gitto S, Bortolotto C, Draghi AG, Ori Belometti G. Imaging of plantar fascia disorders: findings on plain radiography, ultrasound and magnetic resonance imaging. Insights Imaging. 2017;8(1):69–78. doi:10.1007/s13244-016-0533-2
   PubMed Web of Science ®Google Scholar
• Thomas JL, Christensen JC, Kravitz SR, et al. The diagnosis and treatment of heel pain: a clinical practice guideline-revision 2010. J Foot Ankle Surg. 2010;49(3 Suppl):S1–19. doi:10.1053/j.jfas.2010.01.001
   PubMed Web of Science ®Google Scholar
• Uckay I, Gariani K, Dubois-Ferriere V, Suva D, Lipsky BA. Diabetic foot infections: recent literature and cornerstones of management. Curr Opin Infect Dis. 2016;29(2):145–152. doi:10.1097/QCO.0000000000000243
   PubMed Web of Science ®Google Scholar
• Uckay I, Jornayvaz FR, Lebowitz D, Gastaldi G, Gariani K, Lipsky BA. An overview on diabetic foot infections, including issues related to associated pain, hyperglycemia and limb ischemia. Curr Pharm Des. 2018;24(12):1243–1254. doi:10.2174/1381612824666180302145754
   PubMedGoogle Scholar
• Francia P, Gulisano M, Anichini R, Seghieri G. Diabetic foot and exercise therapy: step by step the role of rigid posture and biomechanics treatment. Curr Diabetes Rev. 2014;10(2):86–99. doi:10.2174/1573399810666140507112536
   PubMedGoogle Scholar
• Gardner AW, Poehlman ET. Exercise rehabilitation programs for the treatment of claudication pain. A meta-analysis. JAMA. 1995;274(12):975–980. doi:10.1001/jama.1995.03530120067043
   PubMed Web of Science ®Google Scholar
• Balducci S, Zanuso S, Cardelli P, et al. Supervised exercise training counterbalances the adverse effects of insulin therapy in overweight/obese subjects with type 2 diabetes. Diabetes Care. 2012;35(1):39–41. doi:10.2337/dc11-1450
   PubMed Web of Science ®Google Scholar
• Tucker PS, Fisher-Wellman K, Bloomer RJ. Can exercise minimize postprandial oxidative stress in patients with type 2 diabetes? Curr Diabetes Rev. 2008;4(4):309–319. doi:10.2174/157339908786241160
   PubMedGoogle Scholar
• Giacomozzi C, D’Ambrogi E, Uccioli L, Macellari V. Does the thickening of Achilles tendon and plantar fascia contribute to the alteration of diabetic foot loading? Clin Biomech (Bristol, Avon). 2005;20(5):532–539. doi:10.1016/j.clinbiomech.2005.01.011
   PubMedGoogle Scholar
• Cerrahoglu L, Kosan U, Sirin TC, Ulusoy A. Range of motion and plantar pressure evaluation for the effects of self-care foot exercises on diabetic patients with and without neuropathy. J Am Podiatr Med Assoc. 2016;106(3):189–200. doi:10.7547/14-095
   PubMedGoogle Scholar
• Goldsmith JR, Lidtke RH, Shott S. The effects of range-of-motion therapy on the plantar pressures of patients with diabetes mellitus. J Am Podiatr Med Assoc. 2002;92(9):483–490. doi:10.7547/87507315-92-9-483
   PubMedGoogle Scholar
• Sweeting D, Parish B, Hooper L, Chester R. The effectiveness of manual stretching in the treatment of plantar heel pain: a systematic review. J Foot Ankle Res. 2011;4:19. doi:10.1186/1757-1146-4-19
   PubMedGoogle Scholar
• Donley BG, Moore T, Sferra J, Gozdanovic J, Smith R. The efficacy of oral nonsteroidal anti-inflammatory medication (NSAID) in the treatment of plantar fasciitis: a randomized, prospective, placebo-controlled study. Foot Ankle Int. 2007;28(1):20–23. doi:10.3113/FAI.2007.0004
   PubMed Web of Science ®Google Scholar
• Schepsis AA, Leach RE, Gorzyca J. Plantar fasciitis. Etiology, treatment, surgical results, and review of the literature. Clin Orthop Relat Res. 1991;266:185–196.
