Hydrogen Sulfide, Adipose Tissue and Diabetes Mellitus

References

• Abe K, Kimura H. The possible role of hydrogen sulfide as an endogenous neuromodulator. J Neurosci. 1996;16(3):1066. doi:10.1523/JNEUROSCI.16-03-01066.1996
   PubMed Web of Science ®Google Scholar
• Sies H, Jones DP. Reactive oxygen species (ROS) as pleiotropic physiological signalling agents. Nat Rev Mol Cell Biol. 2020.
   PubMedGoogle Scholar
• Jain SK, Bull R, Rains JL, et al. Low levels of hydrogen sulfide in the blood of diabetes patients and streptozotocin-treated rats causes vascular inflammation? Antioxid Redox Signal. 2010;12(11):1333–1337. doi:10.1089/ars.2009.2956
   PubMed Web of Science ®Google Scholar
• Yusuf M, Kwong Huat BT, Hsu A, Whiteman M, Bhatia M, Moore PK. Streptozotocin-induced diabetes in the rat is associated with enhanced tissue hydrogen sulfide biosynthesis. Biochem Biophys Res Commun. 2005;333(4):1146–1152. doi:10.1016/j.bbrc.2005.06.021
   PubMed Web of Science ®Google Scholar
• Wu L, Yang W, Jia X, et al. Pancreatic islet overproduction of H2S and suppressed insulin release in Zucker diabetic rats. Lab Invest. 2009;89(1):59–67. doi:10.1038/labinvest.2008.109
   PubMedGoogle Scholar
• Gheibi S, Samsonov AP, Gheibi S, Vazquez AB, Kashfi K. Regulation of carbohydrate metabolism by nitric oxide and hydrogen sulfide: implications in diabetes. Biochem Pharmacol. 2020;113819.
   PubMedGoogle Scholar
• Zhang Y, Yang J, Wang T, et al. Decreased endogenous hydrogen sulfide generation in penile tissues of diabetic rats with erectile dysfunction. J Sex Med. 2016;13(3):350–360. doi:10.1016/j.jsxm.2016.01.002
   PubMedGoogle Scholar
• Kimura H. Signalling by hydrogen sulfide and polysulfides via protein S-sulfuration. Br J Pharmacol. 2020;177:720–733. doi:10.1111/bph.14579
   PubMedGoogle Scholar
• Shibuya N, Koike S, Tanaka M, et al. A novel pathway for the production of hydrogen sulfide from D-cysteine in mammalian cells. Nat Commun. 2013;4(1):1366. doi:10.1038/ncomms2371
   PubMedGoogle Scholar
• Kabil O, Banerjee R. Enzymology of H2S biogenesis, decay and signaling. Antioxid Redox Signal. 2014;20(5):770–782. doi:10.1089/ars.2013.5339
   PubMed Web of Science ®Google Scholar
• Huang CW, Moore PK. H2S synthesizing enzymes: biochemistry and molecular aspects. Handb Exp Pharmacol. 2015;230:3–25.
