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Clinical Trial Report

Elevated free fatty acid level is associated with insulin-resistant state in nondiabetic Chinese people

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Pages 139-147 | Published online: 17 Jan 2019

References

  • Gastaldelli A Gaggini M Defronzo RA Role of adipose tissue insulin resistance in the natural history of type 2 diabetes: results from the San Antonio Metabolism study Diabetes 2017 66 4 815 822 28052966
  • Czech MP Insulin action and resistance in obesity and type 2 diabetes Nat Med 2017 23 7 804 814 28697184
  • Xue H Wang C Li Y Incidence of type 2 diabetes and number of events attributable to abdominal obesity in China: A cohort study J Diabetes 2016 8 2 190 198 25619275
  • Florez JC Newly identified loci highlight beta cell dysfunction as a key cause of type 2 diabetes: where are the insulin resistance genes? Diabetologia 2008 51 7 1100 1110 18504548
  • Fatehi-Hassanabad Z Chan CB Transcriptional regulation of lipid metabolism by fatty acids: a key determinant of pancreatic beta-cell function Nutr Metab 2005 2 1 1
  • Xiao X Liu Y Sun C Evaluation of different obesity indices as predictors of type 2 diabetes mellitus in a Chinese population J Diabetes 2015 7 3 386 392 25047243
  • Boden G Obesity and free fatty acids Endocrinol Metab Clin North Am 2008 37 3 635 646 18775356
  • Zechner R Strauss JG Haemmerle G Lass A Zimmermann R Lipolysis: pathway under construction Curr Opin Lipidol 2005 16 3 333 340 15891395
  • Arner P Insulin resistance in type 2 diabetes: role of fatty acids Diabetes Metab Res Rev 2002 18 Suppl 2 S5 S9 11921432
  • Boden G Effects of free fatty acids (FFA) on glucose metabolism: significance for insulin resistance and type 2 diabetes Exp Clin Endocrinol Diabetes 2003 111 3 121 124 12784183
  • Ma XL Meng L Li LL Ma LN Mao XM Plasma free fatty acids metabolic profile among Uyghurs and Kazaks with or without type 2 diabetes based on GC-MS Exp Clin Endocrinol Diabetes 2017 126 10 604 611 29117617
  • Chung JJ Huber TB Gödel M Albumin-associated free fatty acids induce macropinocytosis in podocytes J Clin Invest 2015 125 6 2307 2316 25915582
  • Tu YM Gong CX Ding L A high concentration of fatty acids induces TNF-α as well as NO release mediated by the P2X4 receptor, and the protective effects of puerarin in RAW264.7 cells Food Funct 2017 8 12 4336 4346 28937704
  • Capurso C Capurso A From excess adiposity to insulin resistance: the role of free fatty acids Vascul Pharmacol 2012 57 2–4 91 97 22609131
  • Eguchi K Manabe I Oishi-Tanaka Y Saturated fatty acid and TLR signaling link β cell dysfunction and islet inflammation Cell Metab 2012 15 4 518 533 22465073
  • American Diabetes Association Standards of medical care in diabetes--2014 Diabetes Care 2014 37 Suppl 1 S14 S80 24357209
  • Matthews DR Hosker JP Rudenski AS Naylor BA Treacher DF Turner RC Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man Diabetologia 1985 28 7 412 419 3899825
  • Schönfeld P Wojtczak L Fatty acids as modulators of the cellular production of reactive oxygen species Free Radic Biol Med 2008 45 3 231 241 18482593
  • Lippi G Mattiuzzi C Targher G Glycated hemoglobin, diabetes, and cardiovascular risk in nondiabetic adults N Engl J Med 2010 362 21 2030
  • Liang H Lum H Alvarez A Garduno-Garcia JdeJ Daniel BJ Musi N A low dose lipid infusion is sufficient to induce insulin resistance and a pro-inflammatory response in human subjects PLoS One 2018 13 4 e0195810 29649324
  • Boden G Obesity, insulin resistance and free fatty acids Curr Opin Endocrinol Diabetes Obes 2011 18 2 139 143 21297467
  • Kopprasch S Srirangan D Bergmann S Graessler J Schwarz PEH Bornstein SR Association between systemic oxidative stress and insulin resistance/sensitivity indices - the PREDIAS study Clin Endocrinol 2016 84 1 48 54
