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Review

Effects of Topical Insulin on Wound Healing: A Review of Animal and Human Evidences

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Pages 719-727 | Published online: 13 Mar 2020

References

  • Sen CK, Gordillo GM, Roy S, et al. Human skin wounds: a major and snowballing threat to public health and the economy. Wound Repair Regener. 2009;17(6):763–771. doi:10.1111/wrr.2009.17.issue-6
  • Hassan WU, Greiser U, Wang W. Role of adipose-derived stem cells in wound healing. Wound Repair Regener. 2014;22(3):313–325. doi:10.1111/wrr.12173
  • Barrientos S, Brem H, Stojadinovic O, Tomic-canic M. Clinical application of growth factors and cytokines in wound healing. Wound Repair Regener. 2014;22(5):569–578. doi:10.1111/wrr.12205
  • Nie C, Yang D, Xu J, Si Z, Jin X, Zhang J. Locally administered adipose-derived stem cells accelerate wound healing through differentiation and vasculogenesis. Cell Transplant. 2011;20(2):205–216. doi:10.3727/096368910X520065
  • Oryan A, Alemzadeh E. Effects of insulin on wound healing: a review of animal and human evidences. Life Sci. 2017;174:59–67. doi:10.1016/j.lfs.2017.02.015
  • Wang L, Yang B, Jiang H, et al. The molecular mechanism study of insulin in promoting wound healing under high-glucose conditions. J Cell Biochem. 2019;120(9):16244–16253.
  • Kakanj P, Moussian B, Gronke S, et al. Insulin and TOR signal in parallel through FOXO and S6K to promote epithelial wound healing. Nat Commun. 2016;7:12972. doi:10.1038/ncomms12972
  • Zhao L, Niu L, Liang H, Tan H, Liu C, Zhu F. pH and glucose dual-responsive injectable hydrogels with insulin and fibroblasts as bioactive dressings for diabetic wound healing. ACS Appl Mater Interfaces. 2017;9(43):37563–37574. doi:10.1021/acsami.7b09395
  • Vatankhah N, Jahangiri Y, Landry GJ, Moneta GL, Azarbal AF. Effect of systemic insulin treatment on diabetic wound healing. Wound Repair Regener. 2017;25(2):288–291. doi:10.1111/wrr.2017.25.issue-2
  • Sridharan K, Sivaramakrishnan G. Efficacy of topical insulin in wound healing: a preliminary systematic review and meta-analysis of randomized controlled trials. Wound Repair Regener. 2017;25(2):279–287. doi:10.1111/wrr.2017.25.issue-2
  • Hrynyk M, Neufeld RJ. Insulin and wound healing. Burns. 2014;40(8):1433–1446. doi:10.1016/j.burns.2014.03.020
  • Pakyari M, Farrokhi A, Maharlooei MK, Ghahary A. Critical role of transforming growth factor beta in different phases of wound healing. Advan Wound Care. 2013;2(5):215–224. doi:10.1089/wound.2012.0406
  • Su Y, Richmond A. Chemokine regulation of neutrophil infiltration of skin wounds. Advan Wound Care. 2015;4(11):631–640. doi:10.1089/wound.2014.0559
  • Behm B, Babilas P, Landthaler M, Schreml S. Cytokines, chemokines and growth factors in wound healing. J Eur Acad Dermatol Venereol. 2012;26(7):812–820. doi:10.1111/jdv.2012.26.issue-7
  • Greaves NS, Ashcroft KJ, Baguneid M, Bayat A. Current understanding of molecular and cellular mechanisms in fibroplasia and angiogenesis during acute wound healing. J Dermatol Sci. 2013;72(3):206–217. doi:10.1016/j.jdermsci.2013.07.008
  • Dhall S, Silva JP, Liu Y, et al. Release of insulin from PLGA-alginate dressing stimulates regenerative healing of burn wounds in rats. Clin sci. 2015;129(12):1115–1129. doi:10.1042/CS20150393
  • Chen X, Liu Y, Zhang X. Topical insulin application improves healing by regulating the wound inflammatory response. Wound Repair Regener. 2012;20(3):425–434. doi:10.1111/wrr.2012.20.issue-3
  • Liu Y, Dhall S, Castro A, Chan A, Alamat R, Martins-Green M. Insulin regulates multiple signaling pathways leading to monocyte/macrophage chemotaxis into the wound tissue. Biol Open. 2018;7:1. doi:10.1242/bio.026187
  • Liu Y, Petreaca M, Martins-Green M. Cell and molecular mechanisms of insulin-induced angiogenesis. J Cell Mol Med. 2009;13(11–12):4492–4504. doi:10.1111/jcmm.2010.13.issue-11-12
  • Lima MH, Caricilli AM, de Abreu LL, et al. Topical insulin accelerates wound healing in diabetes by enhancing the AKT and ERK pathways: a double-blind placebo-controlled clinical trial. PLoS One. 2012;7(5):e36974. doi:10.1371/journal.pone.0036974
  • Paul TN. Treatment by local application of insulin of an infected wound in a diabetic. Lancet (London, England). 1966;2(7463):574–576. doi:10.1016/S0140-6736(66)93041-8
  • Hrynyk M, Martins-green M, Barron AE, Neufeld RJ. Alginate-PEG sponge architecture and role in the design of insulin release dressings. Biomacromolecules. 2012;13(5):1478–1485. doi:10.1021/bm300186k