   PubMedGoogle Scholar
• Ahmad FU, Sattar MA, Rathore HA, et al. Exogenous Hydrogen Sulfide (H2S) reduces blood pressure and prevents the progression of diabetic nephropathy in spontaneously hypertensive rats. Ren Fail. 2012;34(2):203–210. doi:10.3109/0886022X.2011.643365
   PubMed Web of Science ®Google Scholar
• Suzuki K, Sagara M, Aoki C, Tanaka S, Aso Y. Clinical implication of plasma hydrogen sulfide levels in Japanese patients with Type 2 diabetes. Inter Med. 2017;56(1):17–21. doi:10.2169/internalmedicine.56.7403
   PubMedGoogle Scholar
• Ali MY, Whiteman M, Low CM, Moore PK. Hydrogen sulphide reduces insulin secretion from HIT-T15 cells by a KATP channel-dependent pathway. J Endocrinol. 2007;195(1):105–112. doi:10.1677/JOE-07-0184
   PubMed Web of Science ®Google Scholar
• Yang G, Yang W, Wu L, Wang R. H2S, endoplasmic reticulum stress, and apoptosis of insulin-secreting beta cells. J Biol Chem. 2007;282(22):16567–16576. doi:10.1074/jbc.M700605200
   PubMed Web of Science ®Google Scholar
• Yang G, Tang G, Zhang L, Wu L, Wang R. The pathogenic role of cystathionine gamma-lyase/hydrogen sulfide in streptozotocin-induced diabetes in mice. Am J Pathol. 2011;179(2):869–879. doi:10.1016/j.ajpath.2011.04.028
   PubMedGoogle Scholar
• Brancaleone V, Roviezzo F, Vellecco V, De Gruttola L, Bucci M, Cirino G. Biosynthesis of H2S is impaired in non-obese diabetic (NOD) mice. Br J Pharmacol. 2008;155:673–680. doi:10.1038/bjp.2008.296
   PubMed Web of Science ®Google Scholar
• Coppack SW. Adipose tissue changes in obesity. Biochem Soc Trans. 2005;33(5):1049. doi:10.1042/BST0331049
   PubMedGoogle Scholar
• Hajer GR, van Haeften TW, Visseren FLJ. Adipose tissue dysfunction in obesity, diabetes, and vascular diseases. Eur Heart J. 2008;29(24):2959–2971. doi:10.1093/eurheartj/ehn387
   PubMed Web of Science ®Google Scholar
• Unamuno X, Gómez-Ambrosi J. Adipokine dysregulation and adipose tissue inflammation in human obesity. 2018;48:e12997.
   Google Scholar
• Feng X, Chen Y, Zhao J, Tang C, Jiang Z, Geng B. Hydrogen sulfide from adipose tissue is a novel insulin resistance regulator. Biochem Biophys Res Commun. 2009;380(1):153–159. doi:10.1016/j.bbrc.2009.01.059
   PubMed Web of Science ®Google Scholar
• Fang L, Zhao J, Chen Y, et al. Hydrogen sulfide derived from periadventitial adipose tissue is a vasodilator. J Hypertens. 2009;27(11):2174–2185. doi:10.1097/HJH.0b013e328330a900
   PubMed Web of Science ®Google Scholar
• Bełtowski J, Jamroz-Wiśniewska A. Hydrogen sulfide in the adipose tissue-physiology, pathology and a target for pharmacotherapy. Molecules (Basel, Switzerland). 2016;22.
   PubMedGoogle Scholar
• Akash MS, Rehman K, Chen S. Role of inflammatory mechanisms in pathogenesis of type 2 diabetes mellitus. J Cell Biochem. 2013;114(3):525–531. doi:10.1002/jcb.24402
   PubMed Web of Science ®Google Scholar
• Richardson VR, Smith KA, Carter AM. Adipose tissue inflammation: feeding the development of type 2 diabetes mellitus. Immunobiology. 2013;218(12):1497–1504. doi:10.1016/j.imbio.2013.05.002
   PubMed Web of Science ®Google Scholar
• Deng J, Wang M, Guo Y, et al. Activation of α7nAChR via vagus nerve prevents obesity-induced insulin resistance via suppressing endoplasmic reticulum stress-induced inflammation in Kupffer cells. Med Hypotheses. 2020;140:109671. doi:10.1016/j.mehy.2020.109671
   PubMedGoogle Scholar
• Crujeiras AB, Cordero P. Molecular basis of the inflammation related to obesity. Oxid Med Cell Longevity. 2019;2019:5250816.
   PubMedGoogle Scholar
• Reilly SM, Saltiel AR. Adapting to obesity with adipose tissue inflammation. Nat Rev Endocrinol. 2017;13(11):633–643. doi:10.1038/nrendo.2017.90
   PubMed Web of Science ®Google Scholar
• Petrus P, Lecoutre S, Dollet L, et al. Glutamine links obesity to inflammation in human white adipose tissue. Cell Metab. 2020;31(2):375–90.e11. doi:10.1016/j.cmet.2019.11.019
   PubMed Web of Science ®Google Scholar
• Saxton SN, Clark BJ, Withers SB, Eringa EC, Heagerty AM. Mechanistic links between obesity, diabetes, and blood pressure: role of perivascular adipose tissue. Physiol Rev. 2019;99(4):1701–1763. doi:10.1152/physrev.00034.2018
   PubMed Web of Science ®Google Scholar
• Zhu Q, Scherer PE. Immunologic and endocrine functions of adipose tissue: implications for kidney disease. Nat Rev Nephrol. 2018;14(2):105–120. doi:10.1038/nrneph.2017.157
   PubMedGoogle Scholar
• Comas F, Latorre J, Cussó O, et al. Hydrogen sulfide impacts on inflammation-induced adipocyte dysfunction. Food Chem Toxicol. 2019;131:110543.
