100
Views
4
CrossRef citations to date
0
Altmetric
Original Research

Differential Expression of Human N-Alpha-Acetyltransferase 40 (hNAA40), Nicotinamide Phosphoribosyltransferase (NAMPT) and Sirtuin-1 (SIRT-1) Pathway in Obesity and T2DM: Modulation by Metformin and Macronutrient Intake

, , ORCID Icon, ORCID Icon, , , & ORCID Icon show all
Pages 2765-2774 | Published online: 27 Dec 2019

References

  • Abdul Rahman A , Abdul Karim N , Abdul Hamid NA , Harun R , Ngah WZ . Senescence-related changes in gene expression of peripheral blood mononuclear cells from octo/nonagenarians compared to their offspring. Oxid Med Cell Longev . 2013;2013:189129. doi:10.1155/2013/189129 24381713
  • Yang H , Lavu S , Sinclair DA . Nampt/PBEF/Visfatin: a regulator of mammalian health and longevity? Exp Gerontol . 2006;41(8):718–726. doi:10.1016/j.exger.2006.06.003 16842957
  • Molina‐Serrano D , Schiza V , Demosthenous C , et al. Loss of Nat4 and its associated histone H4 N-terminal acetylation mediates calorie restriction-induced longevity. EMBO Rep . 2016;17(12):1829–1843. doi:10.15252/embr.201642540 27799288
  • Nayar S , Dasgupta P , Galustian C . Extending the lifespan and efficacies of immune cells used in adoptive transfer for cancer immunotherapies-A review. Oncoimmunology . 2015;4(4):e1002720. doi:10.1080/2162402X.2014.1002720 26155387
  • Heilbronn LK , Ravussin E . Calorie restriction and aging: review of the literature and implications for studies in humans. Am J Clin Nutr . 2003;78(3):361–369. doi:10.1093/ajcn/78.3.361 12936916
  • Bornfeldt KE , Tabas I . Insulin resistance, hyperglycemia, and atherosclerosis. Cell Metab . 2011;14(5):575–585. doi:10.1016/j.cmet.2011.07.015 22055501
  • Madonna R , De Caterina R . Atherogenesis and diabetes: focus on insulin resistance and hyperinsulinemia. Rev Esp Cardiol . 2012;65(4):309–313. doi:10.1016/j.recesp.2011.11.010 22357362
  • Mair W , Dillin A . Aging and survival: the genetics of life span extension by dietary restriction. Annu Rev Biochem . 2008;77:727–754. doi:10.1146/annurev.biochem.77.061206.171059 18373439
  • Koubova J . How does calorie restriction work? Genes Dev . 2003;17(3):313–321. doi:10.1101/gad.1052903 12569120
  • Passtoors WM , Beekman M , Gunn D , et al. Genomic studies in ageing research: the need to integrate genetic and gene expression approaches. J Intern Med . 2008;263(2):153–166. doi:10.1111/jim.2008.263.issue-2 18226093
  • Cuyas E , Verdura S , Llorach-Pares L , et al. Metformin is a direct SIRT1-activating compound: computational modeling and experimental validation. Front Endocrinol (Lausanne) . 2018;9:657. doi:10.3389/fendo.2018.00657 30459716
  • Muller PY , Janovjak H , Miserez AR , Dobbie Z . Processing of gene expression data generated by quantitative real-time RT-PCR. BioTechniques . 2002;32(6):1372–4, 6, 8–9.
