Salidroside-Mitigated Inflammatory Injury of Hepatocytes with Non-Alcoholic Fatty Liver Disease via Inhibition TRPM2 Ion Channel Activation

References

• Sayiner M , Koenig A , Henry L , Younossi ZM . Epidemiology of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis in the United States and the rest of the world. Clin Liver Dis . 2016;20(2):205–214. doi:10.1016/j.cld.2015.10.001 27063264
   PubMed Web of Science ®Google Scholar
• Diehl AM , Day C . Cause, pathogenesis, and treatment of nonalcoholic steatohepatitis. N Engl J Med . 2017;377(21):2063–2072. doi:10.1056/NEJMra1503519 29166236
   PubMed Web of Science ®Google Scholar
• Tana C , Ballestri S , Ricci F , et al. Cardiovascular risk in non-alcoholic fatty liver disease: mechanisms and therapeutic implications. Int J Environ Res Public Health . 2019;16(17):E3104. doi:10.3390/ijerph16173104 31455011
   PubMed Web of Science ®Google Scholar
• Goedeke L , Perry RJ , Shulman GI . Emerging pharmacological targets for the treatment of nonalcoholic fatty liver disease, insulin resistance, and type 2 diabetes. Annu Rev Pharmacol Toxicol . 2019;59:65–87. doi:10.1146/annurev-pharmtox-010716-104727 30625285
   PubMed Web of Science ®Google Scholar
• Engin A . Non-alcoholic fatty liver disease. Adv Exp Med Biol . 2017;960:443–467. doi:10.1007/978-3-319-48382-5_19 28585211
   PubMed Web of Science ®Google Scholar
• Ji Y , Gao Y , Chen H , et al. Indole-3-acetic acid alleviates nonalcoholic fatty liver disease in mice via attenuation of hepatic lipogenesis, and oxidative and inflammatory stress. Nutrients . 2019;11(9):E2062. doi:10.3390/nu11092062 31484323
   PubMed Web of Science ®Google Scholar
• Zhang J , Zhang SD , Wang P , et al. Pinolenic acid ameliorates oleic acid-induced lipogenesis and oxidative stress via AMPK/SIRT1 signaling pathway in HepG2 cells. Eur J Pharmacol . 2019;861:172618. doi:10.1016/j.ejphar.2019.172618 31430456
   PubMed Web of Science ®Google Scholar
• Bartlett PJ , Gaspers LD , Pierobon N , Thomas AP . Calcium-dependent regulation of glucose homeostasis in the liver. Cell Calcium . 2014;55(6):306–316. doi:10.1016/j.ceca.2014.02.007 24630174
   PubMed Web of Science ®Google Scholar
• Ramsey IS , Delling M , Clapham DE . An introduction to TRP channels. Annu Rev Physiol . 2006;68:619–647. doi:10.1146/annurev.physiol.68.040204.100431 16460286
   PubMed Web of Science ®Google Scholar
• Rychkov GY , Barritt GJ . Expression and function of TRP channels in liver cells. Adv Exp Med Biol . 2011;704:667–686.21290321
   PubMed Web of Science ®Google Scholar
• Yamamoto S , Shimizu S . Significance of TRP channels in oxidative stress. Eur J Pharmacol . 2016;793:109–111. doi:10.1016/j.ejphar.2016.11.007 27838397
   PubMed Web of Science ®Google Scholar
• Kheradpezhouh E , Ma L , Morphett A , Barritt GJ , Rychkov GY . TRPM2 channels mediate acetaminophen-induced liver damage. Proc Natl Acad Sci USA . 2014;111(8):3176–3181. doi:10.1073/pnas.1322657111 24569808
   PubMed Web of Science ®Google Scholar
• Ramírez A , Vázquez-Sánchez AY , Carrión-Robalino N , Camacho J . Ion channels and oxidative stress as a potential link for the diagnosis or treatment of liver diseases. Oxid Med Cell Longev . 2016;2016:3928714. doi:10.1155/2016/3928714 26881024
   PubMed Web of Science ®Google Scholar
• Kosakowska O , Bączek K , Przybyt JL , et al. Antioxidant and antibacterial activity of roseroot (Rhodiola rosea L.) dry extracts. Molecules . 2018;23(7):E1767. doi:10.3390/molecules23071767 30022015
   PubMed Web of Science ®Google Scholar
• Chen C , Lin B , Qi S , He J , Zheng H . Protective effects of salidroside on lead acetate-induced oxidative stress and hepatotoxicity in Sprague-Dawley rats. Biol Trace Elem Res . 2019;191(2):426–434. doi:10.1007/s12011-019-1635-8 30666592
   PubMed Web of Science ®Google Scholar