   PubMedGoogle Scholar
• Chi Q, Chi X, Hu X, Wang S, Zhang H, Li S. The effects of atmospheric hydrogen sulfide on peripheral blood lymphocytes of chickens: perspectives on inflammation, oxidative stress and energy metabolism. Environ Res. 2018;167:1–6. doi:10.1016/j.envres.2018.06.051
   PubMedGoogle Scholar
• Barton M, Meyer MR. HuR-ry up: how hydrogen sulfide protects against atherosclerosis. Circulation. 2019;139(1):115–118. doi:10.1161/CIRCULATIONAHA.118.036854
   PubMedGoogle Scholar
• Xie L, Gu Y, Wen M, et al. Hydrogen sulfide induces Keap1 s-sulfhydration and suppresses diabetes-accelerated atherosclerosis via Nrf2 activation. Diabetes. 2016;65(10):3171–3184. doi:10.2337/db16-0020
   PubMed Web of Science ®Google Scholar
• Luo ZL, Ren JD, Huang Z, et al. The role of exogenous hydrogen sulfide in free fatty acids induced inflammation in macrophages. Cell Physiol Biochem. 2017;42:1635–1644. doi:10.1159/000479405
   PubMedGoogle Scholar
• Suzuki K, Olah G, Modis K, et al. Hydrogen sulfide replacement therapy protects the vascular endothelium in hyperglycemia by preserving mitochondrial function. Proc Natl Acad Sci U S A. 2011;108(33):13829–13834. doi:10.1073/pnas.1105121108
   PubMed Web of Science ®Google Scholar
• Cheng Z, Shen X, Jiang X, et al. Hyperhomocysteinemia potentiates diabetes-impaired EDHF-induced vascular relaxation: role of insufficient hydrogen sulfide. Redox Biol. 2018;16:215–225. doi:10.1016/j.redox.2018.02.006
   PubMed Web of Science ®Google Scholar
• Cheng Z, Garikipati VN, Nickoloff E, et al. Restoration of hydrogen sulfide production in diabetic mice improves reparative function of bone marrow cells. Circulation. 2016;134(19):1467–1483. doi:10.1161/CIRCULATIONAHA.116.022967
   PubMed Web of Science ®Google Scholar
• Whiteman M, Gooding KM, Whatmore JL, et al. Adiposity is a major determinant of plasma levels of the novel vasodilator hydrogen sulphide. Diabetologia. 2010;53(8):1722–1726. doi:10.1007/s00125-010-1761-5
   PubMed Web of Science ®Google Scholar
• Pan Z, Wang H, Liu Y, et al. Involvement of CSE/H2S in high glucose induced aberrant secretion of adipokines in 3T3-L1 adipocytes. Lipids Health Dis. 2014;13(1):155. doi:10.1186/1476-511X-13-155
   PubMedGoogle Scholar
• Velmurugan GV, Huang H, Sun H, et al. Depletion of H2S during obesity enhances store-operated Ca2+entry in adipose tissue macrophages to increase cytokine production. Sci Signal. 2015;8(407):ra128. doi:10.1126/scisignal.aac7135
   PubMedGoogle Scholar
• Zhou X, Yang W, Li J. Ca2+- and protein kinase C-dependent signaling pathway for nuclear Factor-κB activation, inducible nitric-oxide synthase expression, and tumor necrosis factor-α production in lipopolysaccharide-stimulated rat peritoneal macrophages. J Biol Chem. 2006;281(42):31337–31347. doi:10.1074/jbc.M602739200
   PubMed Web of Science ®Google Scholar
• Kim Y, Moon JS, Lee KS, et al. Ca2+/calmodulin-dependent protein phosphatase calcineurin mediates the expression of iNOS through IKK and NF-kappaB activity in LPS-stimulated mouse peritoneal macrophages and RAW 264.7 cells. Biochem Biophys Res Commun. 2004;314(3):695–703. doi:10.1016/j.bbrc.2003.12.153
   PubMedGoogle Scholar
• Barazzoni R, Gortan Cappellari G, Ragni M, Nisoli E. Insulin resistance in obesity: an overview of fundamental alterations. Eating Weight Disord. 2018;23(2):149–157. doi:10.1007/s40519-018-0481-6
