112
Views
6
CrossRef citations to date
0
Altmetric
Original Research

Serum CTRP3 Levels In Obese Children: A Potential Protective Adipokine Of Obesity, Insulin Sensitivity And Pancreatic β Cell Function

ORCID Icon, , , ORCID Icon, , , , , & show all
Pages 1923-1930 | Published online: 20 Sep 2019

References

  • Ng M , Fleming T , Robinson M , et al. Global, regional, and national prevalence of overweight and obesity in children and adults during 1980-2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet . 2014;384:766–781. doi:10.1016/S0140-6736(14)60460-8 24880830
  • Ogden CL , Carroll MD , Curtin LR , et al. Prevalence of high body mass index in US children and adolescents, 2007-2008. Jama . 2010;303:242–249. doi:10.1001/jama.2009.2012 20071470
  • Song Y , Wang HJ , Ma J , et al. BMI-for-age Z-score distribution shifts among Chinese children: gender disparity. Obesity (Silver Spring) . 2014;22:1187–1193. doi:10.1002/oby.20676 24318807
  • Zhang J , Wang H , Wang Z , et al. Prevalence and stabilizing trends in overweight and obesity among children and adolescents in China, 2011-2015. BMC Public Health . 2018;18:571. doi:10.1186/s12889-018-5483-9 29716560
  • Koskinen J , Magnussen CG , Sinaiko A , et al. Childhood age and associations between childhood metabolic syndrome and adult risk for metabolic syndrome, type 2 diabetes mellitus and carotid intima media thickness: the international childhood cardiovascular cohort consortium. J Am Heart Assoc . 2017;6:e005632. doi:10.1161/JAHA.117.005632 28862940
  • Hou Y , Wang M , Yang L , et al. Weight status change from childhood to early adulthood and the risk of adult hypertension. J Hypertens . 2019;37:1239–1243. doi:10.1097/HJH.0000000000002016 30557220
  • Balistreri CR , Caruso C , Candore G . The role of adipose tissue and adipokines in obesity-related inflammatory diseases. Mediators Inflamm . 2010;2010:802078. doi:10.1155/2010/802078 20671929
  • Nigro E , Scudiero O , Monaco ML , et al. New insight into adiponectin role in obesity and obesity-related diseases. Biomed Res Int . 2014;2014:658913. doi:10.1155/2014/658913 25110685
  • Li X , Jiang L , Yang M , et al. Expression of CTRP3, a novel adipokine, in rats at different pathogenic stages of type 2 diabetes mellitus and the impacts of GLP-1 receptor agonist on it. J Diabetes Res . 2014;2014:398518. doi:10.1155/2014/398518 25177707
  • Peterson JM , Seldin MM , Wei Z , et al. CTRP3 attenuates diet-induced hepatic steatosis by regulating triglyceride metabolism. Am J Physiol Gastrointest Liver Physiol . 2013;305:G214–G224. doi:10.1152/ajpgi.00102.2013 23744740
  • Kwon MR , Cress E , Clark WA , et al. The adipokine C1q TNF related protein 3 (CTRP3) is elevated in the breast milk of obese mothers. Peer J . 2018;6:e4472. doi:10.7717/peerj.4472 29527418
  • Ban B , Bai B , Zhang M , et al. Low serum cartonectin/CTRP3 concentrations in newly diagnosed type 2 diabetes mellitus: in vivo regulation of cartonectin by glucose. PLoS One . 2014;9:e112931. doi:10.1371/journal.pone.0112931 25409499
  • Wolf RM , Steele KE , Peterson LA , et al. Lower circulating C1q/TNF-Related Protein-3 (CTRP3) levels are associated with obesity: a cross-sectional study. PLoS One . 2015;10:e133955. doi:10.1371/journal.pone.0133955
  • Peterson JM , Wei Z , Wong GW . C1q/TNF-related protein-3 (CTRP3), a novel adipokine that regulates hepatic glucose output. J Biol Chem . 2010;285:39691–39701. doi:10.1074/jbc.M110.180695 20952387
  • Deng W , Li C , Zhang Y , et al. Serum C1q/TNF-related protein-3 (CTRP3) levels are decreased in obesity and hypertension and are negatively correlated with parameters of insulin resistance. Diabetol Metab Syndr . 2015;7:33. doi:10.1186/s13098-015-0029-0 25878729
  • Li H , Ji CY , Zong XN , et al. Body mass index growth curves for Chinese children and adolescents aged 0 to 18 years. Chin J Pediatr . 2009;47:493–498.
  • Tanner JM . Growth and maturation during adolescence. Nutr Rev . 1981;39:43–55. doi:10.1111/j.1753-4887.1981.tb06734.x 7010232
  • The Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Report of the expert committee on the diagnosis and classification of diabetes mellitus. Diabetes Care . 1997;20:1183–1197. doi:10.2337/diacare.20.7.118318 9203460
  • Wang F , Chen T , Sun L , et al. Circulating PGRN levels are increased but not associated with insulin sensitivity or beta-cell function in chinese obese children. Dis Markers . 2018;2018:3729402. doi:10.1155/2018/3729402 30151059
  • Wallace TM , Levy JC , Matthews DR . Use and abuse of HOMA modeling. Diabetes Care . 2004;27:1487–1495. doi:10.2337/diacare.27.6.1487 15161807
  • Andrade MI , Oliveira JS , Leal VS , et al. Identification of cutoff points for homeostatic model assessment for insulin resistance index in adolescents: systematic review. Rev Paul Pediatr . 2016;34:234–242. doi:10.1016/j.rpped.2015.08.006 26559605