  • Rottenberg H , Wu S . Mitochondrial dysfunction in lymphocytes from old mice: enhanced activation of the permeability transition. Biochem Biophys Res Commun . 1997;240(1):68–74. doi:10.1006/bbrc.1997.7605 9367884
  • Imai SI , Guarente L . It takes two to tango: NAD(+) and sirtuins in aging/longevity control. NPJ Aging Mech Dis . 2016;2:16017. doi:10.1038/npjamd.2016.17 28721271
  • Van Gool F , Galli M , Gueydan C , et al. Intracellular NAD levels regulate tumor necrosis factor protein synthesis in a sirtuin-dependent manner. Nat Med . 2009;15(2):206–210. doi:10.1038/nm.1906 19151729
  • Montecucco F , Cea M , Cagnetta A , et al. Nicotinamide phosphoribosyltransferase as a target in inflammation- related disorders. Curr Top Med Chem . 2013;13(23):2930–2938. doi:10.2174/15680266113136660208 24171767
  • Presumey J , Courties G , Louis-Plence P , et al. Nicotinamide phosphoribosyltransferase/visfatin expression by inflammatory monocytes mediates arthritis pathogenesis. Ann Rheum Dis . 2013;72(10):1717–1724. doi:10.1136/annrheumdis-2012-202403 23313810
  • Li Y , Zhang Y , Dorweiler B , et al. Extracellular Nampt promotes macrophage survival via a nonenzymatic interleukin-6/STAT3 signaling mechanism. J Biol Chem . 2008;283(50):34833–34843. doi:10.1074/jbc.M805866200 18945671
  • Al Dubayee MS , Alayed H , Almansour R , et al. Differential expression of human peripheral mononuclear cells phenotype markers in type 2 diabetic patients and type 2 diabetic patients on metformin. Front Endocrinol (Lausanne) . 2018;9:537. doi:10.3389/fendo.2018.00537 30356719
  • Borradaile NM , Pickering JG . Nicotinamide phosphoribosyltransferase imparts human endothelial cells with extended replicative lifespan and enhanced angiogenic capacity in a high glucose environment. Aging Cell . 2009;8(2):100–112. doi:10.1111/ace.2009.8.issue-2 19302375
  • Dandona P , Aljada A , Dhindsa S , Garg R . Insulin as an anti-inflammatory and antiatherosclerotic hormone. Clin Cornerstone . 2003;Suppl 4:S13–20. doi:10.1016/S1098-3597(03)90062-7
  • Aljada A , Ghanim H , Mohanty P , Syed T , Bandyopadhyay A , Dandona P . Glucose intake induces an increase in activator protein 1 and early growth response 1 binding activities, in the expression of tissue factor and matrix metalloproteinase in mononuclear cells, and in plasma tissue factor and matrix metalloproteinase concentrations. Am J Clin Nutr . 2004;80(1):51–57. doi:10.1093/ajcn/80.1.51 15213027
  • Dandona P , Aljada A , Mohanty P , et al. Insulin inhibits intranuclear nuclear factor kappaB and stimulates IkappaB in mononuclear cells in obese subjects: evidence for an anti-inflammatory effect? J Clin Endocrinol Metab . 2001;86(7):3257–3265. doi:10.1210/jcem.86.7.7623 11443198
  • Alshahrani A , Bin Khunayfir A , Al Rayih M , et al. Phenotypic characterization of human monocytes following macronutrient intake in healthy humans. Front Immunol . 2017;8:1293. doi:10.3389/fimmu.2017.01293 29109719
  • Yoshino J , Mills KF , Yoon MJ , Imai S . Nicotinamide mononucleotide, a key NAD(+) intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice. Cell Metab . 2011;14(4):528–536. doi:10.1016/j.cmet.2011.08.014 21982712
  • Chalkiadaki A , Guarente L . High-fat diet triggers inflammation-induced cleavage of SIRT1 in adipose tissue to promote metabolic dysfunction. Cell Metab . 2012;16(2):180–188. doi:10.1016/j.cmet.2012.07.003 22883230
  • Garten A , Petzold S , Schuster S , Korner A , Kratzsch J , Kiess W . Nampt and its potential role in inflammation and type 2 diabetes. Handb Exp Pharmacol . 2011;203:147–164.