   PubMed Web of Science ®Google Scholar
• Feller DD, Feist E. Conversion of methionine and threonine to fatty acids by adipose tissue. Can J Biochem Physiol. 1963;41(1):269–273. doi:10.1139/y63-034
   PubMedGoogle Scholar
• Heeren J, Scheja L. Brown adipose tissue and lipid metabolism. Curr Opin Lipidol. 2018;29(3):180–185. doi:10.1097/MOL.0000000000000504
   PubMedGoogle Scholar
• Antonopoulos AS, Tousoulis D. The molecular mechanisms of obesity paradox. Cardiovasc Res. 2017;113(9):1074–1086. doi:10.1093/cvr/cvx106
   PubMed Web of Science ®Google Scholar
• Kim WJ, Lee W, Jung Y, Jang HJ, Kim YK, Kim SN. PPARβ/δ agonist GW501516 inhibits TNFα-induced repression of adiponectin and insulin receptor in 3T3-L1 adipocytes. Biochem Biophys Res Commun. 2019;510(4):621–628. doi:10.1016/j.bbrc.2019.02.013
   PubMedGoogle Scholar
• Palit SP, Patel R, Jadeja SD, Rathwa N, Mahajan A, Ramachandran AV. A genetic analysis identifies a haplotype at adiponectin locus: association with obesity and type 2 diabetes. Sci Rep. 2020;10:2904.
   PubMedGoogle Scholar
• Bermúdez VJ, Rojas E, Toledo A, et al. Single-nucleotide polymorphisms in adiponectin, AdipoR1, and AdipoR2 genes: insulin resistance and type 2 diabetes mellitus candidate genes. Am J Ther. 2013;20(4):414–421. doi:10.1097/MJT.0b013e318235f206
   PubMedGoogle Scholar
• Huang CY, Yao WF, Wu WG, Lu YL, Wan H, Wang W. Endogenous CSE/H2 S system mediates TNF-alpha-induced insulin resistance in 3T3-L1 adipocytes. Cell Biochem Funct. 2013;31:468–475. doi:10.1002/cbf.2920
   PubMedGoogle Scholar
• Manna P, Jain SK. Vitamin D up-regulates glucose transporter 4 (GLUT4) translocation and glucose utilization mediated by cystathionine-gamma-lyase (CSE) activation and H2S formation in 3T3L1 adipocytes. J Biol Chem. 2012;287:42324–42332. doi:10.1074/jbc.M112.407833
   PubMed Web of Science ®Google Scholar
• Manna P, Jain SK. Hydrogen sulfide and L-cysteine increase phosphatidylinositol 3,4,5-trisphosphate (PIP3) and glucose utilization by inhibiting phosphatase and tensin homolog (PTEN) protein and activating phosphoinositide 3-kinase (PI3K)/serine/threonine protein kinase (AKT)/protein kinase Czeta/lambda (PKCzeta/lambda) in 3T3l1 adipocytes. J Biol Chem. 2011;286:39848–39859.
   PubMed Web of Science ®Google Scholar
• Manna P, Jain SK. Hydrogen sulfide and L-cysteine increase phosphatidylinositol 3,4,5-trisphosphate (PIP3) and glucose utilization by inhibiting phosphatase and tensin homolog (PTEN) protein and activating phosphoinositide 3-kinase (PI3K)/serine/threonine protein kinase (AKT)/protein kinase Cζ/λ (PKCζ/λ) in 3T3l1 adipocytes. J Biol Chem. 2011;286(46):39848–39859.
   PubMedGoogle Scholar
• Xue R, Hao DD, Sun JP, et al. Hydrogen sulfide treatment promotes glucose uptake by increasing insulin receptor sensitivity and ameliorates kidney lesions in type 2 diabetes. Antioxid Redox Signal. 2013;19:5–23. doi:10.1089/ars.2012.5024
   PubMed Web of Science ®Google Scholar
• Geng B, Cai B, Liao F, et al. Increase or decrease hydrogen sulfide exert opposite lipolysis, but reduce global insulin resistance in high fatty diet induced obese mice. PLoS One. 2013;8(9):e73892. doi:10.1371/journal.pone.0073892
   PubMed Web of Science ®Google Scholar
• Geng B. [Adipocytic endogenous hydrogen sulfide-function,regulation and diseases]. Sheng li Ke Xue Jin Zhan [Progress in Physiology]. 2017;48(1):37–41. Chinese.