   PubMed Web of Science ®Google Scholar
• Gill LH, Kiebzak GM. Outcome of nonsurgical treatment for plantar fasciitis. Foot Ankle Int. 1996;17(9):527–532. doi:10.1177/107110079601700903
   PubMedGoogle Scholar
• Crawford F, Atkins D, Young P, Edwards J. Steroid injection for heel pain: evidence of short-term effectiveness. A randomized controlled trial. Rheumatology (Oxford). 1999;38(10):974–977. doi:10.1093/rheumatology/38.10.974
   PubMed Web of Science ®Google Scholar
• Acevedo JI, Beskin JL. Complications of plantar fascia rupture associated with corticosteroid injection. Foot Ankle Int. 1998;19(2):91–97. doi:10.1177/107110079801900207
   PubMed Web of Science ®Google Scholar
• Sellman JR. Plantar fascia rupture associated with corticosteroid injection. Foot Ankle Int. 1994;15(7):376–381. doi:10.1177/107110079401500706
   PubMed Web of Science ®Google Scholar
• Rasenberg N, Riel H, Rathleff MS, Bierma-Zeinstra SMA, van Middelkoop M. Efficacy of foot orthoses for the treatment of plantar heel pain: a systematic review and meta-analysis. Br J Sports Med. 2018;52(16):1040–1046. doi:10.1136/bjsports-2017-097892
   PubMed Web of Science ®Google Scholar
• Wheeler PC. The addition of a tension night splint to a structured home rehabilitation programme in patients with chronic plantar fasciitis does not lead to significant additional benefits in either pain, function or flexibility: a single-blinded randomised controlled trial. BMJ Open Sport Exerc Med. 2017;3(1):e000234. doi:10.1136/bmjsem-2017-000232
   PubMedGoogle Scholar
• Tisdel CL, Harper MC. Chronic plantar heel pain: treatment with a short leg walking cast. Foot Ankle Int. 1996;17(1):41–42. doi:10.1177/107110079601700109
   PubMed Web of Science ®Google Scholar
• Shikoff MD, Figura MA, Postar SE. A retrospective study of 195 patients with heel pain. J Am Podiatr Med Assoc. 1986;76(2):71–75. doi:10.7547/87507315-76-2-71
   PubMedGoogle Scholar
• Davis PF, Severud E, Baxter DE. Painful heel syndrome: results of nonoperative treatment. Foot Ankle Int. 1994;15(10):531–535. doi:10.1177/107110079401501002
   PubMed Web of Science ®Google Scholar
• Daly PJ, Kitaoka HB, Chao EY. Plantar fasciotomy for intractable plantar fasciitis: clinical results and biomechanical evaluation. Foot Ankle. 1992;13(4):188–195. doi:10.1177/107110079201300404
   PubMedGoogle Scholar
• Fallat LM, Cox JT, Chahal R, Morrison P, Kish J. A retrospective comparison of percutaneous plantar fasciotomy and open plantar fasciotomy with heel spur resection. J Foot Ankle Surg. 2013;52(3):288–290. doi:10.1053/j.jfas.2012.10.005
   PubMedGoogle Scholar
• Oliva F, Piccirilli E, Tarantino U, Maffulli N. Percutaneous release of the plantar fascia. New surgical procedure. Muscles Ligaments Tendons J. 2017;7(2):338–340. doi:10.11138/mltj/2017.7.2.338
   PubMedGoogle Scholar
• Catal B, Keskinbora M, Uysal MA, Sahin M, Gulabi D, Demiralp B. Endoscopic plantar fasciotomy; deep fascial versus superficial fascial approach: a prospective randomized study. J Foot Ankle Surg. 2017;56(5):1001–1008. doi:10.1053/j.jfas.2017.04.021
   PubMedGoogle Scholar
• Chou AC, Ng SY, Su DH, Singh IR, Koo K. Radiofrequency microtenotomy is as effective as plantar fasciotomy in the treatment of recalcitrant plantar fasciitis. Foot Ankle Surg. 2016;22(4):270–273. doi:10.1016/j.fas.2015.11.006
   PubMed Web of Science ®Google Scholar
• Barrett SJ, O’Malley R. Plantar fasciitis and other causes of heel pain. Am Fam Physician. 1999;59(8):2200–2206.
   PubMedGoogle Scholar
• Kinley S, Frascone S, Calderone D, Wertheimer SJ, Squire MA, Wiseman FA. Endoscopic plantar fasciotomy versus traditional heel spur surgery: a prospective study. J Foot Ankle Surg. 1993;32(6):595–603.
