A Pilot Study Assessing the Possible Combined Effect of Physical Activity and PNPLA3 rs738409 Polymorphism on the Risk for Non-Alcoholic Fatty Liver Disease in the Japanese Elderly General Population

References

• Drew L. Fighting the fatty liver. Nature. 2017;550:S102–S103. doi:10.1038/550S102a
   PubMed Web of Science ®Google Scholar
• Sarwar R, Pierce N, Koppe S. Obesity and nonalcoholic fatty liver disease: current perspectives. Diabetes Metab Syndr Obes. 2018;11:533–542. doi:10.2147/DMSO
   PubMed Web of Science ®Google Scholar
• Seto WK, Yuen MF. Nonalcoholic fatty liver disease in asia: emerging perspectives. J Gastroenterol. 2017;52:164–174. doi:10.1007/s00535-016-1264-3
   PubMed Web of Science ®Google Scholar
• Yoshitaka H, Hamaguchi M, Kojima T, et al. Nonoverweight nonalcoholic fatty liver disease and incident cardiovascular disease: a post hoc analysis of a cohort study. Medicine. 2017;96:e6712. doi:10.1097/MD.0000000000006712
   PubMed Web of Science ®Google Scholar
• Borel AL, Nazare JA, Smith J, et al. Visceral, subcutaneous abdominal adiposity and liver fat content distribution in normal glucose tolerance, impaired fasting glucose and/or impaired glucose tolerance. Int J Obes (Lond). 2015;39:495–501. doi:10.1038/ijo.2014.163
   PubMedGoogle Scholar
• Dhana K, Berghout MA, Peeters A, et al. Obesity in older adults and life expectancy with and without cardiovascular disease. Int J Obes (Lond). 2016;40:1535–1540. doi:10.1038/ijo.2016.94
   PubMedGoogle Scholar
• Gan L, Chitturi S, Farrell GC. Mechanisms and implications of age-related changes in the liver: nonalcoholic fatty liver disease in the elderly. Curr Gerontol Geriatr Res. 2011;2011:831536. doi:10.1155/2011/831536
   PubMedGoogle Scholar
• Miyake T, Kumagi T, Hirooka M, et al. Significance of exercise in nonalcoholic fatty liver disease in men: a community-based large cross-sectional study. J Gastroenterol. 2015;50:230–237. doi:10.1007/s00535-014-0959-6
   PubMedGoogle Scholar
• Romero-Gomez M, Zelber-Sagi S, Trenell M. Treatment of nafld with diet, physical activity and exercise. J Hepatol. 2017;67:829–846. doi:10.1016/j.jhep.2017.05.016
   PubMed Web of Science ®Google Scholar
• Hashida R, Kawaguchi T, Bekki M, et al. Aerobic vs. Resistance exercise in non-alcoholic fatty liver disease: a systematic review. J Hepatol. 2017;66:142–152. doi:10.1016/j.jhep.2016.08.023
   PubMed Web of Science ®Google Scholar
• Zhang L, You W, Zhang H, et al. Pnpla3 polymorphisms (rs738409) and non-alcoholic fatty liver disease risk and related phenotypes: a meta-analysis. J Gastroenterol Hepatol. 2015;30:821–829. doi:10.1111/jgh.2015.30.issue-5
   PubMed Web of Science ®Google Scholar
• Shen JH, Li YL, Li D, et al. The rs738409 (i148m) variant of the pnpla3 gene and cirrhosis: a meta-analysis. J Lipid Res. 2015;56:167–175.
   PubMedGoogle Scholar
• Huang Y, Cohen JC, Hobbs HH. Expression and characterization of a pnpla3 protein isoform (i148m) associated with nonalcoholic fatty liver disease. J Biol Chem. 2011;286:37085–37093. doi:10.1074/jbc.M111.290114
   PubMed Web of Science ®Google Scholar
• Oniki K, Saruwatari J, Izuka T, et al. Influence of the pnpla3 rs738409 polymorphism on non-alcoholic fatty liver disease and renal function among normal weight subjects. PLoS One. 2015;10:e0132640. doi:10.1371/journal.pone.0132640
   PubMedGoogle Scholar
• Jette M, Sidney K, Blumchen G. Metabolic equivalents (mets) in exercise testing, exercise prescription, and evaluation of functional capacity. Clin Cardiol. 1990;13:555–565. doi:10.1002/clc.v13:8
   PubMed Web of Science ®Google Scholar
• The Korean Association for the Study of the Liver. KASL clinical practice guidelines: management of nonalcoholic fatty liver disease. Clin Mol Hepatol. 2013;19:325–348. doi:10.3350/cmh.2013.19.4.325
   PubMedGoogle Scholar
• European Association for the Study of the Liver, European Association for the Studyof Diabetes, European Association for the Study of Obesity. EASL-EASD-EASO clinical practice guidelines for the management of non-alcoholic fatty liver disease. J Hepatol. 2016;64:1388–1402. doi:10.1016/j.jhep.2015.11.004
   PubMed Web of Science ®Google Scholar
• Wang M, Kong L, Li Z, et al. Covariance estimators for generalized estimating equations (gee) in longitudinal analysis with small samples. Stat Med. 2016;35:1706–1721.
   PubMed Web of Science ®Google Scholar
• Salazar A, Ojeda B, Duenas M, et al. Simple generalized estimating equations (gees) and weighted generalized estimating equations (wgees) in longitudinal studies with dropouts: guidelines and implementation in r. Stat Med. 2016;35:3424–3448. doi:10.1002/sim.6947
   PubMed Web of Science ®Google Scholar
• Shen J, Wong GL, Chan HL, et al. Pnpla3 gene polymorphism and response to lifestyle modification in patients with nonalcoholic fatty liver disease. J Gastroenterol Hepatol. 2015;30:139–146. doi:10.1111/jgh.12656
   PubMed Web of Science ®Google Scholar
• Marzuillo P, Grandone A, Perrone L, et al. Weight loss allows the dissection of the interaction between abdominal fat and pnpla3 (adiponutrin) in the liver damage of obese children. J Hepatol. 2013;59:1143–1144. doi:10.1016/j.jhep.2013.06.027
   PubMedGoogle Scholar
• Kantartzis K, Peter A, Machicao F, et al. Dissociation between fatty liver and insulin resistance in humans carrying a variant of the patatin-like phospholipase 3 gene. Diabetes. 2009;58:2616–2623. doi:10.2337/db09-0279
   PubMed Web of Science ®Google Scholar
• Cassidy S, Chau JY, Catt M, et al. Low physical activity, high television viewing and poor sleep duration cluster in overweight and obese adults; a cross-sectional study of 398,984 participants from the uk biobank. Int J Behav Nutr Phys Act. 2017;14:57. doi:10.1186/s12966-017-0514-y
   PubMedGoogle Scholar
• Lampure A, Castetbon K, Hanafi M, et al. Relative influence of socioeconomic, psychological and sensory characteristics, physical activity and diet on 5-year weight gain in french adults. Nutrients. 2017;9:1179. doi:10.3390/nu9111179
   PubMedGoogle Scholar
• Liu CJ. Prevalence and risk factors for non-alcoholic fatty liver disease in asian people who are not obese. J Gastroenterol Hepatol. 2012;27:1555–1560. doi:10.1111/j.1440-1746.2012.07222.x
   PubMed Web of Science ®Google Scholar
• Smith BW, Adams LA. Nonalcoholic fatty liver disease and diabetes mellitus: pathogenesis and treatment. Nat Rev Endocrinol. 2011;7:456–465. doi:10.1038/nrendo.2011.72
   PubMed Web of Science ®Google Scholar