   PubMedGoogle Scholar
• Lee WH, Rho JG, Han HS, et al. Self-assembled hyaluronic acid nanoparticle suppresses fat accumulation via CD44 in diet-induced obese mice. Carbohydr Polym. 2020;237:116161. doi:10.1016/j.carbpol.2020.116161
   PubMedGoogle Scholar
• Duncan RE, Ahmadian M, Jaworski K, Sarkadi-Nagy E, Sul HS. Regulation of lipolysis in adipocytes. Annu Rev Nutr. 2007;27(1):79–101. doi:10.1146/annurev.nutr.27.061406.093734
   PubMedGoogle Scholar
• Abranches MV, Oliveira FC, Conceicao LL, Peluzio MD. Obesity and diabetes: the link between adipose tissue dysfunction and glucose homeostasis. Nutr Res Rev. 2015;28:121–132. doi:10.1017/S0954422415000098
   PubMed Web of Science ®Google Scholar
• Tsai CY, Peh MT, Feng W, Dymock BW, Moore PK. Hydrogen sulfide promotes adipogenesis in 3T3L1 cells. PLoS One. 2015;10:e0119511. doi:10.1371/journal.pone.0119511
   PubMed Web of Science ®Google Scholar
• Haj-Yasein NN, Berg O, Jerneren F, Refsum H, Nebb HI, Dalen KT. Cysteine deprivation prevents induction of peroxisome proliferator-activated receptor gamma-2 and adipose differentiation of 3T3-L1 cells. Biochim Biophys Acta. 2017;1862:623–635.
   PubMed Web of Science ®Google Scholar
• Cai J, Shi X, Wang H, et al. Cystathionine gamma lyase-hydrogen sulfide increases peroxisome proliferator-activated receptor gamma activity by sulfhydration at C139 site thereby promoting glucose uptake and lipid storage in adipocytes. Biochim Biophys Acta. 2016;1861:419–429. doi:10.1016/j.bbalip.2016.03.001
   PubMed Web of Science ®Google Scholar
• Haj-Yasein NN, Berg O, Jernerén F, Refsum H, Nebb HI, Dalen KT. Cysteine deprivation prevents induction of peroxisome proliferator-activated receptor gamma-2 and adipose differentiation of 3T3-L1 cells. Biochimica Et Biophysica Acta Molecular and Cell Biology of Lipids. 2017;1862(6):623–635.
   PubMed Web of Science ®Google Scholar
• Soltis EE, Cassis LA. Influence of perivascular adipose tissue on rat aortic smooth muscle responsiveness. Clin Exp Hypertension Part A. 1991;13(2):277–296. doi:10.3109/10641969109042063
   PubMed Web of Science ®Google Scholar
• Kassam SI, Lu C, Buckley N, Gao YJ, Lee RM. Modulation of thiopental-induced vascular relaxation and contraction by perivascular adipose tissue and endothelium. Br J Anaesth. 2012;109(2):177–184. doi:10.1093/bja/aes127
   PubMedGoogle Scholar
• Oriowo MA. Perivascular adipose tissue, vascular reactivity and hypertension. Med Principl Pract. 2015;24(Suppl 1):29–37. doi:10.1159/000356380
   PubMedGoogle Scholar
• Szasz T, Webb RC. Perivascular adipose tissue: more than just structural support. Clin sci. 2012;122(1):1–12. doi:10.1042/CS20110151
   Web of Science ®Google Scholar
• Gollasch M. Vasodilator signals from perivascular adipose tissue. Br J Pharmacol. 2012;165(3):633–642. doi:10.1111/j.1476-5381.2011.01430.x
   PubMed Web of Science ®Google Scholar
• Stasko A, Brezova V, Zalibera M, Biskupic S, Ondrias K. Electron transfer: a primary step in the reactions of sodium hydrosulphide, an H2S/HS−donor. Free Radic Res. 2009;43(6):581–593. doi:10.1080/10715760902977416
   PubMed Web of Science ®Google Scholar
• Gamper N, Zaika O, Li Y, et al. Oxidative modification of M-type K+ channels as a mechanism of cytoprotective neuronal silencing. EMBO J. 2006;25(20):4996–5004. doi:10.1038/sj.emboj.7601374
   PubMedGoogle Scholar
• Schleifenbaum J, Kohn C, Voblova N, et al. Systemic peripheral artery relaxation by KCNQ channel openers and hydrogen sulfide. J Hypertens. 2010;28(9):1875–1882. doi:10.1097/HJH.0b013e32833c20d5
   PubMed Web of Science ®Google Scholar
• Kohn C, Schleifenbaum J, Szijarto IA, et al. Differential effects of cystathionine-gamma-lyase-dependent vasodilatory H2S in periadventitial vasoregulation of rat and mouse aortas. PLoS One. 2012;7(8):e41951.