   PubMedGoogle Scholar
• Al-Mayahi M, Cian A, Kressmann B, et al. Associations of diabetes mellitus with orthopaedic infections. Infect Dis (Lond). 2016;48(1):70–73. doi:10.3109/23744235.2015.1082620
   PubMed Web of Science ®Google Scholar
• Wu YH, Lun JJ, Chen WS, Chong FC. The electrophysiological and functional effect of shock wave on peripheral nerves. Conf Proc IEEE Eng Med Biol Soc. 2007;2007:2369–2372. doi:10.1109/IEMBS.2007.4352803
   Google Scholar
• Mariotto S, de Prati AC, Cavalieri E, Amelio E, Marlinghaus E, Suzuki H. Extracorporeal shock wave therapy in inflammatory diseases: molecular mechanism that triggers anti-inflammatory action. Curr Med Chem. 2009;16(19):2366–2372. doi:10.2174/092986709788682119
   PubMed Web of Science ®Google Scholar
• Dizon JN, Gonzalez-Suarez C, Zamora MT, Gambito EDRE. Effectiveness of extracorporeal shock wave therapy in chronic plantar fasciitis. Am J Phys Med Rehabil. 2014;93(8):735. doi:10.1097/PHM.0000000000000121
   PubMedGoogle Scholar
• Steffens D, Maher CGRE. Effectiveness of extracorporeal shock wave therapy in chronic plantar fasciitis. Am J Phys Med Rehabil. 2014;93(5):458–459. doi:10.1097/PHM.0000000000000061
   PubMedGoogle Scholar
• Mardani-Kivi M, Karimi Mobarakeh M, Hassanzadeh Z, et al. Treatment outcomes of corticosteroid injection and extracorporeal shock wave therapy as two primary therapeutic methods for acute plantar fasciitis: a prospective randomized clinical trial. J Foot Ankle Surg. 2015;54(6):1047–1052. doi:10.1053/j.jfas.2015.04.026
   PubMedGoogle Scholar
• Abate M, Schiavone C, Di Carlo L, Salini V. Achilles tendon and plantar fascia in recently diagnosed type II diabetes: role of body mass index. Clin Rheumatol. 2012;31(7):1109–1113. doi:10.1007/s10067-012-1955-y
   PubMed Web of Science ®Google Scholar
• Boules M, Batayyah E, Froylich D, et al. Effect of surgical weight loss on plantar fasciitis and health-care use. J Am Podiatr Med Assoc. 2018;108(6):442–448. doi:10.7547/15-169
   PubMedGoogle Scholar
• Thomson CE, Crawford F, Murray GD. The effectiveness of extra corporeal shock wave therapy for plantar heel pain: a systematic review and meta-analysis. BMC Musculoskelet Disord. 2005;6:19. doi:10.1186/1471-2474-6-19
   PubMedGoogle Scholar
• Babcock MS, Foster L, Pasquina P, Jabbari B. Treatment of pain attributed to plantar fasciitis with botulinum toxin a: a short-term, randomized, placebo-controlled, double-blind study. Am J Phys Med Rehabil. 2005;84(9):649–654. doi:10.1097/01.phm.0000176339.73591.d7
   PubMed Web of Science ®Google Scholar
• Vahdatpour B, Mokhtarian A, Raeissadat SA, Dehghan F, Nasr N, Mazaheri M. Enhancement of the effectiveness of extracorporeal shock wave therapy with topical corticosteroid in treatment of chronic plantar fasciitis: a randomized control clinical trial. Adv Biomed Res. 2018;7:62. doi:10.4103/abr.abr_40_17
   PubMedGoogle Scholar
• Macias DM, Coughlin MJ, Zang K, Stevens FR, Jastifer JR, Doty JF. Low-level laser therapy at 635 nm for treatment of chronic plantar fasciitis: a placebo-controlled, randomized study. J Foot Ankle Surg. 2015;54(5):768–772. doi:10.1053/j.jfas.2014.12.014
   PubMed Web of Science ®Google Scholar
• Wronka KS, Sinha A. Calcaneal osteomyelitis following steroid injection for plantar fasciitis: a case report. Foot Ankle Spec. 2012;5(4):253–255. doi:10.1177/1938640012451313
   PubMedGoogle Scholar
• Aragon-Sanchez J, Lazaro-Martinez JL, Pulido-Duque J, Maynar M. From the diabetic foot ulcer and beyond: how do foot infections spread in patients with diabetes? Diabet Foot Ankle. 2012;3.
   Google Scholar
• Mismar A, Yousef M, Badran D, Younes N. Ascending infection of foot tendons in diabetic patients. Int J Low Extrem Wounds. 2013;12(4):271–275. doi:10.1177/1534734613493290
   PubMedGoogle Scholar