Polymorphisms of the NLRC4 Gene are Associated with the Onset Age, Positive Rate of GADA and 2-h Postprandial C-Peptide in Patients with Type 1 Diabetes

References

• Atkinson MA, Eisenbarth GS, Michels AW. Type 1 diabetes. Lancet. 2014;383(9911):69–82. doi:10.1016/S0140-6736(13)60591-7
   PubMed Web of Science ®Google Scholar
• Bluestone JA, Herold K, Eisenbarth G. Genetics, pathogenesis and clinical interventions in type 1 diabetes. Nature. 2010;464(7293):1293–1300. doi:10.1038/nature08933
   PubMed Web of Science ®Google Scholar
• Xie Z, Chang C, Zhou Z. Molecular mechanisms in autoimmune type 1 diabetes: a critical review. Clin Rev Allergy Immunol. 2014;47(2):174–192. doi:10.1007/s12016-014-8422-2
   PubMed Web of Science ®Google Scholar
• Mayer-Davis EJ, Dabelea D, Lawrence JM. Incidence trends of type 1 and type 2 diabetes among youths, 2002–2012. N Engl J Med. 2017;377(3):301.
   PubMedGoogle Scholar
• Patterson CC, GG D, Gyurus E, Green A, Soltesz G, Group ES. Incidence trends for childhood type 1 diabetes in Europe during 1989–2003 and predicted new cases 2005-20: a multicentre prospective registration study. Lancet. 2009;373(9680):2027–2033. doi:10.1016/S0140-6736(09)60568-7
   PubMed Web of Science ®Google Scholar
• Noble JA. Immunogenetics of type 1 diabetes: a comprehensive review. J Autoimmun. 2015;64:101–112. doi:10.1016/j.jaut.2015.07.014
   PubMed Web of Science ®Google Scholar
• Pociot F, Lernmark A. Genetic risk factors for type 1 diabetes. Lancet. 2016;387(10035):2331–2339. doi:10.1016/S0140-6736(16)30582-7
   PubMed Web of Science ®Google Scholar
• Lehuen A, Diana J, Zaccone P, Cooke A. Immune cell crosstalk in type 1 diabetes. Nat Rev Immunol. 2010;10(7):501–513. doi:10.1038/nri2787
   PubMed Web of Science ®Google Scholar
• Xie Z, Huang G, Wang Z, Luo S, Zheng P, Zhou Z. Epigenetic regulation of toll-like receptors and its roles in type 1 diabetes. J Mol Med (Berl). 2018;96(8):741–751. doi:10.1007/s00109-018-1660-7
   PubMedGoogle Scholar
• Bauernfeind F, Ablasser A, Bartok E, et al. Inflammasomes: current understanding and open questions. Cell Mol Life Sci. 2011;68(5):765–783. doi:10.1007/s00018-010-0567-4
   PubMed Web of Science ®Google Scholar
• Martinon F, Burns K, Tschopp J. The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. Mol Cell. 2002;10(2):417–426. doi:10.1016/S1097-2765(02)00599-3
   PubMed Web of Science ®Google Scholar
• Sutterwala FS, Mijares LA, Li L, Ogura Y, Kazmierczak BI, Flavell RA. Immune recognition of Pseudomonas aeruginosa mediated by the IPAF/NLRC4 inflammasome. J Exp Med. 2007;204(13):3235–3245. doi:10.1084/jem.20071239
   PubMedGoogle Scholar
• Shaw PJ, McDermott MF, Kanneganti TD. Inflammasomes and autoimmunity. Trends Mol Med. 2011;17(2):57–64.
   PubMed Web of Science ®Google Scholar
• Baroja-Mazo A, Martin-Sanchez F, Gomez AI, et al. The NLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory response. Nat Immunol. 2014;15(8):738–748. doi:10.1038/ni.2919
   PubMed Web of Science ®Google Scholar
• Hoffman HM, Rosengren S, Boyle DL, et al. Prevention of cold-associated acute inflammation in familial cold autoinflammatory syndrome by interleukin-1 receptor antagonist. Lancet. 2004;364(9447):1779–1785. doi:10.1016/S0140-6736(04)17401-1
   PubMed Web of Science ®Google Scholar
• Vandanmagsar B, Youm YH, Ravussin A, et al. The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance. Nat Med. 2011;17(2):179–188. doi:10.1038/nm.2279
   PubMed Web of Science ®Google Scholar
• Dieude P, Guedj M, Wipff J, et al. NLRP1 influences the systemic sclerosis phenotype: a new clue for the contribution of innate immunity in systemic sclerosis-related fibrosing alveolitis pathogenesis. Ann Rheum Dis. 2011;70(4):668–674. doi:10.1136/ard.2010.131243
   PubMedGoogle Scholar
• Jin Y, Mailloux CM, Gowan K, et al. NALP1 in vitiligo-associated multiple autoimmune disease. N Engl J Med. 2007;356(12):1216–1225. doi:10.1056/NEJMoa061592
   PubMed Web of Science ®Google Scholar