   PubMed Web of Science ®Google Scholar
• Emilova R, Dimitrova D, Mladenov M, Daneva T, Schubert R, Gagov H. Cystathionine gamma-lyase of perivascular adipose tissue with reversed regulatory effect in diabetic rat artery. Biotechnol Biotechnol Equip. 2015;29(1):147–151. doi:10.1080/13102818.2014.991565
   PubMed Web of Science ®Google Scholar
• Queiroz M, Sena CM. Perivascular adipose tissue in age-related vascular disease. Ageing Res Rev. 2020;59:101040. doi:10.1016/j.arr.2020.101040
   PubMedGoogle Scholar
• Köhn C, Schleifenbaum J, Szijártó IA, et al. Differential effects of cystathionine-γ-lyase-dependent vasodilatory H2S in periadventitial vasoregulation of rat and mouse aortas. PLoS One. 2012;7(8):e41951.
   PubMed Web of Science ®Google Scholar
• Orlov SN, Gusakova SV, Smaglii LV, Koltsova SV, Sidorenko SV. Vasoconstriction triggered by hydrogen sulfide: evidence for Na(+),K(+),2Cl(-)cotransport and L-type Ca(2+) channel-mediated pathway. Biochem Biophys Rep. 2017;12:220–227. doi:10.1016/j.bbrep.2017.09.010
   PubMedGoogle Scholar
• Yamauchi T, Kamon J, Waki H, et al. The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat Med. 2001;7(8):941–946. doi:10.1038/90984
   PubMed Web of Science ®Google Scholar
• Ran J, Hirano T, Fukui T, et al. Angiotensin II infusion decreases plasma adiponectin level via its type 1 receptor in rats: an implication for hypertension-related insulin resistance. Metabolism. 2006;55(4):478–488. doi:10.1016/j.metabol.2005.10.009
   PubMedGoogle Scholar
• Chu NF, Spiegelman D, Hotamisligil GS, Rifai N, Stampfer M, Rimm EB. Plasma insulin, leptin, and soluble TNF receptors levels in relation to obesity-related atherogenic and thrombogenic cardiovascular disease risk factors among men. Atherosclerosis. 2001;157(2):495–503. doi:10.1016/S0021-9150(00)00755-3
   PubMedGoogle Scholar
• Fruhbeck G, Catalan V, Gomez-Ambrosi J, Rodriguez A. Aquaporin-7 and glycerol permeability as novel obesity drug-target pathways. Trends Pharmacol Sci. 2006;27(7):345–347. doi:10.1016/j.tips.2006.05.002
   PubMedGoogle Scholar
• Gomez-Ambrosi J, Catalan V, Ramirez B, et al. Plasma osteopontin levels and expression in adipose tissue are increased in obesity. J Clin Endocrinol Metab. 2007;92(9):3719–3727. doi:10.1210/jc.2007-0349
   PubMedGoogle Scholar
• Furuhashi M, Fucho R, Gorgun CZ, Tuncman G, Cao H, Hotamisligil GS. Adipocyte/macrophage fatty acid-binding proteins contribute to metabolic deterioration through actions in both macrophages and adipocytes in mice. J Clin Invest. 2008;118:2640–2650. doi:10.1172/JCI34750
   PubMed Web of Science ®Google Scholar
• Matsuzawa Y. Therapy Insight: adipocytokines in metabolic syndrome and related cardiovascular disease. Nat Clin Pract Cardiovasc Med. 2006;3(1):35–42. doi:10.1038/ncpcardio0380
   PubMedGoogle Scholar
• Fruhbeck G. The Sir David Cuthbertson Medal Lecture. Hunting for new pieces to the complex puzzle of obesity. Proc Nutr Soc. 2006;65:329–347.
