Advanced search
Publication Cover
Diabetes, Metabolic Syndrome and Obesity Volume 13, 2020 - Issue
Submit an article Journal homepage
119
Views
6
CrossRef citations to date
0
Altmetric
Original Research

Lower Levels of Circulating Adiponectin in Elderly Patients with Metabolic Inflammatory Syndrome: A Cross-Sectional Study

Lina Ma1 Department of Geriatrics, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing100053, People’s Republic of ChinaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0001-7630-6960View further author information
ORCID Icon,
Yanhong Xu1 Department of Geriatrics, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing100053, People’s Republic of China;2 Department of Geriatrics, Miyun Teaching Hospital of Capital Medical University, Beijing101500, People’s Republic of ChinaView further author information
,
Yaxin Zhang1 Department of Geriatrics, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing100053, People’s Republic of ChinaView further author information
,
Tong Ji1 Department of Geriatrics, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing100053, People’s Republic of ChinaView further author information
&
Yun Li1 Department of Geriatrics, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing100053, People’s Republic of ChinaView further author information
Pages 591-596 | Published online: 28 Feb 2020

References

  • The Global Burden of Metabolic Risk Factors for Chronic Diseases Collaboration. Cardiovascular disease, chronic kidney disease, and diabetes mortality burden of cardiometabolic risk factors from 1980 to 2010: a comparative risk assessment. Lancet Diabetes Endocrinol. 2014;2(8):634–647. doi:10.1016/S2213-8587(14)70102-0
  • Esser N, Legrand-Poels S, Piette J, et al. Inflammation as a link between obesity, metabolic syndrome and type 2 diabetes. Diabetes Res Clin Pract. 2014;105(2):141–150. doi:10.1016/j.diabres.2014.04.006
  • Hotamisligil GS. Inflammation and metabolic disorders. Nature. 2006;444:860–867. doi:10.1038/nature05485
  • Hu R, Xie Y, Lu B, et al. Metabolic inflammatory syndrome: a novel concept of holistic integrative medicine for management of metabolic diseases. AME Med J. 2018;3:51. doi:10.21037/amj
  • Hu R. Concept and clinical significance of metabolic inflammatory syndrome. Clin Focus. 2016;31(9):960–963.
  • Li R, Hu R. Progress in the pathogenesis of metabolic inflammatory syndrome. Fudan Univ J Med Sci. 2017;44(3):380–384.
  • Hu R, Xie Y, Lu B, et al. High detective rate of “metabolic inflammatory syndrome” in patients with type 2 diabetes. Chin J Endocrinol Metab. 2016;32:27–32.
  • Adiyaman SC, Ozer M, Saydam BO, et al. The role of adiponectin in maintaining metabolic homeostasis. Curr Diabetes Rev. 2019. doi:10.2174/1573399815666190702155733
  • Lara-Castro C, Fu Y, Chung BH, et al. Adiponectin and the metabolic syndrome: mechanisms mediating risk for metabolic and cardiovascular disease. Curr Opin Lipidol. 2007;18:263–270. doi:10.1097/MOL.0b013e32814a645f
  • Shih CH, Hsu BG, Hou JS, et al. Association of low serum adiponectin levels with aortic arterial stiffness in patients with type 2 diabetes. J Clin Med. 2019;8(6):E887. doi:10.3390/jcm8060887
  • Yanai H, Yoshida H. Beneficial Effects of adiponectin on glucose and lipid metabolism and atherosclerotic progression: mechanisms and perspectives. Int J Mol Sci. 2019;20(5):E1190. doi:10.3390/ijms20051190
  • Esfahani M, Movahedian A, Baranchi M, et al. Adiponectin: an adipokine with protective features against metabolic syndrome. Iran J Basic Med Sci. 2015;18(5):430–442.
  • Hung WC, Wang CP, Lu LF, et al. Circulating adiponectin level is associated with major adverse cardiovascular events in type 2 diabetic patients with coronary artery disease. Endocr J. 2010;(57):793–802. doi:10.1507/endocrj.K10E-020
  • Schottker B, Herder C, Rothenbacher D, et al. Proinflammatory cytokines, adiponectin, and increased risk of primary cardiovascular events in diabetic patients with or without renal dysfunction: results from the ESTHER study. Diabetes Care. 2013;36(6):1703–1711. doi:10.2337/dc12-1416
  • Schulze MB, Shai I, Rimm EB, et al. Adiponectin and future coronary heart disease events among men with type 2 diabetes. Diabetes. 2005;54:534–539. doi:10.2337/diabetes.54.2.534
  • Krzyzanowska K, Aso Y, Mittermayer F, et al. High-molecular-weight adiponectin does not predict cardiovascular events in patients with type 2 diabetes. Transl Res. 2009;153(4):199–203. doi:10.1016/j.trsl.2009.01.009
  • Woodward L, Akoumianakis I, Antoniades C. Unravelling the adiponectin paradox: novel roles of adiponectin in the regulation of cardiovascular disease. Br J Pharmacol. 2017;174(22):4007–4020. doi:10.1111/bph.v174.22
  • Krause MP, Milne KJ, Hawke TJ. Adiponectin-consideration for its role in skeletal muscle health. Int J Mol Sci. 2019;20(7):E1528. doi:10.3390/ijms20071528
  • Tilg H, Moschen AR. Inflammatory mechanisms in the regulation of insulin resistance. Mol Med. 2008;14:222–231. doi:10.2119/2007-00119.Tilg
  • Nguyen MT, Fernando S, Schwarz N, et al. Inflammation as a therapeutic target in atherosclerosis. J Clin Med. 2019;8(8):E1109. doi:10.3390/jcm8081109
  • Komohara Y, Fujiwara Y, Ohnishi K, et al. Contribution of macrophage polarization to metabolic diseases. J Atheroscler Thromb. 2016;23(1):10–17. doi:10.5551/jat.32359
  • Fang H, Judd RL. Adiponectin regulation and function. Compr Physiol. 2018;8(3):1031–1063.
  • Knights AJ, Funnell AP, Pearson RC, Crossley M, Bell-Anderson KS. Adipokines and insulin action –A sensitive issue. Landes Biosci. 2014;3(4–6):88–96.
  • Hector J, Schwarzloh B, Goehring J, et al. TNF-alpha alters visfatin and adiponectin levels in human fat. Horm Metab Res. 2007;39:250–255. doi:10.1055/s-2007-973075
  • Maeda N, Shimomura I, Kishida K, et al. Diet-induced insulin resistance in mice lacking adiponectin/ACR P30. Nat Med. 2002;8:731–737. doi:10.1038/nm724

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.