• Yuan Y , Wu SJ , Liu X , Zhang LL . Antioxidant effect of salidroside and its protective effect against furan-induced hepatocyte damage in mice. Food Funct . 2013;4(5):763–769. doi:10.1039/c3fo00013c 23507802
   PubMed Web of Science ®Google Scholar
• Sun P , Song SZ , Jiang S , et al. Salidroside regulates inflammatory response in Raw 264.7 macrophages via TLR4/TAK1 and ameliorates inflammation in alcohol binge drinking-Induced liver injury. Molecules . 2016;21(11):E1490. doi:10.3390/molecules21111490 27834881
   PubMed Web of Science ®Google Scholar
• Lin SY , Dan X , Du XX , et al. Protective effects of salidroside against carbon tetrachloride (CCl4)-induced liver injury by initiating mitochondria to resist oxidative stress in mice. Int J Mol Sci . 2019;20:E3187. doi:10.3390/ijms20133187 31261843
   PubMed Web of Science ®Google Scholar
• Zheng T , Yang X , Li W , et al. Salidroside attenuates high-fat diet-induced nonalcoholic fatty liver disease via AMPK-dependent TXNIP/NLRP3 pathway. Oxid Med Cell Longev . 2018;2018:8597897. doi:10.1155/2018/8597897.30140371
   PubMed Web of Science ®Google Scholar
• Li JS , Wang WJ , Sun Y , Zhang YH , Zheng L . Ursolic acid inhibits the development of nonalcoholic fatty liver disease by attenuating endoplasmic reticulum stress. Food Funct . 2015;6(5):1643–1651. doi:10.1039/c5fo00083a 25892149
   PubMed Web of Science ®Google Scholar
• Khambu B , Yan S , Huda N , Liu G , Yin XM . Autophagy in non-alcoholic fatty liver disease and alcoholic liver disease. Liver Res . 2018;2(3):112–119. doi:10.1016/j.livres.2018.09.004 31123622
   PubMedGoogle Scholar
• Marra F , Svegliati-Baroni G . Lipotoxicity and the gut-liver axis in NASH pathogenesis. J Hepatol . 2018;68(2):280–295. doi:10.1016/j.jhep.2017.11.014 29154964
   PubMed Web of Science ®Google Scholar
• Ricchi M , Odoardi MR , Carulli L , et al. Differential effect of oleic and palmitic acid on lipid accumulation and apoptosis in cultured hepatocytes. J Gastroenterol Hepatol . 2009;24(5):830–840. doi:10.1111/j.1440-1746.2008.05733.x 19207680
   PubMed Web of Science ®Google Scholar
• Spahis S , Delvin E , Borys JM , Levy E . Oxidative stress as a critical factor in nonalcoholic fatty liver disease pathogenesis. Antioxid Redox Signal . 2017;26(10):519–541. doi:10.1089/ars.2016.6776 27452109
   PubMed Web of Science ®Google Scholar
• Zhang K , Kim H , Fu Z , et al. Deficiency of the mitochondrial NAD kinase causes stress-induced hepatic steatosis in mice. Gastroenterology . 2018;154(1):224–237. doi:10.1053/j.gastro.2017.09.010 28923496
   PubMed Web of Science ®Google Scholar
• Liu Y , Liao L , Chen Y , Han F . Effects of daphnetin on lipid metabolism, insulin resistance and oxidative stress in OA-treated HepG2 cells. Mol Med Rep . 2019;19(6):4673–4684. doi:10.3892/mmr.2019.10139 30957185
   PubMed Web of Science ®Google Scholar
• Kozai D , Ogawa N , Mori Y . Redox regulation of transient receptor potential channels. Antioxid Redox Signal . 2014;21(6):971–986. doi:10.1089/ars.2013.5616 24161127
   PubMed Web of Science ®Google Scholar
• Kim TK , Nam JH , Ahn WG , et al. Lys1110 of TRPM2 is critical for channel activation. Biochem J . 2013;455(3):319–327. doi:10.1042/BJ20130303 23957292
   PubMed Web of Science ®Google Scholar
• Perraud AL , Takanishi CL , Shen B , et al. Accumulation of free ADP-ribose from mitochondria mediates oxidative stress-induced gating of TRPM2 cation channels. J Biol Chem . 2005;280(7):6138–6148. doi:10.1074/jbc.M411446200 15561722
   PubMed Web of Science ®Google Scholar
• Toda T , Yamamoto S , Yonezawa R , Mori Y , Shimizu S . Inhibitory effects of Tyrphostin AG-related compounds on oxidative stress-sensitive transient receptor potential channel activation. Eur J Pharmacol . 2016;786:19–28. doi:10.1016/j.ejphar.2016.05.033 27238971
   PubMed Web of Science ®Google Scholar