   PubMedGoogle Scholar
• Zhang Y, Zitsman JL, Hou J, et al. Fat cell size and adipokine expression in relation to gender, depot, and metabolic risk factors in morbidly obese adolescents. Obesity (Silver Spring, Md). 2014;22(3):691–697. doi:10.1002/oby.20528
   PubMedGoogle Scholar
• Mihu D, Ciortea R, Mihu CM. Abdominal adiposity through adipocyte secretion products, a risk factor for endometrial cancer. Gynecol Endocrinol. 2013;29(5):448–451. doi:10.3109/09513590.2012.752452
   PubMed Web of Science ®Google Scholar
• Fischer-Posovszky P, Hebestreit H, Hofmann AK, et al. Role of CD95-mediated adipocyte loss in autoimmune lipodystrophy. J Clin Endocrinol Metab. 2006;91(3):1129–1135. doi:10.1210/jc.2005-0737
   PubMedGoogle Scholar
• Prins JB, Walker NI, Winterford CM, Cameron DP. Human adipocyte apoptosis occurs in malignancy. Biochem Biophys Res Commun. 1994;205(1):625–630. doi:10.1006/bbrc.1994.2711
   PubMedGoogle Scholar
• Domingo P, Matias-Guiu X, Pujol RM, et al. Subcutaneous adipocyte apoptosis in HIV-1 protease inhibitor-associated lipodystrophy. AIDS (London, England). 1999;13(16):2261–2267. doi:10.1097/00002030-199911120-00008
   PubMedGoogle Scholar
• Ortiz VE, Vidal-Melo MF, Walsh JL. Strategies for managing oxygenation in obese patients undergoing laparoscopic surgery. Surg Obesity Related Dis. 2015;11(3):721–728. doi:10.1016/j.soard.2014.11.021
   PubMed Web of Science ®Google Scholar
• Gong L, Zou Z, Huang L, Guo S, Xing D. Photobiomodulation therapy decreases free fatty acid generation and release in adipocytes to ameliorate insulin resistance in type 2 diabetes. Cell Signal. 2020;67:109491. doi:10.1016/j.cellsig.2019.109491
   PubMed Web of Science ®Google Scholar
• Hosogai N, Fukuhara A, Oshima K, et al. Adipose tissue hypoxia in obesity and its impact on adipocytokine dysregulation. Diabetes. 2007;56(4):901–911. doi:10.2337/db06-0911
   PubMed Web of Science ®Google Scholar
• Prins JB, Walker NI, Winterford CM, Cameron DP. Apoptosis of human adipocytes in vitro. Biochem Biophys Res Commun. 1994;201(2):500–507. doi:10.1006/bbrc.1994.1730
   PubMedGoogle Scholar
• Papineau D, Gagnon A, Sorisky A. Apoptosis of human abdominal preadipocytes before and after differentiation into adipocytes in culture. Metabolism. 2003;52(8):987–992. doi:10.1016/S0026-0495(03)00165-3
   PubMedGoogle Scholar
• Chaiittianan R, Sutthanut K, Rattanathongkom A. Purple corn silk: a potential anti-obesity agent with inhibition on adipogenesis and induction on lipolysis and apoptosis in adipocytes. J Ethnopharmacol. 2017;201:9–16. doi:10.1016/j.jep.2017.02.044
   PubMed Web of Science ®Google Scholar
• Hamrick MW, Della Fera MA, Choi YH, Hartzell D, Pennington C, Baile CA. Injections of leptin into rat ventromedial hypothalamus increase adipocyte apoptosis in peripheral fat and in bone marrow. Cell Tissue Res. 2007;327(1):133–141. doi:10.1007/s00441-006-0312-3
   PubMedGoogle Scholar
• Jung TW, Kim ST, Lee JH, et al. Phosphatidylcholine causes lipolysis and apoptosis in adipocytes through the tumor necrosis factor alpha-dependent pathway. Pharmacology. 2018;101(3–4):111–119. doi:10.1159/000481571