  • Bonora E , Targher G , Alberiche M , et al. Homeostasis model assessment closely mirrors the glucose clamp technique in the assessment of insulin sensitivity: studies in subjects with various degrees of glucose tolerance and insulin sensitivity. Diabetes Care . 2000;23:57–63. doi:10.2337/diacare.23.1.57 10857969
  • Bacha F , Gungor N , Arslanian SA . Measures of beta-cell function during the oral glucose tolerance test, liquid mixed-meal test, and hyperglycemic clamp test. J Pediatr . 2008;152:618–621. doi:10.1016/j.jpeds.2007.11.044 18410762
  • Yang Y , Li Y , Ma Z , et al. A brief glimpse at CTRP3 and CTRP9 in lipid metabolism and cardiovascular protection. Prog Lipid Res . 2016;64:170–177. doi:10.1016/j.plipres.2016.10.001 27743997
  • Li X , Jiang L , Yang M , et al. CTRP3 improves the insulin sensitivity of 3T3-L1 adipocytes by inhibiting inflammation and ameliorating insulin signalling transduction. Endokrynol Pol . 2014;65:252–258. doi:10.5603/EP.2014.0034 25185846
  • Li X , Jiang L , Yang M , et al. CTRP3 modulates the expression and secretion of adipokines in 3T3-L1 adipocytes. Endocr J . 2014;61:1153–1162. doi:10.1507/endocrj.EJ14-0161 25168658
  • Yoo HJ , Hwang SY , Hong HC , et al. Implication of progranulin and C1q/TNF-related protein-3 (CTRP3) on inflammation and atherosclerosis in subjects with or without metabolic syndrome. PLoS One . 2013;8:e55744. doi:10.1371/journal.pone.0055744 23409033
  • Maeda T , Abe M , Kurisu K , et al. Molecular cloning and characterization of a novel gene, CORS26, encoding a putative secretory protein and its possible involvement in skeletal development. J Biol Chem . 2001;276:3628–3634. doi:10.1074/jbc.M007898200 11071891
  • Wei H , Qu H , Wang H , et al. Plasma C1q/TNF-related protein-3 (CTRP-3) and high-mobility group box-1 (HMGB-1) concentrations in subjects with prediabetes and type 2 diabetes. J Diabetes Res . 2016;2016:9438760. doi:10.1155/2016/9438760 27738641
  • Qu H , Deng M , Wang H , et al. Plasma CTRP-3 concentrations in Chinese patients with obesity and type II diabetes negatively correlate with insulin resistance. J Clin Lipidol . 2015;9:289–294. doi:10.1016/j.jacl.2015.03.006 26073386
  • Zhang J , Zhang B , Cheng Y , et al. Low serum CTRP3 levels are associated with nonalcoholic fatty liver disease in patients with type 2 diabetes mellitus. Cytokine . 2018;106:131–135. doi:10.1016/j.cyto.2017.10.023 29113741
  • Wurm S , Neumeier M , Weigert J , et al. Plasma levels of leptin, omentin, collagenous repeat-containing sequence of 26-kDa protein (CORS-26) and adiponectin before and after oral glucose uptake in slim adults. Cardiovasc Diabetol . 2007;6:7. doi:10.1186/1475-2840-6-7 17311679
  • Choi HJ , Jeon SY , Hong WK , et al. Effect of glucose ingestion in plasma markers of inflammation and oxidative stress: analysis of 16 plasma markers from oral glucose tolerance test samples of normal and diabetic patients. Diabetes Res Clin Pract . 2013;99:e27–e31. doi:10.1016/j.diabres.2012.01.005 23410727
  • Li Y , Wright GL , Peterson JM . C1q/TNF-related protein 3 (CTRP3) function and regulation. Compr Physiol . 2017;7:863–878. doi:10.1002/cphy.c160044 28640446
  • Chiarelli F , Marcovecchio ML . Insulin resistance and obesity in childhood. Eur J Endocrinol . 2008;159(Suppl 1):S67–S74. doi:10.1530/EJE-08-0245 18805916
  • Wolfing B , Buechler C , Weigert J , et al. Effects of the new C1q/TNF-related protein (CTRP-3) “cartonectin” on the adipocytic secretion of adipokines. Obesity (Silver Spring) . 2008;16:1481–1486. doi:10.1038/oby.2008.206 18421280
  • Lihn AS , Pedersen SB , Richelsen B . Adiponectin: action, regulation and association to insulin sensitivity. Obes Rev . 2005;6:13–21. doi:10.1111/j.1467-789X.2005.00159.x 15655035
  • Shoelson SE , Lee J , Goldfine AB . Inflammation and insulin resistance. J Clin Invest . 2006;116:1793–1801. doi:10.1172/JCI29069 16823477
  • Li JY , Wu GM , Hou Z , et al. Expression of C1q/TNF-related protein-3 (CTRP3) in serum of patients with gestational diabetes mellitus and its relationship with insulin resistance. Eur Rev Med Pharmacol Sci . 2017;21:5702–5710. doi:10.26355/eurrev_201712_14016 29272006
  • Della CV , Tuttolomondo A , Pecoraro R , et al. Inflammation, endothelial dysfunction and arterial stiffness as therapeutic targets in cardiovascular medicine. Curr Pharm Des . 2016;22:4658–4668. doi:10.2174/1381612822666160510124801 27160758
  • Trogen G , Bacon J , Li Y , et al. Transgenic overexpression of CTRP3 prevents alcohol-induced hepatic triglyceride accumulation. Am J Physiol Endocrinol Metab . 2018;315:E949–E960. doi:10.1152/ajpendo.00050.2018 29763374