  • Velasquez C Vasquez JS Balcazar N In vitro effect of fatty acids identified in the plasma of obese adolescents on the function of pancreatic β-cells Diabetes Metab J 2017 41 4 303 315 28868828
  • Qu S Zhang T Dong HH Effect of hepatic insulin expression on lipid metabolism in diabetic mice J Diabetes 2016 8 3 314 323 25851734
  • Gastaldelli A Insulin resistance and reduced metabolic flexibility: cause or consequence of NAFLD? Clin Sci 2017 131 22 2701 2704 29109303
  • Roomp K Kristinsson H Schvartz D Combined lipidomic and proteomic analysis of isolated human islets exposed to palmitate reveals time-dependent changes in insulin secretion and lipid metabolism PLoS One 2017 12 4 e0176391 28448538
  • Johns I Goff L Bluck LJ Plasma free fatty acids do not provide the link between obesity and insulin resistance or β-cell dysfunction: results of the Reading, Imperial, Surrey, Cambridge, Kings (RISCK) study Diabet Med 2014 31 11 1310 1315 25047698
  • Arner P Rydén M Fatty Acids, Obesity and Insulin Resistance Obes Facts 2015 8 2 147 155 25895754
  • Dasgupta S Bhattacharya S Biswas A NF-kappaB mediates lipid-induced fetuin-A expression in hepatocytes that impairs adipocyte function effecting insulin resistance Biochem J 2010 429 3 451 462 20482516
  • Hennige AM Staiger H Wicke C Fetuin-A induces cytokine expression and suppresses adiponectin production PLoS One 2008 3 3 e1765 18335040
  • Blüher M Adipose tissue inflammation: a cause or consequence of obesity-related insulin resistance? Clin Sci 2016 130 18 1603 1614 27503945
  • Fischer IP Irmler M Meyer CW A history of obesity leaves an inflammatory fingerprint in liver and adipose tissue Int J Obes 2018 42 3 507 517
  • Li Q Liu X Yin Y Insulin regulates glucose consumption and lactate production through reactive oxygen species and pyruvate kinase M2 Oxid Med Cell Longev 2014 2014 1 10
  • Shirai T Nazarewicz RR Wallis BB The glycolytic enzyme PKM2 bridges metabolic and inflammatory dysfunction in coronary artery disease J Exp Med 2016 213 3 337 354 26926996
  • Min HK Mirshahi F Verdianelli A Activation of the GP130-STAT3 axis and its potential implications in nonalcoholic fatty liver disease Am J Physiol Gastrointest Liver Physiol 2015 308 9 G794 G803 25747354
  • Cai X Fang C Hayashi S Pu-erh tea extract ameliorates high-fat diet-induced nonalcoholic steatohepatitis and insulin resistance by modulating hepatic IL-6/STAT3 signaling in mice J Gastroenterol 2016 51 8 819 829 26794005
  • Zhang D Gao X Wang Q Kakkalide ameliorates endothelial insulin resistance by suppressing reactive oxygen species-associated inflammation J Diabetes 2013 5 1 13 24 23190749
  • Yin J Peng Y Wu J Wang Y Yao L Toll-like receptor 2/4 links to free fatty acid-induced inflammation and β-cell dysfunction J Leukoc Biol 2014 95 1 47 52 24018354
  • Xue Y Guo T Zou L Evodiamine attenuates P2X7-mediated inflammatory injury of human umbilical vein endothelial cells exposed to high free fatty acids Oxid Med Cell Longev 2018 2018 1 10
  • Kristinsson H Smith DM Bergsten P Sargsyan E FFAR1 is involved in both the acute and chronic effects of palmitate on insulin secretion Endocrinology 2013 154 11 4078 4088 24035997
  • Hasnain SZ Prins JB Mcguckin MA Oxidative and endoplasmic reticulum stress in β-cell dysfunction in diabetes J Mol Endocrinol 2016 56 2 R33 R54 26576641
  • Toledo-Corral CM Alderete TL Richey J Sequeira P Goran MI Weigensberg MJ Fasting, post-OGTT challenge, and nocturnal free fatty acids in prediabetic versus normal glucose tolerant overweight and obese Latino adolescents Acta Diabetol 2015 52 2 277 284 25109287
  • Stefan N Stumvoll M Bogardus C Tataranni PA Elevated plasma nonesterified fatty acids are associated with deterioration of acute insulin response in IGT but not NGT Am J Physiol Endocrinol Metab 2003 284 6 E1156 E1161 12582008
  • Dorcely B Katz K Jagannathan R Novel biomarkers for prediabetes, diabetes, and associated complications Diabetes Metab Syndr Obes 2017 10 345 361 28860833