   PubMedGoogle Scholar
• Yang J-Y, Della-Fera MA, Rayalam S, Baile CA. Effect of xanthohumol and isoxanthohumol on 3T3-L1 cell apoptosis and adipogenesis. Apoptosis. 2007;12(11):1953–1963. doi:10.1007/s10495-007-0130-4
   PubMedGoogle Scholar
• Yang JY, Della-Fera MA, Nelson-Dooley C, Baile CA. Molecular mechanisms of apoptosis induced by ajoene in 3T3-L1 adipocytes. Obesity (Silver Spring, Md). 2006;14(3):388–397. doi:10.1038/oby.2006.52
   PubMedGoogle Scholar
• Rayalam S, Yang JY, Ambati S, Della-Fera MA, Baile CA. Resveratrol induces apoptosis and inhibits adipogenesis in 3T3-L1 adipocytes. Phytother Res. 2008;22:1367–1371. doi:10.1002/ptr.2503
   PubMed Web of Science ®Google Scholar
• Ambati S, Yang JY, Rayalam S, Park HJ, Della-Fera MA, Baile CA. Ajoene exerts potent effects in 3T3-L1 adipocytes by inhibiting adipogenesis and inducing apoptosis. Phytother Res. 2009;23(4):513–518. doi:10.1002/ptr.2663
   PubMedGoogle Scholar
• Qi R, Huang J, Wang Q, et al. MicroRNA-224-5p regulates adipocyte apoptosis induced by TNFalpha via controlling NF-kappaB activation. J Cell Physiol. 2018;233:1236–1246. doi:10.1002/jcp.25992
   PubMed Web of Science ®Google Scholar
• Henderson PW, Singh SP, Weinstein AL, et al. Therapeutic metabolic inhibition: hydrogen sulfide significantly mitigates skeletal muscle ischemia reperfusion injury in vitro and in vivo. Plast Reconstr Surg. 2010;126(6):1890–1898. doi:10.1097/PRS.0b013e3181f446bc
   PubMedGoogle Scholar
• Henderson PW, Singh SP, Belkin D, et al. Hydrogen sulfide protects against ischemia-reperfusion injury in an in vitro model of cutaneous tissue transplantation. J Surg Res. 2010;159(1):451–455. doi:10.1016/j.jss.2009.05.010
   PubMedGoogle Scholar
• Aykan A, Ozturk S, Sahin I, Avcu F, Sagkan RI, Isik S. The effects of hydrogen sulfide on adipocyte viability in human adipocyte and adipocyte-derived mesenchymal stem cell cultures under ischemic conditions. Ann Plast Surg. 2015;75(6):657–665. doi:10.1097/SAP.0000000000000595
   PubMedGoogle Scholar
• Powell CR, Dillon KM, Matson JB. A review of hydrogen sulfide (H(2)S) donors: chemistry and potential therapeutic applications. Biochem Pharmacol. 2018;149:110–123. doi:10.1016/j.bcp.2017.11.014
   PubMed Web of Science ®Google Scholar
• Zhao S, Song T, Gu Y, et al. Hydrogen sulfide alleviates liver injury via S-sulfhydrated-Keap1/Nrf2/LRP1 pathway. Hepatology (Baltimore, Md). 2020.
   Google Scholar
• Nin DS, Idres SB, Song ZJ, Moore PK, Deng LW. Biological effects of morpholin-4-Ium 4 Methoxyphenyl (Morpholino) phosphinodithioate and other phosphorothioate-based hydrogen sulfide donors. Antioxid Redox Signal. 2020;32(2):145–158. doi:10.1089/ars.2019.7896
   PubMedGoogle Scholar
• Bayan L, Koulivand PH, Gorji A. Garlic: a review of potential therapeutic effects. Avicenna J Phytomed. 2014;4(1):1–14.
   PubMedGoogle Scholar
• Stein A, Bailey SM. Redox biology of hydrogen sulfide: implications for physiology, pathophysiology, and pharmacology. Redox Biol. 2013;1(1):32–39. doi:10.1016/j.redox.2012.11.006
   PubMedGoogle Scholar