Genistein diet improves body weight, serum glucose and triglyceride levels in both male and female ob/ob mice

References

• Halaas JL , Gajiwala KS , Maffei M , et al. Weight-reducing effects of the plasma protein encoded by the obese gene. Science . 1995;28:543–546. doi:10.1126/science.7624777
   Web of Science ®Google Scholar
• Roden M , Ludwig C , Nowotny P , et al. Relative hypoleptinemia in patients with type 1 and type 2 diabetes mellitus. Int J Obes . 2000;24:976–981. doi:10.1038/sj.ijo.0801266
   Web of Science ®Google Scholar
• Ozata M , Ozdemir IC , Licinio J . Human leptin deficiency casused by a missence mutation: multiple endocrine defects, decreased sympathetic tone, and immune system dysfunction indicate new targets for leptin action, greater central than peripheral resistance to the effects of leptin, and spontaneous correction of leptin-mediated defects. J Clin Endo Metab . 1999;84:3686–3695.
   PubMed Web of Science ®Google Scholar
• Montague CT , Farooqi IS , Whitehead JP , et al. Congenital leptin deficiency is associated with severe early-onset obesity in humans. Nature . 1997;387:903–908. doi:10.1038/43185 9202122
   PubMed Web of Science ®Google Scholar
• Larcher F , Del Rio M , Serrano F , et al. A cutaneous gene therapy approach to human leptin deficiences: correction of the murine ob/ob phenotype using leptin-targeted keratinocyte grafts. Faseb J . 2001;15:1529–1538. doi:10.1096/fj.01-0082com 11427484
   PubMed Web of Science ®Google Scholar
• Valerio CM , Zajdenverg L , Do Oliveira JE , Mory PB , Moyses RS , Godoy-Matos AF . Body composition study by dual-energy x-ray absorpiometry in familial partial lipodystrophy: finding new tools for an objective evaluation. Diabetol Metab Syndr . 2012;4:40. doi:10.1186/1758-5996-4-40 22938045
   PubMed Web of Science ®Google Scholar
• Meehan CA , Cochran E , Kassai A , Brown RJ , Gorden P . Metreleptin for injection to treat the complications of leptin deficiency in patients with congenital or acquired generalized lipodystrophy. Expert Re Clin Pharmacol . 2016;9:59–68. doi:10.1586/17512433.2016.1096772
   PubMed Web of Science ®Google Scholar
• Bhetwal BP , An C , Baker SA , Lyon KL , Perrino BA . Impaired contractile responses and latered protein expression and phosphorylation of Ca2+ sensitization proetins in gastric antrum smooth muscles from ob/ob mice. J Muscle Res Cell Motil . 2013;34:137–149. doi:10.1007/s10974-013-9341-1 23576331
   PubMed Web of Science ®Google Scholar
• Leung L , Kang J , Rayyan E , et al. Decreased basal chloride secretion and altered CFTR, villin and GLUT5 protein expression in jejunum from ob/ob mice. Diabetes Metab Syndrome Obesity . 2014;7:1–10.
   Google Scholar
• Gupta SK , Dongare S , Mathur R , et al. Genistein ameliorates cardiac inflammation and oxidative stress in streptozotocin-induced diabetic cardiomyopathy in rats. Mol Cell Biochem . 2015;408:63–72. doi:10.1007/s11010-015-2483-2 26092427
   PubMed Web of Science ®Google Scholar
• Akiyama T , Ishida J , Nakagawa S , et al. Genistein a specific inhibitor of tyrosine-specific protein kinase. J Biol Chem . 1987;262:5592–5595.3106339
   PubMed Web of Science ®Google Scholar
• Vanden BNL , Novotny NI , Bohl L , et al. Soy genistein administered in soluble chitosan microcapsules maintains antioxidant activity and limits intestinal inflammation. J Nutr Biochem . 2018;62:50–58. doi:10.1016/j.jnutbio.2018.08.009 30245183
   PubMed Web of Science ®Google Scholar
• Rahman Mazumder MA , Hongsprabhas P . Genistein as antioxidant and antibrowning agents in in vivo and in vitro: a review. Biomed Pharmacother . 2016;379–392. doi:10.1016/j.biopha.2016.05.023
   Web of Science ®Google Scholar
• Braxas H , Frafraf M , Karimi Hasanabad S , Ashari Jafarabad M . Effectiveness of genistein supplementation on metabolic factors and antioxidant status in postmenopausal women with type 2 diabetes mellitus. Can J Diabetes . 2019;S1499–S2671:30983.