  • Stofkova A . Resistin and visfatin: regulators of insulin sensitivity, inflammation and immunity. Endocr Regul . 2010;44(1):25–36. doi:10.4149/endo_2010_01_25 20151765
  • Imai S , Kiess W . Therapeutic potential of SIRT1 and NAMPT-mediated NAD biosynthesis in type 2 diabetes. Front Biosci . 2009;14:2983–2995. doi:10.2741/3428
  • Mukherjee R , Kanti Barman P , Kumar Thatoi P , Tripathy R , Kumar Das B , Ravindran B . Non-classical monocytes display inflammatory features: validation in sepsis and systemic lupus erythematous. Sci Rep . 2015;5:13886. doi:10.1038/srep13886 26358827
  • Ziegler-Heitbrock L , Ancuta P , Crowe S , et al. Nomenclature of monocytes and dendritic cells in blood. Blood . 2010;116(16):e74–80. doi:10.1182/blood-2010-02-258558 20628149
  • Ong SM , Hadadi E , Dang TM , et al. The pro-inflammatory phenotype of the human non-classical monocyte subset is attributed to senescence. Cell Death Dis . 2018;9(3):266. doi:10.1038/s41419-018-0327-1 29449647
  • Ghanim H , Aljada A , Hofmeyer D , Syed T , Mohanty P , Dandona P . Circulating mononuclear cells in the obese are in a proinflammatory state. Circulation . 2004;110(12):1564–1571. doi:10.1161/01.CIR.0000142055.53122.FA 15364812
  • Dandona P , Aljada A , Bandyopadhyay A . Inflammation: the link between insulin resistance, obesity and diabetes. Trends Immunol . 2004;25(1):4–7. doi:10.1016/j.it.2003.10.013 14698276
  • Aljada A , Garg R , Ghanim H , et al. Nuclear factor-kappaB suppressive and inhibitor-kappaB stimulatory effects of troglitazone in obese patients with type 2 diabetes: evidence of an antiinflammatory action? J Clin Endocrinol Metab . 2001;86(7):3250–3256. doi:10.1210/jcem.86.7.7564 11443197
  • Aljada A , Friedman J , Ghanim H , et al. Glucose ingestion induces an increase in intranuclear nuclear factor kappaB, a fall in cellular inhibitor kappaB, and an increase in tumor necrosis factor alpha messenger RNA by mononuclear cells in healthy human subjects. Metabolism . 2006;55(9):1177–1185. doi:10.1016/j.metabol.2006.04.016 16919536
  • Aljada A , Mohanty P , Ghanim H , et al. Increase in intranuclear nuclear factor kappaB and decrease in inhibitor kappaB in mononuclear cells after a mixed meal: evidence for a proinflammatory effect. Am J Clin Nutr . 2004;79(4):682–690. doi:10.1093/ajcn/79.4.682 15051615
  • Aljada A , Ghanim H , Mohanty P , Kapur N , Dandona P . Insulin inhibits the pro-inflammatory transcription factor early growth response gene-1 (Egr)-1 expression in mononuclear cells (MNC) and reduces plasma tissue factor (TF) and plasminogen activator inhibitor-1 (PAI-1) concentrations. J Clin Endocrinol Metab . 2002;87(3):1419–1422. doi:10.1210/jcem.87.3.8462 11889219
  • Dandona P , Mohanty P , Hamouda W , et al. Inhibitory effect of a two day fast on reactive oxygen species (ROS) generation by leucocytes and plasma ortho-tyrosine and meta-tyrosine concentrations. J Clin Endocrinol Metab . 2001;86(6):2899–2902. doi:10.1210/jcem.86.6.7745 11397907
  • Pifferi F , Terrien J , Marchal J , et al. Caloric restriction increases lifespan but affects brain integrity in grey mouse lemur primates. Commun Biol . 2018;1:30. doi:10.1038/s42003-018-0024-8 30271916
  • Heilbronn LK , de Jonge L , Frisard MI , et al. Effect of 6-month calorie restriction on biomarkers of longevity, metabolic adaptation, and oxidative stress in overweight individuals: a randomized controlled trial. JAMA . 2006;295(13):1539–1548. doi:10.1001/jama.295.13.1539 16595757
  • Lee A , Morley JE . Metformin decreases food consumption and induces weight loss in subjects with obesity with type II non-insulin-dependent diabetes. Obes Res . 1998;6(1):47–53. doi:10.1002/j.1550-8528.1998.tb00314.x 9526970
  • Giannarelli R , Aragona M , Coppelli A , Del Prato S . Reducing insulin resistance with metformin: the evidence today. Diabetes Metab . 2003;29(4 Pt 2):6S28–35. doi:10.1016/S1262-3636(03)72785-2 14502098
  • Saisho Y . Metformin and inflammation: its potential beyond glucose-lowering effect. Endocr Metab Immune Disord Drug Targets . 2015;15(3):196–205. doi:10.2174/1871530315666150316124019 25772174
  • Cameron AR , Morrison VL , Levin D , et al. Anti-inflammatory effects of metformin irrespective of diabetes status. Circ Res . 2016;119(5):652–665. doi:10.1161/CIRCRESAHA.116.308445 27418629