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Review

The negative and detrimental effects of high fructose on the liver, with special reference to metabolic disorders

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Pages 821-826 | Published online: 27 May 2019

References

  • Vreman RA , Goodell AJ , Rodriguez LA , Porco TC , Lustig RH , Kahn JG . Health and economic benefits of reducing sugar intake in the USA, including effects via non-alcoholic fatty liver disease: a microsimulation model. BMJ Open . 2017;7(8):e013543. doi:10.1136/bmjopen-2016-013543
  • Ter Horst KW , Serlie MJ . Fructose consumption, lipogenesis, and non-alcoholic fatty liver disease. Nutrients . 2017;9(9):E981. doi: 10.3390/nu9090981
  • Delbridge LM , Benson VL , Ritchie RH , Mellor KM . Diabetic cardiomyopathy: the case for a role of fructose in disease etiology. Diabetes . 2016;65(12):3521–3528. doi:10.2337/db16-0682 27879401
  • Softic S , Cohen DE , Kahn CR . Role of dietary fructose and hepatic de novo lipogenesis in fatty liver disease. Dig Dis Sci . 2016;61(5):1282–1293. doi:10.1007/s10620-016-4054-0 26856717
  • Jensen T , Abdelmalek MF , Sullivan S , et al. Fructose and sugar: A major mediator of non-alcoholic fatty liver disease. J Hepatol . 2018;68(5):1063–1075. doi:10.1016/j.jhep.2018.01.019 29408694
  • DiNicolantonio JJ , Subramonian AM , O‘Keefe JH . Added fructose as a principal driver of non-alcoholic fatty liver disease: a public health crisis. Open Heart . 2017;4(2):e000631. doi:10.1136/openhrt-2017-000631 29118995
  • Jegatheesan P , De Bandt JP . Fructose and NAFLD: the multifaceted aspects of fructose metabolism. Nutrients . 2017;9:3.
  • Tran LT , Yuen VG , McNeill JH . The fructose-fed rat: a review on the mechanisms of fructose-induced insulin resistance and hypertension. Mol Cell Biochem . 2009;332(1–2):145–159. doi:10.1007/s11010-009-0184-4 19536638
  • Rippe JM , Angelopoulos TJ . Fructose-containing sugars and cardiovascular disease. Adv Nutr . 2015;6(4):430–439. doi:10.3945/an.114.008177 26178027
  • Tappy L . Fructose-containing caloric sweeteners as a cause of obesity and metabolic disorders. J Exp Biol . 2018;221(PtSuppl 1). doi:10.1242/jeb.164202
  • Tappy L . Fructose metabolism and noncommunicable diseases: recent findings and new research perspectives. Curr Opin Clin Nutr Metab Care . 2018;21(3):214–222. doi:10.1097/MCO.0000000000000460 29406418
  • Macdonald IA . A review of recent evidence relating to sugars, insulin resistance and diabetes. Eur J Nutr . 2016;55(Suppl 2):17–23. doi:10.1007/s00394-016-1340-8 27882410
  • Lirio LM , Forechi L , Zanardo TC , et al. Chronic fructose intake accelerates non-alcoholic fatty liver disease in the presence of essential hypertension. J Diabetes Complications . 2016;30(1):85–92. doi:10.1016/j.jdiacomp.2015.10.008 26597602
  • Alwahsh SM , Gebhardt R . Dietary fructose as a risk factor for non-alcoholic fatty liver disease (NAFLD). Arch Toxicol . 2017;91(4):1545–1563. doi:10.1007/s00204-016-1892-7 27995280
  • Bantle JP . Dietary fructose and metabolic syndrome and diabetes. J Nutr . 2009;139(6):1263S–1268S. doi:10.3945/jn.108.098020 19403723
  • Chiu S , Mulligan K , Schwarz JM . Dietary carbohydrates and fatty liver disease: de novo lipogenesis. Curr Opin Clin Nutr Metab Care . 2018;21(4):277–282. doi:10.1097/MCO.0000000000000469 29697539
  • Nobili V , Mosca A , De Vito R , Raponi M , Scorletti E , Byrne CD . Liver zonation in children with non-alcoholic fatty liver disease: associations with dietary fructose and uric acid concentrations. Liver Int . 2018;38(6):1102–1109. doi:10.1111/liv.13661 29222961
  • Choi Y , Abdelmegeed MA , Song BJ . Diet high in fructose promotes liver steatosis and hepatocyte apoptosis in C57BL/6J female mice: role of disturbed lipid homeostasis and increased oxidative stress. Food Chem Toxicol . 2017;103:111–121. doi:10.1016/j.fct.2017.02.039 28257781
  • Ouyang X , Cirillo P , Sautin Y , et al. Fructose consumption as a risk factor for non-alcoholic fatty liver disease. J Hepatol . 2008;48(6):993–999. doi:10.1016/j.jhep.2008.02.011 18395287
  • Warren BE , Lou PH , Lucchinetti E , et al. Early mitochondrial dysfunction in glycolytic muscle, but not oxidative muscle, of the fructose-fed insulin-resistant rat. Am J Physiol Endocrinol Metab . 2014;306(6):E658–E667. doi:10.1152/ajpendo.00511.2013 24425766
  • Johnson RJ , Nakagawa T , Sanchez-Lozada LG , et al. Sugar, uric acid, and the etiology of diabetes and obesity. Diabetes . 2013;62(10):3307–3315. doi:10.2337/db12-1814 24065788
  • Balakumar M , Raji L , Prabhu D , et al. High-fructose diet is as detrimental as high-fat diet in the induction of insulin resistance and diabetes mediated by hepatic/pancreatic endoplasmic reticulum (ER) stress. Mol Cell Biochem . 2016;423(1–2):93–104. doi:10.1007/s11010-016-2828-5 27699590