   Google Scholar
• Weigt C , Hertrampf T , Flenker U , et al. Effects of estradiol, estrogen receptor subtype-selective agonists and genistein on glucose metabolism in leptin resistant female Zucker diabetic fatty (ZDF) rats. J Steroid Biochem Mol Biol . 2015;154:12–22. doi:10.1016/j.jsbmb.2015.06.002 26134426
   PubMed Web of Science ®Google Scholar
• Weigt C , Hertrampf T , Kluxen FM , et al. Molecular effects of ER-alpha- and beta-selective agonists on regulation of energy homeostasis in obese female Wistar rats. Mol Cell Endocrinol . 2013;377:147–158. doi:10.1016/j.mce.2013.07.007 23871901
   PubMed Web of Science ®Google Scholar
• Penza M , Montani C , Romani A , et al. Genistein affects adipose tissue deposition in a dose-dependent and gender-specific manner. Endocrinology . 2006;147:5740–5751. doi:10.1210/en.2006-0365 16959845
   PubMed Web of Science ®Google Scholar
• Ahmed B , Liu S , Si H . Antiadipogenic effects and mechanisms of combinations of genistein, epigallocatechin-3-Gallate, and/or resveratrol in preadipocytes. J Med Food . 2017;20:162–170. doi:10.1089/jmf.2016.0115 27976976
   PubMed Web of Science ®Google Scholar
• Rockwood SS , Broderick TB , Al-Nakkash L . Feeding obese diabetic mice a genistein diet induces thermogenic and metabolic change. J Medicinal Food . 2018;21:332–339. doi:10.1089/jmf.2017.0084
   Web of Science ®Google Scholar
• Kim SJ , Nian C , Karunakaran S , Clee SM , Isales CM , McIntosh CHS . GIP-overexpressing mice demonstrate reduced diet-induced obesity and steatosis, and improved gluocse homeostasis. PLoS One . 2012;7:e40156. doi:10.1371/journal.pone.0040156 22802954
   PubMed Web of Science ®Google Scholar
• Batterham RL , Cohen MA , Ellis SM , et al. Inhibition of food intake in obese subjects by peptide YY3-36 . N Engl J Med . 2003;349:941–948. doi:10.1056/NEJMoa030204 12954742
   PubMed Web of Science ®Google Scholar
• Simpson K , Parker J , Plumer J , Bloom S . CCK, PYY, and PP: the control of energy balance. Handbook of Exp Pharmacol . 2012;209:209–230.
   Google Scholar
• Mishra AK , Dubey V , Ghosh AR . Obesity: an overview of possible role(s) of gut hormones, lipid sensing and gut microbiota. Metabolism . 2016;65:48–65. doi:10.1016/j.metabol.2015.10.008
   Web of Science ®Google Scholar
• Singhal NS , Patel RT , Qi Y , Lee Y-S , Ahima RS . Loss of resistin ameliorates hyperlipidemia and hepatic steatosis in leptin-deficient mice. Am J Physiol . 2008;295:E331–E338.
   Google Scholar
• Tomita T , Doull V , Kimmel JR , Pollock HG . Pancreatic polypeptide and other hormones in pancreas of obese (ob/ob) mice. Diabetologica . 1984;27:454–459. doi:10.1007/BF00273910
   Web of Science ®Google Scholar
• O’Harte FP , Franklin ZJ , Irwin N . Two novel glucagon receptor agonists prove effective therapeutic agents in high-fat-fed and obese diabetic mice. Diabetes Obes Metab . 2014;16:1214–1222. doi:10.1111/dom.12360 25060150
   PubMed Web of Science ®Google Scholar
• Manell H , Staaf J , Manukyan L , et al. Altered plasma levels of glucagon, GLP-1 and glicentin during OGTT in adolescents with obesity and type 2 diabetes.. J Clin Endo Metab . 2016;101:1181–1189. doi:10.1210/jc.2015-3885
   Web of Science ®Google Scholar
• Al-Nakkash L , Clarke LL , Rottinghaus GE , Chen YJ , Cooper K , Rubin LJ . Dietary genistein stimulates anion secretion across female murine intestine. J Nutr . 2006;136:2785–2790. doi:10.1093/jn/136.11.2785 17056801
   PubMed Web of Science ®Google Scholar
• Al-Nakkash L , Martin JB , Petty D , et al. Dietary genistein induces sex-dependent effects on murine body weight, serum profiles, and vascular function of thoracic aortae. Gender Med . 2012;9:295–308. doi:10.1016/j.genm.2012.07.001
   PubMed Web of Science ®Google Scholar
• Al-Nakkash L , Martin JB , Cannon J , Bhakta A , Leung L , Broderick TB . A 2-month exposure to dietary genistein has sex-dependent effects on serum profile, cardiac protein expresssion, and aortic morphology in mice. Nutr Dietary Suppl . 2014;6:15–23. doi:10.2147/NDS.S57602
   Google Scholar
• Zhu X , Bian H , Wang L , et al. Berberine attenuates nonalcoholoc hepatic steatosis through the AMPK-SREBP-1c-SCD1 pathway. Free Radical Biol Med . 2019;141:192–204. doi:10.1016/j.freeradbiomed.2019.06.019 31226399
   PubMed Web of Science ®Google Scholar
• Ohkawa H , Ohishi N , Yagi K . Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Analyt Biochem . 1979;95:351–358. doi:10.1016/0003-2697(79)90738-3 36810