• Addobbati C, da Cruz HLA, Adelino JE, et al. Polymorphisms and expression of inflammasome genes are associated with the development and severity of rheumatoid arthritis in Brazilian patients. Inflamm Res. 2018;67(3):255–264. doi:10.1007/s00011-017-1119-2
   PubMed Web of Science ®Google Scholar
• Magitta NF, Boe Wolff AS, Johansson S, et al. A coding polymorphism in NALP1 confers risk for autoimmune Addison’s disease and type 1 diabetes. Genes Immun. 2009;10(2):120–124. doi:10.1038/gene.2008.85
   PubMedGoogle Scholar
• Pontillo A, Brandao L, Guimaraes R, Segat L, Araujo J, Crovella S. Two SNPs in NLRP3 gene are involved in the predisposition to type-1 diabetes and celiac disease in a pediatric population from northeast Brazil. Autoimmunity. 2010;43(8):583–589. doi:10.3109/08916930903540432
   PubMed Web of Science ®Google Scholar
• Sun X, Xia Y, Liu Y, et al. Polymorphisms in NLRP1 gene are associated with type 1 diabetes. J Diabetes Res. 2019;2019:7405120. doi:10.1155/2019/7405120
   PubMed Web of Science ®Google Scholar
• Canna SW, de Jesus AA, Gouni S, et al. An activating NLRC4 inflammasome mutation causes autoinflammation with recurrent macrophage activation syndrome. Nat Genet. 2014;46(10):1140–1146. doi:10.1038/ng.3089
   PubMed Web of Science ®Google Scholar
• Romberg N, Al Moussawi K, Nelson-Williams C, et al. Mutation of NLRC4 causes a syndrome of enterocolitis and autoinflammation. Nat Genet. 2014;46(10):1135–1139. doi:10.1038/ng.3066
   PubMed Web of Science ®Google Scholar
• Gomes Torres A, Leite N, Tureck LV, et al. Association between Toll-like receptors (TLR) and NOD-like receptor (NLR) polymorphisms and lipid and glucose metabolism. Gene. 2019;685:211–221. doi:10.1016/j.gene.2018.11.065
   PubMed Web of Science ®Google Scholar
• Yang L, Luo S, Huang G, et al. The diagnostic value of zinc transporter 8 autoantibody (ZnT8A) for type 1 diabetes in Chinese. Diabetes Metab Res Rev. 2010;26(7):579–584. doi:10.1002/dmrr.v26:7
   PubMedGoogle Scholar
• Yi B, Huang G, Zhou ZG. Current and future clinical applications of zinc transporter-8 in type 1 diabetes mellitus. Chin Med J (Engl). 2015;128(17):2387–2394. doi:10.4103/0366-6999.163389
   PubMed Web of Science ®Google Scholar
• Jin P, Huang G, Lin J, Luo S, Zhou Z. Epitope analysis of GAD65 autoantibodies in adult-onset type 1 diabetes and latent autoimmune diabetes in adults with thyroid autoimmunity. Acta Diabetol. 2011;48(2):149–155. doi:10.1007/s00592-010-0250-0
   PubMedGoogle Scholar
• Jin P, Xiang B, Huang G, Zhou Z. The association of cytotoxic T-lymphocyte antigen-4 + 49A/G and CT60 polymorphisms with type 1 diabetes and latent autoimmune diabetes in Chinese adults. J Endocrinol Invest. 2015;38(2):149–154. doi:10.1007/s40618-014-0162-x
   PubMedGoogle Scholar
• Xiang Y, Huang G, Shan Z, et al. Glutamic acid decarboxylase autoantibodies are dominant but insufficient to identify most Chinese with adult-onset non-insulin requiring autoimmune diabetes: LADA China study 5. Acta Diabetol. 2015;52(6):1121–1127. doi:10.1007/s00592-015-0799-8
   PubMedGoogle Scholar
• Iannitti RG, Napolioni V, Oikonomou V, et al. IL-1 receptor antagonist ameliorates inflammasome-dependent inflammation in murine and human cystic fibrosis. Nat Commun. 2016;7:10791. doi:10.1038/ncomms10791
   PubMed Web of Science ®Google Scholar
• Zeller T, Haase T, Muller C, et al. Molecular characterization of the NLRC4 expression in relation to interleukin-18 levels. Circ Cardiovasc Genet. 2015;8(5):717–726. doi:10.1161/CIRCGENETICS.115.001079
   PubMedGoogle Scholar
• Ravimohan S, Maenetje P, Auld SC, et al. A common NLRC4 gene variant associates with inflammation and pulmonary function in human immunodeficiency virus and tuberculosis. Clin Infect Dis. 2019. doi:10.1093/cid/ciz898
   Google Scholar
• Weng J, Zhou Z, Guo L, et al. Incidence of type 1 diabetes in China, 2010-13: population based study. BMJ. 2018;360:j5295. doi:10.1136/bmj.j5295
   PubMed Web of Science ®Google Scholar
• Qu HQ, Polychronakos C. The effect of the MHC locus on autoantibodies in type 1 diabetes. J Med Genet. 2009;46(7):469–471. doi:10.1136/jmg.2009.066647
   PubMedGoogle Scholar