  • Wang DD , Sievenpiper JL , de Souza RJ , et al. The effects of fructose intake on serum uric acid vary among controlled dietary trials. J Nutr . 2012;142(5):916–923. doi:10.3945/jn.111.151951 22457397
  • Lambertz J , Weiskirchen S , Landert S , Weiskirchen R . Fructose: a dietary sugar in crosstalk with microbiota contributing to the development and progression of non-alcoholic liver disease. Front Immunol . 2017;8:1159. doi:10.3389/fimmu.2017.01159 28970836
  • Chen J , Thomsen M , Vitetta L . Interaction of gut microbiota with dysregulation of bile acids in the pathogenesis of nonalcoholic fatty liver disease and potential therapeutic implications of probiotics. J Cell Biochem . 2019;120(3):2713–2720. doi:10.1002/jcb.27635 30443932
  • Wu J , Jin Z , Zheng H , Yan LJ . Sources and implications of NADH/NAD(+) redox imbalance in diabetes and its complications. Diabetes Metab Syndr Obes . 2016;9:145–153. doi:10.2147/DMSO.S106087 27274295
  • Luo X , Wu J , Jing S , Yan LJ . Hyperglycemic stress and carbon stress in diabetic glucotoxicity. Aging Dis . 2016;7(1):90–110. doi:10.14336/AD.2015.0702 26816666
  • Yan LJ . Pathogenesis of chronic hyperglycemia: from reductive stress to oxidative stress. J Diabetes Res . 2014;2014:137919. doi:10.1155/2014/137919 25019091
  • Lanaspa MA , Ishimoto T , Li N , et al. Endogenous fructose production and metabolism in the liver contributes to the development of metabolic syndrome. Nat Commun . 2013;4:2434. doi:10.1038/ncomms3434 24022321
  • Gugliucci A . Formation of fructose-mediated advanced glycation end products and their roles in metabolic and inflammatory diseases. Adv Nutr . 2017;8(1):54–62. doi:10.3945/an.116.013912 28096127
  • Takagi Y , Kashiwagi A , Tanaka Y , Asahina T , Kikkawa R , Shigeta Y . Significance of fructose-induced protein oxidation and formation of advanced glycation end product. J Diabetes Complications . 1995;9(2):87–91.7599353
  • Leung C , Herath CB , Jia Z , et al. Dietary advanced glycation end-products aggravate non-alcoholic fatty liver disease. World J Gastroenterol . 2016;22(35):8026–8040. doi:10.3748/wjg.v22.i35.8026 27672297
  • Aragno M , Mastrocola R . Dietary sugars and endogenous formation of advanced glycation endproducts: emerging mechanisms of disease. Nutrients . 2017;9:4. doi:10.3390/nu9040385
  • Sainz N , Barrenetxe J , Moreno-Aliaga MJ , Martinez JA . Leptin resistance and diet-induced obesity: central and peripheral actions of leptin. Metabolism . 2015;64(1):35–46. doi:10.1016/j.metabol.2014.10.015 25497342
  • Aijala M , Malo E , Ukkola O , et al. Long-term fructose feeding changes the expression of leptin receptors and autophagy genes in the adipose tissue and liver of male rats: a possible link to elevated triglycerides. Genes Nutr . 2013;8(6):623–635. doi:10.1007/s12263-013-0357-3 24085619
  • Sakar Y , Nazaret C , Letteron P , et al. Positive regulatory control loop between gut leptin and intestinal GLUT2/GLUT5 transporters links to hepatic metabolic functions in rodents. PLoS One . 2009;4(11):e7935. doi:10.1371/journal.pone.0007935 19956534
  • Kanerva N , Sandboge S , Kaartinen NE , Mannisto S , Eriksson JG . Higher fructose intake is inversely associated with risk of nonalcoholic fatty liver disease in older finnish adults. Am J Clin Nutr . 2014;100(4):1133–1138. doi:10.3945/ajcn.114.086074 25099548
  • Chiavaroli L , Ha V , de Souza RJ , Kendall CW , Sievenpiper JL . Fructose in obesity and cognitive decline: is it the fructose or the excess energy? Nutr J . 2014;13:27. doi:10.1186/1475-2891-13-27 24666585
  • Tajima R , Kimura T , Enomoto A , et al. No association between fruits or vegetables and non-alcoholic fatty liver disease in middle-aged men and women. Nutrition . 2019;61:119–124. doi:10.1016/j.nut.2018.10.016 30710884
  • Ha V , Sievenpiper JL , de Souza RJ , et al. Effect of fructose on blood pressure: a systematic review and meta-analysis of controlled feeding trials. Hypertension . 2012;59(4):787–795. doi:10.1161/HYPERTENSIONAHA.111.182311 22331380
  • Sievenpiper JL , de Souza RJ , Mirrahimi A , et al. Effect of fructose on body weight in controlled feeding trials: a systematic review and meta-analysis. Ann Intern Med . 2012;156(4):291–304. doi:10.7326/0003-4819-156-4-201202210-00007 22351714
  • Ojeda ML , Nogales F , Munoz Del Valle P , Diaz-Castro J , Murillo ML , Carreras O . Metabolic syndrome and selenium in fetal programming: gender differences. Food Funct . 2016;7(7):3031–3038. doi:10.1039/c6fo00595k 27334401
  • Nogales F , Ojeda ML , Del Valle PM , Serrano A , Murillo ML , Carreras Sanchez O . Metabolic syndrome and selenium during gestation and lactation. Eur J Nutr . 2017;56(2):819–830. doi:10.1007/s00394-015-1129-1 26680597