   PubMed Web of Science ®Google Scholar
• Ellman GL . Tissue sulfhydryl groups. Arch Biochem Biophys . 1959;82:70–77. doi:10.1016/0003-9861(59)90090-6 13650640
   PubMed Web of Science ®Google Scholar
• Al-Nakkash L , Janjulia T , Peterson K , et al. Genistein and exercise do not improve cardiovascular risk factors in the ovariectomized rat. Climacteric . 2014;17:136–147. doi:10.3109/13697137.2013.804503 23679226
   PubMed Web of Science ®Google Scholar
• Zhang YR , Proenca M , Maffei M , Barone M , Leopold L , Firiedman JM . Positional cloning of the mouse obese gene and its human homologue. Nature . 1994;372:425–432. doi:10.1038/372425a0 7984236
   PubMed Web of Science ®Google Scholar
• Cooke PS , Naaz A . Role of estrogens in adipocyte development and function. Exp Biol Med . 2004;229:1127–1135. doi:10.1177/153537020422901107
   PubMed Web of Science ®Google Scholar
• Naaz A , Yellayi S , Zakroczymski MA , et al. The soy isoflavone genistein decreases adipose deposition in mice. Endocrinology . 2003;144:3315–3320. doi:10.1210/en.2003-0076 12865308
   PubMed Web of Science ®Google Scholar
• Chu MJJ , Hickey AJR , Tagaloa S , et al. ob/ob mouse livers show decreased oxidative phosphorylation efficiencies and anaerobic capacities after cold ischemia.. PLoS One . 2014;9:1–10. doi:10.1371/journal.pone.0100609
   Web of Science ®Google Scholar
• Won EY , Yoon MK , Kim SW , et al. Gender-specific metabolomic profiling of obesity in leptin-deficient ob/ob mice by 1H NMR spectroscopy. PLoS One . 2013;8:e75998. doi:10.1371/journal.pone.0075998 24098417
   PubMed Web of Science ®Google Scholar
• Shinozaki S , Chiba T , Kokame K , et al. Site-specific effect of estradiol on gene expression in the adipose tissue of ob/ob mice. Horm Metab Res . 2007;39:192–196. doi:10.1055/s-2007-970417 17373633
   PubMed Web of Science ®Google Scholar
• Chakraborty S , Sachdev A , Salton SR , Chakraborty TR . Stereological analysis of estrogen receptor expression in the hypothalamic arcuate nucleus of ob/ob and agouti mice. Brain Res . 2008;1217:86–95. doi:10.1016/j.brainres.2008.04.031 18502406
   PubMed Web of Science ®Google Scholar
• Yang S , Zhu H , Li Y , et al. Mitochondrial adaptatins to obesity-related oxidant stress. Arch Biochem Biophys . 2000;378:259–268. doi:10.1006/abbi.2000.1829 10860543
   PubMed Web of Science ®Google Scholar
• Townsend DM , Tew KD , Tapiero H . The importance of glutathione in human disease. Biomed Pharmacother . 2003;57:145–155. doi:10.1016/S0753-3322(03)00043-X 12818476
   PubMed Web of Science ®Google Scholar
• Ueno H , Inui A , Iwamoto M , et al. Decreased food intake and body weight in pancreatic polypeptide over-expressing mice. Gastroenterology . 1999;117:1427–1432. doi:10.1016/S0016-5085(99)70293-3 10579984
   PubMed Web of Science ®Google Scholar
• Boey D , Lin S , Enriquez RF , et al. PYY transgenic mice are protected against diet-induced and genetic obesity. Neuropeptides . 2008;42:19–30. doi:10.1016/j.npep.2007.11.003 18164057
   PubMed Web of Science ®Google Scholar
• Kim K-H , Zhao L , Moon Y , Kang C , Sul S . Dominant inhibitory adipocyte-specific secretory factor (ADSF)/resistin enhances adipogenesis and improves insulin sensitivity. PNAS USA . 2004;101:6780–6785. doi:10.1073/pnas.0305905101 15090646
   PubMed Web of Science ®Google Scholar
• Shimazu-Kuwahara S , Harada N , Yamane S , et al. Attenuated secretion of glucose-dependent insulinotropic polypeptide (GIP) does not alleviate hyperphagic obesity and insulin resistance in ob/ob mice. Mol Metab . 2017;6:288–294. doi:10.1016/j.molmet.2017.01.006 28271035
   PubMed Web of Science ®Google Scholar
• Jensen MD , Haymond MW , Rizza RA , Cryer PE , Miles JM . Influence of body fat distribution on free fatty acid metabolism in obesity. J Clin Invest . 1989;83:1168–1173. doi:10.1172/JCI113997 2649512
   PubMed Web of Science ®Google Scholar
• Donnelly KL , Smith CI , Schwarzenberg SJ , Jessurun J , Boldt MD , Parks EJ . Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease. J Clin Invest . 2005;115:1343–1351. doi:10.1172/JCI23621 15864352
   PubMed Web of Science ®Google Scholar
• Lundasen T , Andersson E-M , Snaith M , et al. Inhibition of intestinal bile acid transporter Slc10a2 improves triglyceride metabolism and normalizes elevated plamsa glucose levels in mice. PLoS One . 2012;7:1–14. doi:10.1371/journal.pone.0037787
   Web of Science ®Google Scholar