  • Zhang XJ, Wu X, Wolf SE, Hawkins HK, Chinkes DL, Wolfe RR. Local insulin-zinc injection accelerates skin donor site wound healing. J Surg Res. 2007;142(1):90–96. doi:10.1016/j.jss.2006.10.034
  • Zagon IS, Klocek MS, Sassani JW, McLaughlin PJ. Use of topical insulin to normalize corneal epithelial healing in diabetes mellitus. Arch Ophthalmol. 2007;125(8):1082–1088. doi:10.1001/archopht.125.8.1082
  • Cruz-cazarim ELC, Cazarim MS, Ogunjimi AT, Petrilli R, Rocha EM, Lopez RFV. Prospective insulin-based ophthalmic delivery systems for the treatment of dry eye syndrome and corneal injuries. Eur J Pharm Biopharm. 2019;140:1–10. doi:10.1016/j.ejpb.2019.04.014
  • Apikoglu-rabus S, Izzettin FV, Turan P, Ercan F. Effect of topical insulin on cutaneous wound healing in rats with or without acute diabetes. Clin Exp Dermatol. 2010;35(2):180–185. doi:10.1111/ced.2010.35.issue-2
  • Negrini J, Mozos E, Escamilla A, et al. Effects of topical insulin on second-intention wound healing in the red-eared slider turtle (Trachemys scripta elegans) - a controlled study. BMC Vet Res. 2017;13(1):160. doi:10.1186/s12917-017-1082-8
  • Azevedo F, Pessoa A, Moreira G, et al. Effect of topical insulin on second-degree burns in diabetic rats. Biol Res Nurs. 2016;18(2):181–192. doi:10.1177/1099800415592175
  • Besson JCF, Hernandes L, Campos JM, Morikawa KA, Bersani-amado CA, Matioli G. Insulin complexed with cyclodextrins stimulates epithelialization and neovascularization of skin wound healing in rats. Injury. 2017;48(11):2417–2425. doi:10.1016/j.injury.2017.08.046
  • Abdelkader DH, Tambuwala MM, Mitchell CA, et al. Enhanced cutaneous wound healing in rats following topical delivery of insulin-loaded nanoparticles embedded in poly (vinyl alcohol)-borate hydrogels. Drug Deliv Transl Res. 2018;8(5):1053–1065. doi:10.1007/s13346-018-0554-0
  • Ehterami A, Salehi M, Farzamfar S, et al. In vitro and in vivo study of PCL/COLL wound dressing loaded with insulin-chitosan nanoparticles on cutaneous wound healing in rats’ model. Int J Biol Macromol. 2018;117:601–609. doi:10.1016/j.ijbiomac.2018.05.184
  • Kaur P, Sharma AK, Nag D, et al. Novel nano-insulin formulation modulates cytokine secretion and remodeling to accelerate diabetic wound healing. Nanomedicine. 2019;15(1):47–57. doi:10.1016/j.nano.2018.08.013
  • Lee CH, Hung KC, Hsieh MJ, et al. Core-shell insulin-loaded nanofibrous scaffolds for repairing diabetic wounds. Nanomedicine. 2019;24:102123. doi:10.1016/j.nano.2019.102123
  • Li W, Gao F, Kan J, Deng J, Wang B, Hao S. Synthesis and fabrication of a keratin-conjugated insulin hydrogel for the enhancement of wound healing. Colloids Surf B Biointerfaces. 2019;175:436–444. doi:10.1016/j.colsurfb.2018.12.020
  • Van Ort SR, Gerber RM. Topical application of insulin in the treatment of decubitus ulcers: a pilot study. Nurs Res. 1976;25(1):9–12.
  • Rezvani O, Shabbak E, Aslani A, Bidar R, Jafari M, Safarnezhad S. A randomized, double-blind, placebo-controlled trial to determine the effects of topical insulin on wound healing. Ostomy Wound Manage. 2009;55(8):22–28.
  • Attia EA, Belal DM, El Samahy MH, El Hamamsy MH. A pilot trial using topical regular crystalline insulin vs. aqueous zinc solution for uncomplicated cutaneous wound healing: impact on quality of life. Wound Repair Regener. 2014;22(1):52–57. doi:10.1111/wrr.12122
  • Stephen S, Agnihotri M, Kaur S, Randomized A. Controlled trial to assess the effect of topical insulin versus normal saline in pressure ulcer healing. Ostomy Wound Manage. 2016;62(6):16–23.
  • Martinez-Jimenez MA, Aguilar-Garcia J, Valdes-rodriguez R, et al. Local use of insulin in wounds of diabetic patients: higher temperature, fibrosis, and angiogenesis. Plast Reconstr Surg. 2013;132(6):1015e–9e. doi:10.1097/PRS.0b013e3182a806f0
  • Martinez-jimenez MA, Valadez-castillo FJ, Aguilar-garcia J, et al. Effects of local use of insulin on wound healing in non-diabetic patients. Plastic Surg. 2018;26(2):75–79. doi:10.1177/2292550317740688
  • Zhang Z, Lv L. Effect of local insulin injection on wound vascularization in patients with diabetic foot ulcer. Exp Ther Med. 2016;11(2):397–402. doi:10.3892/etm.2015.2917
  • Bhittani MK, Rehman M, Altaf HN, Altaf OS. Effectiveness of topical insulin dressings in management of diabetic foot ulcers. World J Surg. 2019. doi:10.1007/s00268-019-05321-3
  • Dawoud MHS, Yassin GE, Ghorab DM, Morsi NM. Insulin mucoadhesive liposomal gel for wound healing: a formulation with sustained release and extended stability using quality by design approach. AAPS Pharm Sci Tech. 2019;20(4):158. doi:10.1208/s12249-019-1363-6