• Shimizu T , Dietz RM , Cruz-Torres I , et al. Extended therapeutic window of a novel peptide inhibitor of TRPM2 channels following focal cerebral ischemia. Exp Neurol . 2016;283(Pt A):151–156. doi:10.1016/j.expneurol.2016.06.015 27317297
   PubMed Web of Science ®Google Scholar
• Kheradpezhouh E , Barritt GJ , Rychkov GY . Curcumin inhibits activation of TRPM2 channels in rat hepatocytes. Redox Biol . 2016;7:1–7. doi:10.1016/j.redox.2015.11.001 26609559
   PubMed Web of Science ®Google Scholar
• Gao X , Guo S , Zhang S , Liu A , Shi L , Zhang Y . Matrine attenuates endoplasmic reticulum stress and mitochondrion dysfunction in nonalcoholic fatty liver disease by regulating SERCA pathway. J Transl Med . 2018;16(1):319. doi:10.1186/s12967-018-1685-2 30458883
   PubMed Web of Science ®Google Scholar
• Brzozowski JS , Skelding KA . The multi-functional calcium/calmodulin stimulated protein kinase (CaMK) family: emerging targets for anti-cancer therapeutic intervention. Pharmaceuticals (Basel) . 2019;12(1):E8. doi:10.3390/ph12010008 30621060
   PubMedGoogle Scholar
• Wang Q , Huang L , Yue J . Oxidative stress activates the TRPM2-Ca2+-CaMKII-ROS signaling loop to induce cell death in cancer cells. Biochim Biophys Acta Mol Cell Res . 2017;1864(6):957–967. doi:10.1016/j.bbamcr.2016.12.014 28007458
   PubMed Web of Science ®Google Scholar
• Lee S , Han D , Kang HG , et al. Intravenous sustained-release nifedipine ameliorates nonalcoholic fatty liver disease by restoring autophagic clearance. Biomaterials . 2019;197:1–11. doi:10.1016/j.biomaterials.2019.01.008 30623792
   PubMed Web of Science ®Google Scholar
• Wang Q , Guo W , Hao B , et al. Mechanistic study of TRPM2-Ca2+-CAMK2-BECN1 signaling in oxidative stress-induced autophagy inhibition. Autophagy . 2016;12(8):1340–1354. doi:10.1080/15548627.2016.1187365 27245989
   PubMed Web of Science ®Google Scholar
• Wang Y , Zhao H , Li X , et al. Tangshen Formula alleviates hepatic steatosis by inducing autophagy through the AMPK/SIRT1 pathway. Front Physiol . 2019;10:494. doi:10.3389/fphys.2019.00494.31105592
   PubMed Web of Science ®Google Scholar
• Chu Q , Zhang S , Chen M , et al. Cherry anthocyanins regulate NAFLD by promoting autophagy pathway. Oxid Med Cell Longev . 2019;2019:4825949. doi:10.1155/2019/4825949.30931080
   PubMed Web of Science ®Google Scholar
• Zheng Q , Tan Q , Ren Y , et al. Hyperosmotic stress-induced TRPM2 channel activation stimulates NLRP3 inflammasome activity in primary human corneal epithelial cells. Invest Ophthalmol Vis Sci . 2018;59(8):3259–3268. doi:10.1167/iovs.18-23965 29971445
   PubMed Web of Science ®Google Scholar
• Chung MK , Asgar J , Lee J , Shim MS , Dumler C , Ro JY . The role of TRPM2 in hydrogen peroxide-induced expression of inflammatory cytokine and chemokine in rat trigeminal ganglia. Neuroscience . 2015;297:160–169. doi:10.1016/j.neuroscience.2015.03.067 25849615
   PubMed Web of Science ®Google Scholar
• Polyzos SA , Kountouras J , Polymerou V , Papadimitriou KG , Zavos C , Katsinelos P . Vaspin, resistin, retinol-binding protein-4, interleukin-1α and interleukin-6 in patients with nonalcoholic fatty liver disease. Ann Hepatol . 2016;15(5):705–714. doi:10.5604/16652681.1212429 27493109
   PubMed Web of Science ®Google Scholar
• Jorge AS , Andrade JM , Paraíso AF , et al. Body mass index and the visceral adipose tissue expression of IL-6 and TNF-alpha are associated with the morphological severity of non-alcoholic fatty liver disease in individuals with class III obesity. Obes Res Clin Pract . 2018;12(Suppl 2):1–8. doi:10.1016/j.orcp.2016.03.009
   PubMed Web of Science ®Google Scholar
• Cai X , Fang C , Hayashi S , et al. Pu-erh tea extract ameliorates high-fat diet-induced nonalcoholic steatohepatitis,and insulin resistance by modulating hepatic IL-6/STAT3 signaling in mice. J Gastroenterol . 2016;51(8):819–829. doi:10.1007/s00535-015-1154-0 26794005
   PubMed Web of Science ®Google Scholar